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2006 IEEE/NLM Life Science Systems and Applications Workshop最新文献

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Imaging Across Scale: the Promise of Multi-modal Imaging 跨尺度成像:多模态成像的前景
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250435
L. Larson-Prior, J. Zempel, A. Snyder
{"title":"Imaging Across Scale: the Promise of Multi-modal Imaging","authors":"L. Larson-Prior, J. Zempel, A. Snyder","doi":"10.1109/LSSA.2006.250435","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250435","url":null,"abstract":"Comprehending neural function requires techniques that permit measurement of large-scale activity over complex networks even as we gain greater understanding of the foundations of this activity at the level of single or small populations of neurons. The measurement techniques currently available, while having yielded important and relevant information on the complexity of global neural networks, still provide only snapshots of the full picture. At present, recording and analysis remain linked to the spatial or temporal resolution inherent to each technique. Thus, the ability to integrate electrophysiological and functional imaging techniques to gain access to the spatio-temporal dynamics of neural activity is an important frontier in modern imaging science","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121648324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bifurcation analyses in the cyanobacterial circadian clock model 蓝藻生物钟模型的分岔分析
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250394
G. Kurosawa, K. Aihara, Y. Iwasa
{"title":"Bifurcation analyses in the cyanobacterial circadian clock model","authors":"G. Kurosawa, K. Aihara, Y. Iwasa","doi":"10.1109/LSSA.2006.250394","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250394","url":null,"abstract":"A conspicuous property of the circadian clock in cyanobacteria is that endogenous rhythm continues when protein abundances are kept constant either in the presence of translation and transcription inhibitors. Here we extend the study of a model recently proposed for the cyanobacterial circadian clock. We theoretically show that balanced ratio among KaiA, KaiB, and KaiC proteins is required for the generation of oscillations by using our model recently proposed. Bifurcation analyses show that cooperativity for the mutual inhibitory process in the model does not always enhance the generation of oscillations though cooperativity for the inhibition of transcription and in the nuclear transport of clock proteins in Goodwin type models extensively studied is known to always enhance the generation of oscillations","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122285979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated Classification of Human Histological Images, A Multiple-Instance Learning Approach 人类组织学图像的自动分类，一种多实例学习方法
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-07-13 DOI: 10.1109/LSSA.2006.250411
Dehua Zhao, Yixin Chen, H. Correa
{"title":"Automated Classification of Human Histological Images, A Multiple-Instance Learning Approach","authors":"Dehua Zhao, Yixin Chen, H. Correa","doi":"10.1109/LSSA.2006.250411","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250411","url":null,"abstract":"In this paper, we apply a multiple-instance learning (MIL) method, MILES (multiple-instance learning via embedded instance selection), to human histological image classification. MILES converts a MIL problem to a supervised learning problem by an instance-based feature mapping. 1-norm SVM is then adopted to select features and construct a classifier simultaneously. MILES identifies the sub-images that reflect underlying category concepts, and use them for classification. Experimental validation is provided based on images from different organs and parts of the body. The new approach demonstrates significantly improved performance in comparison with a method based on a Gaussian mixture model","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123441249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
SNiPer 500K: A Novel SNP Genotype Calling Algorithm SNiPer 500K:一种新的SNP基因型调用算法
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-07-13 DOI: 10.1109/LSSA.2006.250407
Jianping Hua, D. Craig, M. Brun, J. Webster, V. Zismann, K. Joshipura, M. Huentelman, E. Dougherty, D. Stephan
