Results in Chemistry最新文献

{"title":"Advancements in calcium ferrite-based photocatalysts: Insights into their synthesis and performance in degrading organic pollutants","authors":"Behram Shehzad ,&nbsp;Muhammad Hamid ,&nbsp;Aqsa Batool ,&nbsp;Muhammad Umer Shafique ,&nbsp;Ayoub Rashid ,&nbsp;Nabisab Mujawar Mubarak ,&nbsp;Omirserik Baigenzhenov ,&nbsp;Andrei Ivanets ,&nbsp;Mahesh Kumar Sah ,&nbsp;Ahmad Hosseini-Bandegharaei","doi":"10.1016/j.rechem.2025.102322","DOIUrl":"10.1016/j.rechem.2025.102322","url":null,"abstract":"<div><div>Over the past two centuries, photocatalysis—the use of light to accelerate chemical reactions—has undergone substantial development. This multidisciplinary field, which is especially thriving with advances in nanotechnology, combines photochemistry, catalysis, and semiconductor physics. Calcium ferrite's low band gap and strong activity underneath sunlight make it a suitable for photocatalytic applications. The effectiveness of calcium ferrites and the related photocatalysts in organic pollution remediation, synthetic techniques, and their photocatalytic characteristics, including the processes governing their activity, are all covered in this paper. Numerous synthesis methods have been explained, including sol-gel, co-precipitation, and hydrothermal processes. The optical and structural characteristics have been examined using characterization methods like as UV–Vis spectroscopy and X-ray diffraction (XRD). The review demonstrates calcium ferrites' potential in environmental remediation technologies by highlighting how well it breaks down organic contaminants in water purification and, at the end, the challenges and future outlooks have been mentioned.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"16 ","pages":"Article 102322"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic potential of Moroccan medicinal plant extracts: a virtual screening using in silico approaches","authors":"Bouchra Rossafi,&nbsp;Amal Bouribab,&nbsp;Oussama Abchir,&nbsp;Meriem Khedraoui,&nbsp;Mhammed El Kouali,&nbsp;Samir Chtita","doi":"10.1016/j.rechem.2025.102365","DOIUrl":"10.1016/j.rechem.2025.102365","url":null,"abstract":"<div><div>The fight against diabetes mellitus remains a major global challenge due to its increasing prevalence, severe health complications, and the need to develop new therapeutic alternatives that are both effective and accessible to improve patient care. The current medications used to combat this disease have limitations, including side effects, which highlight the need for innovative and safer therapeutic approaches capable of specifically targeting key enzymes involved in carbohydrate metabolism, such as alpha-amylase and alpha-glucosidase. In this study, we explored the inhibitory potential of 386 phytochemical compounds extracted from Moroccan plants using an in-silico approach combining virtual screening via molecular docking, ADMET predictions, molecular dynamics simulations and MM/GBSA calculations. Among these evaluated compounds, two promising molecules were identified: myricetin (compound 276) and cholesterol (compound 290), both derived from the same plant, <em>Ajuga iva</em> L. These molecules exhibited strong binding affinities to the enzymes alpha-amylase and alpha-glucosidase, remarkable stability during MD simulations, and a favorable pharmacokinetic profile. These findings highlight the potential of Moroccan phytochemical compounds as natural inhibitors, paving the way for future experimental studies to develop them into antidiabetic treatments.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"16 ","pages":"Article 102365"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substituent effects on the solvent power of the haloolefin HCFO-1233 yd.(Z)","authors":"A. Fan,&nbsp;H. Zhou,&nbsp;D. Maksuta,&nbsp;R.J. Waltman","doi":"10.1016/j.rechem.2025.102367","DOIUrl":"10.1016/j.rechem.2025.102367","url":null,"abstract":"<div><div>The solvent power of the hydrochlorofluoroolefin HCFO-1233 yd.