Single-use biosensors for biomanufacturing: Perspective on the state-of-the-art

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL
Zach Hetzler , Noah Lott , Aditi Dey Poonam , Selen Dalgan , Qingshan Wei
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引用次数: 0

Abstract

The biomanufacturing industry has experienced significant transformations in the past 10 years, driven by changing industry trends and rapidly maturing new technologies. However, the pace of process monitoring technology development has lagged behind. This review focuses on the current major gaps in critical monitoring technology required for industry advancement, with a particular focus on single-use biosensors. There is a large unmet need for single-use biosensors in upstream and downstream processing as the industry transitions to single-use bioreactors. Emerging fields like cell and gene therapy that are still lacking numerous satisfactory at-line product characterization sensors will also be covered.

Abstract Image

用于生物制造的一次性生物传感器:最先进的观点
在过去10年里,在不断变化的行业趋势和迅速成熟的新技术的推动下,生物制造业经历了重大变革。然而,过程监测技术的发展步伐一直滞后。这篇综述的重点是目前工业发展所需的关键监测技术的主要差距,特别关注一次性生物传感器。随着工业向一次性生物反应器的过渡,上游和下游加工中对一次性生物传感器的需求大量未满足。新兴领域,如细胞和基因治疗,仍然缺乏许多令人满意的在线产品表征传感器也将被涵盖。
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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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