Obesity Medicine最新文献

{"title":"A novel therapeutic approach for hormonal imbalance in polycystic ovarian syndrome; evaluating the effects of Nutrition Bio-Shield Supplement in an animal model","authors":"Mehrdad Mosadegh ,&nbsp;Yasaman Sadeghi ,&nbsp;Aref Khalkhali ,&nbsp;Yousef Erfani","doi":"10.1016/j.obmed.2025.100590","DOIUrl":"10.1016/j.obmed.2025.100590","url":null,"abstract":"<div><h3>Background</h3><div>s: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that disrupts hormone balance, leading to infertility and metabolic issues. This study evaluates the effects of a novel nutritional supplement, Nutrition Bio-Shield (NBS), on hormonal regulation in a letrozole-induced PCOS rat model.</div></div><div><h3>Methods</h3><div>Twenty-five female Wistar rats were assigned to five groups: healthy control, PCOS control, and three groups treated with varying doses of NBS (12.5 mg/kg, 25 mg/kg, and 50 mg/kg). PCOS was induced using letrozole, and NBS was administered for 21 days. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, progesterone, and estradiol were measured using radioimmunoassay.</div></div><div><h3>Results</h3><div>NBS treatment significantly improved hormone levels compared to the PCOS control group. The highest dose (50 mg/kg) effectively reduced LH and testosterone while increasing progesterone and estradiol levels (p &lt; 0.05), nearing those of the healthy controls. The 25 mg/kg dose also showed considerable improvement in hormone balance, whereas the 12.5 mg/kg dose had a moderate effect. FSH levels were notably reduced in both 50 mg/kg and 25 mg/kg groups, suggesting a dose-dependent response to NBS treatment.</div></div><div><h3>Conclusion</h3><div>NBS supplementation successfully ameliorated hormonal imbalances in a PCOS rat model, demonstrating its potential as a natural therapeutic option for managing PCOS. Further research is needed to confirm these effects in clinical settings.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"54 ","pages":"Article 100590"},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of safoof-e− muhazzil and orlistat on obesity and markers of obesity","authors":"Mohd Aslam ,&nbsp;Ahmad Faraz ,&nbsp;Zaki Ahmad Siddiqui ,&nbsp;Maaz Ozair ,&nbsp;Hamid Ashraf ,&nbsp;Abdul Mannan","doi":"10.1016/j.obmed.2025.100589","DOIUrl":"10.1016/j.obmed.2025.100589","url":null,"abstract":"<div><h3>Introduction</h3><div>Obesity is truly a pandemic and associated with increased risk of multiple non-communicable diseases. The available pharmacotherapy of obesity is associated with multiple limitations. We have studied the effect of sufoof e muhazzil and compared it with orlistat in non-diabetic patients with obesity.</div></div><div><h3>Material and methods</h3><div>It was an open-label, interventional prospective study including 200 patients with obesity. These patients, aged between 18 and 60 years, had a body mass index (BMI) of 25–40 kg/m². We divided them equally between the Sufoof e Muhazzil and Orlistat groups. The dose of sufoof e muhazzil was 6 gm/day, and orlistat was 120 mg twice daily for 2 months. We assessed the effect on weight, BMI, biochemical, and inflammatory markers at the onset and at the end of the study.</div></div><div><h3>Result</h3><div>The mean age, weight, BMI, and waist circumference were 37.85 years and 35.71 years, 80.7 kg and 74.9 kg, 32.7 kg/m² and 32.4 kg/m², and 113.0 cm and 112.5 cm, respectively, for the orlistat and sufoof groups. There was a significant reduction in weight, BMI, and abdominal circumference in both groups (p value &lt; 0.001 for all). Biochemical and inflammatory parameters also improved significantly in both groups. Sufoof e muhazzil use was associated with greater reductions in weight (5.8 vs 4.4 kg), BMI (2.5 vs 1.9 kg/m²) than orlistat.</div></div><div><h3>Conclusion</h3><div>Both orlistat and sufoof e muhazzil are associated with significant weight reduction and improvement in biochemical and inflammatory parameters. Both the drugs demonstrated excellent safety and tolerability.