Imaging Across Scale: the Promise of Multi-modal Imaging

Abstract

Comprehending neural function requires techniques that permit measurement of large-scale activity over complex networks even as we gain greater understanding of the foundations of this activity at the level of single or small populations of neurons. The measurement techniques currently available, while having yielded important and relevant information on the complexity of global neural networks, still provide only snapshots of the full picture. At present, recording and analysis remain linked to the spatial or temporal resolution inherent to each technique. Thus, the ability to integrate electrophysiological and functional imaging techniques to gain access to the spatio-temporal dynamics of neural activity is an important frontier in modern imaging science