Current Opinion in Biomedical Engineering最新文献_第8页

Nanotechnology-based strategies for advancing point-of-care lateral flow immunoassays 基于纳米技术的策略推进护理点横向流免疫测定

IF 3.9 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2023-09-09 DOI: 10.1016/j.cobme.2023.100504

Peuli Nath, Aniruddha Ray

{"title":"Nanotechnology-based strategies for advancing point-of-care lateral flow immunoassays","authors":"Peuli Nath, Aniruddha Ray","doi":"10.1016/j.cobme.2023.100504","DOIUrl":"https://doi.org/10.1016/j.cobme.2023.100504","url":null,"abstract":"<div><p>Point-of-care tests (POCTs) have the potential to transform medical diagnostics by providing rapid and accurate results at the site of patient care. Of the many different types of POCTs being developed, lateral flow immunoassays (LFIAs) are some of the most widely used due to their simplicity, low cost, and fast response time. Combining recent advances in nanotechnology with the LFIAs has drastically improved their performance in terms of their sensitivity, specificity, and limit of detection, as well as their long-term stability. Nanoparticles, both plasmonic and fluorescent, can be functionalized with antibodies/aptamers and other targeting moieties, thereby enabling the detection of a wide range of biomarkers. Here we discuss various strategies, utilizing nanotechnology, to enhance the performance of these LFIAs in order to break the limits of the currently used conventional assays. Successful deployment of these tests will facilitate widespread use, thereby revolutionizing the current diagnostic and treatment practices, as well as curb future pandemics. Extensive utilization of these tests will also reduce the high medical expenditures, which is a central object of health care reform in every country.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100504"},"PeriodicalIF":3.9,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49817085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using biophysical cues and biomaterials to improve genetic models 利用生物物理线索和生物材料改进遗传模型

IF 3.9 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2023-09-09 DOI: 10.1016/j.cobme.2023.100502

Thomas G. Molley , Adam J. Engler

引用次数: 0

Beyond small molecule-based protein targeting in the era of deep learning 深度学习时代超越基于小分子的蛋白质靶向

IF 3.9 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2023-09-09 DOI: 10.1016/j.cobme.2023.100501

Pranam Chatterjee

引用次数: 0

Cadherins and growth factor receptors: Signaling mechano-switches at intercellular junctions 钙粘蛋白和生长因子受体:细胞间连接的信号机械开关

IF 3.9 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2023-09-09 DOI: 10.1016/j.cobme.2023.100503

Deborah Leckband

{"title":"Cadherins and growth factor receptors: Signaling mechano-switches at intercellular junctions","authors":"Deborah Leckband","doi":"10.1016/j.cobme.2023.100503","DOIUrl":"https://doi.org/10.1016/j.cobme.2023.100503","url":null,"abstract":"<div><p>This review focuses on recent findings that cadherins, like integrins, mechanically initiate signaling cascades that can share elements with integrins but have distinct biological functions. Specifically, we focus on evidence that cadherins and receptor tyrosine kinases (RTKs) form mechano-switches at intercellular junctions that regulate the integrity of barrier tissues, global cell mechanics, and cell proliferation. Epithelial E-cadherin force transduction signaling is further discussed in the context of other cadherin-mediated intercellular signaling that regulates Hippo kinases and YAP localization. This article highlights similarities and differences in force transduction by three, different classical cadherins and argues that cadherins and specific RTK partners constitute general intercellular mechano-switches, with tissue-specific functions. Several examples presented demonstrate the physiological significance of this force activated cadherin/RTK signal transduction mechanism and suggest how mechanically regulated, cadherin-dependent signaling could be harnessed to tune tissue-specific functions.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100503"},"PeriodicalIF":3.9,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49857657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory restoration for improved motor control of prostheses 改善假肢运动控制的感觉恢复

IF 3.9 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2023-09-03 DOI: 10.1016/j.cobme.2023.100498

Lee E. Fisher , Robert A. Gaunt , He Huang

引用次数: 0

“Sustainable open-source medical devices manufactured with green biomaterials and accessible resources” “使用绿色生物材料和可获取资源制造的可持续开源医疗设备”

IF 3.9 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2023-09-03 DOI: 10.1016/j.cobme.2023.100500

