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Current Opinion in Biomedical Engineering最新文献

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Exploiting protein domain modularity to enable synthetic control of engineered cells 利用蛋白质结构域模块化实现对工程细胞的合成控制
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2024-07-02 DOI: 10.1016/j.cobme.2024.100550
Yusef Haikal, John Blazeck
{"title":"Exploiting protein domain modularity to enable synthetic control of engineered cells","authors":"Yusef Haikal,&nbsp;John Blazeck","doi":"10.1016/j.cobme.2024.100550","DOIUrl":"10.1016/j.cobme.2024.100550","url":null,"abstract":"<div><p>The ability to precisely control cellular function in response to external stimuli can enhance the function and safety of cell therapies. In this review, we will detail how the modularity of protein domains has been exploited for cellular control applications, specifically through design of multifunctional synthetic constructs and controllable split moieties. These advances, which build on techniques developed by biologists, protein chemists and drug developers, harness natural evolutionary tendencies of protein domain fusion and fission. In this light, we will highlight recent advances towards the development of novel immunoreceptors, base editors, and cytokines that have achieved intriguing therapeutic potential by taking advantage of well-known protein evolutionary phenomena and have helped cells learn new tricks via synthetic biology. In general, protein modularity, i.e., the relatively facile separation or (re)assembly of functional single protein domains or subdomains, is becoming an enabling phenomenon for cellular engineering by allowing enhanced control of phenotypic responses.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"31 ","pages":"Article 100550"},"PeriodicalIF":4.7,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141692799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regenerative rehabilitation: Looking back and thinking forward 再生康复：回顾过去，展望未来
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2024-06-28 DOI: 10.1016/j.cobme.2024.100548
Fabrisia Ambrosio, Kai Wang
{"title":"Regenerative rehabilitation: Looking back and thinking forward","authors":"Fabrisia Ambrosio,&nbsp;Kai Wang","doi":"10.1016/j.cobme.2024.100548","DOIUrl":"10.1016/j.cobme.2024.100548","url":null,"abstract":"","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"31 ","pages":"Article 100548"},"PeriodicalIF":4.7,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in strategies for liver regeneration and replacement 肝脏再生和替代战略的进展
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2024-06-28 DOI: 10.1016/j.cobme.2024.100549
Savneet Kaur, Pedro Baptista
{"title":"Advances in strategies for liver regeneration and replacement","authors":"Savneet Kaur,&nbsp;Pedro Baptista","doi":"10.1016/j.cobme.2024.100549","DOIUrl":"10.1016/j.cobme.2024.100549","url":null,"abstract":"","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"31 ","pages":"Article 100549"},"PeriodicalIF":4.7,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141637553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Achieving tendon enthesis regeneration across length scales 实现跨长度尺度的肌腱内膜再生
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2024-05-22 DOI: 10.1016/j.cobme.2024.100547
Ismael Bousso , Guy Genin , Stavros Thomopoulos
{"title":"Achieving tendon enthesis regeneration across length scales","authors":"Ismael Bousso ,&nbsp;Guy Genin ,&nbsp;Stavros Thomopoulos","doi":"10.1016/j.cobme.2024.100547","DOIUrl":"10.1016/j.cobme.2024.100547","url":null,"abstract":"<div><p>Surgical reattachment of tendon to bone is a clinical challenge, with unacceptably high retear rates in the early period after repair. A primary reason for these repeated tears is that the multiscale toughening mechanisms found at the healthy tendon enthesis are not regenerated during tendon-to-bone healing. The need for technologies to improve these outcomes is pressing, and the tissue engineering community has responded with many advances that hold promise for eventually regenerating the multiscale tissue interface that transfers loads between the two dissimilar materials, tendon, and bone. This review provides an assessment of the state of these approaches, with the aim of identifying a critical agenda for future progress.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"31 ","pages":"Article 100547"},"PeriodicalIF":3.9,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141141592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biofabrication approaches to fabricating gradients and interfaces in osteochondral tissue engineering 在骨软骨组织工程中制造梯度和界面的生物制造方法
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2024-05-22 DOI: 10.1016/j.cobme.2024.100544
Gagan K. Jalandhra , Kristopher A. Kilian
