Current Opinion in Biomedical Engineering最新文献

Photonic crystal colorimetric sensing in heart-on-a-chip systems

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-01-20 DOI: 10.1016/j.cobme.2025.100578

Lingyu Sun , Yile Fang , Yu Wang , Feika Bian , Yuanjin Zhao

{"title":"Photonic crystal colorimetric sensing in heart-on-a-chip systems","authors":"Lingyu Sun , Yile Fang , Yu Wang , Feika Bian , Yuanjin Zhao","doi":"10.1016/j.cobme.2025.100578","DOIUrl":"10.1016/j.cobme.2025.100578","url":null,"abstract":"<div><div>As an emerging modeling platform for cardiac cells and tissues, heart-on-a-chip systems have aroused great interest and made remarkable progress in recent decades. To expand the practical values of such microphysiological systems, various biosensing modules have been integrated into microfluidic chips to realize real-time monitoring of cardiomyocytes or cardiac tissues under different stimulations. Among them, photonic crystal colorimetric sensors are popular because of their intrinsic biocompatibility, visual characteristics, and lack of need for complex instrumentation. In this review, we will provide an overview of research concerning heart-on-a-chip systems integrated with photonic crystal colorimetric sensors, ranging from the natural structural colors, the fabrication of artificial photonic crystal materials, to their colorimetric sensing principle. The emphasis will be put on how the photonic crystal colorimetric sensors address the current limitations of heart-on-a-chip systems through visual optical signals and thus expand their biomedical applications. Finally, the remaining challenges of colorimetric sensing strategy will be summarized, with its future directions for organs-on-chips being discussed.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"34 ","pages":"Article 100578"},"PeriodicalIF":4.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3M engineering approaches to combat high-shear thrombosis: Integrating modeling, microfluidics, and mechanobiology

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-01-08 DOI: 10.1016/j.cobme.2025.100576

Allan Sun , Arian Nasser , Nicole Alexis Yap , Rui Gao , Lining Arnold Ju

{"title":"3M engineering approaches to combat high-shear thrombosis: Integrating modeling, microfluidics, and mechanobiology","authors":"Allan Sun , Arian Nasser , Nicole Alexis Yap , Rui Gao , Lining Arnold Ju","doi":"10.1016/j.cobme.2025.100576","DOIUrl":"10.1016/j.cobme.2025.100576","url":null,"abstract":"<div><div>Arterial thrombosis remains a significant global health concern, with shear-induced platelet aggregation (SIPA) playing a crucial role. This review focuses on the integration of three key engineering approaches—Computational Modeling Microfluidics and Mechanobiology (3 M)—in understanding and combating high-shear thrombosis. We discuss the biomechanical mechanisms of SIPA, highlighting how platelet mechanoreceptors and von Willebrand factor interactions drive thrombosis under pathological flow conditions. Through computational fluid dynamics (CFD), key hemodynamic metrics including time-averaged wall shear stress, oscillatory shear index, and relative residence time have been developed to predict thrombosis risk. Microfluidic platforms, ranging from straight channels to stenotic geometries, provide insights into platelet behavior under various shear conditions while enabling rapid screening of antithrombotic therapies. The integration of these experimental approaches with CFD analysis offers powerful tools for predicting thrombosis risk and optimizing device designs, particularly in mechanical circulatory support devices (MCSDs). Recent advances in mechanobiology have revealed how mechanical forces trigger cellular responses through membrane damage and mechanosensitive channels, offering new therapeutic targets. This review underscores how the synergy between these 3 M engineering approaches advances our understanding of the complex interplay between hemodynamics and thrombosis, paving the way for improved antithrombotic therapies and medical device designs essential to optimizing MCSDs, such as left ventricular assist devices and extracorporeal membrane oxygenators.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"33 ","pages":"Article 100576"},"PeriodicalIF":4.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in facilitating the translation of bioelectronic medicine therapies

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2024-12-20 DOI: 10.1016/j.cobme.2024.100575

