Results in Chemistry最新文献_第2页

An innovative method for sensitive spectrophotometric estimation of doxorubicin hydrochloride in injections and biological fluids by complex formation with dysprosium

IF 2.5

Results in Chemistry Pub Date : 2025-01-27 DOI: 10.1016/j.rechem.2025.102077

Basima A.A. Saleem, Salim A. Mohammed, Amer Th. Al-Taee

{"title":"An innovative method for sensitive spectrophotometric estimation of doxorubicin hydrochloride in injections and biological fluids by complex formation with dysprosium","authors":"Basima A.A. Saleem, Salim A. Mohammed, Amer Th. Al-Taee","doi":"10.1016/j.rechem.2025.102077","DOIUrl":"10.1016/j.rechem.2025.102077","url":null,"abstract":"<div><div>Doxorubicin hydrochloride is a very important chemical drug widely used in the treatment of number of cancerous diseases. So, it is important to monitor doxorubicin hydrochloride levels during treatment and determine its quantity due to its fatal effect on the heart muscle related to the amount of doses given to a patient. This study adopted a new, simple, rapid, and sensitive spectrophotometric method to determine doxorubicin hydrochloride in an aqueous medium. The method relies on the ability of doxorubicin hydrochloride to form a water-soluble complex with trivalent dysprosium ion. The influences of pH, time, dysprosium quantity, linearity of the calibration curve, temperature and stoichiometric ratio of the product were studied under ideal conditions for the formation of the pink complex between doxorubicin hydrochloride and dysprosium ion. The wavelength in which the compound exhibited the greatest absorption was 534 nm. Beer's law was followed by the calibration curve's linearity in the 0.5–43 μg/L range, with a correlation coefficient of 0.9988. The quantification limit is 0.0352 μg/L, and the detection limit is 0.0112. The relative standard deviation of four replicates was identified to range from 0.032 % to 0.388 %, contingent upon the concentration level of doxorubicin hydrochloride in the sample. In contrast, the accuracy was found to be between 96.33 % and 101.6 %, unaffected by any common excipients present in the samples. The <em>t</em>-test and F-test variables at a 95 % confidence level were analyzed, revealing no significant difference between the recommended and reference techniques.The proposed method has been successfully applied for the determination of doxorubicin hydrochloride in diverse specimens of doxorubicin including pharmaceutical injections and biological fluids (urine and serum).</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102077"},"PeriodicalIF":2.5,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unleashing the cytotoxic potential: Synthesis and evaluation of innovative 4-Phenylbutyrate derivatives for the conquest of ovarian, breast, and lung carcinomas

IF 2.5

Results in Chemistry Pub Date : 2025-01-27 DOI: 10.1016/j.rechem.2025.102076

Mohammad Sharafi Amin , Azar Mostufi , Mahsa Zare , Ali Nosratyan , Mohammad Ahmadi , Masood Fereidoonnezhad

