Obesity Medicine最新文献

{"title":"Impact of bariatric surgery on Type 2 Diabetes Mellitus: A comprehensive 5-year analysis of weight loss, glycemic control, and cardiometabolic outcomes","authors":"Adnan Agha ,&nbsp;Bachar Afandi ,&nbsp;Waad Ibrahim Alhammadi ,&nbsp;Hamad Talal Jumaa Mubarak Almaskari ,&nbsp;Asma Alshamsi ,&nbsp;Mohammed Saleem ,&nbsp;Juma Al Kaabi","doi":"10.1016/j.obmed.2025.100656","DOIUrl":"10.1016/j.obmed.2025.100656","url":null,"abstract":"<div><h3>Background</h3><div>Bariatric surgery has emerged as a potent intervention for patients with obesity and Type 2 Diabetes Mellitus (T2DM).</div></div><div><h3>Objectives</h3><div>To assess 5-year outcomes of bariatric surgery in Middle Eastern patients with T2DM and develop a predictive model for diabetes remission.</div></div><div><h3>Setting</h3><div>Tertiary care center, United Arab Emirates.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of 238 T2DM patients (161 females, 67.6 %; mean age 46.8 ± 11.6 years) who underwent bariatric surgery from 2013 to 2019. Procedures included laparoscopic sleeve gastrectomy (LSG; n = 138, 58.0 %), Roux-en-Y gastric bypass (RYGB; n = 85, 35.7 %), and adjustable gastric banding (AGB; n = 15; 6.3 %). Clinical, biochemical and cardiometabolic parameters were followed for 5 years. Multivariate logistic regression analysis identified independent predictors of diabetes remission.</div></div><div><h3>Results</h3><div>Sustained total weight loss of 26.2 %, 29.2 %, and 27.2 % was achieved at 1, 3, and 5 years respectively. HbA1c decreased from 7.8 ± 1.5 % to 6.1 ± 1.0 % at 5 years (p &lt; 0.001). By 5 years, 95.4 % of patients discontinued diabetes medications. Complete diabetes remission (HbA1c &lt;6.0 % without medications) was achieved in 52.9 %, exceeding rates typically reported in randomized controlled trials of bariatric surgery (23–29 %) in Western populations. Multivariate analysis revealed baseline HbA1c &lt;8 % (OR 2.84, 95 % CI 1.52–5.31, p = 0.001), diabetes duration &lt;5 years (OR 3.21, 95 % CI 1.78–5.79, p &lt; 0.001), and weight loss &gt;20 % at 1 year (OR 4.15, 95 % CI 2.23–7.72, p &lt; 0.001) as independent predictors of sustained remission (C-statistic = 0.842).</div></div><div><h3>Conclusions</h3><div>Bariatric surgery provides sustained improvements in weight loss and glycemic control in Middle Eastern T2DM patients over 5 years. The identification of key predictors enables better patient selection and personalized treatment strategies.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"58 ","pages":"Article 100656"},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional East African medicinal plants as modulators of gut microbiota in obesity-associated diabetes: A short communication","authors":"Okechukwu Paul-Chima Ugwu ,&nbsp;Dominic Terkimbi Swase ,&nbsp;Michael Ben Okon ,&nbsp;Anyanwu Chinyere Nkemjika ,&nbsp;Regan Mujinya","doi":"10.1016/j.obmed.2025.100654","DOIUrl":"10.1016/j.obmed.2025.100654","url":null,"abstract":"<div><div>The prevalence of obesity and type 2 diabetes mellitus (T2DM) is rapidly growing in East Africa as a result of urbanisation, changing diets, and sedentary lifestyles. According to the International Diabetes Federation (IDF), 4.2 per cent of the adult population in sub-Saharan Africa (24 million people) has diabetes, which is expected to be more than 55 million by 2045, with East Africa making its fair share of the burden. Gut microbiota dysbiosis, which is observed as the loss of short-chain fatty acid (SCFA)-producing bacteria and a rise in the pro-inflammatory taxa, is a key mechanistic connection between obesity and T2DM. The traditional medications, including metformin, sulfonylureas, insulin, and the new anti-obesity medications, are all clinically effective, but they are expensive, less available, and have low tolerance in the East African population. Conversely, native medicinal plants <em>Moringa oleifera, Warburgia ugandensis, Aloe secundiflora</em>, and <em>Azadirachta indica</em> are clinically accessible, acceptable and have antimicrobial, prebiotic, and anti-inflammatory phytochemicals that can potentially alter the composition and activity of gut microbiota. This short communication narratively reviewed recent discoveries in the fields of ethnopharmacology, phytochemistry, and microbiome science in PubMed, Scopus, Web of Science, and Google Scholar from 2015 to 2025. The discussion focuses on the translational pathways between phytochemical-microbiota interactions and metabolic health outcomes, as well as the existing gaps in the evidence base and the need for systematic methodologies and clinical validation in East African settings. We suggest interdisciplinary trials that include phytochemical standardisation or microbiome sequencing and culturally appropriate community-based approaches.