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Engineered intravenous therapies for trauma 为创伤设计静脉注射疗法
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100456
Trey J. Pichon , Nathan J. White , Suzie H. Pun
{"title":"Engineered intravenous therapies for trauma","authors":"Trey J. Pichon ,&nbsp;Nathan J. White ,&nbsp;Suzie H. Pun","doi":"10.1016/j.cobme.2023.100456","DOIUrl":"10.1016/j.cobme.2023.100456","url":null,"abstract":"<div><p>Trauma leading to severe hemorrhage and shock on average kills patients within 3–6 h after injury. With average prehospital transport times reaching 1–6 h in low- to middle-income countries, stopping the bleeding and reversing hemorrhagic shock is vital. First-generation intravenous hemostats rely on traditional drug delivery platforms, such as self-assembling systems, fabricated nanoparticles, and soluble polymers due to their active targeting, biodistribution, and safety. We discuss some challenges in translating these therapies to patients, as very few have successfully made it through preclinical evaluation in large animals, and none have translated to the clinic. Finally, we discuss the physiology of hemorrhagic shock, highlight a new low-volume resuscitant (LVR) PEG-20k, and end with considerations for the rational design of LVRs.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100456"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9828358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Biosignal-based co-adaptive user-machine interfaces for motor control 基于生物信号的电机控制协同自适应用户-机器界面
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100462
Maneeshika M. Madduri , Samuel A. Burden , Amy L. Orsborn
{"title":"Biosignal-based co-adaptive user-machine interfaces for motor control","authors":"Maneeshika M. Madduri ,&nbsp;Samuel A. Burden ,&nbsp;Amy L. Orsborn","doi":"10.1016/j.cobme.2023.100462","DOIUrl":"10.1016/j.cobme.2023.100462","url":null,"abstract":"<div><p>User-machine interfaces map biological signals measured from the user to control commands for external devices. The mapping from biosignals to device inputs is performed by a decoding algorithm. Adaptation of both the user and decoder—co-adaptation—provides opportunities to improve the inclusivity and usability of interfaces for diverse users and applications. User learning leads to robust interface control that can generalize across environments and contexts. Decoder adaptation can personalize interfaces, account for day-to-day signal variability, and improve overall performance. Co-adaptation therefore creates opportunities to shape the user and decoder system to achieve robust and generalizable personalized interfaces. However, co-adaptation creates a two-learner system with dynamic interactions between the user and decoder. Engineering co-adaptive interfaces requires new tools and frameworks to analyze and design user-decoder interactions. In this article, we review adaptive decoding, user learning, and co-adaptation in user-machine interfaces, primarily brain-computer, myoelectric, and kinematic interfaces, for motor control. We then discuss performance criteria for co-adaptive interfaces and propose a game-theoretic approach to designing user-decoder co-adaptation.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100462"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45485912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Intracellular antibodies and biodegraders: Beyond small molecules and back again 细胞内抗体和生物降解剂:超越小分子，再回来
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100455
D. Cardella, D. Sanchez-Guzman, T.H. Rabbitts
{"title":"Intracellular antibodies and biodegraders: Beyond small molecules and back again","authors":"D. Cardella,&nbsp;D. Sanchez-Guzman,&nbsp;T.H. Rabbitts","doi":"10.1016/j.cobme.2023.100455","DOIUrl":"10.1016/j.cobme.2023.100455","url":null,"abstract":"<div><p>Intracellular antibodies have been deployed as powerful research tools for the last 20 years for inhibition of proteins to convey specific information about protein function. Accordingly, intracellular antibodies have been used for target validation in oncology and were the first reagents to inhibit “undruggable” targets, such as RAS mutants and LMO2. Their versatility allows addition of effector functions to invoke cell phenotypes following target engagement inside cells. Moreover, the paratope–epitope interaction of intracellular antibodies has been recently exploited to develop small molecule surrogates. We will discuss the flexibility that intracellular antibodies provide for discovery research and for new generations of therapeutics in all clinical indications where an aberrant protein expression is involved (oncology, neurological disease, infection, inflammation).</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100455"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48432158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular dynamics simulation of membrane systems in the context of traumatic brain injury 创伤性脑损伤中膜系统的分子动力学模拟
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100453
A.T.N. Vo , M.A. Murphy , P.K. Phan , T.W. Stone , R.K. Prabhu
