Current Opinion in Biomedical Engineering最新文献_第8页

Recent advances in facilitating the translation of bioelectronic medicine therapies 促进生物电子医学疗法翻译的最新进展。

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-03-01 Epub Date: 2024-12-20 DOI: 10.1016/j.cobme.2024.100575

Alex Baldwin , Gregory States , Victor Pikov , Pallavi Gunalan , Sahar Elyahoodayan , Kevin Kilgore , Ellis Meng

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引用次数: 0

Beyond static models: Mechanically dynamic matrices reveal new insights into cancer and fibrosis progression 超越静态模型：机械动态矩阵揭示了癌症和纤维化进展的新见解

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-03-01 Epub Date: 2024-11-29 DOI: 10.1016/j.cobme.2024.100570

M. Walker , D. Gourdon , M. Cantini

{"title":"Beyond static models: Mechanically dynamic matrices reveal new insights into cancer and fibrosis progression","authors":"M. Walker , D. Gourdon , M. Cantini","doi":"10.1016/j.cobme.2024.100570","DOIUrl":"10.1016/j.cobme.2024.100570","url":null,"abstract":"<div><div>The dynamic mechanical nature of extracellular matrices (ECMs) is crucial for the mechanosensitive regulation of cell fate. This is evident in pathological conditions such as cancer and fibrosis, which are characterised by highly fibrotic tissue developing over time. This fibrotic progression not only alters tissue mechanics, but also coincides with the reprogramming of resident cells, promoting their differentiation into aberrant phenotypes and increasing drug resistance. Hydrogels, with their tuneable mechanical and biochemical properties, emerge as powerful ECM mimetics to model and study these abnormal, mechanically-driven cell differentiation phenomena. In this review, after establishing how conventional, mechanically static hydrogels contribute to our understanding of the role of altered mechanosensing in cell differentiation during cancer and fibrosis, we explore the research opportunities given by advanced dynamic matrices. Models employing hydrogels that are fast relaxing, plastic or even with temporally switchable mechanics reveal the otherwise hidden role of time-dependent phenomena during disease development.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"33 ","pages":"Article 100570"},"PeriodicalIF":4.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What lies beyond—Insights into elastic microscaffolds with metamaterial properties for cell studies 什么是超越-洞察弹性微支架与超材料性质的细胞研究

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-03-01 Epub Date: 2024-11-22 DOI: 10.1016/j.cobme.2024.100568

Magdalena Fladung , Alexander Berkes , Tim Alletzhaeusser , Yi Chen , Natalie Munding , Motomu Tanaka , Martin Wegener , Martin Bastmeyer

{"title":"What lies beyond—Insights into elastic microscaffolds with metamaterial properties for cell studies","authors":"Magdalena Fladung , Alexander Berkes , Tim Alletzhaeusser , Yi Chen , Natalie Munding , Motomu Tanaka , Martin Wegener , Martin Bastmeyer","doi":"10.1016/j.cobme.2024.100568","DOIUrl":"10.1016/j.cobme.2024.100568","url":null,"abstract":"<div><div>Recent advances in additive manufacturing have opened up new possibilities to print almost arbitrary structures with submicrometer resolution. An intriguing application is the fabrication of metamaterial-based scaffolds with unprecedented precision and with defined effective elastic properties for mechanobiological research. This field of study has already led to promising results but remains wide open. The vast possibilities, together with the high interdisciplinary character and current lack of established protocols or literature on the subject, are intriguing on the one hand but might discourage researchers who are new to this field. In this review, we aim to provide insights into the work with such microstructured bio-metamaterials, mainly based on our own experience with 2D systems, hoping to encourage further mechanobiological studies. Finally, we present some considerations for expanding to the third dimension to more closely resemble the <em>in</em> <em>vivo</em> situation.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"33 ","pages":"Article 100568"},"PeriodicalIF":4.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3M engineering approaches to combat high-shear thrombosis: Integrating modeling, microfluidics, and mechanobiology 对抗高剪切血栓形成的3M工程方法：集成建模、微流体和机械生物学

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-03-01 Epub Date: 2025-01-08 DOI: 10.1016/j.cobme.2025.100576