{"title":"Biofabrication approaches to fabricating gradients and interfaces in osteochondral tissue engineering","authors":"Gagan K. Jalandhra ,&nbsp;Kristopher A. Kilian","doi":"10.1016/j.cobme.2024.100544","DOIUrl":"10.1016/j.cobme.2024.100544","url":null,"abstract":"<div><p>Osteochondral tissue represents a complex biochemical and biophysical gradient between two distinctly different types of tissue. Its poor regeneration capabilities necessitate tissue engineering intervention; however, its complex structure and composition pose an immense engineering challenge. Though bone and cartilage engineering separately have seen success, fabricating the graded interface between these two dissimilar tissue types requires understanding and collaboration between multiple often-disunited disciplines. This review showcases innovative tissue engineering strategies utilised for fabrication of osteochondral interfaces in an attempt to bridge this gap, and highlights the potential of biofabrication techniques – namely 3D bioprinting – in providing a path towards future advancement in osteochondral and interfacial tissue engineering.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"31 ","pages":"Article 100544"},"PeriodicalIF":3.9,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468451124000242/pdfft?md5=ac09ea58a86dcaf7dabc0dee563a2455&pid=1-s2.0-S2468451124000242-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141144586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interface tissues of the mesoderm: Periosteum, ligament, interosseous membrane, & myofascial tissues, an inspiration for next generation medical textiles 中胚层的界面组织：骨膜、韧带、骨间膜和肌筋膜组织，新一代医用纺织品的灵感来源
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2024-05-20 DOI: 10.1016/j.cobme.2024.100543
Sotiria Anastopolous , Lucy Ngo , Joanna Ng , Vina Putra , Melissa L. Knothe Tate
{"title":"Interface tissues of the mesoderm: Periosteum, ligament, interosseous membrane, & myofascial tissues, an inspiration for next generation medical textiles","authors":"Sotiria Anastopolous ,&nbsp;Lucy Ngo ,&nbsp;Joanna Ng ,&nbsp;Vina Putra ,&nbsp;Melissa L. Knothe Tate","doi":"10.1016/j.cobme.2024.100543","DOIUrl":"10.1016/j.cobme.2024.100543","url":null,"abstract":"<div><p>Deriving from the mesoderm at mesenchymal condensation, in the nascent musculoskeletal system, interface tissues include periosteum, ligament, interosseous membrane, and joint capsules. They comprise common structural proteins, collagen, and elastin, woven into anisotropic composites with toughness and elasticity adapted to withstand prevailing dynamic loads. Together with their composite fibrous weave structure, the interface tissues' respective resident cells imbue unique properties to the tissues. For example, the progenitor cells of the periosteal cambium layer express claudin, a tight junction protein that confers anisotropic and smart functional barrier properties to the periosteal membrane; <em>e.g.</em> where permeability is higher in the muscle to bone direction than <em>vice versa</em> under high flow rates typical for trauma. This review compares properties of interface tissues, focusing on periosteum, the interosseous membrane (a specialized ligament structure), and the deep (investing) fascia. It highlights current gaps in understanding as well as opportunities to create and advance manufacture next generation medical textiles and devices that emulate interface tissue properties.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"31 ","pages":"Article 100543"},"PeriodicalIF":4.7,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141145693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regeneration at the interface of mental and physical health after trauma 创伤后身心健康界面的再生
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2024-05-18 DOI: 10.1016/j.cobme.2024.100545
Melanie Haffner-Luntzer , Stefan O. Reber , Markus Huber-Lang , Anita Ignatius
{"title":"Regeneration at the interface of mental and physical health after trauma","authors":"Melanie Haffner-Luntzer ,&nbsp;Stefan O. Reber ,&nbsp;Markus Huber-Lang ,&nbsp;Anita Ignatius","doi":"10.1016/j.cobme.2024.100545","DOIUrl":"10.1016/j.cobme.2024.100545","url":null,"abstract":"<div><p>Trauma, both psychological and physical, represents a complex and pervasive challenge to individual well-being. This paper explores the dynamic interplay between mental and physical health in the context of trauma, shedding light on the processes of regeneration that occur at their interface. Drawing from a comprehensive review of basic, clinical and interdisciplinary research, this paper elucidates the bidirectional relationships between mental and physical health outcomes following traumatic experiences. Especially the influence of inflammation, gut microbiome, stress hormones and the activation of the HPA axis are explored in more detail. In conclusion, stress-related disorders and mental diseases should be taken into account when patients display a disturbed healing after physical injury. Awareness for the significant impact of mental health on trauma outcome should be increased among physicians.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"31 ","pages":"Article 100545"},"PeriodicalIF":3.9,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468451124000254/pdfft?md5=fc5830e9ae927d2be644401d3b22fff4&pid=1-s2.0-S2468451124000254-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141133443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and recent advances in engineering the osteochondral interface 骨软骨界面工程学的挑战和最新进展
