Results in Chemistry最新文献

{"title":"Enhancing palbociclib efficacy with low toxicity in breast cancer using polycaprolactone-based nanocarriers","authors":"Nastaran Zerang ,&nbsp;Zohreh Mirjafary ,&nbsp;Hamid Saeidian ,&nbsp;Morteza Rouhani","doi":"10.1016/j.rechem.2025.102283","DOIUrl":"10.1016/j.rechem.2025.102283","url":null,"abstract":"<div><div>Breast cancer, stands as a prevalent form of cancer that results in a significant number of fatalities annually. Palbociclib (PAL) functions by impeding the activity of CDK4 and CDK6 proteins, thereby halting the division and generation of new cells within the body. Polycaprolactone-palbociclib (PAL@PCL) nanocapsules were synthesized in the present study. The physicochemical characteristics of the synthesized nanocapsules were examined using ultraviolet–visible spectroscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, and dynamic light scattering analysis. Additionally, the release profile of PAL from the nanocapsules was assessed and analyzed. Moreover, an analysis was carried out on the biological attributes of the PAL@PCL nanocapsules, with a specific emphasis on evaluating cytotoxicity through <em>in vitro</em> experimentation using the MTT assay method on the MCF-7 cell line. Throughout the 40-day period, the nanocapsules demonstrated an average hydrodynamic diameter of 240 nm and an average dispersion index of 0.31. The zeta potential of the PAL@PCL nanocapsules remained negative, indicating their continued stability throughout the entire period. The TEM images indicated that the nanocapsules preserved a spherical morphology with a consistent size distribution, highlighting their ability to resist aggregation. The evaluation of cytotoxic effects and determination of the IC₅₀ value demonstrate a slow and regulated drug release from the nanocapsules, resulting in improved therapeutic characteristics and overall efficiency of the nanocapsules.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102283"},"PeriodicalIF":2.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing a sensitive electrochemical immunosensor for CEA detection utilizing MWCNT/Co(OH)2 as an electrode surface modifying nanocomposite","authors":"Ali Shamsazar ,&nbsp;Mahsa Soheili Moghaddam ,&nbsp;Asadollah Asadi ,&nbsp;Jun Hong","doi":"10.1016/j.rechem.2025.102274","DOIUrl":"10.1016/j.rechem.2025.102274","url":null,"abstract":"<div><div>The development of a sensitive and rapid approach is crucial for the accurate determination of cancer markers in treatment. The present research aimed to design an electrochemical immunosensor with a sandwich-type structure to achieve highly accurate determination of carcinoembryonic antigen (CEA). The CEA has attracted the most attention in research as a protein biomarker for monitoring patients for timely diagnosis of colon cancer or the stages of disease recurrence in people who have already been treated for colorectal cancer. The MWCNT/Co(OH)₂ nanocomposite served as a modifier to improve the electrical conductivity and active surface area of the glassy carbon electrode (GCE). The Co(OH)₂ as an excellent intermediary facilitated the electron transfer on the GCE surface. This innovative immunosensor results in high sensitivity, permitting the prompt identification of CEA biomarkers in samples. Under optimal circumstances, the measurement range for CEA was broad, from 0.1 pg/mL to 100 ng/mL, while the limit of detection (LOD) was 59 fg/mL. The immunosensor demonstrated satisfactory stability, outstanding selectivity, and excellent reproducibility.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102274"},"PeriodicalIF":2.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New formulation of metalworking fluids using emulsifiers and alkanolamines for enhanced resistance to microbial degradation","authors":"Abdolreza Abri,&nbsp;Yahya Jamal Sadeghi","doi":"10.1016/j.rechem.2025.102275","DOIUrl":"10.1016/j.rechem.2025.102275","url":null,"abstract":"<div><div>Water-miscible metalworking fluids (MWFs), commonly used in metal forming operations, are lubricants that must be safe for direct human contact. The proper selection of materials in a new metalworking fluid, while being environmentally friendly, helps to inhibit microbial growth, reduce operational issues, extend tool life, and ultimately lower costs. A common issue with MWFs is microbial degradation by bacteria and fungi, which is facilitated by available nutrients, such as carbon, at population densities exceeding 10⁶ CFU/ml. In this study, alkanolamines, oleic acid, and boric acid were evaluated for their effectiveness as antimicrobial agents. The inherent biological resistance of the MWF was assessed using an unknown biological inoculum collected from a device at Iran's Tractor Manufacturing Company, in accordance with ASTM E2275 standards. The results indicated that the new fluid, in the absence of conventional biocides, maintained its inherent biological resistance for more than five weeks.