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"54 ","pages":"Article 100589"},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity-driven hunger: From pathophysiology to intervention","authors":"Ahmad Khusairi Azemi ,&nbsp;Yahkub Babatunde Mutalub ,&nbsp;Monsurat Abdulwahab ,&nbsp;Aida Hanum Ghulam Rasool ,&nbsp;Sagir Mustapha ,&nbsp;Siti Qusyasyiah Ahmad Suhaimi ,&nbsp;Siti Safiah Mokhtar","doi":"10.1016/j.obmed.2025.100588","DOIUrl":"10.1016/j.obmed.2025.100588","url":null,"abstract":"<div><div>Obesity is a complex metabolic disorder driven by an imbalance between energy intake and expenditure. A critical pathogenetic component of obesity is dysregulated hunger and satiety mechanisms, driven by both central and peripheral factors. This review explores the pathophysiology of obesity-induced hunger, focusing on key mechanisms involving neurohormonal signals, gut-brain communication, and the dysregulation of appetite-related pathways. It discusses the roles of hormones such as ghrelin, leptin, and insulin, as well as the influence of inflammatory processes on hunger regulation. Additionally, environmental and psychological factors contributing to food cravings and reward-driven eating are considered. The article also examines current and emerging therapeutic interventions targeting hunger and appetite control, including pharmacologic treatments, such as glucagon-like peptide-1 (GLP-1) receptor agonists, lifestyle modifications, and bariatric surgery. Novel strategies under investigation, including appetite-regulating peptides, are highlighted. Bridging the understanding of the intricate mechanisms driving obesity-related hunger with therapeutic advances provides a comprehensive framework for more effective treatment strategies to combat obesity and its associated comorbidities which will ultimately improve patient outcomes.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"54 ","pages":"Article 100588"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of simple and specialized non-invasive tools in predicting of metabolic dysfunction-associated fatty liver disease severity and prognosis","authors":"Marjan Mokhtare ,&nbsp;Shahin Sharafeh ,&nbsp;Mohammadjavad Sotoudeheian ,&nbsp;Amir M. Sadeghian ,&nbsp;Said A. Al-Busafi","doi":"10.1016/j.obmed.2025.100582","DOIUrl":"10.1016/j.obmed.2025.100582","url":null,"abstract":"<div><h3>Objectives</h3><div>Metabolic-associated fatty liver disease (MAFLD) is a universal health concern. Detecting advanced fibrosis significantly impacts prognosis. This study designated to assess the accuracy of FIB-4, FIB-6, Agile3+, Agile4, and NAFLD fibrosis score (NFS) in predicting disease severity.</div></div><div><h3>Design and Methods</h3><div>Clinical, laboratory, and FibroScan findings of adult MAFLD patients were recorded. A fibrosis (F) score over 10 kPa indicates advanced fibrosis. We assessed the area under the receiver operating characteristic curve (AUROCC), along with the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy with various cutoff values. Reliability was analyzed with the intra-class correlation coefficient (ICC).</div></div><div><h3>Results</h3><div>Advanced fibrosis was found in 5 of 103 patients (4.85%). AUROCC values were as follows: 0.967 for Agile3+, 0.951 for FIB-6, 0.932 for NFS, 0.909 for Agile4, and 0.869 for FIB-4. The PPVs ranged from 18.18% (FIB-4) to 57.09% (NFS), followed by 75.02% (FIB-6), and 18.18% (Agile4) to 100% (Agile3+). All tools achieved acceptable NPVs above 96%. The ICC between the fibrosis score and other tools was 0.772 (95% CI: 0.696-0.834). Significant differences were noted in gamma-glutamyl transferase (p=0.039), diabetes mellitus (P=0.011), platelet count, hemoglobin A1C, alkaline phosphatase, triglycerides, fasting blood glucose, and Vitamin D levels</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"54 ","pages":"Article 100582"},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological therapy for Gestational Diabetes Mellitus: A comprehensive overview","authors":"Tanu Gautam ,&nbsp;Amreen Shamsad ,&nbsp;Renu Singh ,&nbsp;S. Shabihe Raza Baqri ,&nbsp;Monisha Banerjee","doi":"10.1016/j.obmed.2025.100587","DOIUrl":"10.1016/j.obmed.2025.100587","url":null,"abstract":"<div><div>Gestational diabetes mellitus (GDM) is a prevalent metabolic condition affecting pregnant women, impairing glucose tolerance, and causing short- and long-term effects on mother, fetus, and neonate. The goal of management