Obesity Medicine最新文献

{"title":"Rethinking obesity metrics in Southeast Asia: Evidence from Haiphong highlights urgent gaps","authors":"Riza Amalia , Henny Indreswari , Fatimah Setiani","doi":"10.1016/j.obmed.2025.100625","DOIUrl":"10.1016/j.obmed.2025.100625","url":null,"abstract":"","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"56 ","pages":"Article 100625"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intertwined pathways of SARS-CoV-2 infection and its clinical repercussions on glucose homeostasis: Exploring the rise of new-onset diabetes","authors":"Vertika Awasthi ,&nbsp;Rupinder Kaur ,&nbsp;Chirag Pasricha,&nbsp;Pratima Kumari,&nbsp;Suruchi Chaubey,&nbsp;Sarita Jangra,&nbsp;Sanjana Mehta,&nbsp;Ravinder Singh","doi":"10.1016/j.obmed.2025.100624","DOIUrl":"10.1016/j.obmed.2025.100624","url":null,"abstract":"<div><div>Coronavirus disease 2019 (COVID-19) and diabetes seem to have a bidirectional relationship. People suffering from diabetes mellitus (DM) are at higher risk than non-diabetics to contract SARS-CoV-2 infections and acquire COVID-19-related health issues. Diabetes is consistently linked to higher disease risk and death among COVID-19 patients. Data also suggest that multiple phenotypic expression alterations caused by SARS-CoV-2 could complicate the pathogenesis of pre-existing diabetes or result in additional pathological conditions. Clinical research data shows that SARS-CoV-2 infection promotes metabolic abnormalities in humans. Furthermore, recent studies concerning new-onset diabetes (NOD) in COVID-19 affected population, who had previously been infected with the virus, reinforce the notion that SARS-CoV-2 has a direct influence on glucose metabolism. Data from various sources indicated that SARS-CoV-2 infected individuals had a greater prevalence of Diabetic Ketoacidosis (DKA), which might be related to a blatant assault on the beta (β)cells of the pancreas. This virus has also been attributed to binding with the ACE 2 receptors found in critical body tissues as well as organs such as β islet cells of the pancreas, small intestine, kidneys and adipose tissues, causing Ketosis-prone diabetes (KPD), which is a very prevalent form of diabetes in Asia, especially India. It has been observed that despite the lack of autoantibodies, the people so affected experience short, transitory insulin deficit that produces DKA at first, but they recover from this β-cell secretory failure over time. This paper highlights the complex interplay between SARS-CoV-2 and its clinical implications on diabetic pathobiology, emphasizing how the cause-effect relationship operates bidirectionally between the two.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"56 ","pages":"Article 100624"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and Climate Change: A Two-way Street with Global Health Implications","authors":"Esther Ugo Alum ,&nbsp;Regina Idu Ejemot-Nwadiaro ,&nbsp;Peter A. Betiang ,&nbsp;Mariam Basajja ,&nbsp;Daniel Ejim Uti","doi":"10.1016/j.obmed.2025.100623","DOIUrl":"10.1016/j.obmed.2025.100623","url":null,"abstract":"<div><div>Obesity and climate change are critical global challenges of the 21st century, with shared drivers and far-reaching impacts on public health, environmental sustainability, and socioeconomic equity. Both crises are fueled by factors such as unsustainable food systems, urbanization, and systemic inequities. Industrialized food production contributes to greenhouse gas emissions, deforestation, and resource depletion while promoting calorie-dense, nutrient-poor diets that exacerbate obesity rates. Climate-induced food insecurity further intensifies the malnutrition paradox, where undernutrition and obesity coexist, disproportionately affecting vulnerable populations. This short communication explores the complex connections between obesity and climate change, examining their mutual drivers, public health implications, and role in food systems. The novelty of this communication lies in its amalgamation of emerging, underexplored bidirectional mechanisms, including thermoregulatory effects and differential emissions contributions, supported by recent evidence. Rather than serving as a comprehensive review, this paper aims to offer a concise