(Z) is investigated using electron-withdrawing and electron-donating substituents on the “parent” (Z)-1-<strong><em>X</em></strong>-2,3,3-trifluoropropene, where <strong><em>X</em></strong> = NH₂, OH, CH₃O, CH₃, F, H, Cl, COOH, CF₃, CN, and NO₂. The magnitude of the partial atomic charge on the 1‑hydrogen atom correlates to the Hammett σ⁺ substituent constant. The intermolecular interaction between CH₃OH and the 1‑hydrogen atom is strengthened by electron-withdrawing 1-substituents producing smaller hydrogen bond distances and larger interaction energies. This work develops a Hammett-based structure-property correlation model to quantify electronic “push–pull” effects in HFO and HCFO solvent systems, guiding HCFO solvent design optimization to enhance its compatibility with PFPE lubricant polarity for hard disk drive application.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"16 ","pages":"Article 102367"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical probe for total determination and speciation of selenium (IV& VI) species in water, drug formulations and foodstuffs using Thoron–I as selective chelating agent","authors":"H. Alwael","doi":"10.1016/j.rechem.2025.102362","DOIUrl":"10.1016/j.rechem.2025.102362","url":null,"abstract":"<div><div>The present study reports a highly sensitive, selective and cost effectiveness-sensing probe for total determination and speciation of selenium (IV &amp; VI) species in complex matrices. The established probe was based upon controlled electrolysis of Se⁴⁺-Thoron<strong>–</strong>I chelate at hanging mercury-dropping electrode (HMDE) combining adsorptive differential pulse-adsorptive cathodic stripping voltammetry (Ads DP-CSV) and measuring the consequent cathodic peak currents (I_p,c) at −0.5 and − 1.1 V <em>vs.</em> Ag/AgCl electrode in aqueous solution of pH 2. At the optimal conditions of peak potentials at −0.5 and − 1.1 V, the plots of I_p,c <em>versus</em> Se⁴⁺ concentration were linear over the concentrations range 6.3 × 10⁻⁹–8.2 × 10⁻⁸ and 5.0 × 10⁻¹² <strong>-</strong> 1.45 × 10⁻¹⁰ M with limits of detection (LOD) and quantification (LOQ) of 1.6 × 10⁻¹² M and 5 × 10⁻¹² M of Se⁴⁺, respectively. The sensing probe was favorably used for detection of trace levels of Se⁶⁺ after reduction to Se⁴⁺. The probe also displayed excellent sensitivity and selectivity towards detection of selenium species in water, foodstuffs and drug formulations. The probe was validated by analysis of selenium in certified reference material (CRM, IAEA- Soil-7) and in drug formulations. The average recoveries for the spiked water samples were ranged from 99.4 ± 0.60 to 110.0 ± 6.3. The probe was also validated by comparing the results with the inductively coupled plasma–optical emission spectrometry (ICP-OES) data using Student t and F tests at 95 % probability. Sequential and total determination of trace levels of inorganic Se⁴⁺and/or Se⁶⁺ was also achieved by the proposed probe.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"16 ","pages":"Article 102362"},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of dielectric properties of starch nanoparticles derived from arrowroot (Maranta arundinaceae L.) rhizomes","authors":"M. Ramya ,&nbsp;Rajita Ramanarayanan ,&nbsp;S. Esakki Muthu ,&nbsp;Karthik Kannan ,&nbsp;Jhelai Sahadevan ,&nbsp;A. Dinesh ,&nbsp;Lalitha Gnanasekaran ,&nbsp;Manikandan Ayyar ,&nbsp;S. Santhoshkumar","doi":"10.1016/j.rechem.2025.102348","DOIUrl":"10.1016/j.rechem.2025.102348","url":null,"abstract":"<div><div>This study presents a novel, green approach to tailoring the dielectric properties of starch by mechanical means alone, without chemical modification. The correlation between ball milling-induced structural changes and dielectric performance is reported for the first time using native arrowroot starch, highlighting its potential as a sustainable material for eco-friendly electronic applications<strong>.</strong> The structure and characteristics of starch granules are drastically changed by ball milling. Ball milling reduces granule size and produces irregular, porous structures by destroying the spherical or oval geometry of raw starch (SR), according to SEM pictures. The XRD study reveals decrease of crystallinity from 28 % (SR) to 13 % (milled starch, SM), and the peaks that were typical of A-type starch vanished, signifying amorphization. The binding energies of the C1s and O1s peaks fluctuate in the XPS measurements, indicating oxidation state alterations and bond rupture. Raman spectroscopy, which shows a weakening of vibrational signals, further validates structural amorphization. Due to structural disturbance and decreased interfacial polarisation, dielectric measurements reveal decreased impedance, dielectric constant, and loss factor for SM. Due to higher resistance, SM has lesser electrical conductivity than SR. With SM showing a wider semicircle, which denotes more resistance and decreased charge carrier mobility, the Cole-Cole plot shows changed relaxation behaviour.