Current Opinion in Biomedical Engineering最新文献_第5页

The next phase of mammalian synthetic biology: Trends and applications 哺乳动物合成生物学的下一阶段：趋势和应用

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-06-04 DOI: 10.1016/j.cobme.2025.100608

Wilson W. Wong, Ahmad S. Khalil

引用次数: 0

Bioengineering gradients for controlled embryo and organ modeling 控制胚胎和器官建模的生物工程梯度

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-05-31 DOI: 10.1016/j.cobme.2025.100605

Shiyu Sun , Zhuowei Zhou , Aoife Tang , Jianping Fu

{"title":"Bioengineering gradients for controlled embryo and organ modeling","authors":"Shiyu Sun , Zhuowei Zhou , Aoife Tang , Jianping Fu","doi":"10.1016/j.cobme.2025.100605","DOIUrl":"10.1016/j.cobme.2025.100605","url":null,"abstract":"<div><div>Symmetry breaking and tissue patterning are fundamental processes in mammalian development. Understanding these events is essential not only for advancing mammalian developmental biology but also for the ongoing efforts to create <em>in vitro</em> models of mammalian embryogenesis and organogenesis using stem cells. This review highlights recent bioengineering innovations designed to control exogenous and endogenous gradients of soluble biochemical signals and insoluble biophysical cues, effectively guiding cell differentiation and spatial organization in embryo and organ modeling. Specifically, we discuss microfluidics- and micropatterning-based multicellular culture systems, as well as approaches that use porous beads loaded with soluble factors and engineered cells as synthetic signaling centers to replicate dynamic <em>in vivo</em> signaling. We evaluate the effectiveness and limitations of each technique in influencing cell fate decisions, morphogenesis, and patterning, and explore their applications in modeling mammalian development. Finally, we outline emerging approaches that leverage bioengineered tools to construct mammalian embryo and organ models for both basic research and translational applications.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100605"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in hydrogel-based platforms for periodontal tissue regeneration 基于水凝胶的牙周组织再生平台研究进展

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-07-16 DOI: 10.1016/j.cobme.2025.100615

Reihaneh Khademi, Mahshid Kharaziha

{"title":"Recent advances in hydrogel-based platforms for periodontal tissue regeneration","authors":"Reihaneh Khademi, Mahshid Kharaziha","doi":"10.1016/j.cobme.2025.100615","DOIUrl":"10.1016/j.cobme.2025.100615","url":null,"abstract":"<div><div>Periodontitis is a severe and progressive inflammatory disease triggered by microbial infection, destroying essential tooth-supporting structures, including the alveolar bone, gingiva, periodontal ligament, and cementum. While traditional therapies like scaling and root planning can effectively manage disease progression, they often fail to restore the natural architecture and functionality of periodontal tissues due to the limited regenerative capacity of these structures. Periodontal tissue engineering has emerged as a promising solution to this challenge. This technology is based on multifunctional biomaterials, especially hydrogels, for restoring damaged alveolar bone, periodontal ligament, and root cementum. This review aims to provide a comprehensive overview of the properties required for hydrogels to facilitate periodontal tissue regeneration. Moreover, it discusses the use of hydrogels as delivery systems for cells, drugs, and growth factors, as well as their role in photothermal therapy and periodontal tissue regeneration. Finally, the review addresses the current challenges associated with the use of hydrogels and outlines the potential future directions for integrating hydrogels into periodontitis treatment and diagnosis.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100615"},"PeriodicalIF":4.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organoids and derived models to study the microenvironments of bacterial infections 研究细菌感染微环境的类器官和衍生模型

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-05-14 DOI: 10.1016/j.cobme.2025.100595

Katrina Lyon, Kai Yee Eng, Francesco Boccellato, Antonella D'Amore

{"title":"Organoids and derived models to study the microenvironments of bacterial infections","authors":"Katrina Lyon, Kai Yee Eng, Francesco Boccellato, Antonella D'Amore","doi":"10.1016/j.cobme.2025.100595","DOIUrl":"10.1016/j.cobme.2025.100595","url":null,"abstract":"<div><div>The microenvironment of an infection is the biological space surrounding the interaction between the pathogen and the host. Focusing on epithelial barriers, the apical microenvironment corresponds to the lumen of the organ, where the pathogen must survive amidst body fluids, microbiota, and cellular secretions. On the opposite side, the basal microenvironment includes stromal cells, endothelial cells of blood vessels, and immune cells recruited to combat infection. The first distinguishing element between the apical and basal domains is the epithelium itself, which consists of polarized cells that secrete different molecules to their apical and basal domains. Organoids and other stem cell-derived culture systems have emerged as valuable models for studying epithelial barriers and their capacities for pathogen recognition, inflammatory signalling, and differentiation. By mimicking multiple aspects of epithelial biology <em>in vitro</em>, organoids provide an opportunity to investigate infections from the initial attack to the subsequent defences. This review explores how organoids, stem cell-derived planar cultures, and micro-physiological systems are transforming our understanding of infection microenvironments.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100595"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microneedle-assisted nanomedicine: Emerging strategies for transdermal drug delivery 微针辅助纳米医学：经皮给药的新策略

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-05-21 DOI: 10.1016/j.cobme.2025.100602

