ACS Applied Electronic Materials最新文献

{"title":"Qinlian Hongqu Decoction Modulates FXR/TGR5/GLP-1 Pathway to Improve Insulin Resistance in NAFLD Mice: Bioinformatics and Experimental Study","authors":"Zhongyi Zhang,&nbsp;Yunliang He,&nbsp;Mei Zhao,&nbsp;Xin He,&nbsp;Zubing Zhou,&nbsp;Yuanyuan Yue,&nbsp;Tao Shen,&nbsp;Juncheng Liu,&nbsp;Gan Zhang* and Yong Zhang*,&nbsp;","doi":"10.1021/acsomega.4c0746310.1021/acsomega.4c07463","DOIUrl":"https://doi.org/10.1021/acsomega.4c07463https://doi.org/10.1021/acsomega.4c07463","url":null,"abstract":"<p ><b>Background:</b> Qinglian Hongqu decoction (QLHQD), a traditional Chinese herbal remedy, shows potential in alleviating metabolic issues related to nonalcoholic fatty liver disease (NAFLD). However, its precise mode of action remains uncertain. <b>Objective:</b> This study aims to evaluate the efficacy and mechanisms of QLHQD in treating NAFLD. <b>Methods:</b> This study utilized a NAFLD mouse model to assess the effects of QLHQD on lipid metabolism, including blood lipids and hepatic steatosis, as well as glucose metabolism, including blood glucose levels, OGTT results, and serum insulin. Network pharmacology, bioinformatics, and molecular docking were used to explore how QLHQD may improve NAFLD treatment. Key proteins involved in these mechanisms were validated via WB and immunohistochemistry. Additionally, the expression of downstream pathway targets was examined to further validate the insulin resistance mechanism by which QLHQD improves NAFLD. <b>Results:</b> Animal studies demonstrated that QLHQD alleviated lipid abnormalities, hepatic steatosis, blood glucose levels, the insulin resistance index, and the OGTT results in NAFLD mice (<i>P</i> &lt; 0.05 or 0.01). Network pharmacology and bioinformatics analyses indicated that the effects of QLHQD on NAFLD might involve bile acid secretion pathways. Subsequent validation through Western blotting, immunohistochemistry, and qPCR demonstrated that QLHQD may influence fat metabolism and insulin sensitivity in NAFLD mice via the FXR/TGR5/GLP-1 signaling pathway. <b>Conclusion:</b> QLHQD significantly alleviates glucose and lipid metabolism disorders in a high-fat diet-induced NAFLD mouse model. Its mechanism of action may involve the activation of the FXR/TGR5/GLP-1 signaling pathway in the gut, which reduces lipid accumulation and insulin resistance.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"9 45","pages":"45447–45466 45447–45466"},"PeriodicalIF":3.7,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c07463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composite of Hydrolyzed PAN and β-Cyclodextrin Forms a Nanofiber Membrane with an Excellent Removal Effect on Various Cationic Dyes and Copper Ions","authors":"Deqiang Chen,&nbsp;Zezhao Ding,&nbsp;Liming Zou*,&nbsp;Yanli Wang and Xianghui Zeng,&nbsp;","doi":"10.1021/acs.langmuir.4c0339710.1021/acs.langmuir.4c03397","DOIUrl":"https://doi.org/10.1021/acs.langmuir.4c03397https://doi.org/10.1021/acs.langmuir.4c03397","url":null,"abstract":"<p >The presence of dyes and heavy metals in wastewater represents a significant environmental and public health hazard, necessitating the development of efficient materials for their removal. In this study, we modified hydrolyzed polyacrylonitrile (PAN-H) and combined it with β-cyclodextrin (β-CD) by using an electrostatic spinning technique to fabricate composite nanofibrous membranes for water treatment applications. The resulting PAN-H/β-CD nanofiber membranes exhibit spindle-shaped fibers and porous structures with a high density of charged functional groups, which significantly enhance their selective adsorption capacity compared to pure PAN fibers. Furthermore, post-treatment with a sodium bicarbonate solution further improved this capacity, resulting in the membranes demonstrating a remarkable adsorption efficiency for cationic dyes. The adsorption process conformed to the Langmuir and pseudo-second-order kinetic models, with maximum adsorption capacities of 216.94 mg/g for methylene blue (MB), 471.59 mg/g for malachite green (MG), 299 mg/g for crystal violet (CV), and 43.95 mg/g for copper ions. The selective adsorption of these positively charged contaminants, particularly cationic dyes and metallic copper, indicates that PAN-H/β-CD membranes have significant potential for the treatment of wastewater containing similar pollutants.