Results in Chemistry最新文献

{"title":"An investigation of the monoamine oxidase inhibition properties of benzothiazole derivatives","authors":"Anandie le Roux ,&nbsp;Anél Petzer ,&nbsp;Stephanus J. Cloete ,&nbsp;Jacobus P. Petzer","doi":"10.1016/j.rechem.2025.102142","DOIUrl":"10.1016/j.rechem.2025.102142","url":null,"abstract":"<div><div>Literature reports that alkyloxy substituted coumarin derivatives inhibit the monoamine oxidase (MAO) enzymes, specifically the MAO-B isoform. To further investigate this finding, the present study synthesised and evaluated a series of alkyloxy substituted benzothiazole derivatives as potential inhibitors of human MAO-A and MAO-B. The results showed that 6-((4-nitrobenzyl)oxy)benzo[<em>d</em>]thiazole (<strong>1f</strong>) was the most potent MAO-A inhibitor with an IC₅₀ value of 0.336 μM, while the most potent MAO-B inhibitors were 6-((3-chlorobenzyl)oxy)benzo[<em>d</em>]thiazole (<strong>1e</strong>) and 4-((benzo[<em>d</em>]thiazol-6-yloxy)methyl)benzonitrile (<strong>1i</strong>), which both demonstrated IC₅₀ values of 0.0028 μM. For comparison, the reference MAO-A and MAO-B inhibitors, toloxatone and safinamide, exhibited IC₅₀ values of 1.67 and 0.240 μM, respectively. Potential binding modes and interactions of the inhibitors with MAO were proposed with molecular docking. This study concluded that the benzothiazole derivatives were potent and specific MAO-B inhibitors. Inhibitors of MAO-A are used to treat neuropsychiatric disorders (e.g., depression and anxiety disorder), while MAO-B inhibitors are established therapy for Parkinson's disease.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102142"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dendritic fibrous NiMn2O4 in concrete-based materials for oxidative desulfurization of real fuel","authors":"Seyed Mahdi Saadatmand ,&nbsp;Amin Honarbakhsh ,&nbsp;Seyed Mojtaba Movahedifar ,&nbsp;Mehdi Nobahari ,&nbsp;Rahele Zhiani","doi":"10.1016/j.rechem.2025.102165","DOIUrl":"10.1016/j.rechem.2025.102165","url":null,"abstract":"<div><div>Dendritic nanofibrous NiMn₂O₄ (<em>DF</em>NiMn₂O₄) was sustainably synthesized from Ni(NO₃)₂ and Mn(NO₃)₂. It was subsequently incorporated into concrete mortar. The effectiveness of <em>DF</em>NiMn₂O₄ and photocatalytic mortar in light-driven petroleum desulfurization was evaluated. The photoluminescence spectra and desulfurization efficiency of the <em>DF</em>NiMn₂O₄, after immersion in an artificial concrete pore fluid, were assessed to determine its synthetic steadfastness. The desulfurization efficiency of the mortar enhanced as the <em>DF</em>NiMn₂O₄ dosage increased. This concrete demonstrates excellent efficiency in promoting desulfurization under environmentally sustainable conditions. The approach outlined in this study provides multiple advantages, such as considerable economic benefits and compatibility with diverse functional groups. Additionally, these reactions can efficiently process various compounds, including synthetic fuels, sulfur mustard simulants, and natural gasoline. The study revealed that the addition of <em>DF</em>NiMn₂O₄ improved the durability, mechanical properties, and overall resilience of the cement samples. The incorporation of <em>DF</em>NiMn₂O₄ led to a decrease in chloride ion permeability and a reduction in the material's void volume. Additionally, the presence of <em>DF</em>NiMn₂O₄ enhanced the cement mortar's ability to resist compressive forces compared to the control samples.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102165"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new modelling approach for the pyrolysis step in biomass gasification","authors":"Otto A. Ortiz,&nbsp;Laura M. Orozco,&nbsp;Luis A. Rios","doi":"10.1016/j.rechem.2025.102146","DOIUrl":"10.1016/j.rechem.2025.102146","url":null,"abstract":"<div><div>The main goal of this work was to develop an improved pyrolysis model that can be used for gasification simulation. The improvement consisted in introducing additional mass and energy balance equations to two highly cited models, as well as introducing a set of tar model compounds, which are important for modelling the subsequent gasification stages. These changes led to novel results such as: the new model does not give negative concentrations and yields of the products (the already reported ones do), yields of tar model molecules can be predicted in a more accurate fashion that previous models, empirical correlations with extremely low fitting used in reported models are no longer needed. After applying several selection criteria, an improved empirical model for the pyrolysis step in biomass gasification was developed. This improved model allowed obtaining all the parameters that are needed for the further simulation of the gasification process: yield of main pyrolytic fractions, concentrations of gas molecules, element composition of char, element composition of tar and concentrations of molecules present in tar. Reported models have not covered this last issue and it is crucial for the modelling of the gasification reactions. The selected model has element mass balance deviations lower than 6 % and low deviations from the experimental results reported for several biomass samples. The minimum of a sum of squares method, used to solve the equation systems, allowed imposing the positive-value condition for yields and concentrations, leading to physically sound results.