Current Opinion in Biomedical Engineering最新文献_第2页

Editorial overview: Current perspectives in bioelectronic medicine: Mechanisms, technologies, and clinical frontiers 编辑概述：生物电子医学的当前观点：机制、技术和临床前沿

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-06-26 DOI: 10.1016/j.cobme.2025.100610

Tracy Cui, Douglas J. Weber

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Organoid bioprinting to pattern the matrix microenvironment 类器官生物打印以模拟基质微环境

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-06-05 DOI: 10.1016/j.cobme.2025.100607

Daiyao Zhang , Carla Huerta-López , Sarah C. Heilshorn

{"title":"Organoid bioprinting to pattern the matrix microenvironment","authors":"Daiyao Zhang , Carla Huerta-López , Sarah C. Heilshorn","doi":"10.1016/j.cobme.2025.100607","DOIUrl":"10.1016/j.cobme.2025.100607","url":null,"abstract":"<div><div>The development of organoid cultures has propelled the fields of cell biology, tissue engineering, and regenerative medicine forward. These cultures better mimic <em>in vivo</em> tissue structure and function compared to 2D cell culture; however, organoids are limited in size and do not inherently allow precise control over tissue architecture and cell heterogeneity. Hand-wrought organoid biofabrication approaches enable the production of larger and more complex tissues, but they still lack reproducible control of spatiotemporal tissue patterns. In contrast, bioprinting is a collection of machine-wrought technologies that are emerging as powerful tools in tissue engineering and disease modeling, but have not yet been widely applied to organoids. When combined with advances in biomaterials science, bioprinting offers the possibility to control spatiotemporal cellular and microenvironmental features. The interactions between biomaterial inks, support baths, and embedded cells provide the opportunity to guide the maturation and functionality of engineered tissues. This review describes how recent advances in organoid technology, bioprinting, and biomaterials science can be integrated to achieve spatiotemporal patterning of four aspects of the microenvironment: matrix structure and mechanics, matrix ligands and morphogens, co-culture of multiple cell types, and incorporation of vasculature. These insights underscore the potential for organoid bioprinting to advance the fabrication of <em>in vitro</em> tissue mimics for applications in drug screening, disease modeling, and regenerative medicine.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100607"},"PeriodicalIF":4.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Editorial overview: Scaffold-based and scaffold-free approaches for mechanobiology, in vitro disease modeling and treatment 综述：基于支架和无支架的机械生物学、体外疾病建模和治疗方法

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-06-05 DOI: 10.1016/j.cobme.2025.100609

Angelo Accardo, Enrico D. Lemma

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The next phase of mammalian synthetic biology: Trends and applications 哺乳动物合成生物学的下一阶段：趋势和应用

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-06-04 DOI: 10.1016/j.cobme.2025.100608

Wilson W. Wong, Ahmad S. Khalil

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Microfluidic and organ-on-a-chip approaches to model the tumor microenvironment 微流控和器官芯片方法模拟肿瘤微环境

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-06-02 DOI: 10.1016/j.cobme.2025.100606

Valentin Bonnet , Emmanouil Angelidakis , Sébastien Sart , Charles N. Baroud

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Bioengineering gradients for controlled embryo and organ modeling 控制胚胎和器官建模的生物工程梯度

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-05-31 DOI: 10.1016/j.cobme.2025.100605

Shiyu Sun , Zhuowei Zhou , Aoife Tang , Jianping Fu

{"title":"Bioengineering gradients for controlled embryo and organ modeling","authors":"Shiyu Sun , Zhuowei Zhou , Aoife Tang , Jianping Fu","doi":"10.1016/j.cobme.2025.100605","DOIUrl":"10.1016/j.cobme.2025.100605","url":null,"abstract":"<div><div>Symmetry breaking and tissue patterning are fundamental processes in mammalian development. Understanding these events is essential not only for advancing mammalian developmental biology but also for the ongoing efforts to create <em>in vitro</em> models of mammalian embryogenesis and organogenesis using stem cells. This review highlights recent bioengineering innovations designed to control exogenous and endogenous gradients of soluble biochemical signals and insoluble biophysical cues, effectively guiding cell differentiation and spatial organization in embryo and organ modeling. Specifically, we discuss microfluidics- and micropatterning-based multicellular culture systems, as well as approaches that use porous beads loaded with soluble factors and engineered cells as synthetic signaling centers to replicate dynamic <em>in vivo</em> signaling. We evaluate the effectiveness and limitations of each technique in influencing cell fate decisions, morphogenesis, and patterning, and explore their applications in modeling mammalian development. Finally, we outline emerging approaches that leverage bioengineered tools to construct mammalian embryo and organ models for both basic research and translational applications.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100605"},"PeriodicalIF":4.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Recent advances in niosome-based transdermal drug delivery systems 基于niosome的透皮给药系统的最新进展

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-05-24 DOI: 10.1016/j.cobme.2025.100603

Lefkothea Antonara , Efstathia Triantafyllopoulou , Maria Chountoulesi , Natassa Pippa , Nefeli Lagopati , Paraskevas P. Dallas , Dimitrios M. Rekkas , Maria Gazouli

