Current Opinion in Biomedical Engineering最新文献_第4页

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-12-01 Epub Date: 2025-08-05 DOI: 10.1016/j.cobme.2025.100617

Vedat Cicek, Ulas Bagci

{"title":"Eye tracking in cardiology","authors":"Vedat Cicek, Ulas Bagci","doi":"10.1016/j.cobme.2025.100617","DOIUrl":"10.1016/j.cobme.2025.100617","url":null,"abstract":"<div><div>Eye-tracking technology has a strong potential to transform diagnostic medicine and medical education, yet its applications in cardiovascular medicine remain limited. In this study, we present evidence demonstrating how eye-tracking can enhance diagnostic accuracy and procedural proficiency in cardiology. Quantitative analysis of visual attention patterns during electrocardiogram interpretation, cardiac imaging assessment, and interventional procedures reveals distinct scan paths between expert cardiologists and trainees. Integration of eye-tracking metrics in cardiovascular training programs facilitates rapid skill development and enables objective competency assessment. Real-time analysis of eye movements during cardiac interventions can improve procedural accuracy and reduce complications. These findings establish eye-tracking as an essential tool for advancing cardiovascular medicine through improved diagnostics, procedural outcomes, and evidence-based education. We provide a systematic framework for implementing eye-tracking in clinical cardiology and identify critical research priorities, presenting our vision for the future integration of this technology in cardiology practice.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"36 ","pages":"Article 100617"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering the NET-biomaterial interface to treat disease 设计net生物材料界面来治疗疾病

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-12-01 Epub Date: 2025-10-25 DOI: 10.1016/j.cobme.2025.100629

Preethi Raghavan , Chinekwu Nwagwu , Joel A. Finbloom , Tejal A. Desai

{"title":"Engineering the NET-biomaterial interface to treat disease","authors":"Preethi Raghavan , Chinekwu Nwagwu , Joel A. Finbloom , Tejal A. Desai","doi":"10.1016/j.cobme.2025.100629","DOIUrl":"10.1016/j.cobme.2025.100629","url":null,"abstract":"<div><div>Neutrophil extracellular traps (NETs) are matrices composed of DNA and antimicrobial proteins that are released from neutrophils to entrap and degrade pathogens. Overproduction of these biological networks can induce hyperinflammation in infectious diseases and autoimmune disorders and exacerbate cancer metastasis formation. Systemic administration of immunosuppressive therapeutics and NET-degrading drugs can have adverse side effects, underscoring the importance of creating controlled release formulations to target NETs. In this review, we discuss the NET-biomaterial interface for drug delivery to address infection, inflammation, and cancer. First, we examine how drug delivery platforms can be engineered for localized delivery of NET-modulating or NET-degrading drugs. Then, we consider a class of NET-inspired materials that can replicate NET function and pathogen degradation without triggering downstream hyperinflammation. Finally, we discuss current challenges in the field and how biomaterials can be further developed to elucidate fundamental insights on NET biology and target NET dysregulation in various disease states.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"36 ","pages":"Article 100629"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular mechanoactivation of antigen-presenting cells and T cells for cancer immunotherapy 肿瘤免疫治疗中抗原提呈细胞和T细胞的细胞机械活化

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-12-01 Epub Date: 2025-09-19 DOI: 10.1016/j.cobme.2025.100619

Davoud Ghazanfari , Liqin Ren , Melissa S. Cantú, Michael R. King

{"title":"Cellular mechanoactivation of antigen-presenting cells and T cells for cancer immunotherapy","authors":"Davoud Ghazanfari , Liqin Ren , Melissa S. Cantú, Michael R. King","doi":"10.1016/j.cobme.2025.100619","DOIUrl":"10.1016/j.cobme.2025.100619","url":null,"abstract":"<div><div>Cells convert mechanical stimuli into biochemical signals through mechanotransduction, a process that has emerged as a promising approach in cancer immunotherapy. Mechanical forces alter extracellular protein conformation, particularly mechanosensitive ion channels, leading to Ca<sup>2+</sup> influx and subsequent cascades of events that modulate cellular function and behavior. Recent discoveries indicate the potential of mechanotransduction as a novel approach for enhancing immune cell activation in cancer treatment modalities. Antigen-presenting cells (APCs) and T cells have become the focus of novel approaches to combat cancer. While current clinical <em>ex vivo</em> methods for APC activation often demonstrate limited efficiency, mechanotransduction techniques demonstrate remarkable potential for dramatically enhancing APC activation, potentially leading to improved therapeutic outcomes. Researchers have explored the mechanosensitivity of T cells to enhance CAR T therapy's specificity and controllability. Additionally, scientists have mechanically activated cancer cells engineered to express priming antigens, which are critical for synthetic Notch (SynNotch) CAR T cell therapy. Among the various mechanotransduction stimuli, fluid shear stress (FSS) and ultrasound have emerged as new and effective approaches for immune cell activation. This article reviews the latest discoveries in the mechanoactivation of APCs, T cells, and engineered CAR T cells utilizing FSS and ultrasound.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"36 ","pages":"Article 100619"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green nano-semiconductors and nanometals to avert complex phenomena of antimicrobial resistance (AMR) 绿色纳米半导体和纳米金属避免抗菌素耐药性（AMR）的复杂现象