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"40 45","pages":"24074–24085 24074–24085"},"PeriodicalIF":3.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating Waste with Waste: Activated Bauxite Residue (ABR) as a Potential Wastewater Treatment","authors":"Fei Cheng,&nbsp;Jingya Pang,&nbsp;Scott Berggren,&nbsp;Himanshu Tanvar,&nbsp;Brajendra Mishra and Maricor J. Arlos*,&nbsp;","doi":"10.1021/acsomega.4c0669910.1021/acsomega.4c06699","DOIUrl":"https://doi.org/10.1021/acsomega.4c06699https://doi.org/10.1021/acsomega.4c06699","url":null,"abstract":"<p >Bauxite residue (or red mud) is a highly alkaline waste generated during the extraction of alumina. As a result of the substantial accumulation of bauxite residue in tailings facilities, there is a growing interest in exploring the potential for reusing this material for other purposes. The main objective of this study is to evaluate the use of activated bauxite residue (ABR) for remediating oil sands process-affected water (OSPW) and as a supplement to municipal wastewater treatment through bench-scale, proof-of-concept studies. The ABR is produced through a reduction roasting process that alters the physicochemical properties of bauxite residue, resulting in the generation of potentially effective adsorbent media. The treatment performance via chemical and biological activity removals (cytotoxicity, estrogenicity, and mutagenicity) was also assessed. For OSPW, ABR treatment resulted in the effective removal of recalcitrant acid-extractable organics (AEOs), with kinetics following the pseudo-second-order and comparable adsorption capacity to other waste materials (e.g., petroleum coke). ABR also effectively reduced the estrogenicity and mutagenicity of OSPW, albeit cytotoxicity increased at higher dosages, possibly due to some components leaching out of the material (e.g., metals). For municipal wastewater, ABR treatment reduced fecal coliform concentrations (&gt;99%), total phosphorus (up to 98%), total ammonia-nitrogen (63%), estrogenicity (nondetectable), and mutagenicity (nondetectable), especially in the primary effluent. The ultimate end use of ABR is for the recovery of valuable metals (especially iron) and as a construction material, but additional work is needed to optimize the dosage (currently in the g/L range) and maximize the use of ABR as an adsorbent prior to its subsequent uses.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"9 45","pages":"45251–45262 45251–45262"},"PeriodicalIF":3.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c06699","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverse Self-Assembled Molecular Architectures Promoted by C–H···O and C–H···Cl Hydrogen Bonds in a Triad of α-Diketone, α-Ketoimine, and an Imidorhenium Complex: A Unified Analysis Based on XRD, NEDA, SAPT, QTAIM, and IBSI Studies","authors":"Ankita Sinha,&nbsp;Suphal Sen,&nbsp;Tejender Singh,&nbsp;Aniruddha Ghosh,&nbsp;Satyen Saha,&nbsp;Krishanu Bandyopadhyay,&nbsp;Arindam Dey,&nbsp;Suparna Banerjee* and Jaydip Gangopadhyay*,&nbsp;","doi":"10.1021/acsomega.4c0770210.1021/acsomega.4c07702","DOIUrl":"https://doi.org/10.1021/acsomega.4c07702https://doi.org/10.1021/acsomega.4c07702","url":null,"abstract":"&lt;p &gt;X-ray structural elucidation, supramolecular self-assembly, and energetics of existential noncovalent interactions for a triad comprising α-diketone, α-ketoimine, and an imidorhenium complex are highlighted in this report. Molecular packing reveals a self-assembled 2D network stabilized by the C–H···O H-bonds for the α-diketone (benzil), and the first structural report of Brown and Sadanaga stressing