Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry Pub Date : 2025-05-01 DOI:10.1016/j.rechem.2025.102271

Hussam Elddin Nabeih Khasawneh , Ali Abdulrazzaq Abdulhussein Alrikabi , Amran M. AL-Erjan , Mustafa Jawad Kadham , Raed Fanoukh Aboqader Al-Aouadi , Natrayan Lakshmaiya , Roziyeva Muhayyo , Stefan Bräse , Hadeer M. Farhan

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Abstract

1,2,4-Oxadiazole derivatives, a prominent class of nitrogen-containing heterocycles, have gained considerable attention recently due to their broad spectrum of biological activities. This review focuses on the most recent developments (2018–2024) in the exploration of their therapeutic potential. Studies have highlighted the efficacy of 1,2,4-oxadiazole derivatives in multiple domains, including anticancer, antimicrobial, antidiabetic, anti-inflammatory, and neuroprotective applications. These compounds have demonstrated promising results, particularly in combating drug-resistant pathogens, managing metabolic disorders, and offering potential treatments for neurodegenerative diseases. With a growing body of research supporting their diverse biological roles, 1,2,4-oxadiazole derivatives continue to be a significant focus in drug discovery and development. This review compiles key findings from recent studies, offering insights into their therapeutic applications and potential future directions for research.

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揭示1,2,4-恶二唑衍生物的治疗潜力：最新综述

1,2,4-恶二唑衍生物是一类重要的含氮杂环化合物，近年来因其广泛的生物活性而受到广泛关注。本综述重点介绍了在探索其治疗潜力方面的最新进展（2018-2024）。研究强调了1,2,4-恶二唑衍生物在多个领域的功效，包括抗癌、抗菌、抗糖尿病、抗炎和神经保护应用。这些化合物已显示出有希望的结果，特别是在对抗耐药病原体、管理代谢紊乱和为神经退行性疾病提供潜在治疗方面。随着越来越多的研究支持其多种生物学作用，1,2,4-恶二唑衍生物继续成为药物发现和开发的重要焦点。本综述汇编了近期研究的主要发现，为其治疗应用和潜在的未来研究方向提供了见解。

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