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Mechanosensing pathways in the progression of pulmonary fibrosis 肺纤维化进展中的机械传感途径
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2025-05-17 DOI: 10.1016/j.cobme.2025.100598
Elisa B. Nieves , Andrés J. García
{"title":"Mechanosensing pathways in the progression of pulmonary fibrosis","authors":"Elisa B. Nieves ,&nbsp;Andrés J. García","doi":"10.1016/j.cobme.2025.100598","DOIUrl":"10.1016/j.cobme.2025.100598","url":null,"abstract":"<div><div>Fibrotic diseases are characterized by the excess production of extracellular matrix components that leads to changes in tissue mechanics and function. Mechanosensing altered during the onset of pulmonary fibrosis is hypothesized to form a positive-feedback loop that contributes to the progression of the disease. However, the exact mechanism(s) leading to fibrotic tissue remodeling as opposed to homeostatic tissue remodeling remains unknown. The development of innovative laboratory models of pulmonary fibrosis has facilitated mechanistic studies of pathogenic mechanosensing and identified new anti-fibrotic candidates. This brief review will cover recent (&lt;5 years) publications that explore mechanotransduction pathways contributing to the development of pulmonary fibrosis and innovative laboratory models that can advance the field.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100598"},"PeriodicalIF":4.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144204784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut-on-chip and liver-on-chip platforms for pathophysiological modeling 用于病理生理建模的肠道芯片和肝脏芯片平台
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2025-05-17 DOI: 10.1016/j.cobme.2025.100601
Chiara Coricciati , Eleonora Mello , Elisa De Luca , Giuseppe Gigli , Alberto Rainer , Pamela Mozetic
{"title":"Gut-on-chip and liver-on-chip platforms for pathophysiological modeling","authors":"Chiara Coricciati ,&nbsp;Eleonora Mello ,&nbsp;Elisa De Luca ,&nbsp;Giuseppe Gigli ,&nbsp;Alberto Rainer ,&nbsp;Pamela Mozetic","doi":"10.1016/j.cobme.2025.100601","DOIUrl":"10.1016/j.cobme.2025.100601","url":null,"abstract":"<div><div>Organs-on-chips (OoCs) are micro-engineered systems recapitulating the microenvironment and functions of native organs, thus representing a platform for studying complex biological processes <em>in vitro</em>. Advances in OoC technology have transformed the landscape of disease modeling, opening new avenues for research and therapeutic development. Gut- and liver-on-chip models are particularly relevant, given the involvement of these two organs in several physiological processes. Indeed, the intricate interactions between the gastrointestinal and hepatic systems, named gut-liver axis, play a key role in metabolic processes and in the pathogenesis of several conditions such as non-alcoholic fatty liver disease and inflammatory bowel disease. This review summarizes the advancements in the field of gut- and liver-on-chip models over the past five years, focusing on their application in disease modeling. By highlighting recent developments and open challenges, we aim to underscore the potential of these systems in enhancing our understanding of disease mechanisms and improving therapeutic strategies.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100601"},"PeriodicalIF":4.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell Niche Properties as Tuned by Physical Factors: ECM Proteins as Mechanochemical Switches 由物理因素调节的细胞生态位特性：ECM蛋白作为机械化学开关
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2025-05-17 DOI: 10.1016/j.cobme.2025.100600
Arnaud Miéville, Viola Vogel
{"title":"Cell Niche Properties as Tuned by Physical Factors: ECM Proteins as Mechanochemical Switches","authors":"Arnaud Miéville,&nbsp;Viola Vogel","doi":"10.1016/j.cobme.2025.100600","DOIUrl":"10.1016/j.cobme.2025.100600","url":null,"abstract":"<div><div>The discovery that proteins can act as mechanochemical switches lies at the core of the new field of mechanobiology. Nanotools enabled to establish that structural changes induced by mechanical stress or mechano-regulated proteolytic activity alter the accessibility or presentation of binding sites and thereby modulate cellular functions. Current research highlights extracellular matrix (ECM) fiber tension as a powerful modulator of cell functions, with significant implications for tissue pathology and potential applications in clinical diagnostics and therapeutics. With the goal of developing mechanopharmaceuticals, this current opinion aims to discuss emerging insights into mechanochemical switches in the ECM and how alterations in their tensional states can influence cellular behavior and disease progression.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100600"},"PeriodicalIF":4.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organoids and derived models to study the microenvironments of bacterial infections 研究细菌感染微环境的类器官和衍生模型
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2025-05-14 DOI: 10.1016/j.cobme.2025.100595
Katrina Lyon, Kai Yee Eng, Francesco Boccellato, Antonella D'Amore