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"16 ","pages":"Article 102348"},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the pulmonary oxidative stress and histopathological changes in Swiss albino mice following exposure to MWCNT-NPs","authors":"Iqra Nasim ,&nbsp;Rab Nawaz ,&nbsp;Nadia Ghani ,&nbsp;Mohammad Raish ,&nbsp;Muhammad Atif Irshad ,&nbsp;Maryam Nasim ,&nbsp;Ali Irfan ,&nbsp;Samina Aslam ,&nbsp;Bakar Bin Khatab Abbasi ,&nbsp;Yousef A. Bin Jardan","doi":"10.1016/j.rechem.2025.102360","DOIUrl":"10.1016/j.rechem.2025.102360","url":null,"abstract":"<div><div>Carbon nanotubes (CNTs) have wide range of usage in industrial applications due to their exceptional characteristics. There have been some concerns regarding their possible negative health impacts, especially in working environment. Present study highlights the effects of dose, exposure duration, and particle size of multi-walled carbon nanotube nanoparticles (MWCNT-NPs) on the histopathology and pulmonary oxidative stress in <em>Swiss albino</em> mice. Experiments were carried out using twenty mice, which were divided into six groups. Two groups were exposed to MWCNT-NPs through oral gavage for seven days at doses of 0.45 μg and 0.90 μg, respectively. A third group served as the control and received only distilled water for the same seven-day period. Other two groups were treated with MWCNT-NPs for fourteen days at the same dosages of 0.45 μg and 0.90 μg. The final group served as the fourteen-day control and received distilled water only. Glutathione (GSH) and glutathione disulfide (GSSG), the two main oxidative stress indicators were evaluated in the study. Comparing the experimental group to the control group, the results showed a substantial decline in GSH levels and an increase in GSSG concentrations at the same time. The histopathology indicated that MWCNT-NPs had a major effect on lung health, including the possibility of Acute Lung Injury (ALI), disruption of respiratory function, pulmonary edema, and enhanced permeability. The redox potential was estimated using the Nernst equation to understand the redox status. The negative value of results indicated an oxidative imbalance. These findings showed that MWCNT-NPs induced pulmonary oxidative stress in response to short term exposure, as indicated by alterations in the levels of GSH and GSSG and the negative redox potential. The study emphasizes the importance of assessing oxidative stress in evaluations of nanomaterial toxicity and provides crucial insights into the respiratory effects of exposure to multi-walled carbon nanotube nanoparticles.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"16 ","pages":"Article 102360"},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naringenin: A potential anticancer drug","authors":"Yi Zhang,&nbsp;Haixin Ding,&nbsp;Xue Zhao,&nbsp;Yutong Li,&nbsp;Pengling Ge","doi":"10.1016/j.rechem.2025.102358","DOIUrl":"10.1016/j.rechem.2025.102358","url":null,"abstract":"<div><div>Natural products, as vital bioactive components for human health maintenance, have garnered widespread attention for their medicinal value. Naringenin (NGE), a naturally occurring flavonoid abundant in citrus fruits, exhibits multiple pharmacological activities (including anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, and anticancer effects), despite its pharmacokinetic limitations such as poor oral bioavailability and rapid metabolism. Research has demonstrated that NGE exhibits broad-spectrum anticancer activity by targeting multiple molecular mechanisms, including induction of tumor cell apoptosis, modulation of cell cycle progression, and interference with key signaling pathways such as TGF-β1, PI3K/AKT/mTOR, and NF-κB. Recent advances in nanodrug delivery systems have effectively addressed these pharmacokinetic limitations while substantially improving NGE's anticancer efficacy. This review systematically summarizes current research progress on NGE's natural sources, anticancer mechanisms, and novel delivery strategies, with the aim of providing a scientific foundation for NGE-based anticancer drug development and clinical translation.