Results in Chemistry最新文献

{"title":"Selenium health impacts and Sub-Saharan regional nutritional challenges: Review","authors":"Loti Kasezga Botha,&nbsp;Sydney Namaumbo,&nbsp;Noel Jabesi Kapito,&nbsp;Patrick Ndovie,&nbsp;Deborah Charles Tsukuluza,&nbsp;Fatema Jagot,&nbsp;Angstone Thembachako Mlangeni","doi":"10.1016/j.rechem.2024.101920","DOIUrl":"10.1016/j.rechem.2024.101920","url":null,"abstract":"<div><div>Selenium is an important micronutrient that plays key functions in antioxidant defense, immune function, and thyroid health. However, its benefits and risks are closely linked to selenium methylation, a process that significantly influences its biological activity and potential toxicity. This review critically analyse the role of selenium methylation in modulating selenium’s effects on health, highlighting its impact on both protective and adverse outcomes. it also discusses the current understanding of selenium’s essential functions and toxicity risks, emphasizing the complexities of Se methylation. The review addresses notable research gaps and controversies, including inconsistent findings on selenium’s cancer-preventive properties, the diverse biological activities of different selenium species, and the challenges in determining optimal selenium intake levels. By synthesizing existing knowledge and identifying key areas for further investigation, this review aims to advance readers’ understanding of selenium’s multifaceted roles that guide future research and public health strategies.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101920"},"PeriodicalIF":2.5,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, biological activity, and modelling protein docking of divalent, trivalent, and tetravalent metal ion complexes of new azo dye ligand (N,N,O) derived from benzimidazole","authors":"Ali Mahmood Taher ,&nbsp;Hussein Ali Kadhim Kyhoiesh ,&nbsp;Azal Shakir Waheeb ,&nbsp;Khalid J. Al-Adilee ,&nbsp;Layth S. Jasim","doi":"10.1016/j.rechem.2024.101911","DOIUrl":"10.1016/j.rechem.2024.101911","url":null,"abstract":"<div><div>The ligand 2-[2′-(benzimidazole)azo]-4,6-dimethyl benzoic acid (BADMB) was employed to create coordination complexes with Pd(II), Co(III), and Pt(IV) ions. A variety of analytical methods were utilized to verify the structures of the synthesized chelates, including microanalysis, ¹H NMR, ¹³C NMR, UV–Vis spectroscopy, FT-IR, mass spectrometry, magnetic susceptibility, molar conductivity, X-ray diffraction (XRD), and thermal analysis. The stoichiometry of the metal complexes was 1:1 [M:L] in the case of both Pd(II) and Pt(IV) complexes while that of the Co(III) complex was 1:2 [M:L]. The results of molar conductivity measurements confirmed that all of the complexes are electrolytes and that they fall within the range 15.74–40.11 Ω⁻¹ cm² mol⁻¹. The findings indicated that the Co(III) and Pt(IV) complexes adopt an octahedral geometry, with the formulas [Co(BADMB)₂]Cl·H₂O and [Pt(BADMB)Cl₃]·H₂O, respectively. In contrast, the Pd(II) complex, represented by the general formula [Pd(BADMB)Cl]·H₂O, has a square planar geometry. BADMB acts as a trident (N,N,O) ligand through two nitrogen atoms from the benzimidazole ring and an azo group and one oxygen atom of the carboxyl group. The antimicrobial activity of these compounds was evaluated against a variety of microorganisms, including <em>Streptococcus</em>, <em>Staphylococcus aureus</em>, <em>Penicillium</em> spp., and <em>Aspergillus</em>, as well as multidrug resistance. In addition, all compounds were active against <em>Penicillium spp.</em> fungi compared to the other microorganisms examined. Moreover, the cytotoxic effects of the BADMB, Pd(II), and Pt(IV) complexes were evaluated in a human hepatocellular carcinoma cell line (HepG2) and a normal cell line (WRL68). A molecular docking study was performed using MOE 2015 software and the PDBsum online server. The compounds showed a binding free energy greater than 5 kcal/mol and an RMSD value was present in the range of 1.41 to 2.01 Å, indicating their potential as ligands for further molecular studies with selected targets.