Atefeh Zarepour , Asieh Soozanipour , Arezoo Khosravi

{"title":"Microneedle-assisted nanomedicine: Emerging strategies for transdermal drug delivery","authors":"Atefeh Zarepour , Asieh Soozanipour , Arezoo Khosravi","doi":"10.1016/j.cobme.2025.100602","DOIUrl":"10.1016/j.cobme.2025.100602","url":null,"abstract":"<div><div>Transdermal drug delivery provides a non-invasive and patient-friendly alternative to conventional administration routes, such as injections and oral medications. Among the latest innovations, microneedles have emerged as a promising technology, offering painless and minimally invasive drug delivery through the skin. MNs allow for precise and controlled drug release, improving therapeutic outcomes while minimizing side effects. Recent advances have focused on integrating nanomaterials—such as nanoparticles, liposomes, and polymeric carriers—into MN systems to enhance drug penetration, targeting, and release kinetics. This combination can overcome the skin's natural barrier, enabling accurate dosing and improved patient compliance. This review explores the principles and advantages of nanomaterial-based microneedles for transdermal delivery, highlighting their role in improving treatment efficiency and patient outcomes. Additionally, we discuss critical challenges in microneedle development, including fabrication scalability, skin compatibility, and long-term stability. Finally, future directions for clinical translation are examined, underscoring their strong potential in modern therapeutic strategies.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100602"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporally-patterned biomaterials for organoid culture 用于类器官培养的时空模式生物材料

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-05-08 DOI: 10.1016/j.cobme.2025.100594

Luis F. Arrieta-Viana , Andrés J. García

引用次数: 0

Gut-on-chip and liver-on-chip platforms for pathophysiological modeling 用于病理生理建模的肠道芯片和肝脏芯片平台

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-05-17 DOI: 10.1016/j.cobme.2025.100601

Chiara Coricciati , Eleonora Mello , Elisa De Luca , Giuseppe Gigli , Alberto Rainer , Pamela Mozetic

{"title":"Gut-on-chip and liver-on-chip platforms for pathophysiological modeling","authors":"Chiara Coricciati , Eleonora Mello , Elisa De Luca , Giuseppe Gigli , Alberto Rainer , Pamela Mozetic","doi":"10.1016/j.cobme.2025.100601","DOIUrl":"10.1016/j.cobme.2025.100601","url":null,"abstract":"<div><div>Organs-on-chips (OoCs) are micro-engineered systems recapitulating the microenvironment and functions of native organs, thus representing a platform for studying complex biological processes <em>in vitro</em>. Advances in OoC technology have transformed the landscape of disease modeling, opening new avenues for research and therapeutic development. Gut- and liver-on-chip models are particularly relevant, given the involvement of these two organs in several physiological processes. Indeed, the intricate interactions between the gastrointestinal and hepatic systems, named gut-liver axis, play a key role in metabolic processes and in the pathogenesis of several conditions such as non-alcoholic fatty liver disease and inflammatory bowel disease. This review summarizes the advancements in the field of gut- and liver-on-chip models over the past five years, focusing on their application in disease modeling. By highlighting recent developments and open challenges, we aim to underscore the potential of these systems in enhancing our understanding of disease mechanisms and improving therapeutic strategies.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100601"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging the microscale mechanical properties of cancer using optical coherence elastography 利用光学相干弹性成像技术对癌症的微观力学特性进行成像

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-07-11 DOI: 10.1016/j.cobme.2025.100614

Rowan W. Sanderson , Brendan F. Kennedy

引用次数: 0

Recent advances in niosome-based transdermal drug delivery systems 基于niosome的透皮给药系统的最新进展

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-05-24 DOI: 10.1016/j.cobme.2025.100603

Lefkothea Antonara , Efstathia Triantafyllopoulou , Maria Chountoulesi , Natassa Pippa , Nefeli Lagopati , Paraskevas P. Dallas , Dimitrios M. Rekkas , Maria Gazouli

{"title":"Recent advances in niosome-based transdermal drug delivery systems","authors":"Lefkothea Antonara , Efstathia Triantafyllopoulou , Maria Chountoulesi , Natassa Pippa , Nefeli Lagopati , Paraskevas P. Dallas , Dimitrios M. Rekkas , Maria Gazouli","doi":"10.1016/j.cobme.2025.100603","DOIUrl":"10.1016/j.cobme.2025.100603","url":null,"abstract":"<div><div>Niosomes are promising drug delivery nanosystems for transdermal administration. They exhibit several advantages for drug delivery and targeting applications, (i.e. biocompatibility, increased physical stability, modified drug release properties, low cost, and easy scale-up). Additionally, they are deemed as favorable candidates caused by their capability to enhance skin permeation, which is the main challenge in transcutaneous delivery. The aim of this review is to summarize from a critical point of view the most recent niosome-based nanoparticulate formulations for transdermal administration and their added value in pharmaceutical technology and engineering. The formulation protocols, the main excipients and Active Pharmaceutical Ingredients (APIs), and the main physicochemical and biological properties and applications of niosome-based transdermal drug delivery systems are discussed and analyzed. Taking into account their scale-up in the pharmaceutical industry, the critical quality attributes (CQAs), along with the most critical design and process parameters, are reviewed in depth, while existing limitations are also considered. Niosomes are candidate drug delivery platforms with added value in transdermal administration.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"35 ","pages":"Article 100603"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyaluronic acid-based models of the brain microenvironment: Challenges and advances 基于透明质酸的大脑微环境模型：挑战和进展

IF 4.2 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-09-01 Epub Date: 2025-07-02 DOI: 10.1016/j.cobme.2025.100613

Anna Weldy , Sanjay Kumar

引用次数: 0