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Current Opinion in Biomedical Engineering最新文献

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Expanding the targets of therapeutic electrophysical stimulation - For the advancement of peripheral nerve regenerative rehabilitation 扩大治疗性电物理刺激的靶点——促进周围神经再生康复
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-12-01 DOI: 10.1016/j.cobme.2023.100515
Shixuan Xu, Akira Ito
{"title":"Expanding the targets of therapeutic electrophysical stimulation - For the advancement of peripheral nerve regenerative rehabilitation","authors":"Shixuan Xu,&nbsp;Akira Ito","doi":"10.1016/j.cobme.2023.100515","DOIUrl":"https://doi.org/10.1016/j.cobme.2023.100515","url":null,"abstract":"<div><p><span>Peripheral nerve injury (PNI) causes long-term dysfunction and significantly affect patients' </span>quality of life<span><span><span>. However, regenerative rehabilitation, which combines rehabilitation and regenerative medicine approaches, has shown promising progress in promoting </span>nerve regeneration after PNI. This article reviews rehabilitation methods and therapeutic </span>electrophysical agents<span> (EPAs) for promoting nerve regeneration, their possible mechanisms, and the progress achieved to date in the treatment of PNI using regenerative rehabilitation with EPAs. We also discuss several factors that have the potential to optimize treatment outcomes, including the intervention target, timing, and duration. This review provides a comprehensive overview of advancements in the treatment of PNI, possible strategies to maximize treatment efficacy, and the challenges that need to be addressed.</span></span></p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100515"},"PeriodicalIF":3.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138466742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pooled screening with next-generation gene editing tools. 利用新一代基因编辑工具进行联合筛选。
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-12-01 Epub Date: 2023-06-21 DOI: 10.1016/j.cobme.2023.100479
Liqun Zhou, Luojia Yang, Yanzhi Feng, Sidi Chen
{"title":"Pooled screening with next-generation gene editing tools.","authors":"Liqun Zhou, Luojia Yang, Yanzhi Feng, Sidi Chen","doi":"10.1016/j.cobme.2023.100479","DOIUrl":"10.1016/j.cobme.2023.100479","url":null,"abstract":"<p><p>Pooled screening creates a pool of cells with genetic variants, allowing for the simultaneous examination for changes in behavior or function. By selectively inducing mutations or perturbing expression, it enables scientists to systematically investigate the function of genes or genetic elements. Emerging gene editing tools, such as CRISPR, coupled with advances in sequencing and computational capabilities, provide growing opportunities to understand biological processes in humans, animals, and plants as well as to identify potential targets for therapeutic interventions and agricultural research. In this review, we highlight the recent advances of pooled screens using next-generation gene editing tools along with relevant challenges and describe potential future directions of this technology.</p>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"1 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10786633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54234068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanome-guided strategies in regenerative rehabilitation 再生康复的机制引导策略
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-11-30 DOI: 10.1016/j.cobme.2023.100516
Diego Jacho, Eda Yildirim-Ayan
{"title":"Mechanome-guided strategies in regenerative rehabilitation","authors":"Diego Jacho,&nbsp;Eda Yildirim-Ayan","doi":"10.1016/j.cobme.2023.100516","DOIUrl":"https://doi.org/10.1016/j.cobme.2023.100516","url":null,"abstract":"<div><p><span>Regenerative Rehabilitation represents a multifaceted approach that merges mechanobiology with therapeutic intervention to harness the body's intrinsic </span>tissue repair<span> and regeneration capacity. This review delves into the intricate interplay<span><span><span><span> between mechanical loading and cellular responses in the context of musculoskeletal tissue healing. It emphasizes the importance of understanding the phases involved in </span>translating<span><span> mechanical forces into biochemical responses at the cellular level. The review paper also covers the mechanosensitivity of macrophages, fibroblasts, and </span>mesenchymal stem cells, which play a crucial role during regenerative rehabilitation since these cells exhibit unique mechanoresponsiveness during different stages of the tissue healing process. Understanding how mechanical loading amplitude and frequency applied during regenerative rehabilitation influences </span></span>macrophage polarization<span>, fibroblast-to-myofibroblast transition (FMT), and mesenchymal stem cell differentiation is crucial for developing effective therapies for musculoskeletal tissues. In conclusion, this review underscores the significance of mechanome-guided strategies in regenerative rehabilitation. By exploring the mechanosensitivity of different cell types and their responses to mechanical loading, this field offers promising avenues for accelerating tissue healing and functional recovery, ultimately enhancing the quality of life<span> for individuals with musculoskeletal injuries and </span></span></span>degenerative diseases.</span></span></p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"29 ","pages":"Article 100516"},"PeriodicalIF":3.9,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138769743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical point of care devices for diagnosis of urinary tract infections 诊断尿路感染的光学护理点装置