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102275"},"PeriodicalIF":2.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phyto-mediated polymeric incorporated silver nano-bio-composite for improved dermal complication management: A review","authors":"Min He ,&nbsp;Jun Hu ,&nbsp;Jiaxin Deng ,&nbsp;Xueqiang Chen ,&nbsp;Anil Kumar Singh ,&nbsp;Pooja V. Nagime ,&nbsp;Himanshu Paliwal ,&nbsp;Sudarshan Singh ,&nbsp;Opeyemi Joshua Olatunji","doi":"10.1016/j.rechem.2025.102272","DOIUrl":"10.1016/j.rechem.2025.102272","url":null,"abstract":"<div><div>The intricacies of skin conditions and the limitation of traditional therapeutic strategies make dermal treatment fairly difficult. Recent advancements in nanotechnology field have demonstrated promise in dealing such problems, specifically, the application of biogenic synthesized metallic nano-bio-composites. This review is focused upon synthesis, characterization, and transformation of metallic nanoparticles (NPs) into polymeric composite for the management of dermal complications, with emphasis on how they can enhance drug delivery, promote wound healing, and mitigate inflammation. By employing bioactive-rich substances from plants, the phyto-mediated approach confirms biocompatibility and reduced cytotoxic potential metallic NPs with 99.9 % of antibacterial activity. Such nanocomposites furnish augmented physicochemical properties, including targeted therapeutic action, regulated release, and improved stability, upon combination with polymers and metallic NPs, such as silver nanoparticles (AgNPs). The mechanism responsible for their activity in the treatment of dermal complication due to their excellent antibacterial, antioxidant, and anti-inflammatory activity with a focus on wound healing application have been presented in the paper. Additionally, the review encourages the interdisciplinary strategies to optimize their clinical applicability, while evaluating their current limitations and future research directions. Thus, the review highlights the potential of phyto-mediated polymeric incorporated metallic nano-bio-composites as revolutionizing solution for the management of dermal complications, paving the way for the next-generation therapeutic approaches.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102272"},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanostructure-controlled Cu-doped MnO2 for ozone synergistic catalytic disinfection","authors":"JianGuo Huang ,&nbsp;Rashid Khan ,&nbsp;Chunhui Zhai ,&nbsp;Xianting Ding ,&nbsp;Li-Sha Zhang ,&nbsp;Jin-Ming Wu ,&nbsp;Zhizhen Ye","doi":"10.1016/j.rechem.2025.102269","DOIUrl":"10.1016/j.rechem.2025.102269","url":null,"abstract":"<div><div>The development of efficient disinfection techniques that can persistently eradicate viruses or disrupt their transmission is of paramount significance for curbing the spread of pandemics. Existing disinfection techniques commonly suffer from secondary pollution and difficulty in achieving continuous disinfection while ensuring safety and effectiveness, particularly in crowded environments. In this study, we adopted ozone synergistic catalytic oxidation (OSCO) technology for the highly efficient disinfection of bacteria and viruses. The OSCO route is based on the catalytic decomposition of ozone into active radicals in the presence of an optimized rod-like Cu/MnO₂ catalyst. The high catalytic activity of the Cu-doped MnO₂ catalyst can be attributed to the presence of numerous oxygen vacancies, which facilitate the catalytic decomposition of ozone into active radicals. This method serves multiple purposes, including the eradication of bacteria and viruses as well as the prompt decomposition of ozone to prevent any potential leakage. A disinfection rate of 99.9 % for both <em>Staphylococcus albicans</em> and <em>H1N1</em> viruses was achieved within 20 min. The catalyst also demonstrated exceptional efficiency in degrading residual ozone, achieving a high removal rate of 99.99 % within 25 min, thus assuring safe disinfection. Density functional theory (DFT) calculations further supported that Cu doping induced lattice defects in MnO₂, promoting the formation of interfacial oxygen vacancies and in turn favoring the catalytic oxidation process. The current OSCO technology offers a highly efficient and secure disinfection method with a wide range of potential applications in various fields.