yet policy-relevant perspective that emphasizes overlooked linkages and actionable solutions. By clearly framing the scope and contribution of this short communication, we aim to distinguish our work from broader literature reviews and highlight its relevance for integrated health-environment policy development. Recommendations include leveraging technology, fostering global collaboration, and advancing interdisciplinary research to address these intersecting crises holistically. Aligning with public health and environmental goals is essential for creating a resilient and equitable future for both human and planetary well-being. This short communication was developed through an extensive review of scholarly articles, policy reports, and case studies addressing the intersections of obesity and climate change. Sources were identified via databases such as PubMed, Scopus, and Google Scholar, with keywords including “obesity,” “climate change,” “food systems,” and “public health policies.” The analysis focused on identifying shared drivers, mutual impacts, and actionable strategies. Emphasis was placed on evidence-based insights and multidisciplinary approaches to propose integrated solutions that address both crises.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"56 ","pages":"Article 100623"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving paradigms in nutrition therapy for Diabetes: From carbohydrate counting to precision diets","authors":"Esther Ugo Alum ,&nbsp;David Chukwu Obasi ,&nbsp;Jacinta Nnennaya Abba ,&nbsp;Ugonna Cassandra Aniokete ,&nbsp;Prince Nkemakolam Okoroh ,&nbsp;Ada Ak Akwari","doi":"10.1016/j.obmed.2025.100622","DOIUrl":"10.1016/j.obmed.2025.100622","url":null,"abstract":"<div><div>The global prevalence of diabetes is on the rise, necessitating advanced strategies for effective management. Nutrition therapy plays a critical role in managing diabetes, contributing to glycemic control, weight regulation, and complication prevention. Historically centered around carbohydrate counting and standardized meal plans, nutrition strategies have evolved toward more flexible, patient-centered approaches. Emerging evidence underscores the importance of individualized dietary interventions tailored to patients’ cultural preferences, metabolic profiles, and comorbid conditions. Approaches such as the Mediterranean diet, Dietary Approaches to Stop Hypertension (DASH), and plant-based diets have demonstrated significant benefits in both type 1 and type 2 diabetes. The integration of digital tools, behavioral science, and emerging insights from nutrigenomics and the gut microbiome further supports a paradigm shift toward precision nutrition. In this commentary, we highlight the evolution of nutrition therapy in diabetes care, emphasizing the transition from generic recommendations to personalized dietary strategies aimed at improving long-term outcomes. It emphasizes the potential of precision nutrition to optimize glycemic control, mitigate complications, and improve patient adherence. We argue that the future of diabetes care depends on a personalized nutrition model that accounts for metabolic individuality, cultural context, and digital health integration. Our discussion highlights a critical transition in practice and research priorities, offering a timely framework for clinicians and policymakers navigating the evolving landscape of diabetes management. Peer-reviewed articles, clinical guidelines, and systematic reviews were sourced from databases such as PubMed, Scopus, and Google Scholar. The analysis focused on studies evaluating carbohydrate counting, personalized nutrition, and their respective impacts on glycemic control and patient outcomes. Key topics included advancements in nutrigenomics, metabolomics, and the integration of precision medicine in dietary interventions. The findings were synthesized to highlight current challenges, emerging trends, and potential solutions in implementing personalized nutrition strategies for diabetes care.