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-11-08 DOI: 10.1016/j.cobme.2023.100513
Weiming Xu , Esha Venkat , Hatice Ceylan Koydemir
{"title":"Optical point of care devices for diagnosis of urinary tract infections","authors":"Weiming Xu ,&nbsp;Esha Venkat ,&nbsp;Hatice Ceylan Koydemir","doi":"10.1016/j.cobme.2023.100513","DOIUrl":"10.1016/j.cobme.2023.100513","url":null,"abstract":"<div><p>Urinary tract infections (UTIs) are common bacterial infections affecting any part of the urinary system. Accurate and rapid UTI diagnosis is crucial for initiating appropriate and effective treatment and preventing further complications. Traditional diagnostic methods based on culturing require specialized expertise, controlled environments for culturing urine specimens, and specific analysis environments, and these methods are time-consuming. In contrast, optical devices offer tremendous advantages, including enhanced sensitivity, user-friendliness, and portability. These devices can be integrated with conventional methods to enhance the accessibility of diagnosis techniques, especially in resource-limited settings. Further research is needed to optimize optical devices' analytical performance and cost-effectiveness to harness their full potential in UTI diagnosis. This review delves into recent advancements in optics-based devices for urinary pathogen detection. After providing a succinct overview of UTIs and existing clinical practices for their detection, diagnosis, and treatment, the most recent studies about optical diagnostic technologies for UTI diagnosis were reviewed, and an exploration of the future prospects and conclusive insights were discussed. Unveiling the potential of optical technology for UTI diagnosis promises to revolutionize healthcare and exemplifies the inexhaustible possibilities at the intersection of science and medicine.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100513"},"PeriodicalIF":3.9,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468451123000697/pdfft?md5=4d80843e0e0fdf3c39596b93289611a9&pid=1-s2.0-S2468451123000697-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135516015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein engineering technologies for development of next-generation genome editors 开发下一代基因组编辑器的蛋白质工程技术
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-11-01 DOI: 10.1016/j.cobme.2023.100514
Jackson Winter , Shraddha Shirguppe , Pablo Perez-Pinera
{"title":"Protein engineering technologies for development of next-generation genome editors","authors":"Jackson Winter ,&nbsp;Shraddha Shirguppe ,&nbsp;Pablo Perez-Pinera","doi":"10.1016/j.cobme.2023.100514","DOIUrl":"10.1016/j.cobme.2023.100514","url":null,"abstract":"<div><p><span>Base editors and prime editors have emerged as promising tools for the modeling and treatment of genetic diseases due to their ability to introduce targeted modifications in the </span>genomic DNA<span> of living cells. Several engineering approaches have been applied to improve their performance, ranging from simple protein design<span> approaches to complex directed evolution schemes that can probe a vast landscape of mutational variants with minimal user intervention. These extensive efforts have led to new generations of editors with enhanced properties such as increased editing activity, tailored editing windows, increased targetability, smaller construct size for viral delivery, and decreased off-target effects. In this manuscript we review protein engineering technologies that have been recently utilized to create an ever-evolving landscape of high-performance gene editing tools specifically designed for genetic targets of interest and that have redefined what is possible in the field of precision medicine.</span></span></p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100514"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135222101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-use biosensors for biomanufacturing: Perspective on the state-of-the-art 用于生物制造的一次性生物传感器:最先进的观点
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-10-31 DOI: 10.1016/j.cobme.2023.100512
Zach Hetzler , Noah Lott , Aditi Dey Poonam , Selen Dalgan , Qingshan Wei