Andrés Díaz Lantada , Carmelo De Maria

{"title":"“Sustainable open-source medical devices manufactured with green biomaterials and accessible resources”","authors":"Andrés Díaz Lantada , Carmelo De Maria","doi":"10.1016/j.cobme.2023.100500","DOIUrl":"10.1016/j.cobme.2023.100500","url":null,"abstract":"<div><p>Additive manufacturing technologies, especially affordable 3D printers and bioprinters, emerge as sustainability promotion resources, thanks to the possibility of processing green and circular biomaterials from industrial waste, creating value with them. Among industries benefiting from these possibilities, healthcare sector, which takes advantage from the personalization degree of biomedical devices and products achievable through 3D (bio)printing, stands out as socially impactful. Indeed, biomedical devices manufactured with green and circular biomaterials using accessible resources can contribute to achieving equitable and eco-efficient solutions, while generating economic growth and decent work. This is of special relevance for low and middle-income settings, which may benefit from point-of-care production of medical technologies for solving challenging supply chain issues, directly manufacturing open-source solutions from the cloud and employing do-it-yourself materials. In order to generate debate on how to promote the impacts in this area, the current study summarizes research and innovation trends and discusses existing capabilities and challenges. Opinions of authors are presented and supported by an important set of publications and projects focused on healthcare equity and sustainability.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"28 ","pages":"Article 100500"},"PeriodicalIF":3.9,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46637089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Nature-inspired sustainable medical materials 自然启发的可持续医疗材料

IF 3.9 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2023-09-03 DOI: 10.1016/j.cobme.2023.100499

Matthew H.W. Chin, Julia Linke, Marc-Olivier Coppens

引用次数: 0

Artificial intelligence for biomedical engineering of polysaccharides: A short overview 人工智能在多糖生物医学工程中的应用综述

IF 3.9 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100463

Hanieh Shokrani , Amirhossein Shokrani , Farzad Seidi , Justyna Kucińska-Lipka , Balbina Makurat-Kasprolewicz , Mohammad Reza Saeb , Seeram Ramakrishna

{"title":"Artificial intelligence for biomedical engineering of polysaccharides: A short overview","authors":"Hanieh Shokrani , Amirhossein Shokrani , Farzad Seidi , Justyna Kucińska-Lipka , Balbina Makurat-Kasprolewicz , Mohammad Reza Saeb , Seeram Ramakrishna","doi":"10.1016/j.cobme.2023.100463","DOIUrl":"https://doi.org/10.1016/j.cobme.2023.100463","url":null,"abstract":"<div><p>The advent of computer-aided concepts and cognitive algorithms, along with fuzzy sets and fuzzy logic thoughts, supported the idea of ‘making computers think like people’ (Lotfi A. Zadeh, <em>IEEE Spectrum</em>, 21 (26–32), 1984). Such a school of thought enabled the sophistication of mission-oriented development of biomaterials and biosystems with the aid of ‘Artificial Intelligence’ (AI). Since polysaccharides (PSA) are medically safe and rely on stimuli-responsiveness, we herein highlight the importance of using AI-based algorithms in PSA-based biomedical engineering. Since manufacturing PSA-based biomaterials by AI experiences a very early stage of maturity, pattern recognition and behavior visualization by ‘Machine Learning’ (ML) models are not stressed herein. Nevertheless, exceptional chemical features of PSA such as surface modification and high adaptability facilitate ML-aided innovations. PSA-based biomaterials reveal diverse biomedical properties; therefore, summarizing, sorting, and recalling the best scenarios and optimization of the performance features of PSA still seems far from reach. We just highlight herein PSA-based biomedical engineering by the aid of AI to establish an agenda for the future. Herein, the outlook of targeted drug delivery vehicles, skin tissue engineering templates, wound healing systems, cancer treatment platforms, biosensors, personalized detection complexes, and particularly AI-aided bioprinting are generally covered.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"27 ","pages":"Article 100463"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49815352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable electrospun materials with enhanced blood compatibility for wound healing applications—A mini review 具有增强血液相容性的可持续静电纺丝材料用于伤口愈合应用-一个小回顾

IF 3.9 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100457

Mohan Prasath Mani , Ahmad Athif Mohd Faudzi , Seeram Ramakrishna , Ahmad Fauzi Ismail , Saravana Kumar Jaganathan , Nick Tucker , Rajasekar Rathanasamy

引用次数: 2

Editorial overview - Neural engineering: Traumatic brain injury 编辑综述-神经工程：创伤性脑损伤

IF 3.9 3区工程技术

Current Opinion in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100468

Lakiesha N. Williams, Michelle C. LaPlaca

引用次数: 0