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"58 ","pages":"Article 100654"},"PeriodicalIF":0.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145160160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes mellitus: Complications, emerging therapeutic targets, and evolving treatment approaches","authors":"Sharfuddin Mohd,&nbsp;Lekkala Lithin Kumar,&nbsp;Vancha Harish,&nbsp;Rakesh Kumar,&nbsp;Aakriti Chaudhary,&nbsp;Vikas Sharma","doi":"10.1016/j.obmed.2025.100652","DOIUrl":"10.1016/j.obmed.2025.100652","url":null,"abstract":"<div><div>Diabetes Mellitus (DM) is a chronic metabolic disorder effecting the carbohydrate, protein and lipid metabolism, primarily caused by elevated blood glucose levels, due to the insulin deficiency or impaired glucose uptake by the body cells. Its clinical manifestations including polydipsia, polyuria, polyphagia, blurry vision, extreme fatigue can lead to severe complications such as diabetic nephropathy, neuropathy, retinopathy, and cardiomyopathy imposing substantial global health and economic burdens. This review synthesizes current evidence on the pathophysiology and clinical spectrum of DM complications, highlighting the roles of glucotoxicity, lipotoxicity, oxidative stress, advanced glycation end-products, mitochondrial dysfunction, maladaptive inflammation, and microvascular rarefaction. Additionally, emerging biomarkers linked to the pathogenesis of diabetic complications are summarized and reviewed. The novel therapeutic targets, include glucokinase, AMPK, SIRT1, SIRT3, GPR120 activators, TGR5, GPR119 agonists, PTP1B and G-FAT inhibitors as next generation drugs. Advanced treatment strategies encompass gene and cell-based approaches next-generation drug delivery systems-nanocarriers, nanopumps, closed-loop “smart” insulin technologies. We also review applications of artificial intelligence and machine learning for early detection, progression prediction, treatment optimization and personalized care, alongside insights from recent clinical trials and innovation trends in the patent landscape.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"58 ","pages":"Article 100652"},"PeriodicalIF":0.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sleep and weight loss in a 12-month digital lifestyle intervention","authors":"Aila J. Ahola ,&nbsp;Anu Joki ,&nbsp;Mikko S. Venäläinen ,&nbsp;Sakris K.E. Kupila ,&nbsp;Laura-Unnukka Suojanen ,&nbsp;E. Juulia Paavonen ,&nbsp;Kirsi H. Pietiläinen","doi":"10.1016/j.obmed.2025.100653","DOIUrl":"10.1016/j.obmed.2025.100653","url":null,"abstract":"<div><h3>Objectives</h3><div>We studied how sleep quality and chronotype relate to weight loss in a 12-month real-world digital lifestyle intervention, the Healthy Weight Coaching.</div></div><div><h3>Methods</h3><div>Patients self-reported weight and waist circumference and completed a set of customized sleep-related online questionnaires at baseline, 3-, 6-, 9-, and 12-months. Primary outcomes were percent changes in weight and waist circumference, calculated from baseline to each follow-up time point. Using generalized linear regression for repeated measures, we explored associations between sleep variables (individual variables and factor analysis-derived clusters) and changes in measures of obesity across the program. Additionally, we investigated how changes in reported sleep are associated with weight loss outcomes.</div></div><div><h3>Results</h3><div>Baseline data included 1883 individuals (82.6 % women, median age 52 years, median BMI 39.1 kg/m²). Reporting sleep apnoea was associated with less successful weight loss across the program [weight, B = 0.760 (95 % CI = 0.446–1.073), p &lt; 0.001; waist, B = 1.275 (95 % CI = 0.780–1.771), p &lt; 0.001]. <em>Eveningness</em> and <em>Tiredness</em> factors were associated with poorer weight [B = 0.206 (95 % CI = 0.027–0.385), p = 0.024 and B = 0.613 (95 % CI = 0.371–0.855), p &lt; 0.001, respectively] and waist circumference [B = 0.434 (95 % CI = 0.155–0.713), p = 0.002 and B = 0.720 (95 % CI = 0.337–1.102), p &lt; 0.001, respectively] reduction over the 12-month program. Increase in reported daytime alertness, over the program, was beneficial for weight loss outcomes.</div></div><div><h3>Conclusions</h3><div>Addressing evening chronotype and reasons for reduced daytime alertness may be associated with enhanced weight loss; however this study does not establish causality. Additional research is needed to adapt interventions for those with sleep apnoea.