{"title":"Unleashing the cytotoxic potential: Synthesis and evaluation of innovative 4-Phenylbutyrate derivatives for the conquest of ovarian, breast, and lung carcinomas","authors":"Mohammad Sharafi Amin , Azar Mostufi , Mahsa Zare , Ali Nosratyan , Mohammad Ahmadi , Masood Fereidoonnezhad","doi":"10.1016/j.rechem.2025.102076","DOIUrl":"10.1016/j.rechem.2025.102076","url":null,"abstract":"<div><div>The compound 4-phenylbutyrate (4-PBA) has been identified as a potential anticancer agent due to its favorable safety profile, exhibiting minimal side effects. This makes 4-PBA a promising candidate for further development as an anticancer drug. To develop new and potentially more effective anticancer agents, a series of novel derivatives of 4-PBA were synthesized. The chemical structures of the newly synthesized compounds were confirmed through spectroscopic analyses, including <sup>1</sup>H NMR, <sup>13</sup>C NMR, and FTIR spectra. Furthermore, the cytotoxic activity of all the synthesized compounds was evaluated against three different human cancer cell lines - MCF-7 (breast carcinoma), A549 (lung carcinoma), and SKOV-3 (ovarian carcinoma) – as well as MRC5 (normal lung) using the MTT assay. The results revealed that most of the synthesized compounds exhibited significant cytotoxic effects on the A549 and MCF-7 cell lines, while demonstrating a lesser degree of cytotoxicity against SKOV-3. Compound A4 demonstrated particularly potent anticancer activity across all the studied cancer cell lines. Molecular docking studies revealed that the synthesized compounds could inhibit enzymes, including pyruvate dehydrogenase kinase 2 (PDB ID: <span><span>2BU8</span><svg><path></path></svg></span>) and histone deacetylase complex (PDB ID: <span><span>1C3R</span><svg><path></path></svg></span>), by forming hydrogen bonds and hydrophobic interactions. In addition, the pharmacokinetic properties, ADME characteristics, of the synthesized compounds were computationally predicted. These predicted ADME profiles further enhanced the potential of these compounds as effective anticancer agents.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102076"},"PeriodicalIF":2.5,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational evaluation of Khaya ivorensis against plasmodium falciparum aminopeptidase N (PfM1AP) enzyme: Molecular docking, simulation and ADMET studies

IF 2.5

Results in Chemistry Pub Date : 2025-01-25 DOI: 10.1016/j.rechem.2025.102072

Chinenye Ugwah-Oguejiofor , Abayomi Adegboyega , Christiana Salubi , Rita Asomadu , Iyabo Adebisi , Taiwo Oladehinde , Joseph Apata , Mustapha Salihu , Solomon Agu , Ijeoma Esiaba , Titilayo Johnson

{"title":"Computational evaluation of Khaya ivorensis against plasmodium falciparum aminopeptidase N (PfM1AP) enzyme: Molecular docking, simulation and ADMET studies","authors":"Chinenye Ugwah-Oguejiofor , Abayomi Adegboyega , Christiana Salubi , Rita Asomadu , Iyabo Adebisi , Taiwo Oladehinde , Joseph Apata , Mustapha Salihu , Solomon Agu , Ijeoma Esiaba , Titilayo Johnson","doi":"10.1016/j.rechem.2025.102072","DOIUrl":"10.1016/j.rechem.2025.102072","url":null,"abstract":"<div><div>The extract obtained from the stem bark of <em>Khaya ivorensis</em> has been utilized for malaria treatment. Given the rising resistance of malaria parasites to current medications, exploring new pharmacological targets is essential. Metalloaminopeptidases, particularly <em>Pf</em>M1AP, have been identified as promising targets due to their vital role in the survival of the parasite. This study employed computational modeling to evaluate the binding affinities and interaction characteristics of 165 compounds found in <em>K. ivorensis</em> with <em>Pf</em>M1AP. The top five compounds showed binding affinities ranging from −18.306 to −13.073 kcal/mol, significantly higher than the standard ligand's − 7.97 kcal/mol. Among these, pentagalloylglucose displayed the strongest binding affinity and most stable interactions, suggesting its potential as a <em>Pf</em>M1AP inhibitor. ADMET analysis revealed some limitations regarding oral bioavailability and permeability through the blood-brain barrier; however, these compounds exhibited favorable safety profiles with low predicted toxicity levels. Despite the pharmacokinetic challenges, their high binding affinities and stable interactions indicate their potential as effective antimalarial agents. These results highlight the need for further experimental validation and optimization to improve the drug-like properties of these compounds, particularly concerning bioavailability and pharmacokinetic issues. Ultimately, this research contributes to the growing body of work aimed at developing innovative antimalarial treatments and lays the groundwork for future studies focused on targeted approaches against malaria.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102072"},"PeriodicalIF":2.5,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of polyaromatic derivatives of indenopyrrole and investigation of their absorption and emission behaviors

