Exploring female infertility: A comprehensive review of polycystic ovary syndrome (PCOS) and its impact on reproductive health

Q2 Medicine

Obesity Medicine Pub Date : 2025-05-01 DOI:10.1016/j.obmed.2025.100619

Suparna Parua , Mahuya Patra Purkait , Aniruddha Bhattacharjee , Rajesh Thangarajan , Subramanian Rammohan , Kamirul Islam , Koushik Bhattacharya , Alak Kumar Syamal

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引用次数: 0

Abstract

Polycystic ovary syndrome (PCOS), a complicated endocrine disorder that causes female infertility, affects 6–10 % of reproductive-age women. Although it is necessary to intricate the relationship between PCOS and reproductive health to illuminate how it affects female fertility. Pathophysiology describing that how the hormonal imbalances cause ovarian cyst formation following clinical issues in ovulation. These imbalances include low FSH, high LH, and high androgens as well as increased AMH, all of which disrupt normal follicular development and ovulation. PCOS related metabolic problems such insulin resistance, obesity, and dyslipidaemia have been carefully investigated for reproductive health implications along with the pharmacological aspects. The effects of oral contraceptives, anti-androgens (such as spironolactone), and insulin-sensitizing drugs (such as metformin) on ovulation and fertility heve been reviewed. This article examines the use of the Rotterdam criteria and imaging techniques such as transvaginal ultrasound for diagnosing PCOS, while also exploring comprehensive management strategies including pharmacological treatments, alternative medicine approach and lifestyle modifications like diet and exercise to improve metabolic and reproductive outcomes. Besides those explorations of emerging treatments and early-stage studies for PCOS, including the potential of supplementary therapies like myo-inositol and lifestyle modifications tailored to individual metabolic profiles. It also highlights the latest studies on the factors contributing to PCOS and their implications for personalized treatment approaches. Emphasizing the importance of a holistic management plan, the article addresses both physical and emotional well-being, including the psychosocial impact of PCOS on mental health and overall quality of life.

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探讨女性不孕症：多囊卵巢综合征（PCOS）及其对生殖健康影响的综合综述

多囊卵巢综合征（PCOS）是一种导致女性不孕的复杂内分泌紊乱，影响了6 - 10%的育龄妇女。虽然多囊卵巢综合征与生殖健康之间的关系错综复杂，以阐明其如何影响女性生育能力是必要的。病理生理学描述如何荷尔蒙失衡导致卵巢囊肿形成后的临床问题排卵。这些失衡包括低FSH，高LH，高雄激素以及AMH增加，所有这些都会破坏正常的卵泡发育和排卵。多囊卵巢综合征相关的代谢问题，如胰岛素抵抗、肥胖和血脂异常，已经被仔细研究了生殖健康的影响以及药理学方面。口服避孕药、抗雄激素（如螺内酯）和胰岛素增敏药物（如二甲双胍）对排卵和生育的影响已经进行了综述。本文探讨了使用鹿特丹标准和经阴道超声等成像技术诊断多囊卵巢综合征，同时也探讨了综合管理策略，包括药物治疗，替代医学方法和生活方式的改变，如饮食和运动，以改善代谢和生殖结果。除了对多囊卵巢综合征的新兴治疗方法和早期研究的探索，包括潜在的补充疗法，如肌醇和针对个人代谢特征的生活方式改变。它还重点介绍了导致多囊卵巢综合征的因素及其对个性化治疗方法的影响的最新研究。文章强调了整体管理计划的重要性，涉及身体和情感健康，包括多囊卵巢综合征对心理健康和整体生活质量的心理社会影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.