</div></div><div><h3>Trial registration</h3><div>The trial is registered at clinicaltrials.cov (Clinical Trials Identifier NCT04019249).</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"58 ","pages":"Article 100653"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of quality of life among type 2 diabetes mellitus and hypertensive patients in Punjab region: A WHOQoL-BREF based hospital study","authors":"Priyanka Garg,&nbsp;Palakurthi Yanadaiah","doi":"10.1016/j.obmed.2025.100651","DOIUrl":"10.1016/j.obmed.2025.100651","url":null,"abstract":"<div><h3>Aim</h3><div>According to recent WHO report, type 2 diabetes mellitus along with associated conditions like hypertension are the most prevalent and alarming disorders especially in low-income settings. The prognosis rates of type 2 diabetes mellitus with hypertension depends on the quality of life of the patients. It arises concern to perform research on this group of patients to reduce the poor outcomes and to improve the prognosis of the disease. This study merely focuses on evaluating the quality of life of patients with type 2 diabetes mellitus and hypertension.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted at Christian Medical College &amp; Hospital in Ludhiana, Punjab, India, using a WHOQoL-BREF questionnaire. The research was conducted among 126 hypertensive and type 2 diabetes mellitus patients, aged between 18 and 70 years. Each patient received informed consent before filling the questionnaire. The data was analyzed using SPSS 16, ANOVA, and an independent student t-test.</div></div><div><h3>Results</h3><div>The study determined 59.5 % as female and 40.5 % being male. Further, the findings reported that environmental health domain exhibited the highest mean score of 29.3 while the social relationship domain exhibited the lowest quality of life. The variables like BMI, and duration of diseases showed a strong statistical significance with quality of life.</div></div><div><h3>Conclusion</h3><div>The study concluded that increase in BMI and duration of disease will significantly reduce the quality of life in patients suffering with type 2 diabetes with hypertension.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"58 ","pages":"Article 100651"},"PeriodicalIF":0.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the waist circumference and waist–to–height ratio as most reliable indicators to determine abdominal obesity among adolescents: Findings from a cross-sectional study in Kazakhstan","authors":"Ainur S. Ospanova ,&nbsp;Aiman S. Kerimkulova ,&nbsp;Vijay Kumar Chattu ,&nbsp;Ainur O. Samigatova ,&nbsp;Akbayan Markabaeva ,&nbsp;Riza Nurpeissova ,&nbsp;Meruyert O. Zhakupbekova","doi":"10.1016/j.obmed.2025.100650","DOIUrl":"10.1016/j.obmed.2025.100650","url":null,"abstract":"<div><h3>Background</h3><div>Childhood obesity is a significant public health issue in Kazakhstan and worldwide. The prevalence of teenager obesity has increased almost three times over the past 20 years among adolescents from 12 to 19 years old. This study aimed to evaluate the waist–to–height ratio (WHtR) as the most informative method for identifying abdominal obesity among young people of 12–13 years old.</div></div><div><h3>Methods</h3><div>In this cross–sectional study of 1519 adolescents aged 12–13years (mean age: 12.3 ± 0.46years), data were obtained from the from all the seven secondary schools in Semey city (Kazakhstan) science during 2015–2016. Statistical analyses were performed using SPSS (version 22).</div></div><div><h3>Results</h3><div>The prevalence of overweight and obesity in terms of body mass index (BMI) among adolescents was 24.6 %. Excess weight is significantly higher among girls, but obesity is less pronounced in comparison with boys. According to body BMI by ethnicity overweight is more prevalent among Russian teenagers. The prevalence of abdominal obesity (WC˃90^Th percentile) was 1.2 % among boys (n = 9) and 5.3 % among girls (n = 41). According to the WHtR, the obesity among boys (n = 57) was 7.7 % and 7.5 % among girls (n = 58) respectively.</div></div><div><h3>Conclusions</h3><div>The prevalence of overweight and obesity was found to be 24.6 % in adolescents. Underweight or overweight were significantly higher among girls, but obesity was less pronounced compared with boys (р˃0,001). Our study recommends to use both WC and WHtR in determining abdominal obesity among adolescents.