Role of biocompatible PMMA-PEG@Ag nanocomposite in the specific delivery of doxorubicin and resveratrol

Abstract

Doxorubicin (DOX) is the most widely employed chemotherapeutic drug, despite it is frequently associated with severe adverse effects. Resveratrol (RES) is a polyphenolic stilbene derivative found in red wine and grapes, and it is well known for its antioxidant properties. Numerous reports have been proved its excellent potential in anti-inflammatory, anti-aging, and cancer-treatment. Among various cancer deaths, an appealing solution to this might be the targeted distribution of DOX, combined with such natural biomaterials via nanoscale level drug carriers. Earlier, we have reported PEG-PMMA copolymer based nano-carriers that could delivered curcumin only to tumours in a pH-dependent manner and yield an enhanced therapeutic impact. In this connection, here we have proposed a PMMA-PEG@Ag nanocomposite to deliver these natural and commercial drugs (RES and DOX) towards the harmful human tumours. Powder X-ray diffraction (XRD) and scanning electron microscopy (SEM) in conjunction with various spectral techniques were used to investigate its morphology, size (nano-cube like structure around ∼2 nm) and other physical properties. Their potential toxicity towards HEK293, A549, and HeLa cancer cell lines was investigated via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and also the half maximal inhibitory concentration (IC₅₀) values were determined from the MTT assay. The observed in-vitro results revealed that they are effective nanocarriers for biological medications. Furthermore, this PMMA-PEG@Ag nanocomposite loaded with two medicines (RES and DOX) has displayed amazing pharmacokinetic and pharmacodynamic behaviour. Due to their multifunctional properties, this finding may be able to overcome the drawbacks of traditional cancer therapy and open up new therapeutic prospects.