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102146"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of a new colorimetric chemosensor based on indicator displacement assay for rapid and selective detection of total phosphate","authors":"Zahra Aryan,&nbsp;Habibollah Khajehsharifi,&nbsp;Hamid Reza Rajabi","doi":"10.1016/j.rechem.2025.102145","DOIUrl":"10.1016/j.rechem.2025.102145","url":null,"abstract":"<div><div>The present study introduces a simple, rapid, and selective method for detecting and determining total phosphate anions (Pi) using an indicator displacement assay (IDA) approach. A simple probe of Yttrium: Eriochrome cyanine R (Y: ECR complex) was chosen to detect Pi. When phosphate anions were added to the Y: ECR complex solution, it caused a color change from purple to yellow, at an optimal pH of 7.00. As the concentration of Y³⁺ increased, the absorption intensity at 441 nm gradually decreased, while a new absorption peak appeared at 531 nm (Δλ = 90 nm). Then, adding phosphate anions to the resulting complex solution increased the absorption intensity at 531 nm and an increase at 441 nm. This significant change was due to the release of ECR and forming a more stable complex between the Pi and Y³⁺. A linear response (R² = 0.9924) was observed within the Pi concentration range of 2.27 to 39.3 μM, with a detection limit of 0.55 μM. A good relative standard deviation (RSD = 1.39 %) was achieved over 10 replicates under optimal conditions. The IDA-based chemosensor was successfully used to recover the total phosphate in water samples (94.25–99.60 %) and urine samples (97.80–103.60 %).</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102145"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cadmium removal from aqueous solutions using olive stone activated carbon","authors":"Karam Haddad ,&nbsp;Mohammad Ghafer ,&nbsp;Hana Salman ,&nbsp;Hossam El-Rakkad","doi":"10.1016/j.rechem.2025.102137","DOIUrl":"10.1016/j.rechem.2025.102137","url":null,"abstract":"<div><div>Activated Carbon (AC) was made from olive stone (OS), which is the basic material in olive industry wastes, by chemical treatment using phosphoric acid H₃PO₄ at 80 % concentration, then a heat treatment at 500 °C for two hours. Olive stone activated carbon (OSAC) was used as an adsorbent to remove Cadmium from aqueous solutions. The morphological and functional groups of the OSAC were determined by SEM, XRD, and FTIR analysis. The optimal conditions for the removal process were studied, and the results showed that the conditions required to reach the highest removal capacity are as follows: contact time of 180 min, particle size of ds ≤ 100 μm, solution pH of 6–7 and OSAC concentration of 0.1 g per 25 mL. The results showed that the adsorption in this study follows the Freundlich model with the correlation coefficient (R² = 0.9943) with maximum removal efficiency (91.6 %), which indicates that the adsorption is competitive and the effective sites are not equal in adsorption capacity.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102137"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidant-free annulation of α-hydroxy ketones with diamines using aluminum(III) chloride: A supramolecular approach for practical quinoxaline synthesis","authors":"Maryam Farajpour Mojdehi,&nbsp;Hani Sayahi,&nbsp;Saeed K. Amini,&nbsp;Farshid Mohsenzadeh,&nbsp;Hossein Reza Darabi,&nbsp;Kioumars Aghapoor","doi":"10.1016/j.rechem.2025.102148","DOIUrl":"10.1016/j.rechem.2025.102148","url":null,"abstract":"<div><div>The conventional reaction of α-hydroxy ketones (acyloins) with arene-1,2-diamines typically requires an oxidant to facilitate a tandem oxidative condensation, resulting in quinoxaline derivatives. In this study, an innovative approach has been introduced that eliminates the need for an oxidant, serving as an alternative to tandem oxidative protocols. Inspired by the ability of 3-hydroxyflavones to chelate Al(III) ions, this study focused on exploring the self-activation of acyloins with AlCl₃ in the oxidant-free synthesis of quinoxalines via the formation of the acyloin@AlCl₃ complex. Thus, when