therapy during pregnancy is to obtain optimal glycemic control by preventing hyperglycemia and maintaining safety. The increasing prevalence of GDM worldwide is a rising concern, underscoring the need for dietary adjustments and improved detection, diagnostic and treatment strategies to overcome adverse consequences. International guidelines recommend pharmaceutical interventions for GDM when lifestyle adjustments do not attain glycemic control. Insulin is first-line treatment, but oral anti-hyperglycemic medications serve as often-used alternatives. Metformin and glyburide effectively regulate increased blood glucose in pregnancy. Metformin is preferred due to its ease of administration, reduced risk of hypoglycemia, and potential for improved long-term outcomes. Whereas glyburide is administered cautiously due to potential feto-maternal risk. In this review, the pharmaceutical alternatives for GDM have been discussed in detail, along with pharmacology and pharmacokinetics. The effects of metabolic and glycemic control on feto-maternal morbidity have also been elaborated, along with efficacy as well as side effects and long-term outcomes. However, their long-term safety profiles and fetal exposure remain unclear. By focusing on this research gap, we can explore effective management therapy by evaluating feto-maternal long-term outcomes through follow-up studies, comparing efficacy of pharmacological interventions, pharmacogenomics, digital health technologies, emerging pharmaceutical alternatives (GLP-1-Ra &amp; SGLT-2 inhibitors), and personalized medicine. By incorporating these advancements into clinical practice by healthcare professionals, the risk of adverse effects may decrease to improve health and well-being.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"54 ","pages":"Article 100587"},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Betula alnoides bark: Insilico and preclinical insights into its antioxidant and lipid-lowering effects in hypercholesterolemia","authors":"Shahbaz Khan ,&nbsp;Alka Lohani ,&nbsp;Prashant Tiwari ,&nbsp;Sunil Kumar Kadiri","doi":"10.1016/j.obmed.2025.100583","DOIUrl":"10.1016/j.obmed.2025.100583","url":null,"abstract":"<div><h3>Aim</h3><div>Hyperlipidemia characterized by elevated cholesterol levels and formation of Reactive Oxygen Species (ROS) is a critical risk factor for coronary heart diseases. In traditional Indian Ayurveda and herbal medicine, various parts of <em>Betula alnoides</em> are reputed for their therapeutic uses. The main aim of this study is to explore the hypolipidemic and antioxidant effects of <em>Betula alnoides</em> bark extracts (petroleum ether and ethyl acetate) in rats with induced hypercholesterolemia.</div></div><div><h3>Methods</h3><div>Soxhlet extraction method was used to extract <em>Betula alnoides</em> bark powder, utilizing petroleum ether and ethyl acetate as solvents and both the extracts underwent phytochemical screening to identify a range of phytoconstituents. The acute oral toxicity was evaluated on male albino rats, adhering to OECD guideline No. 420. DPPH and nitric oxide scavenging assay was used to determine antioxidant capacity of bark extracts. Hypolipidemic activity was evaluated by inducing hyperlipidemia through a high-fat diet and measuring serum biochemical markers like total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides.</div></div><div><h3>Results</h3><div>The extraction yields were found to be 1.4% ± 0.65% for the petroleum ether extract and 3.2% ± 0.80% for the ethyl acetate extract. In the acute toxicity study, it was found that the bark extracts showed no signs of toxicity. The findings indicated that the DPPH/Nitric oxide free radical scavenging capacity of <em>Betula alnoides</em> bark extracts increased with higher concentrations. When compared to the petroleum ether bark extract, the ethyl acetate bark extract showed a noticeably better antioxidant capacity. Both petroleum ether and ethyl acetate extracts (50 mg/kg and 100 mg/kg) and fenofibrate (65 mg/kg), exhibited significant hypolipidemic effects.