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"16 ","pages":"Article 102358"},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis and biological evaluation of aryl chalcone derivatives of pyridine-benzoxazole-pyimidine-oxazole as anticancer agents","authors":"Abdulrhman Alsayari ,&nbsp;S. Tasqeeruddin ,&nbsp;Shaheen Sultana ,&nbsp;Laxminarayana Eppakayala","doi":"10.1016/j.rechem.2025.102359","DOIUrl":"10.1016/j.rechem.2025.102359","url":null,"abstract":"<div><div>A new library of aryl chalcone derivatives of pyridine-benzoxazole-pyimidine-oxazole (<strong>27a-j</strong>) and their chemical structures were confirmed by analytical data. Further, all the newly synthesized compounds (<strong>27a-j</strong>) were evaluated for their anticancer applications against human cancer cell lines by the MTT method. Here, the chemotherapeutic agent etoposide is used as a positive control. The obtained results were compared with etoposide. Most of the screened compounds displayed remarkable anticancer activity on all cell lines. Among them, five compounds exhibited more potent anticancer activity as compared to the positive control. Mainly, one compound, <strong>27j,</strong> displayed superior activity on four cell lines. Furthermore, all the compounds displayed selective cytotoxicity against cancer cells but not against normal Vero cells (IC50 ≥19 μM), supporting the design method as a selective anticancer agents.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"16 ","pages":"Article 102359"},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title: Identification of natural FtsZ inhibitors through computational approaches to combat drug-resistant tuberculosis","authors":"Rajkamal Bharti ,&nbsp;Shruti Mishra ,&nbsp;Achyut Pandey","doi":"10.1016/j.rechem.2025.102354","DOIUrl":"10.1016/j.rechem.2025.102354","url":null,"abstract":"<div><div>The Mycobacterial cell division protein FtsZ is a promising target for addressing multidrug-resistant tuberculosis (MDR-TB). We employed computational strategies to screen a large library of natural compounds for FtsZ inhibitors. Our virtual screening process involved high-throughput docking simulations, standard precision and extra precision docking, and in silico ADME analysis to evaluate the drug-likeness of selected compounds. Four promising ligands were identified, with two emerging as potential FtsZ ligands: CID_5487121 (Capuramycin) and CID_71452248 (Deacetylkirschsteinin). These molecules exhibited high docking affinities and consistent behavior throughout molecular dynamics simulations. Our findings demonstrate the potential of these compounds as leads for further experimental validation and development of novel therapeutics against MDR-TB. Additionally, the molecular dynamics simulations provided insights into the stability and interaction patterns of these compounds with the FtsZ protein, highlighting their potential as strong inhibitors. The comprehensive ADME analysis ensured that these compounds possess favorable drug-like properties, making them viable candidates for further development.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"16 ","pages":"Article 102354"},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ugi reaction in the synthesis of Janus dendrimers as nanocarriers of chlorambucil and ibuprofen","authors":"Israel Barajas-Mendoza,&nbsp;Teresa Ramírez-Ápan,&nbsp;Marcos Martínez-García","doi":"10.1016/j.rechem.2025.102361","DOIUrl":"10.1016/j.rechem.2025.102361","url":null,"abstract":"<div><div>The synthesis and characterization of Janus dendrimers conjugated with two drugs: chlorambucil and ibuprofen are reported. The dendrons by the Ugi reaction were obtained. The 2-aminoethanol, 3-aminopropanol and 5-aminopentanol were used as the amine resources, which allowed obtaining several Ugi adducts with different aliphatic chain lengths. The newly Janus dendrimers compounds were evaluated against human cancer cell lines. The Janus dendrimer from 2-aminoethanol in the length of the aliphatic chain showed potent activity againts prostatic adenocarcinoma PC-3 (IC₅₀ 8.88 ± 0.7) and mammary adenocarcinoma MCF-7 (IC₅₀ 9.14 ± 1.0) μM. In addition, the feasibility of incorporating different drugs in the reaction was verified, which opens new possibilities for the functionalization of dendrimers in the therapeutic context.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"16 ","pages":"Article 102361"},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}