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"56 ","pages":"Article 100622"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syzygium aromaticum loaded copper oxide nanoparticles ameliorates diabetic nephropathy by diminishing oxidative stress and inflammatory responses in Wistar rats","authors":"Momin Aramash ,&nbsp;Manisha N. Chalse ,&nbsp;Aniroodha V. Pethkar ,&nbsp;Urmila M. Aswar","doi":"10.1016/j.obmed.2025.100621","DOIUrl":"10.1016/j.obmed.2025.100621","url":null,"abstract":"<div><h3>Background and aims</h3><div>Diabetic nephropathy (DN) is a major disorder of prolonged diabetes mellitus (DM) which ends up in chronic renal failure. Here, we report the beneficial effects of copper oxide nanoparticles loaded with <em>Syzygium aromaticum</em> extract (SaCuONpls) on DN in Wistar rats. <em>Syzygium aromaticum</em> is a spice with numerous therapeutic uses. Altered copper concentration in the blood is responsible for various diseases and affects different organs. Moreover minor copper deficiencies can promote the progression of many pathologies including DM.</div></div><div><h3>Methods</h3><div>Diabetes induced nephropathy was produced by administration of nicotinamide and streptozotocin. Rats with a blood glucose of more than 250 mg/dL were considered hyperglycemic. Diabetic rats were left untreated for 42 days for the development of nephropathy that was characterized by a marked decline in urine creatinine levels and increased levels of microproteinuria. The nephropathic rats were orally treated with SaCuONpls (2.5, 5, and 10 mg/kg) and the standard drug, glimepiride (10 mg/kg) for 42 days. At the end of the experiment, the serum parameters, urine parameters, oxidative stress, and inflammatory markers were studied and kidneys were removed for histology (H&amp;E, PAS, and MT staining).</div></div><div><h3>Results</h3><div>Treatment of SaCuONpls significantly improved the serum and urine biochemistry, antioxidant potential by increasing activity of SOD, CAT and GSH and declined the oxidative stress mediated by MDA and NO and the ameliorative effect of proinflammatory mediators (NF-κB, TNF-α, IL-1β and IL-6) was noticed. SaCuONpls mitigated adverse histopathological changes.</div></div><div><h3>Conclusions</h3><div>The therapeutic potential of SaCuONpls was ascertained by enhanced renal function.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"56 ","pages":"Article 100621"},"PeriodicalIF":0.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144137885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring uric acid as a biomarker in lipedema and lymphedema: A metabolomics study with prospective validation","authors":"Fahad Alkhalfan ,&nbsp;Naseer Sangwan ,&nbsp;Anu Aggarwal ,&nbsp;Alliefair Scalise ,&nbsp;José O. Alemán ,&nbsp;Bhairavi Rajasekar ,&nbsp;Douglas Joseph ,&nbsp;Kimberly Peterson ,&nbsp;Annelise Hamer ,&nbsp;Mariya Ali ,&nbsp;John R. Bartholomew ,&nbsp;Scott J. Cameron","doi":"10.1016/j.obmed.2025.100618","DOIUrl":"10.1016/j.obmed.2025.100618","url":null,"abstract":"<div><h3>Aims</h3><div>Lipedema is a condition often mistaken for other causes of limb swelling including lymphedema and obesity. Lipedema may have a unique metabolic profile. Interrogation of the metabolome is a strategy that could reveal unique biomarkers to distinguish lipedema from lymphedema and obesity.</div></div><div><h3>Methods</h3><div>Unbiased metabolomics was utilized to examine 38 BMI-matched overweight patients compared with patients with lipedema, lymphedema, and lipolymphedema. Machine learning identified biomarkers to distinguish diseases, and further examined in a validation cohort of 198 patients with each disorders. Adjustments were made for baseline clinical and demographic variables.</div></div><div><h3>Results</h3><div>Plasma metabolomics firstly revealed uric acid as a biomarker that performs well to distinguish between phenotypically similar diseases in patients with elevated BMI. In a validation cohort of 64 patients with lipedema, uric acid (5.05 mg/dL) was compared with 64 patients with lymphedema (5.4 mg/dl), and 70 overweight patients without these conditions (4.6 mg/dL, p &lt; 0.05). Uric acid-to-cystatin c ratio distinguished between all three groups (Lipedema: 5.2; Lymphedema: 6.3; overweight: 4.0, p &lt; 0.01); however, significance was lost after adjustment for renal function.