</div></div><div><h3>Conclusion</h3><div>The ethyl acetate extract demonstrated superior hypolipidemic activity compared to the petroleum ether extract. Lupeol binds strongly to SOD, SGLT2, and APOE proteins, showing significant docking scores and engaging multiple amino acids through various stabilizing interactions. These findings suggest that <em>Betula alnoides</em> bark extracts possess promising antioxidant and anti-hyperlipidemic properties.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"54 ","pages":"Article 100583"},"PeriodicalIF":0.0,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytokines as key players in obesity low grade inflammation and related complications","authors":"Daniel Ejim Uti ,&nbsp;Item Justin Atangwho ,&nbsp;Wilson Achu Omang ,&nbsp;Esther Ugo Alum ,&nbsp;Uket Nta Obeten ,&nbsp;Precious A. Udeozor ,&nbsp;Samuel A. Agada ,&nbsp;Inalegwu Bawa ,&nbsp;Celestine O. Ogbu","doi":"10.1016/j.obmed.2025.100585","DOIUrl":"10.1016/j.obmed.2025.100585","url":null,"abstract":"<div><div>Environmental factors, genetic factors, and metabolic factors all have a role in the development of obesity, which is a complex worldwide health challenge. Furthermore, the pathophysiology of adipose tissue is characterized by elevated levels of inflammatory cytokines, which suggests the presence of persistent low-grade inflammation. The findings of this review shed insight on the role that cytokines play in the establishment and progression of low-grade inflammation in obese individuals. Additionally, it investigates the possibility of using them as diagnostic markers and therapy targets for obesity, respectively. The cytokines in question are produced by adipose tissue, which is an active endocrine organ. Included in the list of examples are TNF-α, IL-6, IL-1β, and MCP-1. These cytokines contribute to dyslipidemia and insulin resistance. The paper also discusses how immune cells, macrophages, and adipocytes interact to aggravate inflammatory processes. Adipokines such as adiponectin and leptin are also investigated, along with their regulatory functions in inflammatory signalling pathways and metabolic balance. The article discusses recent studies that target inflammatory cytokines and adipokines for both therapeutic and diagnostic applications. It is essential to comprehend these complex relationships in order to create novel treatment approaches that address the metabolic effects of obesity and enhance public health outcomes. This article provides a comprehensive resource for scholars who want to understand and initiate studies aimed at reducing inflammation linked to obesity and the health issues that come with it.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"54 ","pages":"Article 100585"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic efficacy of hydroalcoholic extract of Euphorbia prostrata Aiton in NAD-STZ-induced diabetic nephropathy: A multifaceted intervention targeting oxidative stress and inflammation","authors":"Nikhil Garg ,&nbsp;Ashi Mannan ,&nbsp;Maneesh Mohan,&nbsp;Thakur Gurjeet Singh","doi":"10.1016/j.obmed.2024.100579","DOIUrl":"10.1016/j.obmed.2024.100579","url":null,"abstract":"<div><h3>Aim</h3><div>The aim of the current study is to evaluate the effect of Hydroalcoholic Extract of <em>Euphorbia prostrata</em> (EPHAE) in diabetic nephropathy (DN) induced by NAD-STZ in rats.</div></div><div><h3>Methods</h3><div>NAD (230 mg/kg) was administered 15 min prior to the administration of STZ (65 mg/kg) in rats for the induction of DN. Body weight, glucose, insulin levels as well as behavioural parameters like polydipsia and polyphagia was noted. Biochemical estimations of AGEs, gluconeogenic enzymes, SOD, GSH, Cat, and TBARS was done using appropriate assays as well as levels of HDL, LDL, VLDL, cholesterol, TGs, albumin, BUN, creatine, urea, uric acid and kidney index were done using autoanalyzer. ELISA was employed for the determination of IL-1β, IL-6, TNF-α, TGF-β, and NF-κB.