Current Opinion in Biomedical Engineering最新文献

Fuel, form, and memory: The motility-driven journey of cancer cells 燃料、形态和记忆：癌细胞的运动驱动之旅

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-22 DOI: 10.1016/j.cobme.2025.100624

Carolina Trenado-Yuste , Celeste M. Nelson

引用次数: 0

Cellular mechanoactivation of antigen-presenting cells and T cells for cancer immunotherapy 肿瘤免疫治疗中抗原提呈细胞和T细胞的细胞机械活化

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-19 DOI: 10.1016/j.cobme.2025.100619

Davoud Ghazanfari , Liqin Ren , Melissa S. Cantú, Michael R. King

{"title":"Cellular mechanoactivation of antigen-presenting cells and T cells for cancer immunotherapy","authors":"Davoud Ghazanfari , Liqin Ren , Melissa S. Cantú, Michael R. King","doi":"10.1016/j.cobme.2025.100619","DOIUrl":"10.1016/j.cobme.2025.100619","url":null,"abstract":"<div><div>Cells convert mechanical stimuli into biochemical signals through mechanotransduction, a process that has emerged as a promising approach in cancer immunotherapy. Mechanical forces alter extracellular protein conformation, particularly mechanosensitive ion channels, leading to Ca<sup>2+</sup> influx and subsequent cascades of events that modulate cellular function and behavior. Recent discoveries indicate the potential of mechanotransduction as a novel approach for enhancing immune cell activation in cancer treatment modalities. Antigen-presenting cells (APCs) and T cells have become the focus of novel approaches to combat cancer. While current clinical <em>ex vivo</em> methods for APC activation often demonstrate limited efficiency, mechanotransduction techniques demonstrate remarkable potential for dramatically enhancing APC activation, potentially leading to improved therapeutic outcomes. Researchers have explored the mechanosensitivity of T cells to enhance CAR T therapy's specificity and controllability. Additionally, scientists have mechanically activated cancer cells engineered to express priming antigens, which are critical for synthetic Notch (SynNotch) CAR T cell therapy. Among the various mechanotransduction stimuli, fluid shear stress (FSS) and ultrasound have emerged as new and effective approaches for immune cell activation. This article reviews the latest discoveries in the mechanoactivation of APCs, T cells, and engineered CAR T cells utilizing FSS and ultrasound.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"36 ","pages":"Article 100619"},"PeriodicalIF":4.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging and the extracellular matrix: A tumor-permissive microenvironment driving cancer progression 衰老和细胞外基质：肿瘤容许微环境驱动癌症进展

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-08-26 DOI: 10.1016/j.cobme.2025.100618

Lauren Hawthorne , Jun Yang , Pinar Zorlutuna

{"title":"Aging and the extracellular matrix: A tumor-permissive microenvironment driving cancer progression","authors":"Lauren Hawthorne , Jun Yang , Pinar Zorlutuna","doi":"10.1016/j.cobme.2025.100618","DOIUrl":"10.1016/j.cobme.2025.100618","url":null,"abstract":"<div><div>Aging is a significant cancer risk factor, yet its impact on the extracellular matrix (ECM) in tumor initiation and progression has been traditionally overlooked. While significant amounts of research focus on cellular and genetic links between aging and cancer, recent studies highlight how age-induced ECM changes create a tumor-permissive environment. Here we review this emerging research area, where age-related ECM alterations, such as age-induced increases in matrix stiffness, biochemical changes, and resultant dysregulated mechanosensitive pathways, are explored for their influence in cancer initiation and progression. Additionally, recent studies have showed how aged cells contribute to ECM alterations, further reinforcing tumor-permissive changes. This review examines both aspects of ECM aging, i.e. material-driven and cell-driven, and highlights current understandings of how ECM aging influences interactions within the tumor microenvironment in multiple cancer types, with a focus on biomechanical aspects. We also discuss emerging age-mimetic in vitro models facilitating studies of age-dependent cancer progression and therapeutic responses. Finally, we review therapeutic strategies that target aging-associated components or ECM changes to improve treatment efficacy.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"36 ","pages":"Article 100618"},"PeriodicalIF":4.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eye tracking in cardiology 心脏病学中的眼动追踪

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-08-05 DOI: 10.1016/j.cobme.2025.100617

Vedat Cicek, Ulas Bagci

{"title":"Eye tracking in cardiology","authors":"Vedat Cicek, Ulas Bagci","doi":"10.1016/j.cobme.2025.100617","DOIUrl":"10.1016/j.cobme.2025.100617","url":null,"abstract":"<div><div>Eye-tracking technology has a strong potential to transform diagnostic medicine and medical education, yet its applications in cardiovascular medicine remain limited. In this study, we present evidence demonstrating how eye-tracking can enhance diagnostic accuracy and procedural proficiency in cardiology. Quantitative analysis of visual attention patterns during electrocardiogram interpretation, cardiac imaging assessment, and interventional procedures reveals distinct scan paths between expert cardiologists and trainees. Integration of eye-tracking metrics in cardiovascular training programs facilitates rapid skill development and enables objective competency assessment. Real-time analysis of eye movements during cardiac interventions can improve procedural accuracy and reduce complications. These findings establish eye-tracking as an essential tool for advancing cardiovascular medicine through improved diagnostics, procedural outcomes, and evidence-based education. We provide a systematic framework for implementing eye-tracking in clinical cardiology and identify critical research priorities, presenting our vision for the future integration of this technology in cardiology practice.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"36 ","pages":"Article 100617"},"PeriodicalIF":4.2,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial electrospun nanofibers for wound dressing applications 用于伤口敷料的抗菌静电纺纳米纤维

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-07-26 DOI: 10.1016/j.cobme.2025.100616

