The role of simple and specialized non-invasive tools in predicting of metabolic dysfunction-associated fatty liver disease severity and prognosis

Q2 Medicine

Obesity Medicine Pub Date : 2025-01-25 DOI:10.1016/j.obmed.2025.100582

Marjan Mokhtare , Shahin Sharafeh , Mohammadjavad Sotoudeheian , Amir M. Sadeghian , Said A. Al-Busafi

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引用次数: 0

Abstract

Objectives

Metabolic-associated fatty liver disease (MAFLD) is a universal health concern. Detecting advanced fibrosis significantly impacts prognosis. This study designated to assess the accuracy of FIB-4, FIB-6, Agile3+, Agile4, and NAFLD fibrosis score (NFS) in predicting disease severity.

Design and Methods

Clinical, laboratory, and FibroScan findings of adult MAFLD patients were recorded. A fibrosis (F) score over 10 kPa indicates advanced fibrosis. We assessed the area under the receiver operating characteristic curve (AUROCC), along with the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy with various cutoff values. Reliability was analyzed with the intra-class correlation coefficient (ICC).

Results

Advanced fibrosis was found in 5 of 103 patients (4.85%). AUROCC values were as follows: 0.967 for Agile3+, 0.951 for FIB-6, 0.932 for NFS, 0.909 for Agile4, and 0.869 for FIB-4. The PPVs ranged from 18.18% (FIB-4) to 57.09% (NFS), followed by 75.02% (FIB-6), and 18.18% (Agile4) to 100% (Agile3+). All tools achieved acceptable NPVs above 96%. The ICC between the fibrosis score and other tools was 0.772 (95% CI: 0.696-0.834). Significant differences were noted in gamma-glutamyl transferase (p=0.039), diabetes mellitus (P=0.011), platelet count, hemoglobin A1C, alkaline phosphatase, triglycerides, fasting blood glucose, and Vitamin D levels

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简单和专门的非侵入性工具在预测代谢功能障碍相关脂肪性肝病严重程度和预后中的作用

目的：代谢性脂肪性肝病（MAFLD）是一个普遍关注的健康问题。发现晚期纤维化显著影响预后。本研究旨在评估FIB-4、FIB-6、Agile3+、Agile4和NAFLD纤维化评分（NFS）预测疾病严重程度的准确性。设计与方法记录成年MAFLD患者的临床、实验室和纤维扫描结果。纤维化(F)评分超过10kpa为晚期纤维化。我们评估了受试者工作特征曲线下的面积（AUROCC），以及不同截止值的敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）和准确性。用类内相关系数（ICC）分析信度。结果103例患者中有5例（4.85%）出现晚期纤维化。AUROCC值如下：Agile3+为0.967，FIB-6为0.951，NFS为0.932，Agile4为0.909，FIB-4为0.869。ppv范围从18.18% （FIB-4）到57.09% (NFS)，其次是75.02% （FIB-6）和18.18% （Agile4）到100% （Agile3+）。所有工具的npv均达到96%以上。纤维化评分与其他工具之间的ICC为0.772 （95% CI: 0.696-0.834）。在γ -谷氨酰转移酶（p=0.039）、糖尿病（p= 0.011）、血小板计数、血红蛋白A1C、碱性磷酸酶、甘油三酯、空腹血糖和维生素D水平方面存在显著差异

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.