aromatic 1,2-diamines were exposed to the activated acyloin@AlCl₃ complex under ethanolic conditions, high to excellent yields of quinoxalines were achieved. Additionally, the effect of other metal chlorides on the reaction was systematically investigated. To elucidate the specific role of aluminum(III) chloride in the annulation process, density functional theory was employed to show that the benzoin is activated in the presence of AlCl₃ for further condensation reaction. Experimental validation of the model reaction, conducted through cyclic voltammetry corroborated the theoretical findings, demonstrating that benzoin exhibits greater electrochemical activity than benzene-1,2-diamine (<em>ortho</em>-PD) in the presence of AlCl₃. Collectively, these data revealed the self-activation of benzoin as the host through the incorporation of AlCl₃ as the guest.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102148"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New structural scaffolds to enhance the metabolic stability of arginine-derived PAD4 inhibitors","authors":"Yijiang Jia ,&nbsp;Sina Bahraminejad ,&nbsp;Chenyao Jiang ,&nbsp;Ayijiang Taledaohan ,&nbsp;Dejian Ma ,&nbsp;Jianxiong Jiang ,&nbsp;Yuji Wang ,&nbsp;Jiawang Liu","doi":"10.1016/j.rechem.2025.102162","DOIUrl":"10.1016/j.rechem.2025.102162","url":null,"abstract":"<div><div>Although arginine-derived PAD inhibitors represented by Cl-amidine (<strong>2</strong>) showed strong inhibition of PAD4 enzymes and exhibited efficacies in a variety of cellular assays and animal studies, their metabolic instability is a significant challenge for pre-clinical and clinical research. On the basis of the structure of a well-known PAD4 inhibitor BB-Cl-amidine (<strong>3</strong>), we designed two metabolically stable scaffolds, providing two arginine-derived PAD4 inhibitors (<strong>7</strong> and <strong>8</strong>). We evaluated their PAD4 enzyme inhibitory activity <em>in vitro</em> and assessed their metabolic stability using liver microsomal assays. These compounds exhibited PAD4 enzyme inhibitory activity (<strong>7</strong>, IC₅₀ = 124.93 ± 10.21 μM; <strong>8</strong>, IC₅₀ = 46.49 ± 4.46 μM). Hydrolysis of haloacetamidine warheads into hydroxyacetamidine, Compound <strong>7</strong> (t_1/2 &gt; 60 min), significantly improved the metabolic stability of the lead BB-Cl-amidine (t_1/2 = 18.11 min). Compound <strong>8</strong> (t_1/2 &gt; 60 min), the isostere of <strong>7</strong>, also displayed enhanced metabolic stability. Therefore, these two structural scaffolds represent promising new leads for stable PAD4 inhibitors and valuable tools for exploring the reactive cavity of PAD enzymes.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102162"},"PeriodicalIF":2.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of sol-gel and co-precipitation techniques for synthesizing Calotropis Procera-mediated bismuth ferrite for biomedical and environmental applications","authors":"Akasha Fatima ,&nbsp;Muhammad Shahid Khan ,&nbsp;Rabia Ayoub ,&nbsp;Tahira Jabeen ,&nbsp;Yilan Zeng ,&nbsp;Waqar Azeem ,&nbsp;Sana Javaid ,&nbsp;Martin Motola","doi":"10.1016/j.rechem.2025.102149","DOIUrl":"10.1016/j.rechem.2025.102149","url":null,"abstract":"<div><div>Bismuth ferrite (BiFeO₃) nanoparticles were synthesized using <em>Calotropis procera</em> leave extract via sol-gel and co-precipitation methods, yielding distinct structural and functional properties. The sol-gel method produced rhombohedral, rod-like nanoparticles with a crystallite size of 30.25 nm and a lower band gap of 2.31 eV. These characteristics contributed to superior photocatalytic degradation of Rhodamine B, achieving 90.1 % efficiency, alongside enhanced antibacterial activity against <em>Bacillus cereus</em> and <em>Cocci</em>, and higher antioxidant performance with a DPPH radical scavenging rate of 79.99 %. Conversely, the co-precipitation method resulted in rhombohedral, needle-like nanoparticles with a smaller crystallite size of 18.02 nm and a higher band gap of 3.6 eV, leading to lower Rhodamine B degradation efficiency (88.6 %) and reduced antibacterial and antioxidant activities. These findings highlight the effectiveness of the induction of <em>Calotropis procera</em> leave extract and sol-gel method in producing BiFeO₃ nanoparticles with superior properties for environmental and biomedical applications.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102149"},"PeriodicalIF":2.