{"title":"Single-use biosensors for biomanufacturing: Perspective on the state-of-the-art","authors":"Zach Hetzler ,&nbsp;Noah Lott ,&nbsp;Aditi Dey Poonam ,&nbsp;Selen Dalgan ,&nbsp;Qingshan Wei","doi":"10.1016/j.cobme.2023.100512","DOIUrl":"10.1016/j.cobme.2023.100512","url":null,"abstract":"<div><p>The biomanufacturing industry has experienced significant transformations in the past 10 years, driven by changing industry trends and rapidly maturing new technologies. However, the pace of process monitoring technology development has lagged behind. This review focuses on the current major gaps in critical monitoring technology required for industry advancement, with a particular focus on single-use biosensors. There is a large unmet need for single-use biosensors in upstream and downstream processing<span> as the industry transitions to single-use bioreactors. Emerging fields like cell and gene therapy that are still lacking numerous satisfactory at-line product characterization sensors will also be covered.</span></p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100512"},"PeriodicalIF":3.9,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136153275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microfluidic platforms based on SERS imaging and their point-of-care applications 基于SERS成像的微流控平台及其护理点应用
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-10-27 DOI: 10.1016/j.cobme.2023.100510
Hilal Torul , Emine Yıldırım , Uğur Tamer
{"title":"Microfluidic platforms based on SERS imaging and their point-of-care applications","authors":"Hilal Torul ,&nbsp;Emine Yıldırım ,&nbsp;Uğur Tamer","doi":"10.1016/j.cobme.2023.100510","DOIUrl":"https://doi.org/10.1016/j.cobme.2023.100510","url":null,"abstract":"<div><p>Surface-enhanced Raman spectroscopy (SERS) imaging is one of the most prevalent and efficient molecular imaging techniques that may provide enhanced Raman signals of samples such as cells or biomolecules for highly accurate measurement. Furthermore, SERS imaging-based techniques can be adapted to portable systems, making them sufficient to be used for POC applications. In this review, we focused on prominent publications based on SERS imaging techniques in combination with microfluidics platforms for POC analysis of proteins, biomarkers and pathogens over the past five years.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100510"},"PeriodicalIF":3.9,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92042579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The changing landscape of gene editing tool delivery in neurological disorders 神经系统疾病中基因编辑工具传递的变化前景
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-10-12 DOI: 10.1016/j.cobme.2023.100509
Yu-Ju Chen, Abhik Paul, Michael Gregory Collins, Hye Young Lee
{"title":"The changing landscape of gene editing tool delivery in neurological disorders","authors":"Yu-Ju Chen,&nbsp;Abhik Paul,&nbsp;Michael Gregory Collins,&nbsp;Hye Young Lee","doi":"10.1016/j.cobme.2023.100509","DOIUrl":"10.1016/j.cobme.2023.100509","url":null,"abstract":"<div><p>The delivery of gene editing tools has made significant advancements in recent years. This being said, the brain remains a challenging organ for the safe and efficient delivery of gene editing tools. As nonviral delivery vehicles have shown promise with their safety profiles and biocompatibility, there have been efforts to test nonviral delivery vehicles for gene editing tools in the brain. Here, we review recent advancements in gene editing tool development and discuss how they were tested using nonviral delivery vehicles, with a specific focus on brain applications.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100509"},"PeriodicalIF":3.9,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135706116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomaterials: Intelligent biomaterials 2023 生物材料:智能生物材料2023
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-10-06 DOI: 10.1016/j.cobme.2023.100508
Himansu Sekhar Nanda, Masoud Mozafari, Gulden Camci-Unal, Seeram Ramakrishna, Ravin Narain
{"title":"Biomaterials: Intelligent biomaterials 2023","authors":"Himansu Sekhar Nanda,&nbsp;Masoud Mozafari,&nbsp;Gulden Camci-Unal,&nbsp;Seeram Ramakrishna,&nbsp;Ravin Narain","doi":"10.1016/j.cobme.2023.100508","DOIUrl":"https://doi.org/10.1016/j.cobme.2023.100508","url":null,"abstract":"","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100508"},"PeriodicalIF":3.9,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92042580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Futures of BME: Sustainable medical materials 2023 BME的未来:可持续医疗材料2023
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-28 DOI: 10.1016/j.cobme.2023.100507
Seeram Ramakrishna, Aldo R. Boccaccini, Mina Zare
{"title":"Futures of BME: Sustainable medical materials 2023","authors":"Seeram Ramakrishna,&nbsp;Aldo R. Boccaccini,&nbsp;Mina Zare","doi":"10.1016/j.cobme.2023.100507","DOIUrl":"https://doi.org/10.1016/j.cobme.2023.100507","url":null,"abstract":"","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100507"},"PeriodicalIF":3.9,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468451123000636/pdfft?md5=f7d7257320e223763cf7ef68bbf87295&pid=1-s2.0-S2468451123000636-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91956957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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