</div></div><div><h3>Conclusion</h3><div>Metabolomic analysis revealed uric acid may differentiate between lipedema, lymphedema, lipolymphedema and obese individuals without those conditions. In a validation cohort, while uric acid was higher in lipedema and lymphedema, uric acid adjusted by cystatin c clearance revealed uric acid to be a less useful marker to distinguish lipedema from lymphedema in the context of renal insufficiency.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100618"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes mellitus, Obesity and Periodontitis – A three way interconnection","authors":"Pavithra Velusamy ,&nbsp;Sri Chinthu Kenniyan Kumar ,&nbsp;Monica Charlotte Solomon","doi":"10.1016/j.obmed.2025.100615","DOIUrl":"10.1016/j.obmed.2025.100615","url":null,"abstract":"<div><div>Type 2 diabetes mellitus (T2DM) is the most common metabolic and endocrine disorder which causes a rise in blood glucose levels often attributed to insulin resistance or relative insulin insufficiency. The listed complications T2DM include retinopathy, neuropathy, nephropathy, stroke, and peripheral vascular diseases. Apart from these patients having uncontrolled and longstanding T2DM are prone to various cardiovascular disorders and oral diseases. Periodontitis, which involves inflammation of the periodontal ligament and alveolar bone has been listed as the sixth complication of diabetes mellitus for decades. Obesity is a serious social problem and is ranked as the fifth leading cause of mortality worldwide. Insulin resistance makes obesity a major risk factor for T2DM. Diabetes mellitus further adds to the periodontal tissue destruction. The hormones and cytokines in obese persons produce a series of inflammatory reactions that aid in developing periodontal disease. There are several studies linking the inflammatory triad between obesity, diabetes mellitus, and periodontitis. This review elucidates the interconnection between T2DM, obesity, and periodontitis.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100615"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring female infertility: A comprehensive review of polycystic ovary syndrome (PCOS) and its impact on reproductive health","authors":"Suparna Parua ,&nbsp;Mahuya Patra Purkait ,&nbsp;Aniruddha Bhattacharjee ,&nbsp;Rajesh Thangarajan ,&nbsp;Subramanian Rammohan ,&nbsp;Kamirul Islam ,&nbsp;Koushik Bhattacharya ,&nbsp;Alak Kumar Syamal","doi":"10.1016/j.obmed.2025.100619","DOIUrl":"10.1016/j.obmed.2025.100619","url":null,"abstract":"<div><div>Polycystic ovary syndrome (PCOS), a complicated endocrine disorder that causes female infertility, affects 6–10 % of reproductive-age women. Although it is necessary to intricate the relationship between PCOS and reproductive health to illuminate how it affects female fertility. Pathophysiology describing that how the hormonal imbalances cause ovarian cyst formation following clinical issues in ovulation. These imbalances include low FSH, high LH, and high androgens as well as increased AMH, all of which disrupt normal follicular development and ovulation. PCOS related metabolic problems such insulin resistance, obesity, and dyslipidaemia have been carefully investigated for reproductive health implications along with the pharmacological aspects. The effects of oral contraceptives, anti-androgens (such as spironolactone), and insulin-sensitizing drugs (such as metformin) on ovulation and fertility heve been reviewed. This article examines the use of the Rotterdam criteria and imaging techniques such as transvaginal ultrasound for diagnosing PCOS, while also exploring comprehensive management strategies including pharmacological treatments, alternative medicine approach and lifestyle modifications like diet and exercise to improve metabolic and reproductive outcomes. Besides those explorations of emerging treatments and early-stage studies for PCOS, including the potential of supplementary therapies like myo-inositol and lifestyle modifications tailored to individual metabolic profiles. It also highlights the latest studies on the factors contributing to PCOS and their implications for personalized treatment approaches. Emphasizing the importance of a holistic management plan, the article addresses both physical and emotional well-being, including the psychosocial impact of PCOS on mental health and overall quality of life.