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Current Opinion in Biomedical Engineering最新文献

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Sustainable electrospun materials with enhanced blood compatibility for wound healing applications—A mini review 具有增强血液相容性的可持续静电纺丝材料用于伤口愈合应用-一个小回顾
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100457
Mohan Prasath Mani , Ahmad Athif Mohd Faudzi , Seeram Ramakrishna , Ahmad Fauzi Ismail , Saravana Kumar Jaganathan , Nick Tucker , Rajasekar Rathanasamy
{"title":"Sustainable electrospun materials with enhanced blood compatibility for wound healing applications—A mini review","authors":"Mohan Prasath Mani ,&nbsp;Ahmad Athif Mohd Faudzi ,&nbsp;Seeram Ramakrishna ,&nbsp;Ahmad Fauzi Ismail ,&nbsp;Saravana Kumar Jaganathan ,&nbsp;Nick Tucker ,&nbsp;Rajasekar Rathanasamy","doi":"10.1016/j.cobme.2023.100457","DOIUrl":"10.1016/j.cobme.2023.100457","url":null,"abstract":"<div><p>Wound healing is a complex process that requires an appropriate environment to support healing. Wound dressings play a crucial role in wound management by protecting the wound and promoting healing. Recent advancements in wound dressing technology include the development of bio-absorbable electrospun dressings incorporating essential oils, which have shown promise in enhancing wound healing potential. However, there is still a need for sustainable wound dressing technology that is effective, safe, and environmentally friendly. This review addresses this need by emphasizing the potential of bio-absorbable electrospun wound dressings incorporating essential oils and advocating for a paradigm shift toward sustainable crop-origin materials and the elimination of toxic solvents in wound dressing fabrication.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100457"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45371690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Editorial overview - Neural engineering: Traumatic brain injury 编辑综述-神经工程：创伤性脑损伤
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100468
Lakiesha N. Williams, Michelle C. LaPlaca
{"title":"Editorial overview - Neural engineering: Traumatic brain injury","authors":"Lakiesha N. Williams,&nbsp;Michelle C. LaPlaca","doi":"10.1016/j.cobme.2023.100468","DOIUrl":"10.1016/j.cobme.2023.100468","url":null,"abstract":"","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100468"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49370142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomechanics of cardiac development in zebrafish model 斑马鱼心脏发育模型的生物力学研究
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100459
Tanveer Teranikar, Phuc Nguyen, Juhyun Lee
{"title":"Biomechanics of cardiac development in zebrafish model","authors":"Tanveer Teranikar,&nbsp;Phuc Nguyen,&nbsp;Juhyun Lee","doi":"10.1016/j.cobme.2023.100459","DOIUrl":"10.1016/j.cobme.2023.100459","url":null,"abstract":"<div><p>Zebrafish (<em>Danio rerio</em>) larvae are emerging as high-throughput, chemical screening assays for investigating congenital cardiomyopathies. Despite distinct anatomical and genomic differences with humans, zebrafish share a conserved regulatory network of transcription factors modulating heart development with mammals. Consequently, external embryonic fertilization and optical transparency in conjunction with fluorescent reporters localizing endogenous proteins provide an ideal platform for studying molecular mechanisms underlying complex human heart development. In this regard, recent advances in light sheet microscopy (LSM) have enabled non-invasive, <em>in vivo</em> reconstruction of dynamic cardiac biomarkers during early stages of embryonic zebrafish heart development. In this review, we discuss the development of cardiovascular disease progression pipelines using zebrafish and LSM to identify genetic and molecular drivers of human cardiac disease.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100459"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49030410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Genetically-encoded degraders as versatile modulators of intracellular therapeutic targets 基因编码降解物作为细胞内治疗靶点的通用调节剂
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100458
Chuan Dai , Jinpeng Wang , Licheng Tu , Zhuoheng Pan , Jinru Yang , Shuang Zhou , Qinhong Luo , Lizhi Zhu , Yuxin Ye