on the prevalence of &lt;i&gt;only the van der Waals forces&lt;/i&gt; seems to be an oversimplified conjecture. In the α-ketoimine, the imine nitrogen atom undergoes intramolecular N···H interaction to render itself inert toward intermolecular C–H···N interaction and exhibits two types of C–H···O H-bonds in consequence to generate a self-assembled 2D molecular architecture. The imidorhenium complex features a self-aggregated 3D packing engendered by the interplay of C–H···Cl H-bonds along with the ancillary C–H···π, C···C, and C···Cl contacts. To the best of our knowledge, in rhenium chemistry, this imidorhenium complex unravels the first example of self-associated 3D molecular packing constructed by the directional hydrogen bonds of C–H···Cl type. The presence of characteristic supramolecular synthons, viz., R&lt;sub&gt;2&lt;/sub&gt;&lt;sup&gt;2&lt;/sup&gt;(12), R&lt;sub&gt;2&lt;/sub&gt;&lt;sup&gt;2&lt;/sup&gt;(16), and R&lt;sub&gt;2&lt;/sub&gt;&lt;sup&gt;2&lt;/sup&gt;(14), in the α-diketone, α-ketoimine, and imidorhenium complex, respectively, has prompted us to delve into the energetics of noncovalent interactions. Symmetry-adapted perturbation theory analysis has authenticated a stability order: R&lt;sub&gt;2&lt;/sub&gt;&lt;sup&gt;2&lt;/sup&gt;(14) &gt; R&lt;sub&gt;2&lt;/sub&gt;&lt;sup&gt;2&lt;/sup&gt;(12) &gt; R&lt;sub&gt;2&lt;/sub&gt;&lt;sup&gt;2&lt;/sup&gt;(16) based on the interaction energy values of −25.97, −9.93, and −4.98 kcal/mol, respectively. The respective average contributions of the long-range dispersion, electrostatic, and induction forces are 58.5, 32.8, and 8.7%, respectively, for the intermolecular C–H···O interactions. The C–H···Cl interactions experience comparable contribution from the dispersion force (57.9% on average), although the electrostatic and induction forces contribute much less, 28.0 and 14.1%, respectively, on average. The natural energy decomposition analysis has further attested that the short-range, interfragment charge transfer occurring via the lp(O/Cl) → σ*(C–H) routes contributes 17–25% of the total attractive force for the C–H···O and C–H···Cl interactions. Quantum theory of atoms in molecules analysis unfolds a first-order exponential decay relation (&lt;i&gt;y&lt;/i&gt; = 8.1043&lt;i&gt;e&lt;/i&gt;&lt;sup&gt;–&lt;i&gt;x&lt;/i&gt;/0.4095&lt;/sup&gt;) between the electron density at the bond critical point and the distance of noncovalent interactions. The distances of noncovalent interactions in the lattices are internally governed by the individual packing patterns rather than the chemical nature of the H-bond donors and acceptors. Intrinsic bond strength index analysis shows promise to correlate the electron density at BCP with the SAPT-derived interaction energy for the noncovalent interactions. Tw","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"9 45","pages":"45518–45536 45518–45536"},"PeriodicalIF":3.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c07702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Laboratory Nylon: A Scale-Up Method for High Molecular Weight Polyamides","authors":"Peter M. Meyer,&nbsp;Michael Forrester and Eric W. Cochran*,&nbsp;","doi":"10.1021/acs.iecr.4c0317510.1021/acs.iecr.4c03175","DOIUrl":"https://doi.org/10.1021/acs.iecr.4c03175https://doi.org/10.1021/acs.iecr.4c03175","url":null,"abstract":"<p >Here, we report a benchtop scale two-stage polyamidation process for the synthesis of diacid/diamine (AA-BB) type polyamides (PAs) in quantities sufficient (30 g+) to obtain ASTM dogbones, IZOD bars, and rheology specimens with molecular weights ranging from 15 to 35 kDa and minimal to no discoloration. Despite the extensive body of research in recent years reporting biobased AA-BB type PAs, the scale and molecular weights reported by many researchers are often inadequate for meaningful comparisons with industrial resins. Commercially produced PAs usually use an initially high-pressure, moderate-temperature oligomerization reaction to prevent the diacid’s decarboxylation