{"title":"Molecular dynamics simulation of membrane systems in the context of traumatic brain injury","authors":"A.T.N. Vo ,&nbsp;M.A. Murphy ,&nbsp;P.K. Phan ,&nbsp;T.W. Stone ,&nbsp;R.K. Prabhu","doi":"10.1016/j.cobme.2023.100453","DOIUrl":"10.1016/j.cobme.2023.100453","url":null,"abstract":"<div><p>Traumatic brain injury (TBI), caused by physical insults to the head, involves complex pathophysiological processes that damage the brain at multiple length scales. Unlike macroscale brain tissue damages, nanoscale cellular impairments, including neuron membrane integrity loss and mechanoporation, are elusive in experiments and necessitate the implementation of <em>in silico</em> atomic-level approaches, such as molecular dynamics (MD) simulations. MD studies have rapidly developed over the past decades, significantly enhancing our understanding in membrane dynamics and biomechanically plausible damage mechanisms induced by TBI. Hence, in this article, we will give an overview of recent MD membrane system models in the context of TBI and discuss the ongoing advancements as well as challenges in this research area.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100453"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42349353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Toward the use of muscle reinnveration for chronic bidirectional control of prostheses to improve functional outcomes of end users 在慢性假体双向控制中使用肌肉修复来改善最终使用者的功能结果
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-08-26 DOI: 10.1016/j.cobme.2023.100497
Deanna H. Gates , Michael A. Gonzalez , Theodore A. Kung , Cynthia A. Chestek
{"title":"Toward the use of muscle reinnveration for chronic bidirectional control of prostheses to improve functional outcomes of end users","authors":"Deanna H. Gates ,&nbsp;Michael A. Gonzalez ,&nbsp;Theodore A. Kung ,&nbsp;Cynthia A. Chestek","doi":"10.1016/j.cobme.2023.100497","DOIUrl":"10.1016/j.cobme.2023.100497","url":null,"abstract":"<div><p>Regenerative peripheral nerve interfaces (RPNI) and targeted muscle reinnervation (TMR) are surgical approaches for redirecting peripheral nerve growth to denervated muscle targets after amputation. These approaches have demonstrated promise at reducing post-amputation pain and are now frequently performed at the time of amputation. Both TMR and RPNI can also serve as bioamplifiers for efferent neural signals that once went to the lost limb. Through reinnervation of muscle and skin, patients may also afford meaningful afferent feedback. Accordingly, these surgical approaches can be beneficial for bidirectional prostheses. This review discusses recent literature on management of post-amputation pain, prosthetic control, and sensory feedback with each approach. We also discuss how these approaches can be incorporated into wearable systems to improve function in daily life.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100497"},"PeriodicalIF":3.9,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45014862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Optical imaging technologies for in vivo cancer detection in low-resource settings 低资源环境下癌症体内检测的光学成像技术
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-08-23 DOI: 10.1016/j.cobme.2023.100495
Huayu Hou , Ruchika Mitbander , Yubo Tang , Ahad Azimuddin , Jennifer Carns , Richard A. Schwarz , Rebecca R. Richards-Kortum
{"title":"Optical imaging technologies for in vivo cancer detection in low-resource settings","authors":"Huayu Hou ,&nbsp;Ruchika Mitbander ,&nbsp;Yubo Tang ,&nbsp;Ahad Azimuddin ,&nbsp;Jennifer Carns ,&nbsp;Richard A. Schwarz ,&nbsp;Rebecca R. Richards-Kortum","doi":"10.1016/j.cobme.2023.100495","DOIUrl":"10.1016/j.cobme.2023.100495","url":null,"abstract":"<div><p>Cancer continues to affect underserved populations disproportionately. Novel optical imaging technologies, which can provide rapid, non-invasive, and accurate cancer detection at the point of care, have great potential to improve global cancer care. This article reviews the recent technical innovations and clinical translation of low-cost optical imaging technologies, highlighting the advances in both hardware and software, especially the integration of artificial intelligence, to improve <em>in vivo</em> cancer detection in low-resource settings. Additionally, this article provides an overview of existing challenges and future perspectives of adapting optical imaging technologies into clinical practice, which can potentially contribute to novel insights and programs that effectively improve cancer detection in low-resource settings.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100495"},"PeriodicalIF":3.9,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48939444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generative design of therapeutics that bind and modulate protein states 结合和调节蛋白质状态的疗法的生成设计
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-08-21 DOI: 10.1016/j.cobme.2023.100496
Tianlai Chen , Lauren Hong , Vivian Yudistyra , Sophia Vincoff , Pranam Chatterjee
{"title":"Generative design of therapeutics that bind and modulate protein states","authors":"Tianlai Chen ,&nbsp;Lauren Hong ,&nbsp;Vivian Yudistyra ,&nbsp;Sophia Vincoff ,&nbsp;Pranam Chatterjee","doi":"10.1016/j.cobme.2023.100496","DOIUrl":"10.1016/j.cobme.2023.100496","url":null,"abstract":"<div><p>Numerous therapeutic approaches have been developed to enable interrogation and modulation of protein isoforms, but often require laborious experimental development or screening of binders to targets of interest. In this article, we focus on efficient, state-of-the-art computational methods to design both small molecule and protein-based binders to target proteins, and highlight recent generative artificial intelligence approaches to binder design, which represents the most promising direction to enable targeting and modulation of any protein state. Integrated with advances in protein-modifying architectures, the strategies described here may serve as the foundation for therapeutic development in the near future.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100496"},"PeriodicalIF":3.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43208713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cytoskeletal safeguards: Protecting the nucleus from mechanical perturbations 细胞骨架保护：保护细胞核免受机械扰动