{"title":"Genetically-encoded degraders as versatile modulators of intracellular therapeutic targets","authors":"Chuan Dai ,&nbsp;Jinpeng Wang ,&nbsp;Licheng Tu ,&nbsp;Zhuoheng Pan ,&nbsp;Jinru Yang ,&nbsp;Shuang Zhou ,&nbsp;Qinhong Luo ,&nbsp;Lizhi Zhu ,&nbsp;Yuxin Ye","doi":"10.1016/j.cobme.2023.100458","DOIUrl":"10.1016/j.cobme.2023.100458","url":null,"abstract":"<div><p>Targeted protein degradation (TPD) is an emerging therapeutic approach that has attracted significant interest. The traditional TPD degraders rely on small molecules that can only target proteins of interest (POI) with known small-molecule binders or appropriate binding pockets. Recently, several genetic-encoded TPD (GE-TPD) strategies have been developed in which the degrader molecules are expressed in cells based on genetic information. GE-TPD discovers POI binders through techniques such as yeast and phage display and expands the E3 ligase toolbox through genetic encoding. In this review, we assess the progress of GE-TPD technologies in recent years and highlight innovative technologies that have the potential to advance the development of GE-TPD.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100458"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47736307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mining microbial organisms to discover and characterize novel CRISPR-Cas systems 挖掘微生物以发现和表征新型CRISPR-Cas系统
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100469
Ourania Raftopoulou , Rodolphe Barrangou
{"title":"Mining microbial organisms to discover and characterize novel CRISPR-Cas systems","authors":"Ourania Raftopoulou ,&nbsp;Rodolphe Barrangou","doi":"10.1016/j.cobme.2023.100469","DOIUrl":"https://doi.org/10.1016/j.cobme.2023.100469","url":null,"abstract":"<div><p>The need for new genome manipulation tools is leading the way for the continued discovery of novel clustered regularly interspaced short palindromic repeats— CRISPR associated sequences (CRISPR-Cas) systems. Researchers have been analyzing the genomes of prokaryotes and more recently metagenomic sequencing data to find novel and diverse CRISPR-Cas systems and their associated genome editing effectors. In this review, we provide an overview of <em>in silico</em>, <em>in vitro</em>, and <em>in vivo</em> analyses performed to characterize key elements of CRISPR-Cas systems, encompassing the CRISPR array, Cas proteins, guide ribonucleic acid (RNAs), and protospacer-adjacent motif (PAM) which defines targeting. We also highlight subsequent <em>in vitro</em> and <em>in vivo</em> assays employed to validate CRISPR function and Cas effector activity in the context of genome editing in various cellular contexts.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100469"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49815321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Corrigendum to “Emerging trends of discrete Poly(ethylene glycol) in biomedical applications” [Curr Opin Biomed Eng 24 (2022) 100419] “离散聚乙二醇在生物医学应用中的新兴趋势”更正[Curr Opin Biomed Eng 24（2022）100419]
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100467
Jinming Hu, Shiyong Liu
{"title":"Corrigendum to “Emerging trends of discrete Poly(ethylene glycol) in biomedical applications” [Curr Opin Biomed Eng 24 (2022) 100419]","authors":"Jinming Hu,&nbsp;Shiyong Liu","doi":"10.1016/j.cobme.2023.100467","DOIUrl":"https://doi.org/10.1016/j.cobme.2023.100467","url":null,"abstract":"","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100467"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49815353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contemporary standpoint and future of 3D bioprinting in tissue/organs printing 3D生物打印在组织/器官打印中的当代观点和未来
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100461
Vundrala Sumedha Reddy, Brindha Ramasubramanian, Vedant Mohan Telrandhe, Seeram Ramakrishna
{"title":"Contemporary standpoint and future of 3D bioprinting in tissue/organs printing","authors":"Vundrala Sumedha Reddy,&nbsp;Brindha Ramasubramanian,&nbsp;Vedant Mohan Telrandhe,&nbsp;Seeram Ramakrishna","doi":"10.1016/j.cobme.2023.100461","DOIUrl":"10.1016/j.cobme.2023.100461","url":null,"abstract":"<div><p>Additive manufacturing, often known as three-dimensional (3D) printing, is driving significant progress in a diverse range of fields, such as engineering, manufacturing, food, and medicine. Realistic tissue models and organ transplantation can provide necessary innovative opportunities to tackle countless medical and health care obstacles. These can be achieved by incorporation of 3D printing into tissue engineering, using live cells encapsulated in natural or synthetic biomaterials. This evolution of 3D bioprinting has been the focus of our article. Here, we methodically discussed the current stance, history, techniques, materials, and taxonomy of 3D bioprinting along with the challenges encountered.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100461"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49053978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