{"title":"SNiPer 500K: A Novel SNP Genotype Calling Algorithm","authors":"Jianping Hua, D. Craig, M. Brun, J. Webster, V. Zismann, K. Joshipura, M. Huentelman, E. Dougherty, D. Stephan","doi":"10.1109/LSSA.2006.250407","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250407","url":null,"abstract":"The fast development in high-throughput single nucleotide polymorphism (SNP) genotyping technology provides unprecedented power for genome-wide SNP association studies. However, inaccurate genotyping can lead to false association between markers and phenotype. We introduce a new SNP genotyping scheme, SNiPer 500K, for Affymetrix 500K GeneChip. SNiPer 500K designs a parametric classifier for each SNP, by using expectation-maximization algorithm to estimate the parameters. A quality index provided by SNiPer 500K shows that it can reliably genotype about 65% of all SNPs, with superior call rate, better Hardy-Weinberg equilibrium and reproducibility. SNiPer 500K provides a good balance between coverage and accuracy for high-throughput SNP genotyping and would prove to be an invaluable tool for genome-wide association study","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124043294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimating Oligo-nucleotide Microarray Expression by Hybridization Process Modelling 用杂交过程模型估计寡核苷酸微阵列表达
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-07-13 DOI: 10.1109/LSSA.2006.250398
F. Diaz, R. Malutan, Pedro Gómez, R. Martínez, B. Stetter, M. Paz, E. Garcia, J. Pelaez
{"title":"Estimating Oligo-nucleotide Microarray Expression by Hybridization Process Modelling","authors":"F. Diaz, R. Malutan, Pedro Gómez, R. Martínez, B. Stetter, M. Paz, E. Garcia, J. Pelaez","doi":"10.1109/LSSA.2006.250398","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250398","url":null,"abstract":"Oligonucleotide microarray technology has become widely spread in genetic probing for different purposes. This technology has shown to be highly reliable and dependable, although not free from problems regarding expression estimation, as it relies on the differential or contrasted hybridization of test probes. In many cases hybridization results do not show the expected behaviour, thus affecting to the reliability of expression estimation. In the present paper a modelling of the hybridization process is proposed which can be used to predict and correct expression levels on a specific test probe, improving the reliability of the results. Some examples from real microarray processing are shown and discussed","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131475530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Indium Phosphide Optical MEMS for Chemical and Biological Sensing 用于化学和生物传感的磷化铟光学MEMS
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-07-13 DOI: 10.1109/LSSA.2006.250369
N. Siwak, J. McGee, R. Ghodssi
{"title":"Indium Phosphide Optical MEMS for Chemical and Biological Sensing","authors":"N. Siwak, J. McGee, R. Ghodssi","doi":"10.1109/LSSA.2006.250369","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250369","url":null,"abstract":"We present a resonant cantilever sensor for use in chemical and biological sensing applications. Electrostatically actuated suspended indium phosphide (InP) waveguides are used as the sensing cantilevers. This sensor uses an integrated optical detection scheme which eliminates the need for free space optical components seen in traditional systems. Discussions on device design as well as data collection methods are presented. Mass sensitivity in the range of Deltam = 6.6times10-15 g is reported, comparable to similar cantilever sensor designs. Integration of waveguide cantilever sensors with on chip optical sources and detectors is also discussed","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131853784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Development of a Cortical Visual Neuroprostheses for the Blind 盲人皮质视觉神经假体的研制
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-07-13 DOI: 10.1109/LSSA.2006.250387
José Manuel Ferrández, Eduardo Fernández
{"title":"Development of a Cortical Visual Neuroprostheses for the Blind","authors":"José Manuel Ferrández, Eduardo Fernández","doi":"10.1109/LSSA.2006.250387","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250387","url":null,"abstract":"A bioinspired visual neuroprostheses, interfaced with the occipital cortex, as a means through which a limited but useful visual sense could be restored to profoundly blind people is proposed. While the full restoration of vision is unlikely in the near future, the discrimination of shape and location of objects could allow blind subjects to 'navigate' in a familiar environment and to read enlarged text, resulting in a substantial improvement in the quality of life of blind and visually impaired persons. The whole system is described including the bioinspired visual coder, the current source neural stimulator and the penetrating cortical multielectrode array. Finally this approach emphasize the role of neural plasticity to achieve the desired behaviour of the system","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"885 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133088717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Zebrafish Cell/Neuron Quantitation by Modified Circular Hough Transform 基于改进圆形霍夫变换的斑马鱼细胞/神经元定量