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101911"},"PeriodicalIF":2.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the alumina solubility in low-temperature KF-NaF-AlF3 melts using electrochemical methods","authors":"Sai Krishna Padamata ,&nbsp;Daniel Gunnarsson ,&nbsp;Rauan Meirbekova ,&nbsp;Andrey Yasinskiy ,&nbsp;Gudrun Saevarsdottir","doi":"10.1016/j.rechem.2024.101928","DOIUrl":"10.1016/j.rechem.2024.101928","url":null,"abstract":"<div><div>Alumina solubility in KF-NaF-AlF₃ melt was estimated using square wave voltammetry and linear sweep voltammetry methods. A 45° inclined and horizontal electrode were used in square wave voltammetry and linear sweep voltammetry, respectively. The electrolyte used in this study had a cryolite ratio (CR) of 1.3 and a potassium ratio (KR) of 0.3 at 800 °C. Voltammograms were recorded on both electrodes at different alumina concentrations in the melt. Based on these studies, the alumina solubility in the studied melt is 3.879 wt%, which agrees with the literature.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101928"},"PeriodicalIF":2.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manual and automated synthesis of modified oligonucleotides on core–shell solid supports","authors":"Luis M. Menéndez-Méndez ,&nbsp;Carme Fàbrega ,&nbsp;Anna Aviñó ,&nbsp;Ramon Eritja ,&nbsp;Yoon-Sik Lee ,&nbsp;Yogesh S. Sanghvi ,&nbsp;Susana Fernández ,&nbsp;Miguel Ferrero","doi":"10.1016/j.rechem.2024.101930","DOIUrl":"10.1016/j.rechem.2024.101930","url":null,"abstract":"<div><div>A critical step in the manufacturing of oligonucleotides is the selection of ideal solid supports. Herein, we evaluate a hybrid core–shell solid support made of polystyrene and polyethyleneglycol, for the preparation of oligonucleotides using phosphoramidite chemistry. The results were compared with those obtained using conventional solid supports including controlled-pore glass and polystyrene NittoPhase®. The core–shell supports provided good yields when phosphoramidites were dissolved in dichloromethane. Automatic DNA synthesizer was used to prepare several oligonucleotides carrying natural phosphate, phosphorothioate linkages, lipid conjugates and mesyl phosphoramidate dimers in acceptable yields. This study represents the first reported use of core–shell particles for the synthesis of chemically modified oligonucleotide sequences of therapeutic significance.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101930"},"PeriodicalIF":2.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoration of carbon nanotubes in the substrate or selective layer of polyvinyl alcohol/polysulfone thin-film composite membrane for nanofiltration applications","authors":"Mahdie Safarpour ,&nbsp;Niloofar Fathi Majd ,&nbsp;Samira Jabbarvand Behrouz ,&nbsp;Samira Arefi-Oskoui ,&nbsp;Alireza Khataee","doi":"10.1016/j.rechem.2024.101917","DOIUrl":"10.1016/j.rechem.2024.101917","url":null,"abstract":"<div><div>Nanofiltration (NF) membranes demonstrate considerable promise for desalinating saline water and wastewater containing mineral salts to overcome the lack of fresh water and improve drinking water quality. This research work aims to detect the influence of carbon nanotubes (CNTs) on the filtration performance of polyvinyl alcohol (PVA)/polysulfone (PSf) thin-film composite NF membranes. For this purpose, CNTs were incorporated in the PSf substrate/PVA selective layer to fabricate a thin-film composite (TFC) with nanocomposite substrate (nTFC) and a thin-film nanocomposite (TFN) membranes, respectively. To fabricate TFC membranes, PSf substrates with different concentrations (16–20 wt%) were made using the phase inversion technique. Then, the selective layer of PVA was formed on the PSf support through cross-linking with glutaraldehyde during dip-coating. The membranes’ NF performance was assessed by filtration of NaCl and Na₂SO₄ solutions at a relatively low pressure of 0.3 MPa. The salt rejection of all prepared membranes followed the sequence of Na₂SO₄ &gt; NaCl, indicating the characteristics of negatively charged membranes. By embedment of 0.05 wt% CNT in the PSf substrate/PVA selective layer, the rejections of over 43% for NaCl and over 80% for Na₂SO₄ were obtained, which is higher than that of TFC-16 as a control membrane (18.1% for NaCl and 74.7% for Na₂SO₄). Furthermore, in the presence of CNTs, the permeance and fouling resistance of the nTFC and TFN membranes have been improved compared to the TFC-16 membrane.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 101917"},"PeriodicalIF":2.5,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization and evaluation biological activity of some 2-mercaptobinzemidazol complexes","authors":"Anfal Salam Al-Mahdawi,&nbsp;Noor Sabah Al-Obaidi,&nbsp;Amna Ali Ahmad,&nbsp;Tabarak Ali Jumaa,&nbsp;Zahraa Ali Abas,&nbsp;Haider Salah Mahdi","doi":"10.1016/j.rechem.2024.101893","DOIUrl":"10.1016/j.rechem.2024.101893","url":null,"abstract":"<div><div>This study involved prepare new four complexes of 2-mercaptobenzomidazole with the metals (Cu, Zn, Cd, and Pb). The synthesized complexes were characterize by measuring ultraviolet spectroscopy, the wave length (λ nm) (318, 333.4) of ligand (272, 296.2, 624.8), (254, 306), (257, 311) and (262, 314) of synthesized complexes respectively, then by infrared spectroscopy (FTIR) the results of the infrared spectroscopic examination showed the shifted in the absorption bands of (S-H) and (N-H) groups of the ligand as a result of coordination, molar conductivity, atomic absorption (AAS) spectroscopy and ratio of elements (CHNS) to determine the formulas of the complexes, the complexes shown a distorted octahedral crystal structure, and the molecular formula of the complexes was [M (C₇H₆N₂S)₂Cl₂]. The synthesized complexes were assessed for their biological activity against different four types of bacteria (<em>Staphylococcus aureus, Escherichia coli, spherical bacteria, Staphylococcus epidermidis, and Klebsiella pneumoniae</em>), in addition to a type of <em>Fungus</em>, <em>Candida albicans</em>, the comparison include the activity of the complexes in relation to the antibiotic penicillin and the activity of 2-mercaptobenzomidazole, the prepared complexes had the highest biological activity compared to ligand and the antibiotic penicillin, the best prepared complex was the cadmium complex, the diameter of inhibition ranged between (27–36 nm) against bacteria and (40 nm) against the fungus, the complexes can be suggested as a more activity antibiotic than ligand and penicillin.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 101893"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, molecular docking, ADMET profiling, and anti-PC3 activity of new Schiff base derivatives","authors":"Duaa Qassim Kamil ,&nbsp;Azal Hussein Wasmi ,&nbsp;Wesam Abed AL Hassan Alhaidry ,&nbsp;Mohammed Kassim Al-Hussainawy ,&nbsp;Hussein Ali Kadhim Kyhoiesh","doi":"10.1016/j.rechem.2024.101916","DOIUrl":"10.1016/j.rechem.2024.101916","url":null,"abstract":"<div><div>Schiff bases are significant compounds that occur naturally or can be synthesized in laboratory settings. In this study, we synthesized three novel Schiff bases, designated as compounds 1 to 4, specifically 4-{(E)-[4-(chloromethyl) phenyl] diazenyl}-2-{[(4-substituted phenyl)imino]-methyl}phenol. The synthesis involved the reaction of 5-{(E)-[4-(chloromethyl) phenyl] diazenyl}-2-hydroxybenzaldehyde with various 4-substituted anilines, including 4-ethyl, 4-bromo, and 4-propoxy aniline. The synthesized compounds were characterized using FTIR spectroscopy and ¹H NMR spectroscopy. To evaluate their biological activity, we employed the diffusion method to test the antibacterial efficacy of these compounds against several bacterial strains, namely <em>Bacillus subtilis</em>, <em>Staphylococcus aureus</em>, and <em>Escherichia coli</em>. Among the