IF 2.5

Results in Chemistry Pub Date : 2025-01-25 DOI: 10.1016/j.rechem.2025.102062

Maedeh Zolfalizadeh, Zarrin Ghasemi, Somayeh Rashtabad Jadidi, Forough Nasuhipur

引用次数: 0

Synthesis of 1H-pyrazolo[3,4-b]pyridine analogues

IF 2.5

Results in Chemistry Pub Date : 2025-01-25 DOI: 10.1016/j.rechem.2025.102075

Yen Nguyen , Greg Petruncio , Schroeder M. Noble , Mikell Paige

引用次数: 0

Magnetic Nanoparticles: Synthesis, characterization and application based on environmental Perspective

IF 2.5

Results in Chemistry Pub Date : 2025-01-23 DOI: 10.1016/j.rechem.2025.102023

Prabu Deivasigamani , Vasu Gajendiran , B. Chitra , P.Senthil Kumar , Nivya Balasubramanian , Sathish Sundararaman , Venkatesan Dhananjeyan , Lalithambegai Subramani , Aravind Kumar Jagadeesan , Selvaraju Sivamani , Rathna Chellappa , Gayathri Rangasamy

{"title":"Magnetic Nanoparticles: Synthesis, characterization and application based on environmental Perspective","authors":"Prabu Deivasigamani , Vasu Gajendiran , B. Chitra , P.Senthil Kumar , Nivya Balasubramanian , Sathish Sundararaman , Venkatesan Dhananjeyan , Lalithambegai Subramani , Aravind Kumar Jagadeesan , Selvaraju Sivamani , Rathna Chellappa , Gayathri Rangasamy","doi":"10.1016/j.rechem.2025.102023","DOIUrl":"10.1016/j.rechem.2025.102023","url":null,"abstract":"<div><div>According to Sustainable DevelopmentGoals (SDG6) access to clean; disinfected water is the most essential human need for prosperity and overall wellness. Billions of people won’t have access to these fundamental services by the end of 2030 unless there is a fourfold increase in global progress. Water contamination by heavy metal pollution is initiated by quick industrialization and urbanization. The ecosystem, including humans and other living things, is in danger because metals are contaminate accessible water supplies. The pollutants in the surface and groundwater, exhibit major toxic characteristics that can pose a severe risk to both people and aquatic life. The drawbacks of various other removal/treatment techniques were analyzed, and the preferred method is adsorption because of its lower usage of chemicals and eco-friendly technique. Owing to enhanced surface acquisition and magnetic qualities, magnetic nanomaterials (MNPs), zero-valent iron (nZVI) and the nZVI incorporated with activated carbon have ample applications in remediating environmental contaminants. These materials were developed using a variety of re-modeling strategies. Furthermore, this paper provides an overview of the sorbent for eradicating toxic contaminants and encompasses exciting opportunities and challenges for research and developing technology improvement through both distinctive as well as efficient strategies.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102023"},"PeriodicalIF":2.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of zeolite-supported CdS/TiO2/Ag2CO3 ternary composite for Photodegradation of methyl Orange