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of a quaternary composite based on RGO/MWCNTs/choline chloride + malonic acid for methyl orange dye adsorption","authors":"Zainab Hussein Abd Al-khuder,&nbsp;Faiq F. Karam","doi":"10.1016/j.rechem.2025.102133","DOIUrl":"10.1016/j.rechem.2025.102133","url":null,"abstract":"<div><div>The objective of this study is to synthesis a quaternary composite of reduced graphene oxide (RGO), miltiwaled carbon nanotube (MWCNTs), choline chloride, and malonic acid by using discrete flame deposition technology to make multi-walled carbon nanotubes. Ascorbic acid was used to produce reduced graphene oxide through reduction and subsequently synthesize the deep eutectic solvent. The product was characterized using several techniques: such as Raman spectroscopy, X-ray difruction (XRD), Fourier transform infrared (FTIR), and field emission scanning electron microscopy (FESEM). The current study used a mixed material made of Deeb Eutictic Sol(DES) like choline chloride and Malonic acid with RGO and MWCNTs to adsorb and remove the dye methyl orange (MO). Some techniques such as: HNMR, C13 and IR tests, were used to examine the data for the eutectic solvents of malonic acid and choline chloride. Efffect of some parametrs upon adsorption of dye were investigated such as weight of adsorbent, the contact time between dye with composite, as well as the temperature, pH and ionic density. Also investigation on the adsorption kinetics, and isotherms were studied. The results showed that according to Giles classification, the adsorption curve on the surface of the prepared compound is (S3) for methyl orange dye, which follows the Freundlich model and enables adsorption. The results of the adsorption study of methyl orange dye at different temperatures showed that the amount of adsorbed dye increases with decreasing temperature, indicating that the adsorption process was thermal and exothermic. The adsorption process of methyl orange dye was studied, where it was found that the highest amount of dye adsorbed on the surface of the prepared compound was pH = 4. The results also showed the effect of ionic strength on the adsorption process of salts (NaCl, CaCO3) where it was found that CaCO3 salts with greater solubility affect the amount of adsorbed material compared to NaCl salts. The results also indicated that the adsorption temperature equation applies to Freundlich and Mecan and does not apply to Langmuir. Therefore, the adsorption is physical adsorption because the surface energy of the adsorbent materials is heterogeneous and multilayered and the enthalpy value for us was a negative value, which confirms the type of adsorption since the adsorption here is physical. The results also showed that the adsorption kinetics study of methyl orange dye is of the pseudo-second order, and its surface adsorption ability was tested by reactivating it after each use by washing it with distilled water, and it was found that it has the ability to adsorption after the activation process with the same efficiency, then a decrease occurs in its surface adsorption ability.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102133"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CNSL green catalyst of sulfone-based Schiff base ligand and its metal(II) complexes: Antibacterial, anticancer and molecular docking studies","authors":"C. Krishna Moorthy ,&nbsp;T. Gomathi ,&nbsp;M. Kannan ,&nbsp;T. Mohana Priya","doi":"10.1016/j.rechem.2025.102131","DOIUrl":"10.1016/j.rechem.2025.102131","url":null,"abstract":"<div><div>Nowadays, the use of many organic solvents poses a serious threat to the atmosphere due to the release of toxic by-products. Therefore, the use of solvent-free green catalysts to solve this problem has brought about a significant change in the field of chemistry. Based on this, a Schiff base ligand is synthesized from the condensation of dapsone (4,4′-sulfonyldianiline) and 4-dimethylaminobenzaldehyde in the presence of green catalyst especially cashwnut shell liquid (CNSL) catalyst. Furthermore, metal(II) complexes Co(II), Ni(II), Cu(II) and Zn(II) were synthesized from a new Schiff base ligand. The composition of the Schiff base ligand and its metal(II) complexes was analyzed by various analytical techniques such as UV, IR, NMR (H¹ &amp; C¹³), Mass spectra and SEM analysis. Schiff base ligand and its complexes were tested <em>in vitro</em> to evaluate their antimicrobial activity against <em>Escherichia coli, Staphylococcus aureus</em> and <em>Candida albicans</em> using a well diffusion method. Schiff base ligand and its complexes were found to exhibit significant antimicrobial activity against all tested bacterial species. The anticancer properties of the Schiff base ligand and its copper(II) complex are evaluated using MTT assay on the human breast cancer cell line MCF-7. Molecular docking study of Cu(II) complex with the target protein HER2 revealed good binding potential.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102131"},"PeriodicalIF":2.5,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}