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-12-01 Epub Date: 2025-10-04 DOI: 10.1016/j.cobme.2025.100626

Amrindra Pal , Harsh Sable , Arun Uniyal , Vishal Chaudhary

{"title":"Green nano-semiconductors and nanometals to avert complex phenomena of antimicrobial resistance (AMR)","authors":"Amrindra Pal , Harsh Sable , Arun Uniyal , Vishal Chaudhary","doi":"10.1016/j.cobme.2025.100626","DOIUrl":"10.1016/j.cobme.2025.100626","url":null,"abstract":"<div><div>Antimicrobial resistance (AMR) is a silent pandemic in the lens of One Health, which is impacting current global healthcare facilities/therapeutics and the environment. AMR is a complex system in which clinical misuse/overuse of antibiotics, environmental contamination, and microbial evolution form a dynamic/adaptive network of resistance propagation for conventional antibiotics, requiring urgent alternatives. This opinion highlights the potential of green-synthesised nano-semiconductors/nanometals (GNSS/GNMS) fabricated using biochemicals procured from plants, microbes, waste/green solvents, to combat AMR. They exhibit multifaceted antimicrobial mechanisms, including oxidative stress induction, membrane disruption, metal ion release, biofilm inhibition, quorum sensing interference, and antibiotic synergism. Moreover, they demonstrated transformative potential in diagnostics, wound healing, agriculture, and wastewater remediation owing to their exceptional physicochemical properties, including band-gap tunability, biocompatibility and low toxicity. The challenges, like synthesis variability and standardisation, that restrict their commercial adaptability are discussed with alternatives to establish them as sustainable solutions to AMR, considering the UN's SDGs.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"36 ","pages":"Article 100626"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organoid bioprinting to pattern the matrix microenvironment 类器官生物打印以模拟基质微环境

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-06-05 DOI: 10.1016/j.cobme.2025.100607

Daiyao Zhang , Carla Huerta-López , Sarah C. Heilshorn

{"title":"Organoid bioprinting to pattern the matrix microenvironment","authors":"Daiyao Zhang , Carla Huerta-López , Sarah C. Heilshorn","doi":"10.1016/j.cobme.2025.100607","DOIUrl":"10.1016/j.cobme.2025.100607","url":null,"abstract":"<div><div>The development of organoid cultures has propelled the fields of cell biology, tissue engineering, and regenerative medicine forward. These cultures better mimic <em>in vivo</em> tissue structure and function compared to 2D cell culture; however, organoids are limited in size and do not inherently allow precise control over tissue architecture and cell heterogeneity. Hand-wrought organoid biofabrication approaches enable the production of larger and more complex tissues, but they still lack reproducible control of spatiotemporal tissue patterns. In contrast, bioprinting is a collection of machine-wrought technologies that are emerging as powerful tools in tissue engineering and disease modeling, but have not yet been widely applied to organoids. When combined with advances in biomaterials science, bioprinting offers the possibility to control spatiotemporal cellular and microenvironmental features. The interactions between biomaterial inks, support baths, and embedded cells provide the opportunity to guide the maturation and functionality of engineered tissues. This review describes how recent advances in organoid technology, bioprinting, and biomaterials science can be integrated to achieve spatiotemporal patterning of four aspects of the microenvironment: matrix structure and mechanics, matrix ligands and morphogens, co-culture of multiple cell types, and incorporation of vasculature. These insights underscore the potential for organoid bioprinting to advance the fabrication of <em>in vitro</em> tissue mimics for applications in drug screening, disease modeling, and regenerative medicine.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100607"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advancements and applications of physics-informed machine learning in biomedical research 基于物理的机器学习在生物医学研究中的最新进展和应用