IF 2.5

Results in Chemistry Pub Date : 2025-01-23 DOI: 10.1016/j.rechem.2025.102063

Weynshet Alamaw , Abi M. Taddesse , Abebaw Adgo , Zewdu Bezu , Endale Teju

{"title":"Synthesis and characterization of zeolite-supported CdS/TiO2/Ag2CO3 ternary composite for Photodegradation of methyl Orange","authors":"Weynshet Alamaw , Abi M. Taddesse , Abebaw Adgo , Zewdu Bezu , Endale Teju","doi":"10.1016/j.rechem.2025.102063","DOIUrl":"10.1016/j.rechem.2025.102063","url":null,"abstract":"<div><div>Co-precipitation was used to produce single, binary, and ternary systems of CdS/TiO<sub>2</sub>:Ag<sub>2</sub>CO<sub>3</sub> with varied molar ratios (1:2, 1:3, and 1:4). The impregnation method was also used to fabricate a zeolite-supported CdS/TiO<sub>2</sub>/Ag<sub>2</sub>CO<sub>3</sub> (ZST) composite. XRD, UV–Vis, FTIR, PL, CV, and EIS instruments were employed to investigate the crystal structure, electronic properties, functional groups, optical characteristics, and other properties of the as-prepared composites. The photodegradation studies of all as-produced photocatalysts were assessed employing a solution of model contaminant methyl orange (MO) and real effluent taken from the Bahir Dar Textile Industry. The photodegradation measurements of the CdS/TiO<sub>2</sub>/Ag<sub>2</sub>CO<sub>3</sub> composite (1:2, 1:3, and 1:4) were shown to be superior to those of single and hybrid constituents due to producing an additional avenue for the generation of e<sup>−</sup>-h<sup>+</sup> pairs. Using a zeolite-supported CdS/TiO<sub>2</sub>/Ag<sub>2</sub>CO<sub>3</sub> (ZST) composite, the influence of operative variables like pH, initial dye quantity, and photocatalyst load on MO dye discoloration was examined. At ideal settings, the percent degradation efficiency for the naked CdS/TiO<sub>2</sub>/Ag<sub>2</sub>CO<sub>3</sub> (T1) and zeolite-supported CdS/TiO<sub>2</sub>/Ag<sub>2</sub>CO<sub>3</sub> (ZST) ternary-based composites on the model dye were 82.4 and 91.6 %, respectively. The influence of various trapping agents reveals that the primary species engaged in the decolorization of MO were <sup>•</sup>O<sub>2</sub><sup>−</sup> and <sup>•</sup>OH. The zeolite-supported photocatalyst also had a greater photodegradation efficiency of MO than real effluent samples, with 92.1 and 73.8 %, respectively.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102063"},"PeriodicalIF":2.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrothermally synthesized Fe3O4 microparticles: Structural, magnetic, Mössbauer and magneto-hyperthermia properties

IF 2.5

Results in Chemistry Pub Date : 2025-01-23 DOI: 10.1016/j.rechem.2025.102066

Gopal Niraula , Jose A.H. Coaquira , Edgar Obed Pérez Reyes , Yasir Javed , Edilso Reguera , Joel Garcia , Surender Kumar Sharma

{"title":"Hydrothermally synthesized Fe3O4 microparticles: Structural, magnetic, Mössbauer and magneto-hyperthermia properties","authors":"Gopal Niraula , Jose A.H. Coaquira , Edgar Obed Pérez Reyes , Yasir Javed , Edilso Reguera , Joel Garcia , Surender Kumar Sharma","doi":"10.1016/j.rechem.2025.102066","DOIUrl":"10.1016/j.rechem.2025.102066","url":null,"abstract":"<div><div>We present hydrothermally prepared Fe<sub>3</sub>O<sub>4</sub> microparticles with diverse morphologies such as long micro-rods (LMRs), short micro-rods (SMRs), and micro-disks (MDs) through thermal-reduction of α-Fe<sub>2</sub>O<sub>3</sub>as support during the crystallization processes. The impact of PO<sub>4</sub><sup>3−</sup> anions was systematically explored with significant influence on tuning the prepared materials' sizes/shapes and phase composition/stoichiometry. A lower concentration of PO<sub>4</sub><sup>3−</sup> anions promotes the growth of a mixed iron-oxide phase, for instance, LMRs/SMRs; whereas a higher one results in a pure single-phase cubic Fe<sub>3</sub>O<sub>4</sub>structure (MDs) The line shape of the Fe2p region using the multiplets splitting model suggests that Fe<sub>3</sub>O<sub>4</sub> is mainly present at the surface as validated through Mossbauer spectroscopy. Magnetization measurements revealed an alteration of the Verwey transition from LMRs/SMRs to MDs. Further, these microstructures were examined for their efficiencies in adjusting the hyperthermia response, with specific absorption rates peaking from 2.8 to 3.4 W/g and are noticeably dominated by the shape anisotropy.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102066"},"PeriodicalIF":2.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Yttrium iron garnet: Dodecahedral substitutions