Allan Sun , Arian Nasser , Nicole Alexis Yap , Rui Gao , Lining Arnold Ju

{"title":"3M engineering approaches to combat high-shear thrombosis: Integrating modeling, microfluidics, and mechanobiology","authors":"Allan Sun , Arian Nasser , Nicole Alexis Yap , Rui Gao , Lining Arnold Ju","doi":"10.1016/j.cobme.2025.100576","DOIUrl":"10.1016/j.cobme.2025.100576","url":null,"abstract":"<div><div>Arterial thrombosis remains a significant global health concern, with shear-induced platelet aggregation (SIPA) playing a crucial role. This review focuses on the integration of three key engineering approaches—Computational Modeling Microfluidics and Mechanobiology (3 M)—in understanding and combating high-shear thrombosis. We discuss the biomechanical mechanisms of SIPA, highlighting how platelet mechanoreceptors and von Willebrand factor interactions drive thrombosis under pathological flow conditions. Through computational fluid dynamics (CFD), key hemodynamic metrics including time-averaged wall shear stress, oscillatory shear index, and relative residence time have been developed to predict thrombosis risk. Microfluidic platforms, ranging from straight channels to stenotic geometries, provide insights into platelet behavior under various shear conditions while enabling rapid screening of antithrombotic therapies. The integration of these experimental approaches with CFD analysis offers powerful tools for predicting thrombosis risk and optimizing device designs, particularly in mechanical circulatory support devices (MCSDs). Recent advances in mechanobiology have revealed how mechanical forces trigger cellular responses through membrane damage and mechanosensitive channels, offering new therapeutic targets. This review underscores how the synergy between these 3 M engineering approaches advances our understanding of the complex interplay between hemodynamics and thrombosis, paving the way for improved antithrombotic therapies and medical device designs essential to optimizing MCSDs, such as left ventricular assist devices and extracorporeal membrane oxygenators.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"33 ","pages":"Article 100576"},"PeriodicalIF":4.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of wireless powering modes for nanotransducer-mediated neuromodulation 纳米传感器介导的神经调节无线供电模式分析

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-03-01 Epub Date: 2024-11-09 DOI: 10.1016/j.cobme.2024.100562

Prachi Kumari , Aleksandra Milojkovic , Kristen Kozielski

引用次数: 0

Generalizable and explainable deep learning for medical image computing: An overview 医学图像计算的可概括和可解释的深度学习：概述

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-03-01 Epub Date: 2024-11-14 DOI: 10.1016/j.cobme.2024.100567

Ahmad Chaddad , Yan Hu , Yihang Wu , Binbin Wen , Reem Kateb

{"title":"Generalizable and explainable deep learning for medical image computing: An overview","authors":"Ahmad Chaddad , Yan Hu , Yihang Wu , Binbin Wen , Reem Kateb","doi":"10.1016/j.cobme.2024.100567","DOIUrl":"10.1016/j.cobme.2024.100567","url":null,"abstract":"<div><h3>Objective</h3><div>This paper presents an overview of generalizable and explainable artificial intelligence (XAI) in deep learning (DL) for medical imaging, with the aim of addressing the urgent need for transparency and explainability in clinical applications.</div></div><div><h3>Methodology</h3><div>We propose to use four CNNs in three medical datasets (brain tumor, skin cancer, and chest x-ray) for medical image classification tasks. Furthermore, we combine ResNet50 with five common XAI techniques to obtain explainable results for model prediction, in order to improve model transparency. We also involve a quantitative metric (confidence increase) to evaluate the usefulness of XAI techniques.</div></div><div><h3>Key findings</h3><div>The experimental results indicate that ResNet50 can achieve feasible accuracy and F1 score in all datasets (e.g., 86.31 % accuracy in skin cancer). Furthermore, the findings show that while certain XAI methods, such as eXplanation with Gradient-weighted Class activation mapping (XgradCAM), effectively highlight relevant abnormal regions in medical images, others, such as EigenGradCAM, may perform less effectively in specific scenarios. In addition, XgradCAM indicates higher confidence increase (e.g., 0.12 in glioma tumor) compared to GradCAM++ (0.09) and LayerCAM (0.08).</div></div><div><h3>Implications</h3><div>Based on the experimental results and recent advancements, we outline future research directions to enhance the generalizability of DL models in the field of biomedical imaging.</div></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"33 ","pages":"Article 100567"},"PeriodicalIF":4.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune cell and engineering for the therapeutics 免疫细胞和治疗工程

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2025-03-01 Epub Date: 2024-11-25 DOI: 10.1016/j.cobme.2024.100569

Jin Hyuck Jeong , Miseol Kim , Hui-Shan Li

引用次数: 0

Enhancing resilience against adversarial attacks in medical imaging using advanced feature transformation training 利用高级特征变换训练增强医学成像对对抗性攻击的复原力

IF 4.7 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2024-12-01 Epub Date: 2024-10-22 DOI: 10.1016/j.cobme.2024.100561

Danish Vasan , Mohammad Hammoudeh

引用次数: 0

The prospect of electroceutical intervention and its implementation toward intractable neuromuscular diseases 电疗干预的前景及其在难治性神经肌肉疾病中的应用