</div></div><div><h3>Results</h3><div>The NAD-STZ induced DN was successfully established as characterized by increased levels of glucose, water and food intake, as well as reduced levels of insulin and body weight. These levels were normalized after administration of EPHAE (150 mg/kg) and glimepiride (10 mg/kg) for 60 days. The levels of AGEs, gluconeogenic enzymes, even oxidative stress parameters like SOD, GSH, Cat and TBARs were found to be normalized after EPHAE and glimepiride administration. Moreover, the levels of HDL were increased whereas the levels of LDL, VLDL, cholesterol, TGs, albumin, BUN, creatine, urea, uric acid and kidney index were found to be decreased after administration of EPHAE and glimepiride in dose-dependent manner. Additionally, ELISA results reveal the reduction in IL-1β, IL-6, TNF-α, TGF-β and NF-κB levels after administration of EPHAE and glimepiride in dose dependent manner.</div></div><div><h3>Conclusions</h3><div>EPHAE demonstrates significant potential in the treatment of DN by regulating oxidative stress and inflammation.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"54 ","pages":"Article 100579"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of AMP-activated protein kinase activators on energy balance and cellular metabolism in type 2 diabetes mellitus","authors":"Saliha Aydin ,&nbsp;Sevval Gulsah Tekinalp ,&nbsp;Bilge Tuzcu ,&nbsp;Furkan Cam ,&nbsp;Mehmet Orkun Sevik ,&nbsp;Esra Tatar ,&nbsp;Deepak Kalaskar ,&nbsp;Muhammet Emin Cam","doi":"10.1016/j.obmed.2024.100577","DOIUrl":"10.1016/j.obmed.2024.100577","url":null,"abstract":"<div><div>Type 2 Diabetes Mellitus (T2DM) is a growing health concern that leads to increased morbidity and mortality rates worldwide. A protein complex called AMP-activated protein kinase (AMPK) regulates energy balance within cells and controls cellular metabolism. Over the past decade, numerous studies have highlighted the remarkable potential of AMPK and its activators in treating T2DM. Key compounds, including biguanides (e.g., metformin), thiazolidinediones, phenolic compounds (e.g., resveratrol), and AICAR, have demonstrated the ability to improve insulin sensitivity, enhance glucose uptake in skeletal muscle, reduce hepatic glucose production, and improve glycemic control. Additionally, AMPK activators have shown promising effects on lipid metabolism, inflammation, and oxidative stress, which are critical factors in the pathogenesis of T2DM. The activation of AMPK by natural products and synthetic drug candidates represents a promising avenue for developing novel treatments targeting T2DM and its complications. This review aims to provide an overview of direct and indirect AMPK activation and its relevance in organs implicated in the development of T2DM.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"53 ","pages":"Article 100577"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of non-communicable chronic diseases in teachers","authors":"Fernando Guimarães Fonseca ,&nbsp;Iury Marcos da Silva Pessoa ,&nbsp;Tolentino Miranda Marco Túlio ,&nbsp;Melline Mota Bispo Froes ,&nbsp;Wender Soares Coelho ,&nbsp;Yure Batista de Sousa ,&nbsp;Desirée Sant'ana Haikal ,&nbsp;Lucineia de Pinho","doi":"10.1016/j.obmed.2024.100567","DOIUrl":"10.1016/j.obmed.2024.100567","url":null,"abstract":"<div><div>Chronic non-communicable diseases (NCDs) significantly impact quality of life and contribute to increased morbidity and mortality rates. This study aimed to analyze the prevalence of NCDs among teachers in the state public school system of Minas Gerais during the COVID-19 pandemic. Conducted as an epidemiological web survey, it included 15,641 teachers from August to September 2020. Data analysis utilized descriptive statistics, the Omnibus test to evaluate variable associations, and a multiple Poisson regression model to estimate association magnitudes. The findings revealed that 30.6% of teachers had chronic NCDs, with higher prevalence in those aged 41 and older, single, earning between three to five minimum wages, having over 20 years of teaching experience, not engaging in physical activity, being ex-smokers, self-rating their health as poor/very poor, and expressing significant fear of COVID-19. The study identified a statistically significant association between NCDs and physical activity, smoking status, self-rated health, and fear of the virus. These results highlight a high prevalence of NCDs among teachers and underscore the urgent need for enhanced prevention and health promotion initiatives within this demographic.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"53 ","pages":"Article 100567"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}