Coumarin derivatives as potential anticancer agents: Synthesis, antiproliferative activity, apoptosis, and molecular docking studies

IF 4.2 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry Pub Date : 2025-06-12 DOI:10.1016/j.rechem.2025.102442

Mahsa Toolabi , Alireza Basiri , Farhad Dorostkar Yaghouti , Mehdi Safdarian , Adileh Ayati , Ayyub Mojaddami

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Abstract

This study presents the synthesis of a series of coumarin derivatives via efficient Ugi synthesis reactions, aimed at exploring their anti-proliferative properties. Out of the twelve synthesized derivatives, most exhibited significant anti-proliferative activity with minimal cytotoxic effects on normal MCF12A cells. Notably, compound 5i showed exceptional activity, achieving IC50 values of 17.69, 19.87, and 30.39 μM against HeLa, MCF-7, and A549 cell lines, respectively, comparable to Doxorubicin. Apoptosis assays revealed a pronounced dose-dependent effect, with apoptosis rates increasing to 22.75 % at 10 μM and 83.50 % at 40 μM. Additionally, molecular docking studies confirmed the compound's strong inhibitory potential against the anti-apoptotic Bcl-2 protein. These results highlight the promising role of compound 5i as an anticancer agent, warranting further exploration in therapeutic applications.

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香豆素衍生物作为潜在的抗癌药物：合成、抗增殖活性、细胞凋亡和分子对接研究

本研究通过高效的Ugi合成反应合成了一系列香豆素衍生物，旨在探索其抗增殖特性。在12个合成的衍生物中，大多数显示出显著的抗增殖活性，对正常MCF12A细胞的细胞毒性作用最小。值得注意的是，化合物5i对HeLa、MCF-7和A549细胞株的IC50值分别为17.69、19.87和30.39 μM，与阿霉素相当。凋亡实验显示出明显的剂量依赖效应，凋亡率在10 μM和40 μM时分别增加到22.75%和83.50%。此外，分子对接研究证实该化合物对抗凋亡Bcl-2蛋白具有较强的抑制潜力。这些结果突出了化合物5i作为抗癌药物的良好作用，值得进一步探索其治疗应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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