青少年和青年1型糖尿病患者估计葡萄糖处置率、颈动脉内膜-中膜厚度和心血管风险预测量表的相关性

Q2 Medicine

Obesity Medicine Pub Date : 2025-02-18 DOI:10.1016/j.obmed.2025.100592

David Sánchez-García, Eloísa Saavedra-Castillo, Mariela Rivas-Hernández, Luis Diego Maximiliano Ramos-Anthony, Graciela Gómez-Martínez, Marcelo Diaz-Sallas, Dania Lizet Quintanilla-Flores

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引用次数: 0

摘要

目的分析1型糖尿病（T1D）青年患者估计葡萄糖处置率（eGDR）、颈动脉内膜-中膜厚度（CIMT）与心血管风险预测量表的相关性。方法采用横断面、分析和回顾性研究。T1D >患者；纳入15年，胰岛素抵抗（IR）定义为eGDR <；8 mg/kg/min，临床前动脉粥样硬化≥0.54 mm的CIMT，计算STENO和ESC心血管风险。使用Pearson相关检验来衡量两者之间的关联强度。结果纳入102例患者，中位年龄19岁，HbA1c为8.2%，糖尿病病程8年。50.9%的患者发现IR， 46.1%的患者发现临床前动脉粥样硬化，中位CIMT为0.52 mm。eGDR与CIMT r = - 0.23, p= 0.021, STENO r = 0.33, p=<；0.001呈负相关，IR组CIMT较高（0.54 vs 0.50 mm, p= 0.047），微血管并发症发生率较高（36.5% vs 18%, p= 0.03），促炎标志物发生率较高（p=<0.001）。结论颈动脉内膜-中膜增厚与胰岛素敏感性呈负相关，eGDR值可作为T1D患者的心血管和增强危险因素，有助于决定治疗方案。

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Correlation between estimated glucose disposal rate, carotid intima-media thickness and cardiovascular risk prediction scales in adolescents and young adults with type 1 diabetes

Aims

To analyze the correlation between estimated glucose disposal rate (eGDR), Carotid intima-media thickness (CIMT) and cardiovascular risk prediction scales in young adults with diabetes type 1 (T1D).

Methods

A cross-sectional, analytical, and retrospective study was conducted. Patients with T1D > 15 years were included, insulin resistance (IR) was defined by eGDR <8 mg/kg/min, and preclinical atherosclerosis as ≥0.54 mm of CIMT, STENO and ESC cardiovascular risk was calculated. Pearson's correlation test was used to measure the strength of association between them.

Results

102 patients with a median age of 19 years, HbA1c of 8.2%, diabetes duration of 8 years were included. IR was found in 50.9% of the patients and preclinical atherosclerosis in 46.1%, with a median CIMT of 0.52 mm. An inverse correlation was obtained between the eGDR and CIMT r = −0.23, p = 0.021, and STENO r = 0.33, p=<0.001, CIMT was higher in the IR group 0.54 vs 0.50 mm, p = 0.047, also was associated with more microvascular complications 36.5% vs 18%, p = 0.03, and proinflammatory markers, p=<0.001.

Conclusions

Carotid intima-media thickening is inversely associated with insulin sensitivity, the eGDR value could be used as a cardiovascular and as a enhance risk factor and could help to decide treatment in patients whit T1D.

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.