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Current Opinion in Biomedical Engineering最新文献

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Ferrogels: A wonder material from mechanobiological perspective 铁凝胶：从机械生物学角度看一种神奇的材料
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.cobme.2023.100449
Soumyadeep Basak , P. Gopinath
{"title":"Ferrogels: A wonder material from mechanobiological perspective","authors":"Soumyadeep Basak ,&nbsp;P. Gopinath","doi":"10.1016/j.cobme.2023.100449","DOIUrl":"10.1016/j.cobme.2023.100449","url":null,"abstract":"<div><p>Forces generated intrinsically or perceived externally by cells have significant implications in cell development biology. This relatively nascent field, mechanobiology, is currently being investigated widely in almost every dimension of biological sciences. From a biomedical point of view, hydrogels, a hydrated network of polymer molecules, have provided many excellent scaffold platforms. Moreover, applying extrinsic force to the cells using a magnetic field has always been preferred. In such a scenario, ferrogel, which is hydrogel incorporating magnetically active nanomaterials, offers an exciting platform that can provide cells with their required niche and apply a controlled amount of extrinsic force using a magnetic field. From tissue engineering to 3D Bioprinting and developing biosensing platforms, ferrogels are gaining tremendous attention worldwide. Therefore, the current literature will focus on the mechanobiological importance of ferrogels and their potential application in biomedicine.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41482018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Intelligent biomaterials for micro and nanoscale 3D printing 微纳米级3D打印智能生物材料
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.cobme.2023.100454
Bing Zhang , Shikang Li , Zhifeng Zhang , Zijie Meng , Jiankang He , Seeram Ramakrishna , Chao Zhang
{"title":"Intelligent biomaterials for micro and nanoscale 3D printing","authors":"Bing Zhang ,&nbsp;Shikang Li ,&nbsp;Zhifeng Zhang ,&nbsp;Zijie Meng ,&nbsp;Jiankang He ,&nbsp;Seeram Ramakrishna ,&nbsp;Chao Zhang","doi":"10.1016/j.cobme.2023.100454","DOIUrl":"10.1016/j.cobme.2023.100454","url":null,"abstract":"<div><p>Micro and nanoscale 3D printing has been broadly employed for the manufacturing of biomimetic architectures in the fields of tissue regeneration, personalized medicine, and smart biodevices. The emerging intelligent biomaterials significantly expand the diversity and functionality of printed structures. In this review, the commonly used micro and nanoscale 3D printing techniques were briefly introduced. Recent innovations on intelligent biomaterials like biopolymers, hydrogels, and metallic/ceramic biomaterials were reviewed. The current limitations and future opportunities of 3D-printed intelligent biomaterials for biomedical applications were highlighted. Overall, this review will help the new researchers to understand the underlying principles, functional properties, and potential applications of intelligent biomaterials in micro and nanoscale 3D printing field.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45904919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Surface design strategies of polymeric biomedical implants for antibacterial properties 高分子生物医学植入物抗菌性能的表面设计策略
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.cobme.2023.100448
Elizabeth L. Meier, Yeongseon Jang
{"title":"Surface design strategies of polymeric biomedical implants for antibacterial properties","authors":"Elizabeth L. Meier,&nbsp;Yeongseon Jang","doi":"10.1016/j.cobme.2023.100448","DOIUrl":"10.1016/j.cobme.2023.100448","url":null,"abstract":"<div><p>Medical implants play an essential role in individuals' health and quality of life to replace, support, or enhance a biological structure in bodies. The selection of materials, considering their properties, is critical for implants depending on their application areas. There is a wide range of polymers used in biomedical implants, where the materials' flexibility and transport capability are needed. Since bacterial adhesion on polymeric surfaces leads to serious infectious diseases and deterioration of the implants, the development of rational surface design strategies is of great importance. Herein, we highlight synthetic, non-biodegradable polymer-based biomedical implants and the recent strategies to create antibacterial surfaces. Different types of polymer-based implants with their uses are summarized, along with their inherent antibacterial properties and additional surface modification strategies. Finally, we discuss the challenges of the current approaches and future perspectives to enhance antibacterial performance and obtain multimodal functionality of polymer-based medical implants.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48873129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Gelatin-based scaffolds: An intuitive support structure for regenerative therapy 明胶支架——再生治疗的直观支撑结构