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"58 ","pages":"Article 100650"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized controlled trial comparing a very low-calorie low-fat ketogenic diet with a standard hypocaloric diet in adults with class I obesity","authors":"Francisco J. Nachon Garcia ,&nbsp;Gabriela E. Saldaña-Davila ,&nbsp;Magdalena Valencia ,&nbsp;Cesar Ochoa-Martínez","doi":"10.1016/j.obmed.2025.100642","DOIUrl":"10.1016/j.obmed.2025.100642","url":null,"abstract":"<div><h3>Background</h3><div>The global rise in obesity, driven by hypercaloric diets and sedentary lifestyles, has intensified interest in novel dietary interventions. Very low-calorie ketogenic diets (VLCKDs) induce rapid weight loss but are typically high in fat. This study assessed the efficacy and safety of a very low-calorie, low-fat, ketogenic diet (VLCLFKD), also known as the Zélé method, versus a standard low-calorie diet (LCD) in adults with class I obesity.</div></div><div><h3>Methods</h3><div>In this 12-week, randomized, double-blind controlled trial (NCT06275347), 88 participants were allocated to VLCLFKD (n = 56) or LCD (n = 32), with 77 completing the protocol. The primary endpoint was weight change; secondary outcomes included body composition, fasting glucose, lipid profile, blood pressure, hepatic and renal function, and acid–base balance. All participants received weekly clinical and dietary support.</div></div><div><h3>Results</h3><div>VLCLFKD led to significantly greater weight loss (−12.4 ± 2.8 kg) than LCD (−7.0 ± 1.9 kg; p &lt; 0.001). Fat mass reduction accounted for 82.1 % of total weight loss in the VLCLFKD group, compared to 38.4 % in the LCD group (p &lt; 0.001), with markedly lower lean mass loss (11.9 % vs. 51.0 %). Significant improvements were observed in fasting glucose (−12.8 mg/dL), total cholesterol (−37.4 mg/dL), triglycerides (−67.4 mg/dL), and blood pressure normalization (88.1 % vs. 71.4 %). Renal and hepatic function and acid–base balance remained stable. No serious adverse events occurred.</div></div><div><h3>Conclusion</h3><div>The VLCLFKD (Zélé method) is a safe, fat-targeted, and metabolically advantageous strategy for class I obesity, delivering superior weight and metabolic outcomes compared with a conventional LCD while preserving lean mass.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"58 ","pages":"Article 100642"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145160161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overweight/obesity and sedentary Behavior: Dual modifiable factors associated with Hypertension–diabetes comorbidity among adults in Haiphong, Vietnam","authors":"Thuc Huy Phan ,&nbsp;Kien Trung Dong ,&nbsp;Diem Thi Hong Nguyen ,&nbsp;Hong Thi Nguyen ,&nbsp;Khoa Xuan Tang ,&nbsp;Anh Hai Cao ,&nbsp;Linh Thuy Nguyen ,&nbsp;Tuyet Thi Hong Nguyen ,&nbsp;Duc Minh Cap","doi":"10.1016/j.obmed.2025.100649","DOIUrl":"10.1016/j.obmed.2025.100649","url":null,"abstract":"<div><h3>Aims</h3><div>Hypertension and diabetes are major global public health challenges. This study aimed to assess the prevalence of comorbid hypertension and diabetes and to identify associated factors among adults in Haiphong, Vietnam.</div></div><div><h3>Materials and methods</h3><div>A large-scale cross-sectional screening study involving 2100 adults was conducted. Participants were selected using multistage sampling from November to December 2023. Data were collected through face-to-face interviews, blood pressure measurements, and anthropometric assessments. Fasting plasma glucose levels were determined using venous blood samples. Univariable and multivariable logistic regression analyses were performed to identify factors associated with comorbid hypertension and diabetes.</div></div><div><h3>Results</h3><div>The prevalence of hypertension, diabetes, and their comorbidity was 21.8 %, 10.6 %, and 4.3 %, respectively. In the overall population, comorbidity was significantly associated with age 50–60 years (adjusted odds ratio [aOR], 5.03; 95 % confidence interval [CI], 1.53–16.60), male sex (aOR, 1.84; 95 % CI, 1.06–3.21), overweight/obesity (aOR, 1.98; 95 % CI, 1.17–3.36), and sedentary behavior ≥8 h/day (aOR, 2.37; 95 % CI, 1.26–4.46). Among males, significant factors included age 50–60, sedentary behavior, and high-risk alcohol use. Among females, comorbidity was associated with overweight/obesity and a family history of diabetes.</div></div><div><h3>Conclusion</h3><div>These findings underscore the need for gender-sensitive interventions to reduce the burden of hypertension–diabetes comorbidity in adults. For males, strategies should address sedentary lifestyles, alcohol-related risks, and age-related screening, while in females, efforts should focus on weight management and early identification of individuals with a family history of diabetes.