The myokinetic interface: Implanting permanent magnets to restore the sensory-motor control loop in amputees 肌动界面：植入永磁体以恢复截肢者的感觉运动控制回路
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100460
Marta Gherardini , Federico Masiero , Valerio Ianniciello , Christian Cipriani
{"title":"The myokinetic interface: Implanting permanent magnets to restore the sensory-motor control loop in amputees","authors":"Marta Gherardini ,&nbsp;Federico Masiero ,&nbsp;Valerio Ianniciello ,&nbsp;Christian Cipriani","doi":"10.1016/j.cobme.2023.100460","DOIUrl":"10.1016/j.cobme.2023.100460","url":null,"abstract":"<div><p>The development of a dexterous hand prosthesis that is controlled and perceived naturally by the amputee is a major challenge in biomedical engineering. Recent years have seen the rapid evolution of surgical techniques and technologies aimed at this purpose, the majority of which probe muscle electrical activity for control, and deliver electrical pulses to nerves for sensory feedback. Here, we report on the <em>myokinetic interface</em> concept that exploits magnetic field principles to achieve natural control and sensory feedback of an artificial hand. Like implantable myoelectric sensors, but using passive implants, localizing magnets implanted in independent muscles could allow monitoring their contractions and thus controlling the corresponding movements in the artificial hand in a biomimetic, direct, independent, and parallel manner. Selectively vibrating the magnets also offers a unique opportunity to study kinesthetic percepts in humans. The myokinetic interface opens new possibilities for interfacing humans with robotic technologies in an intuitive way.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100460"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42170306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainable medical materials printed by melt electrowriting: A mini-review 熔融电解打印的可持续医疗材料:一个小回顾
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100464
Huaizhong Xu , Lei Du
{"title":"Sustainable medical materials printed by melt electrowriting: A mini-review","authors":"Huaizhong Xu ,&nbsp;Lei Du","doi":"10.1016/j.cobme.2023.100464","DOIUrl":"10.1016/j.cobme.2023.100464","url":null,"abstract":"<div><p>The development of melt electrowriting (MEW) technology can print many sustainable medical materials into high-resolution scaffolds to be applied in tissue engineering and regenerative medicine. The printability of the MEW can be highly improved after tuning and avoiding the particular phenomena of jet lag, fiber shifting, jet pulsing, and fiber bridging. Different MEW devices are developed to produce scaffolds with complicated or hierarchical structures to mimic human tissues. It is believed that the MEW technology can be extended to many other medical applications in the following years.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100464"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44616828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiplexed CRISPR-based methods for pathogen nucleic acid detection 基于多重crispr的病原体核酸检测方法
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100471
Caitlin H. Lamb, Brian Kang, Cameron Myhrvold
{"title":"Multiplexed CRISPR-based methods for pathogen nucleic acid detection","authors":"Caitlin H. Lamb,&nbsp;Brian Kang,&nbsp;Cameron Myhrvold","doi":"10.1016/j.cobme.2023.100471","DOIUrl":"10.1016/j.cobme.2023.100471","url":null,"abstract":"<div><p>Bacterial and viral pathogens are devastating to human health and well-being. In many regions, dozens of pathogen species and variants co-circulate. Thus, it is important to detect many different species and variants of pathogens in a given sample through multiplexed detection methods. CRISPR-based nucleic acid detection has shown to be a promising step towards an easy-to-use, sensitive, specific, and high-throughput method to detect nucleic acids from DNA and RNA viruses and bacteria. Here, we review the current state of multiplexed nucleic acid detection methods with a focus on CRISPR-based methods. We also look toward the future of multiplexed point-of-care diagnostics.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100471"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9741828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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