IF 2.5

Results in Chemistry Pub Date : 2025-01-23 DOI: 10.1016/j.rechem.2025.102061

N. Askarzadeh , H. Shokrollahi , L. Karimi

{"title":"Yttrium iron garnet: Dodecahedral substitutions","authors":"N. Askarzadeh , H. Shokrollahi , L. Karimi","doi":"10.1016/j.rechem.2025.102061","DOIUrl":"10.1016/j.rechem.2025.102061","url":null,"abstract":"<div><div>Yttrium iron garnet (YIG) is a widely studied magnetic ceramic known for its low magnetic damping, high electrical resistivity, and low dielectric losses, which make it essential for various applications like microwave and radar systems, spintronic devices, oscillators, filters, phase shifters, and magneto-optical devices. The performance of YIG is closely linked to its physical properties, such as exchange interactions, Curie temperature, magnetic anisotropy, magneto-optic effects, and spin-wave dynamics. In recent years, there has been a growing interest in the impact of doping, particularly with rare earth, bismuth, and strontium elements, on YIG’s properties. Rare earth ions, with their shielded 4f electrons, introduce unique modifications in the dodecahedral sub-lattice, influencing phase formation, structural characteristics, magnetic behavior, and optical performance. This review aims to provide a comprehensive overview of how doping with rare earth elements, bismuth, and strontium affects YIG. It also highlights recent advances in synthesis methods, property optimization, and emerging applications, while emphasizing the role of dopants in tuning YIG for next-generation magneto-optical and spintronic technologies. Finally, the review identifies existing research gaps and suggests potential directions for future studies in this exciting area.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102061"},"PeriodicalIF":2.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrosynthesis of coNi and FeNi LDHs and studying the effect of intercalated cobalt and iron on the electrocatalysis and determination of glucose in human salivary samples

IF 2.5

Results in Chemistry Pub Date : 2025-01-23 DOI: 10.1016/j.rechem.2025.102067

Fatemeh Masoumi, Rahim Mohammad-Rezaei, Mahdi Golmohammadpour

{"title":"Electrosynthesis of coNi and FeNi LDHs and studying the effect of intercalated cobalt and iron on the electrocatalysis and determination of glucose in human salivary samples","authors":"Fatemeh Masoumi, Rahim Mohammad-Rezaei, Mahdi Golmohammadpour","doi":"10.1016/j.rechem.2025.102067","DOIUrl":"10.1016/j.rechem.2025.102067","url":null,"abstract":"<div><div>In this research, two different types of layered double hydroxides (LDHs) based on Fe<img>Ni and Co<img>Ni were electrosynthesized on the surface of carbon ceramic electrode (CCE) as a renewable and polishable substrate and their electrocatalytic response for the detection of glucose in saliva samples were studied. Active surface area and electron transfer performance of CCE/Co-Ni-LDH and CCE/Fe-Ni-LDH were investigated in detail revealing that cobalt is more efficient than iron for intercalation in the LDH structure for electrocatalytic purposes. Based on experimental studies using the chronoamperometry method in the optimized condition, the detection limit, linear range, and sensitivity of the prepared CCE/Co-Ni-LDH for the glucose measurement were found to be 0.104 μM, 0.5–33 μM, and 6.4890 μA μM<sup>−1</sup> cm<sup>−2</sup> respectively, which were remarkably better than CCE/Fe-Ni-LDH. The fastness of the preparation process, renewable surface, and improved analytical performance enabled CCE/Co-Ni-LDH to be a practical sensor for glucose detection in human saliva samples with satisfactory results.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102067"},"PeriodicalIF":2.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0