Expanding the targets of therapeutic electrophysical stimulation - For the advancement of peripheral nerve regenerative rehabilitation

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL
Shixuan Xu, Akira Ito
{"title":"Expanding the targets of therapeutic electrophysical stimulation - For the advancement of peripheral nerve regenerative rehabilitation","authors":"Shixuan Xu,&nbsp;Akira Ito","doi":"10.1016/j.cobme.2023.100515","DOIUrl":null,"url":null,"abstract":"<div><p><span>Peripheral nerve injury (PNI) causes long-term dysfunction and significantly affect patients' </span>quality of life<span><span><span>. However, regenerative rehabilitation, which combines rehabilitation and regenerative medicine approaches, has shown promising progress in promoting </span>nerve regeneration after PNI. This article reviews rehabilitation methods and therapeutic </span>electrophysical agents<span> (EPAs) for promoting nerve regeneration, their possible mechanisms, and the progress achieved to date in the treatment of PNI using regenerative rehabilitation with EPAs. We also discuss several factors that have the potential to optimize treatment outcomes, including the intervention target, timing, and duration. This review provides a comprehensive overview of advancements in the treatment of PNI, possible strategies to maximize treatment efficacy, and the challenges that need to be addressed.</span></span></p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468451123000715","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0

Abstract

Peripheral nerve injury (PNI) causes long-term dysfunction and significantly affect patients' quality of life. However, regenerative rehabilitation, which combines rehabilitation and regenerative medicine approaches, has shown promising progress in promoting nerve regeneration after PNI. This article reviews rehabilitation methods and therapeutic electrophysical agents (EPAs) for promoting nerve regeneration, their possible mechanisms, and the progress achieved to date in the treatment of PNI using regenerative rehabilitation with EPAs. We also discuss several factors that have the potential to optimize treatment outcomes, including the intervention target, timing, and duration. This review provides a comprehensive overview of advancements in the treatment of PNI, possible strategies to maximize treatment efficacy, and the challenges that need to be addressed.

扩大治疗性电物理刺激的靶点——促进周围神经再生康复
周围神经损伤(PNI)可引起长期功能障碍,严重影响患者的生活质量。然而,结合康复和再生医学方法的再生康复在促进PNI后神经再生方面已经显示出有希望的进展。本文综述了促进神经再生的康复方法和治疗性电物理药物(EPAs),它们的可能机制,以及迄今为止在EPAs再生康复治疗PNI方面取得的进展。我们还讨论了有可能优化治疗结果的几个因素,包括干预目标、时间和持续时间。本文综述了PNI治疗的进展、最大化治疗效果的可能策略以及需要解决的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信