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-07-13 DOI: 10.1109/LSSA.2006.250413
Tianming Liu, Jianfeng Lu, Jingxin Nie, Gang Li, Hui Yan, Jingyu Yang, Lei Guo, W. Xia, Stephen T. C. Wong
{"title":"Zebrafish Cell/Neuron Quantitation by Modified Circular Hough Transform","authors":"Tianming Liu, Jianfeng Lu, Jingxin Nie, Gang Li, Hui Yan, Jingyu Yang, Lei Guo, W. Xia, Stephen T. C. Wong","doi":"10.1109/LSSA.2006.250413","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250413","url":null,"abstract":"Microscopic imaging has become a critical step in the analysis of zebrafish phenotype, but tremendous amount of images generated from large number of embryos have become a bottleneck of data interpretation. The availability of an image informatics pipeline will be a significant step towards achieving reproducible quantitation of zebrafish phenotypes in scientific research and high-throughput screening. This paper presents an automated algorithm based on modified circular Hough transform for quantitation of zebrafish cells and neurons in microscopy imaging. Experimental results of three datasets are shown to demonstrate the performance of the algorithm. This algorithm has been integrated into our CBI Platform","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"163 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116636395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Composite Gene Module Discovery using Non-negative Independent Component Analysis 利用非负独立成分分析发现复合基因模块
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-07-13 DOI: 10.1109/LSSA.2006.250434
Ting Gong, J. Xuan, Yitan Zhu, Huaizhou Li, R. Clarke, E. Hoffman, Y. Wang
{"title":"Composite Gene Module Discovery using Non-negative Independent Component Analysis","authors":"Ting Gong, J. Xuan, Yitan Zhu, Huaizhou Li, R. Clarke, E. Hoffman, Y. Wang","doi":"10.1109/LSSA.2006.250434","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250434","url":null,"abstract":"Gene module discovery can provide comprehensive molecular portrait of biological regulation and functional genomics. We present a new analytic strategy - nonnegative independent component analysis to reveal some gene module composite. The results show that by grouping genes in the latent space, we can find statistically more significant enrichment of gene annotations within clusters. Further, this approach has been applied to a muscular dystrophy data set for gene module discovery","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115603719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Wireless Integrated Voltametric and Amperometric Biosensing 无线集成电压和安培生物传感
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-07-13 DOI: 10.1109/LSSA.2006.250428
M. Mollazadeh, K. Murari, C. Sauer, M. Stanaćević, N. Thakor, G. Cauwenberghs
{"title":"Wireless Integrated Voltametric and Amperometric Biosensing","authors":"M. Mollazadeh, K. Murari, C. Sauer, M. Stanaćević, N. Thakor, G. Cauwenberghs","doi":"10.1109/LSSA.2006.250428","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250428","url":null,"abstract":"Central Nervous System (CNS) uses the interplay between signals of different modalities to transfer and process information. Neurological events are characterized by changes in both neurochemical concentrations and the electrical activity of neurons. Electro physiological and neurochemical events are highly correlated as one causes the other and vice-versa. The ability to simultaneously record electrical and chemical activity is of considerable research and diagnostic importance. Here, we present a hardware implementation for wireless power and clock transfer to and serial transmission of digitized neurochemical and electro physiological data from sensors over one RF link. The idea can be extended to sensors of different modalities having widely different data rates. Neurochemical data are acquired in real-time from a custom multichannel very large scale integrated (VLSI) potentiostat chip at 5 Hz. Field potential data were sampled at 400 Hz. A custom VLSI chip powers up and supplies clocks to the potentiostat and telemeters the multiplexed data. All the chips were fabricated in AMI 3M-2P 0.5μ CMOS process. We demonstrate successful operation of the system with wireless powering and telemetry of the multiplexed data.","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127927939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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