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-08-03 DOI: 10.1016/j.cobme.2023.100494
Zanetta Kechagia , Pere Roca-Cusachs
{"title":"Cytoskeletal safeguards: Protecting the nucleus from mechanical perturbations","authors":"Zanetta Kechagia ,&nbsp;Pere Roca-Cusachs","doi":"10.1016/j.cobme.2023.100494","DOIUrl":"10.1016/j.cobme.2023.100494","url":null,"abstract":"<div><p>The cell nucleus plays a key role in cellular mechanoresponses. 3D genome organisation, gene expression, and cell behaviour, in general, are affected by mechanical force application to the nucleus, which is transmitted from the cellular environment via a network of interconnected cytoskeletal components. To effectively regulate cell responses, these cytoskeletal components must not only exert forces but also withstand external forces when necessary. This review delves into the latest research concerning how the cytoskeleton safeguards the nucleus from mechanical perturbations. Specifically, we focus on the three primary cytoskeletal polymers: actin, intermediate filaments, and microtubules, as well as their interactions with the cell nucleus. We discuss how the cytoskeleton acts as a protective shield for the nucleus, ensuring structural integrity and conveying context-specific mechanoresponses.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100494"},"PeriodicalIF":3.9,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46173325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineered stimuli-responsive smart grafts for bone regeneration 用于骨再生的工程化刺激响应智能移植物
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-08-01 DOI: 10.1016/j.cobme.2023.100493
Mohammad Aftab Alam Ansari , Madhusmita Dash , Gulden Camci-Unal , Prashant Kumar Jain , Syam Nukavarapu , Seeram Ramakrishna , Natashya Falcone , Mehmet Remzi Dokmeci , Alireza Hassani Najafabadi , Ali Khademhosseini , Himansu Sekhar Nanda
{"title":"Engineered stimuli-responsive smart grafts for bone regeneration","authors":"Mohammad Aftab Alam Ansari ,&nbsp;Madhusmita Dash ,&nbsp;Gulden Camci-Unal ,&nbsp;Prashant Kumar Jain ,&nbsp;Syam Nukavarapu ,&nbsp;Seeram Ramakrishna ,&nbsp;Natashya Falcone ,&nbsp;Mehmet Remzi Dokmeci ,&nbsp;Alireza Hassani Najafabadi ,&nbsp;Ali Khademhosseini ,&nbsp;Himansu Sekhar Nanda","doi":"10.1016/j.cobme.2023.100493","DOIUrl":"10.1016/j.cobme.2023.100493","url":null,"abstract":"<div><p>Complex tissue regeneration through biomaterial-based strategies has witnessed a substantial structural transformation to facilitate the attachment and migration of host cells. Smart biomaterials offer exceptional features by rearranging themselves into diverse conformations upon exposure to physical (e.g., magnetic, temperature, electric field, and light), chemical (e.g., pH and ionic strength), or biological (e.g., enzymes) stimuli. By engineering conventional biomaterials into three-dimensional smart porous constructs (i.e., grafts) with novel sensory materials through a range of chemical and physical processing routes, it is possible to mimic the diverse mechanical, biological, and physiochemical nature of bone tissue. The resulting smart grafts can efficiently deliver the appropriate signals and guide the stem cells to promote tissue regeneration. In addition, they regulate the release of various bioactive agents in response to external and internal stimuli while combatting infections at the wound sites. This review discusses numerous strategies to engineer synthetic polymers to yield stimuli-responsive smart grafts suitable for bone tissue engineering. Various additives have also been included, ranging from nanoparticles to biologically active agents responsible for the graft's smart function. Furthermore, the review highlights recent trends and developments, contemporary challenges, and future perspectives of smart stimuli-responsive grafts concerning bone tissue engineering.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100493"},"PeriodicalIF":3.9,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47344981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Leveraging user preference in the design and evaluation of lower-limb exoskeletons and prostheses 利用用户偏好设计和评估下肢外骨骼和假体
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-07-27 DOI: 10.1016/j.cobme.2023.100487
Kimberly A. Ingraham , Maegan Tucker , Aaron D. Ames , Elliott J. Rouse , Max K. Shepherd
{"title":"Leveraging user preference in the design and evaluation of lower-limb exoskeletons and prostheses","authors":"Kimberly A. Ingraham ,&nbsp;Maegan Tucker ,&nbsp;Aaron D. Ames ,&nbsp;Elliott J. Rouse ,&nbsp;Max K. Shepherd","doi":"10.1016/j.cobme.2023.100487","DOIUrl":"10.1016/j.cobme.2023.100487","url":null,"abstract":"<div><p>The field of wearable robotics has seen major advances in recent years, largely owing to an intense focus on optimizing device behavior to accomplish a narrow set of objectives. This approach, however, ignores the end user's perceptions, which are often strongly held and may be key to accepting the technology. Consequently, user preference, which is capable of accounting for factors that are difficult to measure but important to the user, has recently emerged as a formally quantifiable outcome metric. In this perspective, we characterize the methods recently developed and employed to optimize for user preference, describe recent accomplishments in lower-limb wearable robotics research incorporating user preferences, highlight current challenges, and position preference as an important meta-criterion to guide the development of wearable robotic systems.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100487"},"PeriodicalIF":3.9,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45899958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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