Silver-functionalized covalent organic polymer as a heterogeneous catalyst for the mannich reaction: A green approach to ondansetron synthesis

In this study, a silver-functionalized covalent organic Polymer (Ag-COP) was developed and utilized as a heterogeneous catalyst for the synthesis of β-amino carbonyl compounds via the Mannich reaction. The porous COP was synthesized through the condensation reaction of melamine and phthalic acid, followed by silver sulfate incorporation via post-synthetic modification. The prepared COP and Ag-COP samples were characterized using FTIR, SEM, XRD, BET, TGA, and EDX to confirm their structural integrity and composition. The catalytic efficiency of Ag-COP was evaluated in the Mannich reaction, demonstrating high yield, reduced reaction time, and excellent recyclability. Furthermore, the Ag-COP catalyst was successfully applied in the synthesis of Ondansetron, achieving high purity, good yield, and a significantly shorter reaction time.