{"title":"Recent advances in niosome-based transdermal drug delivery systems","authors":"Lefkothea Antonara , Efstathia Triantafyllopoulou , Maria Chountoulesi , Natassa Pippa , Nefeli Lagopati , Paraskevas P. Dallas , Dimitrios M. Rekkas , Maria Gazouli","doi":"10.1016/j.cobme.2025.100603","DOIUrl":"10.1016/j.cobme.2025.100603","url":null,"abstract":"<div><div>Niosomes are promising drug delivery nanosystems for transdermal administration. They exhibit several advantages for drug delivery and targeting applications, (i.e. biocompatibility, increased physical stability, modified drug release properties, low cost, and easy scale-up). Additionally, they are deemed as favorable candidates caused by their capability to enhance skin permeation, which is the main challenge in transcutaneous delivery. The aim of this review is to summarize from a critical point of view the most recent niosome-based nanoparticulate formulations for transdermal administration and their added value in pharmaceutical technology and engineering. The formulation protocols, the main excipients and Active Pharmaceutical Ingredients (APIs), and the main physicochemical and biological properties and applications of niosome-based transdermal drug delivery systems are discussed and analyzed. Taking into account their scale-up in the pharmaceutical industry, the critical quality attributes (CQAs), along with the most critical design and process parameters, are reviewed in depth, while existing limitations are also considered. Niosomes are candidate drug delivery platforms with added value in transdermal administration.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100603"},"PeriodicalIF":4.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuning the matrix: Recent advances in mechanobiology unveiled through polyacrylamide hydrogels 调整基质：聚丙烯酰胺水凝胶揭示了机械生物学的最新进展

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-05-22 DOI: 10.1016/j.cobme.2025.100604

Giuseppe Ciccone , Manuel Salmeron-Sanchez

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Microneedle-assisted nanomedicine: Emerging strategies for transdermal drug delivery 微针辅助纳米医学：经皮给药的新策略

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-05-21 DOI: 10.1016/j.cobme.2025.100602

Atefeh Zarepour , Asieh Soozanipour , Arezoo Khosravi

{"title":"Microneedle-assisted nanomedicine: Emerging strategies for transdermal drug delivery","authors":"Atefeh Zarepour , Asieh Soozanipour , Arezoo Khosravi","doi":"10.1016/j.cobme.2025.100602","DOIUrl":"10.1016/j.cobme.2025.100602","url":null,"abstract":"<div><div>Transdermal drug delivery provides a non-invasive and patient-friendly alternative to conventional administration routes, such as injections and oral medications. Among the latest innovations, microneedles have emerged as a promising technology, offering painless and minimally invasive drug delivery through the skin. MNs allow for precise and controlled drug release, improving therapeutic outcomes while minimizing side effects. Recent advances have focused on integrating nanomaterials—such as nanoparticles, liposomes, and polymeric carriers—into MN systems to enhance drug penetration, targeting, and release kinetics. This combination can overcome the skin's natural barrier, enabling accurate dosing and improved patient compliance. This review explores the principles and advantages of nanomaterial-based microneedles for transdermal delivery, highlighting their role in improving treatment efficiency and patient outcomes. Additionally, we discuss critical challenges in microneedle development, including fabrication scalability, skin compatibility, and long-term stability. Finally, future directions for clinical translation are examined, underscoring their strong potential in modern therapeutic strategies.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100602"},"PeriodicalIF":4.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomechanics at the extracellular matrix-focal adhesion interface 细胞外基质-黏附界面的纳米力学

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-05-19 DOI: 10.1016/j.cobme.2025.100599

Rafael Tapia-Rojo , Sergi Garcia-Manyes

{"title":"Nanomechanics at the extracellular matrix-focal adhesion interface","authors":"Rafael Tapia-Rojo , Sergi Garcia-Manyes","doi":"10.1016/j.cobme.2025.100599","DOIUrl":"10.1016/j.cobme.2025.100599","url":null,"abstract":"<div><div>The mechanical properties of the extracellular matrix (ECM) play a crucial role in regulating fundamental cellular processes, including migration, development, and proliferation. Cells generate pulling forces on the ECM, while simultaneously, focal adhesions experience the mechanical cues transmitted from the ECM. However, the molecular mechanisms that enable cells to sense and adapt to their mechanical environment remain poorly understood. Advances in intracellular and extracellular tension sensors have enabled the quantification of the physiologically relevant forces at play, which trigger conformational changes in the involved proteins that can be tracked with single-molecule <em>in vitro</em> techniques. From early AFM experiments focused on stiff ECM proteins like tenascin and fibronectin to recent magnetic tweezers studies of mechanically labile focal adhesion proteins, such as talin and vinculin, we are progressively elucidating the physicochemical principles underlying force-sensing processes. In this review, we discuss recent advances in the study of the nanomechanics of ECM and focal adhesion proteins, highlighting how molecular-scale mechanics drive complex mechanosensing and mechanotransduction processes at the cellular level.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100599"},"PeriodicalIF":4.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0