and the diamine’s evaporation. Subsequently, a second stage employs a higher temperature at reduced pressure and inert sweep gas for molecular weight enrichment without significant oxidative degradation. We have sourced commercial hardware and made simple modifications, such as a robust agitator capable of wall-sweeping, to ensure uniform heat and mass transfer. The resulting PAs exhibit mechanical properties on par with industrially sourced controls, demonstrating the effectiveness of our approach in bridging the gap between academic and industrial PAs. This eliminates one of the significant roadblocks associated with developing new industrially relevant polyamides and should be broadly applicable to researchers struggling with the challenges of polyamidation.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"63 45","pages":"19506–19514 19506–19514"},"PeriodicalIF":3.8,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of Remote-Controllable Diels–Alder Platform on Magnetic Nanoparticles via Layer-by-Layer Assembly for AC Magnetic Field-Triggered Drug Release","authors":"Nanami Fujisawa,&nbsp;Lili Chen and Mitsuhiro Ebara*,&nbsp;","doi":"10.1021/acs.langmuir.4c0299810.1021/acs.langmuir.4c02998","DOIUrl":"https://doi.org/10.1021/acs.langmuir.4c02998https://doi.org/10.1021/acs.langmuir.4c02998","url":null,"abstract":"<p >Diels–Alder chemistry was exploited to develop a remote-controllable drug release platform on magnetic nanoparticles (MNPs). For this purpose, MNPs were decorated with anionic poly(styrenesulfonic acid-<i>co</i>-furfuryl methacrylate) (poly(SS-<i>co</i>-FMA)) and cationic poly(allylamine hydrochloride) by layer-by-layer assembly. The decorated MNPs successfully underwent DA reaction to produce covalent bonding between FMA (diene) and maleimide (dienophile)-terminated model drug. Thermal treatment above 80 °C caused the retro Diels–Alder reaction (rDA) between FMA and the drug, resulting in drug release. The retro DA could be also achieved by applying an alternating-current (AC) magnetic field to the decorated MNPs. This could spatially limit the heat generation around MNP without heating entire system. Drug release could be also accelerated with the irradiation time when a threshold temperature was met or exceeded the required energy for rDA reaction. Our results highlight the potential of DA chemistry as a new strategy to provide a remote controllable drug release platform for improving the therapeutic efficiency.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"40 45","pages":"23895–23901 23895–23901"},"PeriodicalIF":3.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of Germanium from a Solution by a Magnetic Iron-Based Precipitant","authors":"Jie Dai,&nbsp;Ming Liang,&nbsp;Kun Yang* and Libo Zhang*,&nbsp;","doi":"10.1021/acs.langmuir.4c0317410.1021/acs.langmuir.4c03174","DOIUrl":"https://doi.org/10.1021/acs.langmuir.4c03174https://doi.org/10.1021/acs.langmuir.4c03174","url":null,"abstract":"<p >This study presents a method for the precipitation of germanium from a solution using magnetic iron-based precipitants and contrasts this method with the commonly employed neutralization–precipitation technique in industrial production, analyzing and comparing their reaction conditions and the properties of their precipitates. This study analyzes the influence of varying experimental conditions (reaction time, reaction temperature, iron:germanium molar ratio, Fe³⁺:Fe²⁺ molar ratio, and reaction pH) on the germanium precipitation efficiency. With a precipitation time of 30 min, a precipitation temperature of 30 °C, an iron:germanium molar ratio of 30:1, an Fe³⁺:Fe²⁺ molar ratio of 3:1, and a reaction pH of 5.0, the optimal germanium precipitation efficiency achieved was 99.5%. Furthermore, this study employed X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, and vibrating sample magnetometry to analyze the properties and composition of the precipitate, providing support for the conclusion regarding germanium precipitation using magnetic iron-based precipitants. Through theoretical analysis and instrumental testing, it was determined that the precipitation of germanium from a solution using magnetic iron-based precipitants significantly reduces the reaction time compared to those of neutralization–precipitation methods. Moreover, a magnetic iron-based precipitant substantially reduces the amount of precipitate, allows for magnetic separation of the precipitate, and effectively alleviates the problem of the presence of other valuable metals in the precipitate.