Alex Baldwin , Gregory States , Victor Pikov , Pallavi Gunalan , Sahar Elyahoodayan , Kevin Kilgore , Ellis Meng

{"title":"Recent advances in facilitating the translation of bioelectronic medicine therapies","authors":"Alex Baldwin , Gregory States , Victor Pikov , Pallavi Gunalan , Sahar Elyahoodayan , Kevin Kilgore , Ellis Meng","doi":"10.1016/j.cobme.2024.100575","DOIUrl":"10.1016/j.cobme.2024.100575","url":null,"abstract":"<div><div>Bioelectronic medicine is a growing field which involves directly interfacing with the vagus, sacral, enteric, and other autonomic nerves to treat conditions. Therapies based on bioelectronic medicine could address previously intractable diseases and provide an alternative to pharmaceuticals. However, translating a bioelectronic medicine therapy to the clinic requires overcoming several challenges, including titrating stimulation parameters to an individual's physiology, selectively stimulating target nerves without inducing off-target activation or block, and improving accessibility to clinically approved devices. This review describes recent progress towards solving these problems, including advances in mapping and characterizing the human autonomic nervous system, new sensor technology and signal processing techniques to enable closed-loop therapies, new methods for selectively stimulating autonomic nerves without inducing off-target effects, and efforts to develop open-source implantable devices. Recent commercial successes in bringing bioelectronic medicine therapies to the clinic are highlighted showing how addressing these challenges can lead to novel therapies.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"33 ","pages":"Article 100575"},"PeriodicalIF":4.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D fabrication of artificial cell microenvironments for mechanobiology

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2024-12-14 DOI: 10.1016/j.cobme.2024.100574

Annabelle Sonn , Caterina Tomba , Christine Selhuber-Unkel , Barbara Schamberger

引用次数: 0

Beyond static models: Mechanically dynamic matrices reveal new insights into cancer and fibrosis progression

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2024-11-29 DOI: 10.1016/j.cobme.2024.100570

M. Walker , D. Gourdon , M. Cantini

{"title":"Beyond static models: Mechanically dynamic matrices reveal new insights into cancer and fibrosis progression","authors":"M. Walker , D. Gourdon , M. Cantini","doi":"10.1016/j.cobme.2024.100570","DOIUrl":"10.1016/j.cobme.2024.100570","url":null,"abstract":"<div><div>The dynamic mechanical nature of extracellular matrices (ECMs) is crucial for the mechanosensitive regulation of cell fate. This is evident in pathological conditions such as cancer and fibrosis, which are characterised by highly fibrotic tissue developing over time. This fibrotic progression not only alters tissue mechanics, but also coincides with the reprogramming of resident cells, promoting their differentiation into aberrant phenotypes and increasing drug resistance. Hydrogels, with their tuneable mechanical and biochemical properties, emerge as powerful ECM mimetics to model and study these abnormal, mechanically-driven cell differentiation phenomena. In this review, after establishing how conventional, mechanically static hydrogels contribute to our understanding of the role of altered mechanosensing in cell differentiation during cancer and fibrosis, we explore the research opportunities given by advanced dynamic matrices. Models employing hydrogels that are fast relaxing, plastic or even with temporally switchable mechanics reveal the otherwise hidden role of time-dependent phenomena during disease development.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"33 ","pages":"Article 100570"},"PeriodicalIF":4.7,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune cell and engineering for the therapeutics

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2024-11-25 DOI: 10.1016/j.cobme.2024.100569

Jin Hyuck Jeong , Miseol Kim , Hui-Shan Li

引用次数: 0

What lies beyond—Insights into elastic microscaffolds with metamaterial properties for cell studies

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2024-11-22 DOI: 10.1016/j.cobme.2024.100568

Magdalena Fladung , Alexander Berkes , Tim Alletzhaeusser , Yi Chen , Natalie Munding , Motomu Tanaka , Martin Wegener , Martin Bastmeyer