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2024-05-18 DOI: 10.1016/j.cobme.2024.100546
Rachel C. Nordberg , Deborah H. Wen , Dean Wang , Jerry C. Hu , Kyriacos A. Athanasiou
{"title":"Challenges and recent advances in engineering the osteochondral interface","authors":"Rachel C. Nordberg ,&nbsp;Deborah H. Wen ,&nbsp;Dean Wang ,&nbsp;Jerry C. Hu ,&nbsp;Kyriacos A. Athanasiou","doi":"10.1016/j.cobme.2024.100546","DOIUrl":"10.1016/j.cobme.2024.100546","url":null,"abstract":"<div><p>Due to the high incidence of cartilage-related pathologies such as focal defects and osteoarthritis, strategies are needed to restore the structure and function of osteochondral tissue. Articular cartilage and bone have distinctly different properties, rendering challenging the engineering of a robust interface that reduces stress concentrations and delamination. The osteochondral interface, which consists of a tidemark, calcified cartilage, cement line, and surrounding tissues, has a unique structure and function, but there is a dearth of quantitative data to describe it. Elucidating the structure–function relationships through characterization will be essential in defining design criteria for tissue engineering. Osteochondral engineering has used scaffold-based methods that, for example, use polymers in conjunction with ceramics. Excitingly, scaffold-free methods are emerging for engineering the articular cartilage layer, which can be interfaced with an underlying bone substrate. Critical must be the objective of designing an interface that displays mechanics robust enough to withstand the native environment.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"31 ","pages":"Article 100546"},"PeriodicalIF":3.9,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141133564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Merging human physiology and interactive machines to augment sensorimotor function 融合人体生理学和交互式机器，增强感知运动功能
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2024-05-18 DOI: 10.1016/j.cobme.2024.100542
He (Helen) Huang, Gregory S. Sawicki
{"title":"Merging human physiology and interactive machines to augment sensorimotor function","authors":"He (Helen) Huang,&nbsp;Gregory S. Sawicki","doi":"10.1016/j.cobme.2024.100542","DOIUrl":"10.1016/j.cobme.2024.100542","url":null,"abstract":"","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"31 ","pages":"Article 100542"},"PeriodicalIF":3.9,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468451124000229/pdfft?md5=bb4c0d1b78c79792d5bc05113459767a&pid=1-s2.0-S2468451124000229-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141136097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Producing human livers from human stem cells via blastocyst complementation 通过囊胚补体用人类干细胞生产人类肝脏
IF 3.9 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2024-05-16 DOI: 10.1016/j.cobme.2024.100537
Boyukkhanim Ahmadzada , Philipp Felgendreff , Anna M. Minshew , Bruce P. Amiot , Scott L. Nyberg
{"title":"Producing human livers from human stem cells via blastocyst complementation","authors":"Boyukkhanim Ahmadzada ,&nbsp;Philipp Felgendreff ,&nbsp;Anna M. Minshew ,&nbsp;Bruce P. Amiot ,&nbsp;Scott L. Nyberg","doi":"10.1016/j.cobme.2024.100537","DOIUrl":"10.1016/j.cobme.2024.100537","url":null,"abstract":"<div><p>The need for organ transplants exceeds donor organ availability. In the quest to solve this shortage, the most remarkable area of advancement is organ production through the use of chimeric embryos, commonly known as blastocyst complementation. This technique involves the combination of different species to generate chimeras, where the extent of donor cell contribution to the desired tissue or organ can be regulated. However, ethical concerns arise with the use of brain tissue in such chimeras. Furthermore, the ratio of contributed cells to host animal cells in the chimeric system is low in the production of chimeras associated with cell apoptosis. This review discusses the latest innovations in blastocyst complementation and highlights the progress made in creating organs for transplant.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"31 ","pages":"Article 100537"},"PeriodicalIF":3.9,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468451124000175/pdfft?md5=843f78afba04ceafeaed2897e8f28212&pid=1-s2.0-S2468451124000175-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141055251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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