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102269"},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent progress in the synthesis of imidazoquinoline derivatives","authors":"Warda Jahangir ,&nbsp;Sumayya Akram ,&nbsp;Sana Aslam ,&nbsp;Matloob Ahmad ,&nbsp;Muhammad Shahid Nazir ,&nbsp;Sami A. Al-Hussain ,&nbsp;Magdi E.A. Zaki","doi":"10.1016/j.rechem.2025.102270","DOIUrl":"10.1016/j.rechem.2025.102270","url":null,"abstract":"<div><div>Heterocyclic compounds, ubiquitous in nature and on the synthetic scale, are crucial as they acquire a wide spectrum of significant pharmacological properties. Imidazoquinolines, formed by the annulation of imidazole and quinoline rings dominated drug design and development. Imidazoquinoline hybrids have an extensive range of biological applications such as antiviral, antifungal, anticancer, antibacterial, antiallergic, antioxidant, antithrombotic, as agonists of various toll-like and 5-HT_1A receptors to treat various CNS disorders, and as inhibitors of phosphoinositide 3-kinases and cholinesterases. This review article explores multiple synthetic approaches for the preparation of imidazoquinoline isomers, including multicomponent, microwave-assisted, iodine-mediated, electrochemical, electrocatalytic tandem techniques, sequential Heck and oxidative amination reactions, cycloaddition and aza-Michael addition reactions, copper-mediated aerobic three-component cyclization reactions, copper-assisted double oxidative C<img>H amination and halogenation, oxidative annulation reactions and Suzuki cross-coupling reactions.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102270"},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A chalcone/quinolone hybrid drug (COQM) triggers oxidative stress, DNA damage, and apoptosis to induce selective antiproliferative effects in breast cancer cells","authors":"Jun-Ping Shiau ,&nbsp;Wangta Liu ,&nbsp;Chih-Hua Tseng ,&nbsp;Min-Yu Lee ,&nbsp;Cheng-Yao Yang ,&nbsp;Yu-Ning Wang ,&nbsp;Hsueh-Wei Chang","doi":"10.1016/j.rechem.2025.102268","DOIUrl":"10.1016/j.rechem.2025.102268","url":null,"abstract":"<div><div>COQM is a newly developed hybrid compound of chalcone and quinolone, both of which are known to have anticancer and anti-inflammatory abilities. However, the anticancer effect of COQM on breast cancer cells is not yet well understood, and its safety has not been fully investigated. In this study, we investigated the anticancer ability and mechanism of COQM against triple-negative breast cancer cells (TNBC; HCC1937) and non-TNBC cells (SKBR-3) compared with normal breast cells (H184B5F5/M10 (M10)). We found that COQM-treated breast cancer cells exhibited less proliferation, more subG1 accumulation and apoptosis (annexin V), and an increased activation of apoptotic signaling regulators, such as caspases 3, 8, and 9, compared with normal cells. These effects were attenuated by <em>N</em>-acetylcysteine (NAC) pretreatment, suggesting that these anti-breast cancer mechanisms are mediated by oxidative stress. COQM-induced oxidative stress responses were further confirmed by flow cytometry, which revealed a greater generation of reactive oxygen species and mitochondrial superoxide and lower mitochondrial membrane potential and glutathione, in breast cancer than normal cells, attenuated by NAC. Similarly, COQM exhibits greater oxidative stress-dependent DNA damages for γH2AX and 8-hydroxy-2-deoxyguanosine in breast cancer than normal cells, as confirmed via NAC. In brief, we found that COQM exerted anti-breast cancer effects and oxidative stress-mediated mechanisms, and caused minimal damage to normal cells.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102268"},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the adsorption behavior of melphalan anti-cancer drug on MgS nano-cage: A DFT study","authors":"Shahnaz Azari Gharelar ,&nbsp;Shiva Masoudi ,&nbsp;Nasrin Masnabadi ,&nbsp;Mohammad Hadi Ghasemi","doi":"10.1016/j.rechem.2025.102273","DOIUrl":"10.1016/j.rechem.2025.102273","url":null,"abstract":"<div><div>The adsorption behavior of melphalan anti-cancer drug on the MgS nano-cage surface was investigated using DFT and TD-DFT methods by B3LYP/6-31G(d) level of theory. From the obtained adsorption energies of MEL/MgS complexes (I-III), it was determined that the adsorption process is exothermic. The electrical conductivity of the MgS nanocage significantly increased in three complexes. Therefore, it can be used to generate electronic noise in the presence of MEL drug. The working functions of the most stable complex systems will be affected by the adsorption of the target drug. MgS nanocage is a ϕ-type sensor that can be active in the detection of MEL drug. Adsorption process of MEL on MgS nanocage as well as the structural changes after adsorption were studied by UV/Vis absorption, NCI and QTAIM analyses. The wavelength shift towards higher wavelengths in the electronic spectra of MEL/MgS complex indicates the binding and adsorption of MEL drug on MgS nanocage. To investigate the interaction mechanism between drug and adsorbent and also the changes in the properties of MEL drug and MgS nanocages, the geometric parameters, dipole moment, frontier molecular orbitals (FMO), and density of states (DOS), electron location function (ELF) and local orbital locator (LOL) were analyzed. Based on the studies conducted in this study, it can be argued that MgS nanocages with suitable electronic and structural properties can be considered as promising drug sensors for the drug MEL.