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.cobme.2023.100452
Adib Bin Rashid , Nazmir-Nur Showva , Md Enamul Hoque
{"title":"Gelatin-based scaffolds: An intuitive support structure for regenerative therapy","authors":"Adib Bin Rashid ,&nbsp;Nazmir-Nur Showva ,&nbsp;Md Enamul Hoque","doi":"10.1016/j.cobme.2023.100452","DOIUrl":"10.1016/j.cobme.2023.100452","url":null,"abstract":"<div><p>Advanced regenerative therapy aims to repair pathologically damaged tissue by cell transplantation in conjunction with supporting scaffolds. Gelatin-based scaffolds have attracted much attention in recent years due to their great bio-affinity that encourages the regeneration of tissues. Nowadays, by strengthening gelatin-based systems, cutting-edge methods like 3D bioprinting, freeze-drying, microfluidics and gelatin functionalization have shown excellent mimicry of natural tissue. The fabrication of porous gelatin-based scaffolds for wider tissue engineering applications including skin, cartilage, bone, liver, and cardiovascular is reviewed in this work. Additionally, the crosslinking procedures and the physicochemical characteristics of the gelatin-based scaffolds are also studied. Now, gelatin is considered one of the highest potential biomaterials for impending trends in which the gelatin-based scaffolds are used as a support structure for regenerative therapy.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48546113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Advances and challenges on hydrogels for wound dressing 水凝胶伤口敷料的研究进展与挑战
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.cobme.2022.100443
Wenda Wang , Sarute Ummartyotin , Ravin Narain
{"title":"Advances and challenges on hydrogels for wound dressing","authors":"Wenda Wang ,&nbsp;Sarute Ummartyotin ,&nbsp;Ravin Narain","doi":"10.1016/j.cobme.2022.100443","DOIUrl":"10.1016/j.cobme.2022.100443","url":null,"abstract":"<div><p>Hydrogels, due to their hydrophilic nature, tunable chemical, mechanical and biological properties, have shown great promises for wound dressing application. Nevertheless, conventional hydrogels can only passively participate in the wound healing process by maintaining the moisture around wound, which limits the wound healing efficacy. Recent developments of hydrogel wound dressings have focused on the mechanically active adhesive hydrogels and self-adapting hydrogels, which are able to actively accelerate the wound healing process. In this review, we first review the design strategies and function mechanisms of both types of hydrogel dressings, followed by the discussion on the application of those hydrogel dressings for the treatment of different type of wounds. Finally, we present the future trends and research opportunities for the development of next generation “smart” hydrogel materials for wound healing application.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48230760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Intelligent and smart biomaterials for sustainable 3D printing applications 可持续3D打印应用的智能和智能生物材料
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.cobme.2023.100450
Elena Herrera-Ponce de León , Alexander U. Valle-Pérez , Zainab N. Khan , Charlotte A.E. Hauser
{"title":"Intelligent and smart biomaterials for sustainable 3D printing applications","authors":"Elena Herrera-Ponce de León ,&nbsp;Alexander U. Valle-Pérez ,&nbsp;Zainab N. Khan ,&nbsp;Charlotte A.E. Hauser","doi":"10.1016/j.cobme.2023.100450","DOIUrl":"10.1016/j.cobme.2023.100450","url":null,"abstract":"<div><p>Smart and intelligent biomaterials can be designed to carry out special tasks in modern medicine and sustainability, and engineered to identify and respond to environmental stimuli. Therefore, intelligent biomaterials have a large number of applications that can go from health (e.g. tissue engineering, drug delivery and biosensors), to more recently explored environmental applications involving ecosystem restoration (e.g. coral reefs and environmental remediation). The use of 3D printing technology opens the vision towards automated biomanufacturing with more precision and definition. With this broad range of applications, smart and intelligent biomaterials are used separately or in combination with 3D printing to enable the design of eco-friendly and sustainable solutions that can be used to overcome challenges for both; modern medicine and the environment.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49278375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Biomedical imaging: Imaging for regenerative medicine and biomanufacturing 生物医学成像:用于再生医学和生物制造的成像
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.cobme.2023.100451
Melissa C. Skala, Francisco E. Robles, Irene Georgakoudi
{"title":"Biomedical imaging: Imaging for regenerative medicine and biomanufacturing","authors":"Melissa C. Skala,&nbsp;Francisco E. Robles,&nbsp;Irene Georgakoudi","doi":"10.1016/j.cobme.2023.100451","DOIUrl":"10.1016/j.cobme.2023.100451","url":null,"abstract":"","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45292935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative 4D imaging of biomechanical regulation of ventricular growth and maturation 心室生长和成熟生物力学调控的定量4D成像
