Biofabrication approaches to fabricating gradients and interfaces in osteochondral tissue engineering

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL
Gagan K. Jalandhra , Kristopher A. Kilian
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引用次数: 0

Abstract

Osteochondral tissue represents a complex biochemical and biophysical gradient between two distinctly different types of tissue. Its poor regeneration capabilities necessitate tissue engineering intervention; however, its complex structure and composition pose an immense engineering challenge. Though bone and cartilage engineering separately have seen success, fabricating the graded interface between these two dissimilar tissue types requires understanding and collaboration between multiple often-disunited disciplines. This review showcases innovative tissue engineering strategies utilised for fabrication of osteochondral interfaces in an attempt to bridge this gap, and highlights the potential of biofabrication techniques – namely 3D bioprinting – in providing a path towards future advancement in osteochondral and interfacial tissue engineering.

在骨软骨组织工程中制造梯度和界面的生物制造方法
骨软骨组织是两种截然不同的组织类型之间复杂的生物化学和生物物理梯度。骨软骨组织再生能力差,因此有必要进行组织工程干预;然而,其复杂的结构和组成也给工程设计带来了巨大挑战。虽然骨工程和软骨工程分别取得了成功,但要在这两种不同类型的组织之间制造梯度界面,需要多个往往相互割裂的学科之间的理解与合作。本综述展示了用于制造骨软骨界面的创新组织工程策略,试图弥合这一差距,并强调了生物制造技术(即三维生物打印)在为骨软骨和界面组织工程的未来发展提供途径方面的潜力。
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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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