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"40 45","pages":"23973–23985 23973–23985"},"PeriodicalIF":3.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Interplay of Charge Transfer and Excited State Dynamics in MAPbBr3/Bi2Se3 Heterostructures","authors":"Prince Sharma,&nbsp;Naveen Kumar Tailor,&nbsp;Saurabh K. Saini,&nbsp;Kapil Kumar,&nbsp;Mahesh Kumar,&nbsp;Lalita Goswami,&nbsp;Ritu Srivastava,&nbsp;Tejasvini Sharma,&nbsp;Shivani Choudhary and Soumitra Satapathi*,&nbsp;","doi":"10.1021/acsaelm.4c0113510.1021/acsaelm.4c01135","DOIUrl":"https://doi.org/10.1021/acsaelm.4c01135https://doi.org/10.1021/acsaelm.4c01135","url":null,"abstract":"<p >The distinctive surface states of Bi₂Se₃, recognized as topological insulators, have garnered considerable attention for their phenomenal electronic and optical characteristics. Heterostructures (HS) integrating Bi₂Se₃ have emerged as viable prospects for a variety of applications despite hurdles such as attaining high-quality interfaces, complicated fabrication processes, and maximizing optoelectronic performance. The synergistic coupling of Bi₂Se₃ and halide perovskite materials provides potential such as variable bandgaps and improved charge carrier mobility. In this work, we fabricated the HS of Bi₂Se₃ with MAPbBr₃, with the aim of understanding changes in fundamental properties and excited state dynamics under different heterostructuring conditions. We observed the critical role of surface matching conditions in determining lattice compatibility between materials and influencing the crystallization of MAPbBr₃ precursor solutions. We demonstrate the occurrence of several phenomena in these heterostructures using transient absorption analysis. These include charge transfer, extended carrier recombination lifetimes, and bandgap renormalization. We also observe polaron formation, hot carrier cooling, and exciton–exciton annihilation. Additionally, inverse bremsstrahlung and excitonic interactions are identified. Moreover, the investigation of carrier temperature dependence indicates the participation of phonon bottleneck effects and Frohlich phonon emission. Because of their ability to achieve considerable charge transfer efficiencies resulting from strong electron–phonon coupling and excitonic interactions, we hypothesize that such heterostructures offer promise for effective photovoltaic and optoelectronic applications. Further exploration of the integration of other perovskite materials with Bi₂Se₃ is crucial for unlocking their full potential in practical devices.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"6 11","pages":"7809–7823 7809–7823"},"PeriodicalIF":4.3,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Fluid Method-Based Three-Dimensional Simulation of Blood Plasma Separation in a Complex and Elevated-Dimension Microchannel","authors":"Shivji Prasad Yadav,&nbsp;Harsh Deswal,&nbsp;Atul Sharma and Amit Agrawal*,&nbsp;","doi":"10.1021/acs.iecr.4c0240710.1021/acs.iecr.4c02407","DOIUrl":"https://doi.org/10.1021/acs.iecr.4c02407https://doi.org/10.1021/acs.iecr.4c02407","url":null,"abstract":"<p >Separating blood plasma is a critical and common task in daily laboratory analyses for diagnosing blood-related disorders and diseases. Optimizing the efficiency of blood plasma separation microdevices through numerical approaches can substantially reduce the time and expense of disease diagnosis. This work presents a numerical investigation of blood flow within