{"title":"Organoids and derived models to study the microenvironments of bacterial infections","authors":"Katrina Lyon,&nbsp;Kai Yee Eng,&nbsp;Francesco Boccellato,&nbsp;Antonella D'Amore","doi":"10.1016/j.cobme.2025.100595","DOIUrl":"10.1016/j.cobme.2025.100595","url":null,"abstract":"<div><div>The microenvironment of an infection is the biological space surrounding the interaction between the pathogen and the host. Focusing on epithelial barriers, the apical microenvironment corresponds to the lumen of the organ, where the pathogen must survive amidst body fluids, microbiota, and cellular secretions. On the opposite side, the basal microenvironment includes stromal cells, endothelial cells of blood vessels, and immune cells recruited to combat infection. The first distinguishing element between the apical and basal domains is the epithelium itself, which consists of polarized cells that secrete different molecules to their apical and basal domains. Organoids and other stem cell-derived culture systems have emerged as valuable models for studying epithelial barriers and their capacities for pathogen recognition, inflammatory signalling, and differentiation. By mimicking multiple aspects of epithelial biology <em>in vitro</em>, organoids provide an opportunity to investigate infections from the initial attack to the subsequent defences. This review explores how organoids, stem cell-derived planar cultures, and micro-physiological systems are transforming our understanding of infection microenvironments.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100595"},"PeriodicalIF":4.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatiotemporally-patterned biomaterials for organoid culture 用于类器官培养的时空模式生物材料
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2025-05-08 DOI: 10.1016/j.cobme.2025.100594
Luis F. Arrieta-Viana , Andrés J. García
{"title":"Spatiotemporally-patterned biomaterials for organoid culture","authors":"Luis F. Arrieta-Viana ,&nbsp;Andrés J. García","doi":"10.1016/j.cobme.2025.100594","DOIUrl":"10.1016/j.cobme.2025.100594","url":null,"abstract":"<div><div>Spatiotemporally-patterned biomaterials have emerged as powerful tools for enhancing organoid development and functionality by recreating the dynamic complexity of native tissues. Recent innovations in photopatterning, bioprinting, and stimuli-responsive materials have expanded our ability to control the cellular microenvironment with remarkable precision. These advances have significantly improved our ability to control organoid development, leading to better structural organization and functionality. However, transitioning from proof-of-concept studies to standardized, scalable platforms remains challenging. Breakthrough technologies developed in recent years have transformed organoid applications and accelerated their translation. We suggest that the integration of multiple control systems, especially through microfluidics and “smart” materials, offers the most promising path toward realizing the full potential of organoid technologies.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100594"},"PeriodicalIF":4.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Porous microneedles: Transdermal salt bridge for biomedical device engineering 多孔微针：生物医学设备工程的透皮盐桥
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2025-05-07 DOI: 10.1016/j.cobme.2025.100593
Gaobo Wang , Yuina Abe , Soichiro Tottori , Shuto Osaki , Matsuhiko Nishizawa
{"title":"Porous microneedles: Transdermal salt bridge for biomedical device engineering","authors":"Gaobo Wang ,&nbsp;Yuina Abe ,&nbsp;Soichiro Tottori ,&nbsp;Shuto Osaki ,&nbsp;Matsuhiko Nishizawa","doi":"10.1016/j.cobme.2025.100593","DOIUrl":"10.1016/j.cobme.2025.100593","url":null,"abstract":"<div><div>Microneedles (MNs) are an attractive option as a minimally invasive means to break through the stratum corneum of the skin for transdermal drug delivery and the analysis of interstitial fluid. The solid-based porous microneedle (PMN) is a relatively new type of MN with a micro/nanochannel network throughout the whole needle. The PMN, filled with an electrolyte solution serves as a ‘salt bridge’ to create an ionic pathway across the skin surface layer. This review outlines the advantages of the ionically conductive PMN from a biomedical engineering perspective. After a brief description of the fabrication techniques of PMN, the decrease in transdermal resistance by PMN insertion is quantitatively discussed. In addition, possible applications of PMN-based salt bridges are presented, including the skin potential and resistance measurements, intradermal electrochemical analysis, and transdermal molecular transport.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100593"},"PeriodicalIF":4.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diversity in a dish: Leveraging organoids to reflect genetic ancestry and sex differences in health and disease 培养皿中的多样性：利用类器官来反映健康和疾病的遗传血统和性别差异
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2025-04-28 DOI: 10.1016/j.cobme.2025.100592
Fadoua El Abdellaoui Soussi , Francesco Piraino , Janine Scholefield , Sylke Hoehnel-Ka , Magdalena Kasendra
{"title":"Diversity in a dish: Leveraging organoids to reflect genetic ancestry and sex differences in health and disease","authors":"Fadoua El Abdellaoui Soussi ,&nbsp;Francesco Piraino ,&nbsp;Janine Scholefield ,&nbsp;Sylke Hoehnel-Ka ,&nbsp;Magdalena Kasendra","doi":"10.1016/j.cobme.2025.100592","DOIUrl":"10.1016/j.cobme.2025.100592","url":null,"abstract":"<div><div>The interplay between genetic ancestry and biological sex is increasingly recognized as a critical factor influencing health outcomes, treatment efficacy, and drug toxicity. Current research highlights significant disparities in disease susceptibility and therapeutic responses across different ancestral groups and sexes, with underrepresentation of diverse populations in genomic studies impeding progress. Most Genome-Wide Association Studies (GWAS) remain predominantly European, hindering the development of accurate polygenic risk scores (PRS). Additionally, sex-related differences in drug metabolism, immune response, and disease prevalence necessitate sex-stratified analyses. This review