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100619"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the anti-diabetic potential of Ulva lactuca flavonoids in a Drosophila model","authors":"Sotubdhi Sharma ,&nbsp;Asif Mahmud ,&nbsp;Md Amjad Patwary ,&nbsp;Mantasha Mahmud Hia ,&nbsp;Sobnom Mustari Shukti ,&nbsp;Nusrat Jahan Tisha ,&nbsp;Zobada Kanak Khan ,&nbsp;Md Faruque Miah","doi":"10.1016/j.obmed.2025.100616","DOIUrl":"10.1016/j.obmed.2025.100616","url":null,"abstract":"<div><h3>Aims</h3><div>The study aimed to evaluate the anti-diabetic potential of <em>Ulva lactuca</em> crude flavonoids by assessing their effects on external morphology and hemolymph glucose concentrations in <em>Drosophila melanogaster</em> under various dietary conditions, including a high-sugar diet.</div></div><div><h3>Methods</h3><div>Four dietary conditions were tested in <em>D</em>. <em>melanogaster</em> to assess the effects of <em>U. lactuca</em> crude flavonoids: control diet, high-sugar diet, high-sugar with standard diet, and diets with flavonoid concentrations (0.1M, 0.2M, 0.3M). External morphology and hemolymph glucose concentrations were evaluated.</div></div><div><h3>Results</h3><div>Hemolymph glucose concentrations were found 0.045 mg/mL in the high-sugar group and 0.054 mg/mL in the sugar-with-standard diet group, compared to 0.016 mg/mL in control flies. Flavonoid treatments reduced glucose levels in a dose-dependent manner, with 0.1M, 0.2M, and 0.3M flavonoid concentrations lowering glucose to 0.038 mg/mL, 0.035 mg/mL, and 0.017 mg/mL, respectively. The highest concentration (0.3M) nearly restored glucose levels to those of the control, along with a significant decrease in both abdominal width (0.87 ± 0.03 mm) and body weight (1.27 ± 0.04 mg).</div></div><div><h3>Conclusion</h3><div><em>U. lactuca</em> flavonoids effectively reduced glucose levels and mitigated obesity in sugar-treated <em>D. melanogaster</em>, suggesting their potential as safe dietary interventions for metabolic disorders like diabetes.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100616"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights into the anti-obesity actions of coumarins: Therapeutic potential and future directions","authors":"Yasser Fakri Mustafa","doi":"10.1016/j.obmed.2025.100620","DOIUrl":"10.1016/j.obmed.2025.100620","url":null,"abstract":"<div><div>Obesity is a complex and chronic metabolic disorder characterized by excessive fat accumulation, leading to severe health complications such as diabetes, cardiovascular diseases, and metabolic syndromes. Traditional drug and lifestyle changes can help, but they have problems like side effects and don't work for a long time, so people need to look for other ways to treat their conditions. Coumarins, a diverse class of naturally occurring polyphenolic compounds, have garnered significant attention for their potential anti-obesity effects. This review systematically explores the mechanistic pathways of coumarins—including their modulation of lipid metabolism, glucose homeostasis, thermogenic activity, inflammation, and adipogenic signaling—highlighting their multifaceted role in combating obesity. Preclinical studies show that coumarins stop adipocytes from differentiating, speed up lipolysis, and manage key metabolic pathways involving adiponectin, AMPK, and PPARγ. New evidence also suggests that coumarins change the composition of the gut microbiota, which adds to their ability to handle obesity. However, clinical evidence remains limited, with only a few studies investigating their efficacy in human populations. Safety considerations, including potential hepatotoxicity and anticoagulant effects, also necessitate careful evaluation. Future research should focus on optimizing coumarin derivatives, elucidating their precise mechanisms, and conducting large-scale clinical trials to establish their therapeutic potential. This review shows that coumarins have a lot of potential as natural weight loss aids, but more research is needed before these results can be used in patients.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100620"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}