a complex, elevated-dimension microchannel using a continuum-based two-fluid method. The simulations focus on two innovative passive blood-based microchannels designed for blood plasma separation applications that utilize blood’s various geometrical and hydrodynamic phenomena. The study qualitatively illustrates significant phenomena such as the Zweifach–Fung effect (bifurcation law), Fahraeus effect, Fahraeus–Lindquist effect, plasma skimming, and migration of red blood cells within the passive hydrodynamic blood plasma separation microdevice. These phenomena are crucial for achieving effective blood plasma separation within the microdevice. The qualitative analysis conducted in this study aligns with experimental observations, providing confidence in the model’s accuracy. Additionally, the study offers a quantitative analysis of local hematocrit profiles and cell-free layers at different locations within the microdevice, providing blood flow insights. The proposed continuum-based two-fluid method is a valuable tool during the initial design phase of passive blood-based microdevices, offering significant cost and time savings.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"63 45","pages":"19832–19847 19832–19847"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organic Sulfur Markers as Proxies of Depositional Paleoeenvironments Related to Recôncavo and Amazon Basins, Brazil","authors":"Diego Nery do Amaral,&nbsp;Flávia Lima e Cima Miranda,&nbsp;Lua Morena Leôncio de Oliveira,&nbsp;José Roberto Cerqueira,&nbsp;Hélio Jorge Portugal Severiano Ribeiro,&nbsp;Olívia Maria Cordeiro Oliveira,&nbsp;Antônio Fernando de Souza Queiroz,&nbsp;Sérgio Luís Costa Ferreira and Maria Elisabete Machado*,&nbsp;","doi":"10.1021/acsomega.4c0734410.1021/acsomega.4c07344","DOIUrl":"https://doi.org/10.1021/acsomega.4c07344https://doi.org/10.1021/acsomega.4c07344","url":null,"abstract":"<p >This study employed organic sulfur markers (S-markers) associated with geochemistry parameters to evaluate the paleoenvironment of different depositional settings in 24 samples collected in vertical sections of outcrops of the Candeias and Barreirinha Formations in Recôncavo and Amazon basins, respectively. A total of twenty-one S-markers from benzothiophene (BT), dibenzothiophene (DBT), and benzonaphtothiophenes (BNT) classes were optimized and quantified by gas chromatography-triple quadrupole mass spectrometry (GC–MS/MS). S-markers efficiently evaluated and differentiated the depositional paleoenvironment in the source rocks based on the individual compound, in cross-validation with saturated biomarkers, and associated with parameters such as total organic carbon (TOC) and Rock-Eval pyrolysis. Samples from the lacustrine environment presented low concentrations of BT, DBT, and BNT, and samples from the marine environment showed high BT, DBT, and BNT concentrations. The variations in ∑DBT and TOC indicated that the quantity and/or the type of organic matter exert some control over the distribution of DBTs. Although the formations are from different paleoenvironments, the organic matter input was similar, as indicated by high proportions of 1,2-BNT and 2,1-BNT relative to 2,3-BNT, thus characterizing the algal input with a microbial contribution for both sites. The sum of the BNTs was directly related to the amounts of amorphous organic matter (AOM) in the vertical distribution of outcrops. These results are in accordance with the finding that BNTs may originate from the microbial activity. The DBT/Phen vs pristane/phytane (Pr/Ph) relationship attested to differences in the redox conditions of the depositional paleoenvironments of the formations under study. The 4,6-DMDBT/2,4,6-TMDBT and 2,4,6-TMDBT/(2,4,7 + 2,4,8)-TMDBT ratios indicated immaturity for hydrocarbon generation.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"9 45","pages":"45358–45375 45358–45375"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c07344","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}