derivatives tested, derivative 2 exhibited the highest inhibition zone, indicating its potent antibacterial activity. In addition to their antibacterial properties, derivative 3 was assessed for its anti-cancer effects against the PC3 prostate cancer cell line. The results demonstrated a significant reduction in cell viability over time, with an IC₅₀ value of 26.17 μg/mL after 48 h compared to 52.33 μg/mL after 24 h. This suggests that derivative 3 becomes increasingly effective in inhibiting cancer cell proliferation over extended exposure. Furthermore, Schiff bases 1 and 3 were investigated for their ability to inhibit α-amylase derived from the blood of pancreatic cancer patients. Among these, derivative 3 was the most effective, achieving a 39.3 % inhibition at a concentration of 75 μg/mL, highlighting its potential as a therapeutic agent in managing pancreatic cancer. To gain insights into the molecular interactions of the synthesized compounds, docking analysis was performed. Moreover, the synthesized compounds were evaluated against specific bacterial strains using the PDB ID 4URO, further confirming their potential as effective antibacterial agents. In silico ADMET analysis was also conducted to assess the pharmacokinetic properties of the synthesized molecules.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101916"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid synthesis and antifungal evaluation of prenylated chalcones: A structure-activity relationship and molecular docking study","authors":"Rajni Godara ,&nbsp;Kailashpati Tripathi ,&nbsp;Rakesh Kumar ,&nbsp;Parshant Kaushik ,&nbsp;Virendra Singh Rana ,&nbsp;Rajesh Kumar ,&nbsp;Abhishek Mandal ,&nbsp;V. Shanmugam ,&nbsp;Pankaj ,&nbsp;Najam Akhtar Shakil","doi":"10.1016/j.rechem.2024.101912","DOIUrl":"10.1016/j.rechem.2024.101912","url":null,"abstract":"<div><div>Microwave-assisted green synthesis was employed to synthesize a series of prenylated chalcones, resulting from the reaction of 4-prenyloxy-2-hydroxy-acetophenone with diverse benzaldehydes. A comparative analysis of reaction times and yields revealed significant advantages of the microwave method, with reaction times ranging from 1 to 3.2 min, compared to 12 to 48 hrs using conventional methods. The structural elucidation of the synthesized compounds was achieved through a combination of spectroscopic techniques, including IR, ¹H NMR, ¹³C NMR and LC-HRMS. <em>In vitro</em> antifungal assays were performed against <em>Sclerotium rolfsii</em> and <em>Fusarium oxysporum</em> to evaluate the efficacy of these compounds, which was further supported by Structure-activity Relationships (SAR) and molecular docking studies. The most effective compound against <em>S. rolfsii</em>, was found to be 2′-Hydroxy-4-bromo-4′-<em>O</em>-prenylchalcone (<strong>5E</strong>) with ED₅₀ = 23.28 mg L⁻¹, while 2′-Hydroxy-2,6-dichloro-4′-<em>O</em>-prenylchalcone (<strong>5B</strong>) (ED₅₀ = 25.70 mg L⁻¹) exhibited the highest activity against <em>F. oxysporum</em>. The molecular docking study was done for targeting two different fungi, namely, <em>S. rolfsii</em> (<em>DNA directed RNA polymerase</em>: RPB2 gene target) and <em>F. oxysporum</em> (<em>Cutinase:</em> FoCut5a target gene). Docking results showed that the docked molecules exhibited binding energies ranging from −31.0476 to −19.3568 kcal/mol for <em>S. rolfsii</em> and from −38.9474 to −26.5031 kcal/mol for <em>F. oxysporum</em>, highlighting the potential of these compounds as effective inhibitors. Furthermore, additional docking metrics, indicated stable interactions.