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-07-08 DOI: 10.1016/j.cobme.2025.100612

Valentina Roquemen-Echeverri, Clara Mosquera-Lopez

引用次数: 0

Editorial overview: Current perspectives in bioelectronic medicine: Mechanisms, technologies, and clinical frontiers 编辑概述：生物电子医学的当前观点：机制、技术和临床前沿

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-06-26 DOI: 10.1016/j.cobme.2025.100610

Tracy Cui, Douglas J. Weber

引用次数: 0

Nanomechanics at the extracellular matrix-focal adhesion interface 细胞外基质-黏附界面的纳米力学

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-05-19 DOI: 10.1016/j.cobme.2025.100599

Rafael Tapia-Rojo , Sergi Garcia-Manyes

{"title":"Nanomechanics at the extracellular matrix-focal adhesion interface","authors":"Rafael Tapia-Rojo , Sergi Garcia-Manyes","doi":"10.1016/j.cobme.2025.100599","DOIUrl":"10.1016/j.cobme.2025.100599","url":null,"abstract":"<div><div>The mechanical properties of the extracellular matrix (ECM) play a crucial role in regulating fundamental cellular processes, including migration, development, and proliferation. Cells generate pulling forces on the ECM, while simultaneously, focal adhesions experience the mechanical cues transmitted from the ECM. However, the molecular mechanisms that enable cells to sense and adapt to their mechanical environment remain poorly understood. Advances in intracellular and extracellular tension sensors have enabled the quantification of the physiologically relevant forces at play, which trigger conformational changes in the involved proteins that can be tracked with single-molecule <em>in vitro</em> techniques. From early AFM experiments focused on stiff ECM proteins like tenascin and fibronectin to recent magnetic tweezers studies of mechanically labile focal adhesion proteins, such as talin and vinculin, we are progressively elucidating the physicochemical principles underlying force-sensing processes. In this review, we discuss recent advances in the study of the nanomechanics of ECM and focal adhesion proteins, highlighting how molecular-scale mechanics drive complex mechanosensing and mechanotransduction processes at the cellular level.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100599"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diversity in a dish: Leveraging organoids to reflect genetic ancestry and sex differences in health and disease 培养皿中的多样性：利用类器官来反映健康和疾病的遗传血统和性别差异

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-04-28 DOI: 10.1016/j.cobme.2025.100592

Fadoua El Abdellaoui Soussi , Francesco Piraino , Janine Scholefield , Sylke Hoehnel-Ka , Magdalena Kasendra

{"title":"Diversity in a dish: Leveraging organoids to reflect genetic ancestry and sex differences in health and disease","authors":"Fadoua El Abdellaoui Soussi , Francesco Piraino , Janine Scholefield , Sylke Hoehnel-Ka , Magdalena Kasendra","doi":"10.1016/j.cobme.2025.100592","DOIUrl":"10.1016/j.cobme.2025.100592","url":null,"abstract":"<div><div>The interplay between genetic ancestry and biological sex is increasingly recognized as a critical factor influencing health outcomes, treatment efficacy, and drug toxicity. Current research highlights significant disparities in disease susceptibility and therapeutic responses across different ancestral groups and sexes, with underrepresentation of diverse populations in genomic studies impeding progress. Most Genome-Wide Association Studies (GWAS) remain predominantly European, hindering the development of accurate polygenic risk scores (PRS). Additionally, sex-related differences in drug metabolism, immune response, and disease prevalence necessitate sex-stratified analyses. This review underscores the potential of advanced <em>in vitro</em> models, particularly human pluripotent stem cells (hPSCs) and adult stem cell-derived organoids, to bridge these gaps by providing platforms that reflect human genetic diversity and facilitate high-throughput screening. By integrating diverse genetic data and leveraging donor/population-specific organoid models’ researchers can uncover critical genotype-phenotype associations that enhance understanding of health disparities and improve pharmacogenomic applications. To increase reproducibility and throughput, standardized protocols, implementing automation, and employing organoid arrays along with well-controlled pooled populations can streamline workflows and enhance repeatability across studies and geographies. This approach fosters personalized medicine aimed at optimizing treatment efficacy and reducing adverse reactions across diverse populations, promoting equitable healthcare outcomes.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100592"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanosensing pathways in the progression of pulmonary fibrosis 肺纤维化进展中的机械传感途径

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-05-17 DOI: 10.1016/j.cobme.2025.100598

Elisa B. Nieves , Andrés J. García

引用次数: 0