Expanding the targets of therapeutic electrophysical stimulation - For the advancement of peripheral nerve regenerative rehabilitation

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL
Shixuan Xu, Akira Ito
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引用次数: 0

Abstract

Peripheral nerve injury (PNI) causes long-term dysfunction and significantly affect patients' quality of life. However, regenerative rehabilitation, which combines rehabilitation and regenerative medicine approaches, has shown promising progress in promoting nerve regeneration after PNI. This article reviews rehabilitation methods and therapeutic electrophysical agents (EPAs) for promoting nerve regeneration, their possible mechanisms, and the progress achieved to date in the treatment of PNI using regenerative rehabilitation with EPAs. We also discuss several factors that have the potential to optimize treatment outcomes, including the intervention target, timing, and duration. This review provides a comprehensive overview of advancements in the treatment of PNI, possible strategies to maximize treatment efficacy, and the challenges that need to be addressed.

扩大治疗性电物理刺激的靶点——促进周围神经再生康复
周围神经损伤(PNI)可引起长期功能障碍,严重影响患者的生活质量。然而,结合康复和再生医学方法的再生康复在促进PNI后神经再生方面已经显示出有希望的进展。本文综述了促进神经再生的康复方法和治疗性电物理药物(EPAs),它们的可能机制,以及迄今为止在EPAs再生康复治疗PNI方面取得的进展。我们还讨论了有可能优化治疗结果的几个因素,包括干预目标、时间和持续时间。本文综述了PNI治疗的进展、最大化治疗效果的可能策略以及需要解决的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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