Biological activities of chitosan-schiff base-metal (Ag and Zn) nanocomposites

IF 4.2 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry Pub Date : 2025-09-16 DOI:10.1016/j.rechem.2025.102717

Ali Mohammad Amani , Razieh Gholizadeh , Seyed Reza Kasaee , Zahra Zareshahrabadi , Hesam Kamyab , Shreeshivadasan Chelliapan , Sareh Mosleh-Shirazi

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Abstract

A novel sustained-release technique for supplementing with zinc and silver, known as (3-Formyl-4-hydroxybenzyl)triphenylphosphonium chloride-chitosan Schiff base (CSB-Ag-Zn), is presented in the current study. The goal of this system's development was to supply zinc. This system was developed using CSB-Zn-Ag nanocomposites, which had been chelated with Zn²⁺ and Ag⁺, to enhance the utilization ratio of trace elements zinc and silver. Several analytical methods, like transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD), and dynamic light scattering (DLS), were used to characterize the samples. The TEM results indicated that the Ag and Zn nanoparticles had a mean size of 27.5 nm, a low degree of agglomeration, and a roughly spherical shape. They were also evenly distributed throughout the CSB. Furthermore, the mean size of CSB-Ag-Zn NPs was 69.6 nm, indicating that the chitosan coating on the Zn and Ag nanoparticles' surface successfully. The nanocomposite demonstrated potent antibacterial activity with MICs of 4 μg/mL and 2 μg/mL for S. aureus and E. coli, respectively. The antimicrobial activities of CSB-Ag-Zn NPs against different fungi and bacteria types indicated remarkable antibacterial and antifungal effectiveness, potentially useful for future biomedical applications.

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壳聚糖-席夫贱金属（银和锌）纳米复合材料的生物活性

本文提出了一种新的锌银缓释技术，即（3-甲酰基-4-羟基苄基）三苯基氯化磷-壳聚糖希夫碱（CSB-Ag-Zn）。该系统开发的目的是供应锌。该体系采用CSB-Zn-Ag纳米复合材料，与Zn2+和Ag+进行螯合，以提高对微量元素锌和银的利用率。采用透射电子显微镜（TEM）、傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、x射线衍射（XRD）和动态光散射（DLS）等分析方法对样品进行表征。TEM结果表明，Ag和Zn纳米颗粒的平均尺寸为27.5 nm，团聚程度低，形状大致为球形。它们也均匀地分布在整个CSB。结果表明，壳聚糖包覆在锌、银纳米粒子表面的效果良好，平均粒径为69.6 nm。该纳米复合材料对金黄色葡萄球菌和大肠杆菌的mic分别为4 μg/mL和2 μg/mL。CSB-Ag-Zn NPs对不同类型的真菌和细菌的抑菌活性显示出显著的抗菌和抗真菌效果，具有潜在的生物医学应用价值。

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