The role of simple and specialized non-invasive tools in predicting of metabolic dysfunction-associated fatty liver disease severity and prognosis

Q2 Medicine

Obesity Medicine Pub Date : 2025-01-25 DOI:10.1016/j.obmed.2025.100582

Marjan Mokhtare , Shahin Sharafeh , Mohammadjavad Sotoudeheian , Amir M. Sadeghian , Said A. Al-Busafi

{"title":"The role of simple and specialized non-invasive tools in predicting of metabolic dysfunction-associated fatty liver disease severity and prognosis","authors":"Marjan Mokhtare , Shahin Sharafeh , Mohammadjavad Sotoudeheian , Amir M. Sadeghian , Said A. Al-Busafi","doi":"10.1016/j.obmed.2025.100582","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Metabolic-associated fatty liver disease (MAFLD) is a universal health concern. Detecting advanced fibrosis significantly impacts prognosis. This study designated to assess the accuracy of FIB-4, FIB-6, Agile3+, Agile4, and NAFLD fibrosis score (NFS) in predicting disease severity.</div></div><div><h3>Design and Methods</h3><div>Clinical, laboratory, and FibroScan findings of adult MAFLD patients were recorded. A fibrosis (F) score over 10 kPa indicates advanced fibrosis. We assessed the area under the receiver operating characteristic curve (AUROCC), along with the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy with various cutoff values. Reliability was analyzed with the intra-class correlation coefficient (ICC).</div></div><div><h3>Results</h3><div>Advanced fibrosis was found in 5 of 103 patients (4.85%). AUROCC values were as follows: 0.967 for Agile3+, 0.951 for FIB-6, 0.932 for NFS, 0.909 for Agile4, and 0.869 for FIB-4. The PPVs ranged from 18.18% (FIB-4) to 57.09% (NFS), followed by 75.02% (FIB-6), and 18.18% (Agile4) to 100% (Agile3+). All tools achieved acceptable NPVs above 96%. The ICC between the fibrosis score and other tools was 0.772 (95% CI: 0.696-0.834). Significant differences were noted in gamma-glutamyl transferase (p=0.039), diabetes mellitus (P=0.011), platelet count, hemoglobin A1C, alkaline phosphatase, triglycerides, fasting blood glucose, and Vitamin D levels</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"54 ","pages":"Article 100582"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2451847625000028","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

Metabolic-associated fatty liver disease (MAFLD) is a universal health concern. Detecting advanced fibrosis significantly impacts prognosis. This study designated to assess the accuracy of FIB-4, FIB-6, Agile3+, Agile4, and NAFLD fibrosis score (NFS) in predicting disease severity.

Design and Methods

Clinical, laboratory, and FibroScan findings of adult MAFLD patients were recorded. A fibrosis (F) score over 10 kPa indicates advanced fibrosis. We assessed the area under the receiver operating characteristic curve (AUROCC), along with the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy with various cutoff values. Reliability was analyzed with the intra-class correlation coefficient (ICC).

Results

Advanced fibrosis was found in 5 of 103 patients (4.85%). AUROCC values were as follows: 0.967 for Agile3+, 0.951 for FIB-6, 0.932 for NFS, 0.909 for Agile4, and 0.869 for FIB-4. The PPVs ranged from 18.18% (FIB-4) to 57.09% (NFS), followed by 75.02% (FIB-6), and 18.18% (Agile4) to 100% (Agile3+). All tools achieved acceptable NPVs above 96%. The ICC between the fibrosis score and other tools was 0.772 (95% CI: 0.696-0.834). Significant differences were noted in gamma-glutamyl transferase (p=0.039), diabetes mellitus (P=0.011), platelet count, hemoglobin A1C, alkaline phosphatase, triglycerides, fasting blood glucose, and Vitamin D levels

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.