underscores the potential of advanced <em>in vitro</em> models, particularly human pluripotent stem cells (hPSCs) and adult stem cell-derived organoids, to bridge these gaps by providing platforms that reflect human genetic diversity and facilitate high-throughput screening. By integrating diverse genetic data and leveraging donor/population-specific organoid models’ researchers can uncover critical genotype-phenotype associations that enhance understanding of health disparities and improve pharmacogenomic applications. To increase reproducibility and throughput, standardized protocols, implementing automation, and employing organoid arrays along with well-controlled pooled populations can streamline workflows and enhance repeatability across studies and geographies. This approach fosters personalized medicine aimed at optimizing treatment efficacy and reducing adverse reactions across diverse populations, promoting equitable healthcare outcomes.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100592"},"PeriodicalIF":4.7,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rigid and soft microelectrodes for electrophysiology measurement 用于电生理测量的刚性和软微电极
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2025-04-16 DOI: 10.1016/j.cobme.2025.100591
Haoran Gong , Wenwen Weng , Shuhao Zhang , Zhigang Gao , Ning Hu
{"title":"Rigid and soft microelectrodes for electrophysiology measurement","authors":"Haoran Gong ,&nbsp;Wenwen Weng ,&nbsp;Shuhao Zhang ,&nbsp;Zhigang Gao ,&nbsp;Ning Hu","doi":"10.1016/j.cobme.2025.100591","DOIUrl":"10.1016/j.cobme.2025.100591","url":null,"abstract":"<div><div>Electrophysiology measurement is a significant technique to detect electrical activities and analyze cell behaviors. Among various electrophysiological detection methods, microelectrode arrays (MEAs) have been widely investigated in recent years due to their high efficiency and accuracy in analyzing electrophysiological activities of cells and tissues. Rigid MEAs, favored for their convenience and scalability, are widely used in drug selection, pathological analysis, and photothermal research. Soft MEAs, with the flexible geometries and outstanding biocompatibility, are better suited for applications involving three-dimensional organoids. This review provides an overview of recent advances in rigid and soft MEAs over the past five years, focusing on their application in cardiology and neuroscience.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"34 ","pages":"Article 100591"},"PeriodicalIF":4.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanism to translation: Neural prostheses for the lower urinary tract 翻译机制：用于下尿路的神经假体
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2025-04-08 DOI: 10.1016/j.cobme.2025.100590
Maria K. Jantz , Robert A. Gaunt
{"title":"Mechanism to translation: Neural prostheses for the lower urinary tract","authors":"Maria K. Jantz ,&nbsp;Robert A. Gaunt","doi":"10.1016/j.cobme.2025.100590","DOIUrl":"10.1016/j.cobme.2025.100590","url":null,"abstract":"<div><div>Lower urinary tract (LUT) dysfunction is a common symptom of a wide array of neural disorders, including spinal cord injury, multiple sclerosis, and Parkinson's disease. Unfortunately, interventions to treat LUT dysfunction primarily manage symptoms without restoring coordinated bladder control. To regain this control, neural prostheses are being developed that operate through multiple neurophysiological mechanisms.</div><div>Here, we discuss recent advances that use three fundamentally different mechanisms; some systems target LUT reflexes to produce coordinated voiding or continence, others drive non-LUT circuits that indirectly influence bladder and urethral function, while others directly excite or block the motor components of the LUT. The work described here demonstrates substantial advances in the field, yet many of these advances have not been translated to clinical use. We suggest that developing devices to transform the state of clinical bladder care will require that known translational challenges are considered from the outset, even in basic mechanistic research.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"34 ","pages":"Article 100590"},"PeriodicalIF":4.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interplay between extracellular matrix mechanics and cell function in mechanobiology 力学生物学中细胞外基质力学与细胞功能的相互作用
IF 4.7 3区 工程技术
Current Opinion in Biomedical Engineering Pub Date : 2025-03-27 DOI: 10.1016/j.cobme.2025.100589
Peter A. Galie , Paul A. Janmey
{"title":"Interplay between extracellular matrix mechanics and cell function in mechanobiology","authors":"Peter A. Galie ,&nbsp;Paul A. Janmey","doi":"10.1016/j.cobme.2025.100589","DOIUrl":"10.1016/j.cobme.2025.100589","url":null,"abstract":"<div><div>Tissues are composites of cells and extracellular matrix that interact with each other both chemically and mechanically to form functioning organs with defined chemical and physical properties. Changes in the physical properties of the extracellular matrix often alter the function of cells, and reciprocally, modified cell function remodels the extracellular matrix in a complex iterative process that mediates normal development, wound healing, and pathological dysfunction. Recent advances in studying how cells and matrix physically interact with each other reveal new aspects of tissue and matrix mechanics and identify potential targets for therapeutic intervention in pathologic settings.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"34 ","pages":"Article 100589"},"PeriodicalIF":4.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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