Current Opinion in Biomedical Engineering最新文献

Recent advancements and applications of physics-informed machine learning in biomedical research 基于物理的机器学习在生物医学研究中的最新进展和应用

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-07-08 DOI: 10.1016/j.cobme.2025.100612

Valentina Roquemen-Echeverri, Clara Mosquera-Lopez

引用次数: 0

Hyaluronic acid-based models of the brain microenvironment: Challenges and advances 基于透明质酸的大脑微环境模型：挑战和进展

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-07-02 DOI: 10.1016/j.cobme.2025.100613

Anna Weldy , Sanjay Kumar

引用次数: 0

Advances in nanoparticle-mediated transdermal delivery of nucleic acids as therapy of skin disorders and cancer 纳米粒子介导的核酸经皮递送治疗皮肤病和癌症的研究进展

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-06-30 DOI: 10.1016/j.cobme.2025.100611

Fatemeh Mokhles , Juan Gonzalez-Valdivieso , Mohammad Amin Moosavi , Marco Cordani

{"title":"Advances in nanoparticle-mediated transdermal delivery of nucleic acids as therapy of skin disorders and cancer","authors":"Fatemeh Mokhles , Juan Gonzalez-Valdivieso , Mohammad Amin Moosavi , Marco Cordani","doi":"10.1016/j.cobme.2025.100611","DOIUrl":"10.1016/j.cobme.2025.100611","url":null,"abstract":"<div><div>Transdermal delivery of gene and RNA therapies represents a promising strategy in addressing genetic skin disorders and cancers, offering localized treatment with enhanced bioavailability and reduced systemic side effects. Despite these advantages, the stratum corneum presents a formidable barrier to the delivery of nucleic acids due to its dense lipid-protein structure and susceptibility to enzymatic degradation. Recent innovations in nanoparticle technologies, such as cationic liposomes and polymer-based carriers, have overcome these challenges by enhancing penetration, stability, and target specificity. Additionally, techniques like microneedles and iontophoretic applications further facilitate effective delivery into skin layers. Advanced formulations combining nanoparticles with therapeutic agents such as siRNA and CRISPR-Cas9 demonstrate significant potential in tumor growth inhibition, immune modulation, and gene correction. These approaches offer targeted therapeutic options, reduce drug resistance, and support genetic modifications for skin conditions. While challenges like immunogenicity and systemic degradation persist, emerging integration of artificial intelligence (AI) optimizes nanoparticle design and delivery systems. AI-driven advancements promise to refine transdermal delivery technologies, advancing precision medicine in dermatological applications and cancer therapy.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100611"},"PeriodicalIF":4.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial overview: Current perspectives in bioelectronic medicine: Mechanisms, technologies, and clinical frontiers 编辑概述：生物电子医学的当前观点：机制、技术和临床前沿

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-06-26 DOI: 10.1016/j.cobme.2025.100610

Tracy Cui, Douglas J. Weber

引用次数: 0

Organoid bioprinting to pattern the matrix microenvironment 类器官生物打印以模拟基质微环境

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-06-05 DOI: 10.1016/j.cobme.2025.100607

Daiyao Zhang , Carla Huerta-López , Sarah C. Heilshorn

{"title":"Organoid bioprinting to pattern the matrix microenvironment","authors":"Daiyao Zhang , Carla Huerta-López , Sarah C. Heilshorn","doi":"10.1016/j.cobme.2025.100607","DOIUrl":"10.1016/j.cobme.2025.100607","url":null,"abstract":"<div><div>The development of organoid cultures has propelled the fields of cell biology, tissue engineering, and regenerative medicine forward. These cultures better mimic <em>in vivo</em> tissue structure and function compared to 2D cell culture; however, organoids are limited in size and do not inherently allow precise control over tissue architecture and cell heterogeneity. Hand-wrought organoid biofabrication approaches enable the production of larger and more complex tissues, but they still lack reproducible control of spatiotemporal tissue patterns. In contrast, bioprinting is a collection of machine-wrought technologies that are emerging as powerful tools in tissue engineering and disease modeling, but have not yet been widely applied to organoids. When combined with advances in biomaterials science, bioprinting offers the possibility to control spatiotemporal cellular and microenvironmental features. The interactions between biomaterial inks, support baths, and embedded cells provide the opportunity to guide the maturation and functionality of engineered tissues. This review describes how recent advances in organoid technology, bioprinting, and biomaterials science can be integrated to achieve spatiotemporal patterning of four aspects of the microenvironment: matrix structure and mechanics, matrix ligands and morphogens, co-culture of multiple cell types, and incorporation of vasculature. These insights underscore the potential for organoid bioprinting to advance the fabrication of <em>in vitro</em> tissue mimics for applications in drug screening, disease modeling, and regenerative medicine.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100607"},"PeriodicalIF":4.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial overview: Scaffold-based and scaffold-free approaches for mechanobiology, in vitro disease modeling and treatment 综述：基于支架和无支架的机械生物学、体外疾病建模和治疗方法