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102273"},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis of imidazole scaffolds as an effective larvicidal agent against Etiella zinkenella and in vitro antibacterial and antifungal evaluation against Candida albicans with DFT calculations, molecular docking technique and theoretical biological potential","authors":"Ankita M. Rayate ,&nbsp;Manoj R. Gaware ,&nbsp;Dnyaneshwar D. Lokhande ,&nbsp;Amol H. Kategaonkar ,&nbsp;Arun M. Bhagare ,&nbsp;Bharat N. Shelke ,&nbsp;Avinash S. Kale ,&nbsp;Sapana S. Bhamare","doi":"10.1016/j.rechem.2025.102259","DOIUrl":"10.1016/j.rechem.2025.102259","url":null,"abstract":"<div><div>In this paper we have reported synthesis evaluation imidazole by solvent free multi component scaffolds (NEAT Reaction) by simple and very effective protocol. The characterization of compounds by ¹H NMR, ¹³C NMR, Mass and IR spectral studies confirms the structure. The theoretical interpretations of compounds is optimized by 6–311++G (d,p) basic set for employing different parameters using Gaussion-09 software. The antimicrobial activity associated with all the imidazole derivatives showed mild activity towards <em>E. coli</em>, <em>S. typhi</em> and <em>Staphylococcus aureus</em> while good microbial activity against <em>P.vulgaris.</em> The compounds showed promising antifungal activity against <em>Candida albicans.</em> The bioactivity against <em>Etiella zinkenella</em> was evaluated. Significant results were obtained with notable larvicidal activity having Lethal concentration (LC₅₀) = 0.38 ppm associated with compound <strong>6a</strong> with concentration ranging between 0.02‐and 0.08 ppm. Molecular docking of imidazole compounds were done to study the protein interaction and enzyme inhibitor activity. Docking analysis was performed using Autodoc Vina and visualized in Pymol software compound. The study suggested that compound <strong>6d</strong> and <strong>6e</strong> showed good bonding affinity to an enzyme exhibiting highest affinity (binding energy = −6.5 to 6.8 kcal/mol) with protein (4MCT) of <em>P.vulgaris</em> organism. Excellent affinity with binding energy −6.1 kcal/mol with protein (5AEZ) is associated with <em>Candida albicans</em> for compound <strong>6b</strong>, <strong>6c</strong>, <strong>6e</strong> and <strong>6</strong> <strong>f</strong>. The PASS analysis is web-based application used predict the biological activity spectrum of a compound based on structure. It is useful to estimate the probable biological activity profile. The PASS analysis shows that compound <strong>6b</strong> shows high activity for Antieczematic and Gluconate 2-dehydrogenase (acceptor) inhibitor (Pa &gt; 0.07).</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102259"},"PeriodicalIF":2.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulation and optimization of a modified salt extractive distillation process for the production of anhydrous ethanol","authors":"Manish Kumar Yadav ,&nbsp;Saumya Agarwal ,&nbsp;Shilpi Verma ,&nbsp;Vimal Chandra Srivastava ,&nbsp;Urška Lavrenčič Štangar ,&nbsp;Praveen Kumar","doi":"10.1016/j.rechem.2025.102267","DOIUrl":"10.1016/j.rechem.2025.102267","url":null,"abstract":"<div><div>Producing anhydrous ethanol through ethanol dehydration is challenging due to the formation of an ethanol-water azeotrope. Traditional methods use carcinogenic liquid separating agents like benzene to break this azeotrope. This study introduces a modified salt extractive distillation technique using soluble calcium chloride to produce anhydrous ethanol more safely and efficiently. We conducted simulations and optimizations of this new method, with columns operating under 80 % flooding conditions. This process demonstrated an effective energy consumption of 5.25 MJ per kg of ethanol, significantly lower than traditional methods. The innovative approach uses minimal calcium chloride and operates at reduced reflux flow rates, leading to smaller column diameters. Moreover, the energy needed for recovering the salt solution is just 4.4 % of the total energy consumption. Comparisons with existing literature show that our method's energy use is the lowest reported, marking a significant advancement in eco-friendly ethanol production.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102267"},"PeriodicalIF":2.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}