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-06-01 DOI: 10.1016/j.cobme.2022.100438
Jae Min Cho , Mong Lung Steve Poon , Enbo Zhu , Jing Wang , Jonathan T. Butcher , Tzung Hsiai
{"title":"Quantitative 4D imaging of biomechanical regulation of ventricular growth and maturation","authors":"Jae Min Cho ,&nbsp;Mong Lung Steve Poon ,&nbsp;Enbo Zhu ,&nbsp;Jing Wang ,&nbsp;Jonathan T. Butcher ,&nbsp;Tzung Hsiai","doi":"10.1016/j.cobme.2022.100438","DOIUrl":"10.1016/j.cobme.2022.100438","url":null,"abstract":"<div><p>Abnormal cardiac development is intimately associated with congenital heart disease. During development, a sponge-like network of muscle fibers in the endocardium, known as trabeculation, becomes compacted. Biomechanical forces regulate myocardial differentiation and proliferation to form trabeculation, while the molecular mechanism is still enigmatic. Biomechanical forces, including intracardiac hemodynamic flow and myocardial contractile force, activate a host of molecular signaling pathways to mediate cardiac morphogenesis. While mechanotransduction pathways to initiate ventricular trabeculation is well studied, deciphering the relative importance of hemodynamic shear <em>vs</em>. mechanical contractile forces to modulate the transition from trabeculation to compaction requires advanced imaging tools and genetically tractable animal models. For these reasons, the advent of 4D multi-scale light-sheet imaging and complementary multiplex live imaging via micro-CT in the beating zebrafish heart and live chick embryos, respectively. Thus, this review highlights the complementary animal models and advanced imaging needed to elucidate the mechanotransduction underlying cardiac ventricular development.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9806665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of immune cells in therapeutic angiogenesis: Concepts in tissue engineering 免疫细胞在治疗性血管生成中的作用:组织工程中的概念
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-05-29 DOI: 10.1016/j.cobme.2023.100470
Zoleikha Azari , Sara Gorgani , Seyede Atefe Hosseini , Andrew Z. Wang , Hae-Won Kim , Saeid Kargozar
{"title":"The role of immune cells in therapeutic angiogenesis: Concepts in tissue engineering","authors":"Zoleikha Azari ,&nbsp;Sara Gorgani ,&nbsp;Seyede Atefe Hosseini ,&nbsp;Andrew Z. Wang ,&nbsp;Hae-Won Kim ,&nbsp;Saeid Kargozar","doi":"10.1016/j.cobme.2023.100470","DOIUrl":"10.1016/j.cobme.2023.100470","url":null,"abstract":"<div><p>Immune cells can positively regulate new blood vessel formation by secreting proangiogenic mediators and modulating endothelial cell (EC) and endothelial progenitor cell (EPC) activities (e.g., homing). Accordingly, timely management of immune cell behavior is performed to promote angiogenesis and accelerate tissue healing. Different characteristics of biomaterials and scaffolds, including chemical (e.g., composition) and physical (e.g., topography) properties, were proven to influence the angiogenic potential of immune cells. Moreover, specific biomolecular cargoes can be loaded into 3D scaffolds to affect immune cells' behavior in favor of improved angiogenesis. Excess neovascularization can cause pathological conditions, thus establishing a balance between pro- and anti-angiogenic mediators should be taken into account once developing biomaterials and scaffolds for modulating immune cell activities. This review provides an in-depth and concise review of the angiogenic-regulatory effects of immune cells and discusses the importance of its modulation by biomaterials and scaffolds for tissue engineering.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48540205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
AI models for protein design are driving antibody engineering 用于蛋白质设计的人工智能模型正在推动抗体工程
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-05-26 DOI: 10.1016/j.cobme.2023.100473
Michael F. Chungyoun , Jeffrey J. Gray
{"title":"AI models for protein design are driving antibody engineering","authors":"Michael F. Chungyoun ,&nbsp;Jeffrey J. Gray","doi":"10.1016/j.cobme.2023.100473","DOIUrl":"10.1016/j.cobme.2023.100473","url":null,"abstract":"<div><p>Therapeutic antibody engineering seeks to identify antibody sequences with specific binding to a target and optimized drug-like properties. When guided by deep learning, antibody generation methods can draw on prior knowledge and experimental efforts to improve this process. By leveraging the increasing quantity and quality of predicted structures of antibodies and target antigens, powerful structure-based generative models are emerging. In this review, we tie the advancements in deep learning-based protein structure prediction and design to the study of antibody therapeutics.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9918456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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