A novel therapeutic approach for hormonal imbalance in polycystic ovarian syndrome; evaluating the effects of Nutrition Bio-Shield Supplement in an animal model

Q2 Medicine

Obesity Medicine Pub Date : 2025-02-08 DOI:10.1016/j.obmed.2025.100590

Mehrdad Mosadegh , Yasaman Sadeghi , Aref Khalkhali , Yousef Erfani

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引用次数: 0

Abstract

Background

s: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that disrupts hormone balance, leading to infertility and metabolic issues. This study evaluates the effects of a novel nutritional supplement, Nutrition Bio-Shield (NBS), on hormonal regulation in a letrozole-induced PCOS rat model.

Methods

Twenty-five female Wistar rats were assigned to five groups: healthy control, PCOS control, and three groups treated with varying doses of NBS (12.5 mg/kg, 25 mg/kg, and 50 mg/kg). PCOS was induced using letrozole, and NBS was administered for 21 days. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, progesterone, and estradiol were measured using radioimmunoassay.

Results

NBS treatment significantly improved hormone levels compared to the PCOS control group. The highest dose (50 mg/kg) effectively reduced LH and testosterone while increasing progesterone and estradiol levels (p < 0.05), nearing those of the healthy controls. The 25 mg/kg dose also showed considerable improvement in hormone balance, whereas the 12.5 mg/kg dose had a moderate effect. FSH levels were notably reduced in both 50 mg/kg and 25 mg/kg groups, suggesting a dose-dependent response to NBS treatment.

Conclusion

NBS supplementation successfully ameliorated hormonal imbalances in a PCOS rat model, demonstrating its potential as a natural therapeutic option for managing PCOS. Further research is needed to confirm these effects in clinical settings.

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治疗多囊卵巢综合征激素失调的新方法在动物模型上评价营养生物盾补充剂的效果

背景：多囊卵巢综合征（PCOS）是一种常见的内分泌疾病，它会破坏激素平衡，导致不孕和代谢问题。本研究评估了一种新型营养补充剂Nutrition Bio-Shield （NBS）对来曲唑诱导的PCOS大鼠模型激素调节的影响。方法将雌性Wistar大鼠25只分为健康对照组、PCOS对照组和不同剂量NBS （12.5 mg/kg、25 mg/kg、50 mg/kg）治疗组。来曲唑诱导PCOS， NBS治疗21 d。用放射免疫法测定血清黄体生成素（LH）、卵泡刺激素（FSH）、睾酮、孕酮和雌二醇水平。结果与PCOS对照组相比，snbs治疗显著提高了激素水平。最高剂量（50 mg/kg）有效降低黄体生成素和睾酮，同时提高孕酮和雌二醇水平(p <；0.05)，接近健康对照组。25 mg/kg剂量也显示出相当大的激素平衡改善，而12.5 mg/kg剂量则有中等效果。在50 mg/kg和25 mg/kg组中，FSH水平均显著降低，表明对NBS治疗有剂量依赖性反应。结论补充nbs成功地改善了PCOS大鼠模型的激素失衡，显示了其作为治疗PCOS的天然治疗选择的潜力。需要进一步的研究来证实这些在临床环境中的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.