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"58 ","pages":"Article 100649"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between 8 a.m. cortisol levels and insulin resistance in healthy individuals from Algiers","authors":"Nadia Ould Bessi ,&nbsp;Yousra Touahria Miliani ,&nbsp;Rayane Damou ,&nbsp;Meriem Achraf EL Mehdaoui ,&nbsp;Amine Kemache ,&nbsp;Belaid Ait Abdelkader","doi":"10.1016/j.obmed.2025.100648","DOIUrl":"10.1016/j.obmed.2025.100648","url":null,"abstract":"<div><h3>Background</h3><div>Cortisol is a counterregulatory hormone that antagonizes insulin. Its chronic supraphysiological elevation induces insulin resistance, a risk factor for cardiovascular and metabolic diseases. However, the relationship between insulin resistance and normal cortisol concentrations remains controversial. This study evaluates the association between 8:00 a.m. cortisol levels and insulin resistance, as estimated by the HOMA-IR index, and compares the HOMA-IR index with other insulin resistance indices: QUICKI, TyG, and the TG/HDL ratio.</div></div><div><h3>Methods</h3><div>Healthy adult volunteers were recruited. Exclusion criteria included smoking, pregnancy, and use of lipid-lowering medications, steroids, antidiabetic agents, or antihypertensive agents. Fasting measurements included blood glucose, insulin, cortisol, C-peptide, triglycerides, total cholesterol, LDL cholesterol, HDL cholesterol, and AST. Blood pressure was measured, and a questionnaire on clinical, anthropometric, dietary, and lifestyle data was completed.</div></div><div><h3>Results</h3><div>Of 77 participants, 6 were excluded due to impaired biochemical status. A significant association was found between the HOMA-IR index and cortisol levels in the upper normative range (≥95.5 μg/L, p &lt; 0.001). This association was also found with BMI, waist circumference, insomnia, sedentary lifestyle, unbalanced diet, and fruit intake, but not for sweets and vegetable intake (p &gt; 0.05). A correlation was confirmed between insulin resistance (assessed by the HOMA-IR index) and other indices such as QUICKI, the TG/HDL ratio and the TyG index.</div></div><div><h3>Conclusion</h3><div>The QUICKI, TyG and TG/HDL indices are good alternative indicators of insulin resistance, which is more severe in people with cortisol levels in the upper normative range. In addition, a sedentary lifestyle and unbalanced diet also contribute to insulin resistance.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"58 ","pages":"Article 100648"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic impact of bariatric surgery: A meta-analysis of long-term outcome data","authors":"Grace C. Bloomfield ,&nbsp;Marcus H. Cunningham ,&nbsp;Mike Y. Chen ,&nbsp;Dan E. Azagury ,&nbsp;Yewande R. Alimi ,&nbsp;Nicholas J. Prindeze","doi":"10.1016/j.obmed.2025.100645","DOIUrl":"10.1016/j.obmed.2025.100645","url":null,"abstract":"<div><h3>Background</h3><div>Bariatric surgery is a proven method for weight loss and reducing obesity-related comorbidities. While the link between obesity and type 2 diabetes is well established, the long-term impact of bariatric surgery on diabetic patients remains unclear.</div></div><div><h3>Methods</h3><div>A meta-analysis was conducted between 2000 and 2024 on studies reporting outcomes of Roux-en-Y gastric bypass, gastric sleeve, or medical weight loss controls. Data on BMI, type 2 diabetes, and hypertension were collected and analyzed.</div></div><div><h3>Results</h3><div>A total of 20 studies with 4092 patients were included. At 1-year weight loss was similar between the diabetic and general populations at 35–40 % total weight loss (TWL), however by 10–12 years1 year, weight loss was similar between the diabetic and general populations at 35–40 % total weight loss (TWL); however, by 10–12 years, while the general population dropped to 23–28 % TWL, the diabetic group maintained an improved 35–39 % TWL. Short-term diabetes resolution was 83–85 % in the diabetic group and 63–85 % in the general population. However, the long-term diabetes rebound was greater in diabetics, with a rate of 26–51 % resolution vs. 26–60 %. Hypertension resolution at 1-year was lower in diabetics at 44–55 % vs. 63–73 %, with insufficient long-term data. At all times, control groups showed persistent worsening of diabetes and hypertension rates.</div></div><div><h3>Conclusions</h3><div>Bariatric surgery is highly effective for diabetic patients; however long-term outcomes differ from those of the general population. While both groups experienced significant initial weight loss, diabetics maintained better weight control but had higher diabetes recurrence. Roux-en-Y gastric bypass outperformed the gastric sleeve in all measured outcomes.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"57 ","pages":"Article 100645"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}