Fuat Topuz , Tamer Uyar

{"title":"Antibacterial electrospun nanofibers for wound dressing applications","authors":"Fuat Topuz , Tamer Uyar","doi":"10.1016/j.cobme.2025.100616","DOIUrl":"10.1016/j.cobme.2025.100616","url":null,"abstract":"<div><div>Electrospun nanofibers, with their high porosity, mechanical flexibility, ease of functionalization, and structural similarity to the extracellular matrix, represent a versatile platform for advanced wound dressings. Their capacity to incorporate bioactive components and cell-binding motifs facilitates cellular adhesion, proliferation, antimicrobial defense, and tissue regeneration. This review highlights recent progress (since 2020) in the development of antibacterial electrospun wound dressings, emphasizing systems composed of natural and synthetic polymers, as well as their hybrids. The electrospinning technique and the advantages of electrospun wound dressings are first briefly discussed. Key functionalization strategies using antibiotics, antibacterial peptides and phytochemicals, metal ions, and inorganic nanoparticles are then elaborated in the context of their mechanisms for combating bacterial infections. The ability to tailor material composition and achieve controlled release, along with embedding regenerative cues, makes electrospun nanofiber dressings strong candidates for treating both acute and chronic wounds.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"36 ","pages":"Article 100616"},"PeriodicalIF":4.2,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144880340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in hydrogel-based platforms for periodontal tissue regeneration 基于水凝胶的牙周组织再生平台研究进展

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-07-16 DOI: 10.1016/j.cobme.2025.100615

Reihaneh Khademi, Mahshid Kharaziha

{"title":"Recent advances in hydrogel-based platforms for periodontal tissue regeneration","authors":"Reihaneh Khademi, Mahshid Kharaziha","doi":"10.1016/j.cobme.2025.100615","DOIUrl":"10.1016/j.cobme.2025.100615","url":null,"abstract":"<div><div>Periodontitis is a severe and progressive inflammatory disease triggered by microbial infection, destroying essential tooth-supporting structures, including the alveolar bone, gingiva, periodontal ligament, and cementum. While traditional therapies like scaling and root planning can effectively manage disease progression, they often fail to restore the natural architecture and functionality of periodontal tissues due to the limited regenerative capacity of these structures. Periodontal tissue engineering has emerged as a promising solution to this challenge. This technology is based on multifunctional biomaterials, especially hydrogels, for restoring damaged alveolar bone, periodontal ligament, and root cementum. This review aims to provide a comprehensive overview of the properties required for hydrogels to facilitate periodontal tissue regeneration. Moreover, it discusses the use of hydrogels as delivery systems for cells, drugs, and growth factors, as well as their role in photothermal therapy and periodontal tissue regeneration. Finally, the review addresses the current challenges associated with the use of hydrogels and outlines the potential future directions for integrating hydrogels into periodontitis treatment and diagnosis.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100615"},"PeriodicalIF":4.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging the microscale mechanical properties of cancer using optical coherence elastography 利用光学相干弹性成像技术对癌症的微观力学特性进行成像

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-07-11 DOI: 10.1016/j.cobme.2025.100614

Rowan W. Sanderson , Brendan F. Kennedy

引用次数: 0

Recent advancements and applications of physics-informed machine learning in biomedical research 基于物理的机器学习在生物医学研究中的最新进展和应用

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-07-08 DOI: 10.1016/j.cobme.2025.100612

Valentina Roquemen-Echeverri, Clara Mosquera-Lopez

引用次数: 0

Hyaluronic acid-based models of the brain microenvironment: Challenges and advances 基于透明质酸的大脑微环境模型：挑战和进展

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-07-02 DOI: 10.1016/j.cobme.2025.100613

Anna Weldy , Sanjay Kumar

引用次数: 0

Advances in nanoparticle-mediated transdermal delivery of nucleic acids as therapy of skin disorders and cancer 纳米粒子介导的核酸经皮递送治疗皮肤病和癌症的研究进展

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-06-30 DOI: 10.1016/j.cobme.2025.100611

Fatemeh Mokhles , Juan Gonzalez-Valdivieso , Mohammad Amin Moosavi , Marco Cordani

{"title":"Advances in nanoparticle-mediated transdermal delivery of nucleic acids as therapy of skin disorders and cancer","authors":"Fatemeh Mokhles , Juan Gonzalez-Valdivieso , Mohammad Amin Moosavi , Marco Cordani","doi":"10.1016/j.cobme.2025.100611","DOIUrl":"10.1016/j.cobme.2025.100611","url":null,"abstract":"<div><div>Transdermal delivery of gene and RNA therapies represents a promising strategy in addressing genetic skin disorders and cancers, offering localized treatment with enhanced bioavailability and reduced systemic side effects. Despite these advantages, the stratum corneum presents a formidable barrier to the delivery of nucleic acids due to its dense lipid-protein structure and susceptibility to enzymatic degradation. Recent innovations in nanoparticle technologies, such as cationic liposomes and polymer-based carriers, have overcome these challenges by enhancing penetration, stability, and target specificity. Additionally, techniques like microneedles and iontophoretic applications further facilitate effective delivery into skin layers. Advanced formulations combining nanoparticles with therapeutic agents such as siRNA and CRISPR-Cas9 demonstrate significant potential in tumor growth inhibition, immune modulation, and gene correction. These approaches offer targeted therapeutic options, reduce drug resistance, and support genetic modifications for skin conditions. While challenges like immunogenicity and systemic degradation persist, emerging integration of artificial intelligence (AI) optimizes nanoparticle design and delivery systems. AI-driven advancements promise to refine transdermal delivery technologies, advancing precision medicine in dermatological applications and cancer therapy.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100611"},"PeriodicalIF":4.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0