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-06-05 DOI: 10.1016/j.cobme.2025.100609

Angelo Accardo, Enrico D. Lemma

引用次数: 0

The next phase of mammalian synthetic biology: Trends and applications 哺乳动物合成生物学的下一阶段：趋势和应用

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-06-04 DOI: 10.1016/j.cobme.2025.100608

Wilson W. Wong, Ahmad S. Khalil

引用次数: 0

Microfluidic and organ-on-a-chip approaches to model the tumor microenvironment 微流控和器官芯片方法模拟肿瘤微环境

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-06-02 DOI: 10.1016/j.cobme.2025.100606

Valentin Bonnet , Emmanouil Angelidakis , Sébastien Sart , Charles N. Baroud

引用次数: 0

Bioengineering gradients for controlled embryo and organ modeling 控制胚胎和器官建模的生物工程梯度

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-05-31 DOI: 10.1016/j.cobme.2025.100605

Shiyu Sun , Zhuowei Zhou , Aoife Tang , Jianping Fu

{"title":"Bioengineering gradients for controlled embryo and organ modeling","authors":"Shiyu Sun , Zhuowei Zhou , Aoife Tang , Jianping Fu","doi":"10.1016/j.cobme.2025.100605","DOIUrl":"10.1016/j.cobme.2025.100605","url":null,"abstract":"<div><div>Symmetry breaking and tissue patterning are fundamental processes in mammalian development. Understanding these events is essential not only for advancing mammalian developmental biology but also for the ongoing efforts to create <em>in vitro</em> models of mammalian embryogenesis and organogenesis using stem cells. This review highlights recent bioengineering innovations designed to control exogenous and endogenous gradients of soluble biochemical signals and insoluble biophysical cues, effectively guiding cell differentiation and spatial organization in embryo and organ modeling. Specifically, we discuss microfluidics- and micropatterning-based multicellular culture systems, as well as approaches that use porous beads loaded with soluble factors and engineered cells as synthetic signaling centers to replicate dynamic <em>in vivo</em> signaling. We evaluate the effectiveness and limitations of each technique in influencing cell fate decisions, morphogenesis, and patterning, and explore their applications in modeling mammalian development. Finally, we outline emerging approaches that leverage bioengineered tools to construct mammalian embryo and organ models for both basic research and translational applications.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100605"},"PeriodicalIF":4.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in niosome-based transdermal drug delivery systems 基于niosome的透皮给药系统的最新进展

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-05-24 DOI: 10.1016/j.cobme.2025.100603

Lefkothea Antonara , Efstathia Triantafyllopoulou , Maria Chountoulesi , Natassa Pippa , Nefeli Lagopati , Paraskevas P. Dallas , Dimitrios M. Rekkas , Maria Gazouli

{"title":"Recent advances in niosome-based transdermal drug delivery systems","authors":"Lefkothea Antonara , Efstathia Triantafyllopoulou , Maria Chountoulesi , Natassa Pippa , Nefeli Lagopati , Paraskevas P. Dallas , Dimitrios M. Rekkas , Maria Gazouli","doi":"10.1016/j.cobme.2025.100603","DOIUrl":"10.1016/j.cobme.2025.100603","url":null,"abstract":"<div><div>Niosomes are promising drug delivery nanosystems for transdermal administration. They exhibit several advantages for drug delivery and targeting applications, (i.e. biocompatibility, increased physical stability, modified drug release properties, low cost, and easy scale-up). Additionally, they are deemed as favorable candidates caused by their capability to enhance skin permeation, which is the main challenge in transcutaneous delivery. The aim of this review is to summarize from a critical point of view the most recent niosome-based nanoparticulate formulations for transdermal administration and their added value in pharmaceutical technology and engineering. The formulation protocols, the main excipients and Active Pharmaceutical Ingredients (APIs), and the main physicochemical and biological properties and applications of niosome-based transdermal drug delivery systems are discussed and analyzed. Taking into account their scale-up in the pharmaceutical industry, the critical quality attributes (CQAs), along with the most critical design and process parameters, are reviewed in depth, while existing limitations are also considered. Niosomes are candidate drug delivery platforms with added value in transdermal administration.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100603"},"PeriodicalIF":4.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0