Healing wounds in diabetes: Exploring cutting-edge natural extracellular vesicle therapeutics

Q2 Medicine

Obesity Medicine Pub Date : 2025-02-21 DOI:10.1016/j.obmed.2025.100597

Mumtaj Bano Miya , Pankaj Chaturvedi , Vandana Pathak , Prakash Chandra Gupta , Anuradha Kalani

引用次数: 0

Abstract

Managing diabetes-related foot ulcers is challenging due to their slow healing process, peripheral neuropathy, reduced blood flow and increased risk of infection. Exploring alternative approaches, such as medicinal plant-based therapies, could provide promising solutions for diabetic wound healing. The current review discusses the therapeutic potential of different extracellular vesicles for diabetic wound healing. A newly developed oxygenated nanotherapeutic, OXY-Exo^Aloe, is further discussed, which is formulated by combining the medicinal potential of Aloe barbadensis, Azadirachta indica, and Zingiber officinale. The oxygenated nanotherapeutics could offer a multi-faceted approach to wound healing and may revolutionize advancements in nanotechnology and medicinal plant-based therapies for the treatment of diabetic foot ulcers in the future.

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糖尿病伤口愈合：探索先进的天然细胞外囊泡疗法

由于糖尿病相关足溃疡的愈合过程缓慢、周围神经病变、血流量减少和感染风险增加，管理糖尿病相关足溃疡具有挑战性。探索替代方法，如药用植物疗法，可能为糖尿病伤口愈合提供有希望的解决方案。本文综述了不同细胞外囊泡对糖尿病伤口愈合的治疗潜力。进一步讨论了一种新开发的氧合纳米治疗药物OXY-ExoAloe，该药物结合了芦荟，印楝和生姜的药用潜力。氧化纳米疗法可以为伤口愈合提供多方面的方法，并可能在纳米技术和药用植物治疗糖尿病足溃疡方面取得革命性的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.