{"title":"What lies beyond—Insights into elastic microscaffolds with metamaterial properties for cell studies","authors":"Magdalena Fladung , Alexander Berkes , Tim Alletzhaeusser , Yi Chen , Natalie Munding , Motomu Tanaka , Martin Wegener , Martin Bastmeyer","doi":"10.1016/j.cobme.2024.100568","DOIUrl":"10.1016/j.cobme.2024.100568","url":null,"abstract":"<div><div>Recent advances in additive manufacturing have opened up new possibilities to print almost arbitrary structures with submicrometer resolution. An intriguing application is the fabrication of metamaterial-based scaffolds with unprecedented precision and with defined effective elastic properties for mechanobiological research. This field of study has already led to promising results but remains wide open. The vast possibilities, together with the high interdisciplinary character and current lack of established protocols or literature on the subject, are intriguing on the one hand but might discourage researchers who are new to this field. In this review, we aim to provide insights into the work with such microstructured bio-metamaterials, mainly based on our own experience with 2D systems, hoping to encourage further mechanobiological studies. Finally, we present some considerations for expanding to the third dimension to more closely resemble the <em>in</em> <em>vivo</em> situation.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"33 ","pages":"Article 100568"},"PeriodicalIF":4.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generalizable and explainable deep learning for medical image computing: An overview 医学图像计算的可概括和可解释的深度学习：概述

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2024-11-14 DOI: 10.1016/j.cobme.2024.100567

Ahmad Chaddad , Yan Hu , Yihang Wu , Binbin Wen , Reem Kateb

{"title":"Generalizable and explainable deep learning for medical image computing: An overview","authors":"Ahmad Chaddad , Yan Hu , Yihang Wu , Binbin Wen , Reem Kateb","doi":"10.1016/j.cobme.2024.100567","DOIUrl":"10.1016/j.cobme.2024.100567","url":null,"abstract":"<div><h3>Objective</h3><div>This paper presents an overview of generalizable and explainable artificial intelligence (XAI) in deep learning (DL) for medical imaging, with the aim of addressing the urgent need for transparency and explainability in clinical applications.</div></div><div><h3>Methodology</h3><div>We propose to use four CNNs in three medical datasets (brain tumor, skin cancer, and chest x-ray) for medical image classification tasks. Furthermore, we combine ResNet50 with five common XAI techniques to obtain explainable results for model prediction, in order to improve model transparency. We also involve a quantitative metric (confidence increase) to evaluate the usefulness of XAI techniques.</div></div><div><h3>Key findings</h3><div>The experimental results indicate that ResNet50 can achieve feasible accuracy and F1 score in all datasets (e.g., 86.31 % accuracy in skin cancer). Furthermore, the findings show that while certain XAI methods, such as eXplanation with Gradient-weighted Class activation mapping (XgradCAM), effectively highlight relevant abnormal regions in medical images, others, such as EigenGradCAM, may perform less effectively in specific scenarios. In addition, XgradCAM indicates higher confidence increase (e.g., 0.12 in glioma tumor) compared to GradCAM++ (0.09) and LayerCAM (0.08).</div></div><div><h3>Implications</h3><div>Based on the experimental results and recent advancements, we outline future research directions to enhance the generalizability of DL models in the field of biomedical imaging.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"33 ","pages":"Article 100567"},"PeriodicalIF":4.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of wireless powering modes for nanotransducer-mediated neuromodulation

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2024-11-09 DOI: 10.1016/j.cobme.2024.100562

Prachi Kumari , Aleksandra Milojkovic , Kristen Kozielski

引用次数: 0

Rehabilitation of motor and sensory function using spinal cord stimulation: Recent advances 利用脊髓刺激康复运动和感觉功能：最新进展

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2024-10-29 DOI: 10.1016/j.cobme.2024.100566

Marta M. Iversen , Abby T. Harrison , Clay T. Stanley , Ashley N. Dalrymple

引用次数: 0