Mechanome-guided strategies in regenerative rehabilitation

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL
Diego Jacho, Eda Yildirim-Ayan
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引用次数: 0

Abstract

Regenerative Rehabilitation represents a multifaceted approach that merges mechanobiology with therapeutic intervention to harness the body's intrinsic tissue repair and regeneration capacity. This review delves into the intricate interplay between mechanical loading and cellular responses in the context of musculoskeletal tissue healing. It emphasizes the importance of understanding the phases involved in translating mechanical forces into biochemical responses at the cellular level. The review paper also covers the mechanosensitivity of macrophages, fibroblasts, and mesenchymal stem cells, which play a crucial role during regenerative rehabilitation since these cells exhibit unique mechanoresponsiveness during different stages of the tissue healing process. Understanding how mechanical loading amplitude and frequency applied during regenerative rehabilitation influences macrophage polarization, fibroblast-to-myofibroblast transition (FMT), and mesenchymal stem cell differentiation is crucial for developing effective therapies for musculoskeletal tissues. In conclusion, this review underscores the significance of mechanome-guided strategies in regenerative rehabilitation. By exploring the mechanosensitivity of different cell types and their responses to mechanical loading, this field offers promising avenues for accelerating tissue healing and functional recovery, ultimately enhancing the quality of life for individuals with musculoskeletal injuries and degenerative diseases.

再生康复的机制引导策略
再生康复是一种多方面的方法,它将机械生物学与治疗干预相结合,以利用人体固有的组织修复和再生能力。本综述深入探讨了肌肉骨骼组织愈合过程中机械负荷与细胞反应之间错综复杂的相互作用。它强调了了解将机械力转化为细胞水平生化反应所涉及的各个阶段的重要性。该综述论文还涉及巨噬细胞、成纤维细胞和间充质干细胞的机械敏感性,这些细胞在组织愈合过程的不同阶段表现出独特的机械敏感性,因此在再生康复过程中发挥着至关重要的作用。了解再生康复过程中施加的机械负荷幅度和频率如何影响巨噬细胞极化、成纤维细胞向成肌纤维母细胞转化(FMT)和间充质干细胞分化,对于开发有效的肌肉骨骼组织疗法至关重要。总之,本综述强调了再生康复中机械引导策略的重要性。通过探索不同细胞类型的机械敏感性及其对机械负荷的反应,该领域为加速组织愈合和功能恢复提供了前景广阔的途径,最终提高肌肉骨骼损伤和退行性疾病患者的生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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