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101912"},"PeriodicalIF":2.5,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and quality assessments of unary and binary base immersion-fabricated cupric/cuprous oxide nanoflake-coated copper","authors":"Ricky Kristan M. Raguindin","doi":"10.1016/j.rechem.2024.101908","DOIUrl":"10.1016/j.rechem.2024.101908","url":null,"abstract":"<div><div>Mass production practicable fabrication techniques for wide-application-ranged cupric oxide (CuO) or cuprous oxide (Cu₂O) nanostructures are crucial in its research-to-technology thrust. Films of CuO/Cu₂O were grown onto copper as coating via a 16-day unary or binary immersion to solutions of barium hydroxide (Ba(OH)₂) and/or potassium hydroxide (KOH) with varying concentration proportions. Physical inspection and Raman spectroscopy confirms the identity of the grown films to be CuO for all specimens under study except for the copper foil immersed in unary KOH wherein CuO coexists with Cu₂O. Scanning electron microscopy and energy dispersive X-ray spectroscopy (SEM-EDX) reveals the nanoflake morphology of the oxide layers with minimal traces of impurities (maximum impurity: 4.17 At.%) and the abundance of oxygen atoms (41.14–55.68 At.%) among the samples. Copper-to-oxygen ratio of the samples ranged from 0.7 to 1.41. Moreover, analysis of variance (ANOVA) reveals the significant differences of the film and flake thicknesses among the specimens under study. The average nanoflake thickness increases as Ba(OH)₂ amount is decreased as opposed to KOH up to the binary immersed sample with equal component proportions (maximum average: 71.7 nm), then decreases as KOH concentration is increased in expense of Ba(OH)₂ (minimum average: 29.5 nm). The average film thickness is highest for the 75-Ba(OH)₂:25-KOH immersed foil and a decreasing trend is apparent as KOH is further increased at the expense of Ba(OH)₂. Preliminary assessments may qualify the fabricated oxide nanoflakes on copper for potential applications.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101908"},"PeriodicalIF":2.5,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vitro evaluation of antimicrobial efficiency of geranium waste nanomaterial against Escherichia coli and Candida albicans as an alternative to traditional antimicrobials","authors":"Maha M. Kamel ,&nbsp;Abdelfattah Badr ,&nbsp;Dalal Hussien M. Alkhalifah ,&nbsp;Rehab Mahmoud ,&nbsp;Esraa Khaled ,&nbsp;Samah Husseiny ,&nbsp;Sahar Abdel Aleem Abdel Aziz ,&nbsp;Manar Bahaa El Din Mohamed ,&nbsp;Wael N. Hozzein","doi":"10.1016/j.rechem.2024.101900","DOIUrl":"10.1016/j.rechem.2024.101900","url":null,"abstract":"<div><div>Antimicrobial resistance remains a pressing global concern, perpetually challenging medical researchers. Exploring alternatives to traditional antibiotics, particularly those derived from natural sources such as medicinal plants, has garnered significant interest in combating this resistance. In this study, various materials including Mg nanoparticles (NPs), ZnO NPs, Geranium waste (GW), Mg NPs/GW nanocomposite, and ZnO NPs/GW nanocomposite were synthesized using green synthesis methods and characterized using diverse techniques. To evaluate their antimicrobial efficacy, a total of 250 fecal samples were randomly collected on a weekly basis (twice per week) from cattle of different age groups (6 to 9 months) over the study period. <em>Escherichia coli</em> (<em>E. coli</em>) and <em>Candida albicans</em> (<em>C. albicans</em>) were isolated and identified, and the antimicrobial activity of the synthesized materials was assessed against these pathogens. Minimum Inhibitory Concentrations (MICs) results demonstrated that Mg NPs/GW nanocomposite exhibited the most potent activity against <em>E. coli</em>, with a MIC of 7.81 ± 0.4 μg/mL, followed by Mg NPs. Similarly, Minimum Fungicidal Concentrations (MFCc) results indicated that Mg NPs/GW nanocomposite was the most effective against <em>C. albicans</em>, with an MFC of 31.25 ± 0.7 μg/mL. Notably, Mg NPs/GW nanocomposite showed promising results in controlling both <em>E. coli</em> and <em>C. albicans</em>, exhibiting lower MIC and MFC values, thus offering potential in overcoming microbial resistance to conventional antimicrobials.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101900"},"PeriodicalIF":2.5,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}