Medical Journal of Western Black Sea最新文献

{"title":"Baş ve Boyun Sarkomlarının Klinik Gidişleri ve Özellikleri (Tek Merkez Deneyimi)","authors":"Metin Pehlivan, Ayça Iribaş, Bilge Bilgiç, Mert Başaran, Meltem Ekenel","doi":"10.29058/mjwbs.1061947","DOIUrl":"https://doi.org/10.29058/mjwbs.1061947","url":null,"abstract":"Amaç: Yumuşak doku sarkomları genellikle ekstremitelerde veya retroperitonda görülür, %5-10 hastada \u0000ise baş boyun bölgesinde görülür. Yumuşak doku sarkomları baş ve boyun kanserlerinin","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114294069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kronik Hepatit C Hastalarında Uygulanan Direkt Etkili Antiviral Tedavinin Yaşam Kalitesi Üzerine Uzun Dönem Etkisinin Değerlendirilmesi","authors":"Zeynep GÖK SARGIN, D. Yılmaz, İbrahimhalil Düşünceli̇, Yücel Üstündağ","doi":"10.29058/mjwbs.1123005","DOIUrl":"https://doi.org/10.29058/mjwbs.1123005","url":null,"abstract":"Amaç:Kronik hepatit C (KHC) hastalarında, küratif etkinliği yüksek, direkt etkili antiviraller (DAA) ile tedavi sonrası uzun dönemde öz bakım, günlük aktiviteler, ağrı ve emosyonel açıdan hayat kalitesindeki değişimi değerlendirmeyi amaçladık. \u0000Gereç ve Yöntemler :KHC nedeniyle Ocak 2017 ile Haziran 2021 tarihleri arasında DAA tedavisi tamamlanmış olan hastalara günlük yaşam aktiviteleri, öz bakım yeterlilikleri, ağrı seviyeleri, anksiyete ve depresyon varlığını ölçen EQ-5D-3L Genel Yaşam Kalitesi Ölçeği soruları tedavi öncesi ve tedavi sonrası karşılaştırma yapmak amacıyla yöneltildi. DAA tedavisi ile kalıcı viral yanıt sonrası en az 12 ay geçmiş hastalar çalışmaya alındı. \u0000Bulgular:Çalışmaya alınan 90 hastanın ortalama takip süresi 40 ±17.3 aydı. DAA tedavisi sonrası en az bir yıl sonra tüm hastaların yaşam kalitesi indekslerinde tedavi öncesine göre anlamlı olarak artış izlenmiştir (p","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127585536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Vitamin D Levels in Fibromyalgia Patients and the Relation to Functional Status","authors":"E. Aktunc, Şenay ÖZDOLAP ÇOBAN, Tuğçe Köksal, S. Sarıkaya","doi":"10.29058/mjwbs.1099523","DOIUrl":"https://doi.org/10.29058/mjwbs.1099523","url":null,"abstract":"Aim: Fibromyalgia syndrome is a common musculoskeletal disorder, characterized by chronic \u0000widespread pain, multiple tender points, joint stiffness, and systemic symptoms without any underlying \u0000organic disease. The initial aim of the present study was to determine the vitamin D levels in patients \u0000with fibromyalgia and compare these values to those found in healthy subjects. Then, correlations \u0000between functional status, clinical severity of the disease, and vitamin D levels were assessed. \u0000Material and Methods: This case-control study included 137 female fibromyalgia patients and 109 \u0000healthy female counterparts. The severity of pain was assessed by a visual analogue scale and the \u0000functional impact was evaluated through the Fibromyalgia Impact Questionnaire in the patient group. \u0000Vitamin D levels were compared between groups, and the correlation between vitamin D levels and \u0000questionnaire scores was determined. \u0000Results: Vitamin D and parathormone levels did not differ significantly between groups (p=0.858, \u0000p=0.790 respectively). The mean Fibromyalgia Impact Questionnaire scores and the medians for the \u0000visual analogue scale did not differ significantly among vitamin D deficient, insufficient, and sufficient \u0000patients (p=0.548 , p=0.952 respectively). In addition, no significant correlation between vitamin D \u0000levels and the Fibromyalgia Impact Questionnaire score was found(Spearman’s rho=0.056, p=0.513). \u0000Conclusion: This study did not show any significant differences between the vitamin D levels of \u0000fibromyalgia patients and those of healthy subjects. Further, in fibromyalgia patients, there was no \u0000correlation between vitamin D levels and functional status or disease severity","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123469841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation on Demographic Characteristics of Pregnant Patients with Thyroid Dysfunction- Ege University Sample","authors":"M. Erdogan, G. Bayramova, Hatice Özişik, A. Suner","doi":"10.29058/mjwbs.1141211","DOIUrl":"https://doi.org/10.29058/mjwbs.1141211","url":null,"abstract":"Aim: Thyroid diseases can cause maternal and fetal adversities, and proper diagnosis, follow-up and \u0000treatment during pregnancy requires special attention. In the evaluation of thyroid functions during \u0000pregnancy, free thyroxine (FT4) is used primarily with thyroid-stimulating hormone (TSH). Our aim is to \u0000investigate the prevalence and the effects of thyroid dysfunction during pregnancy. \u0000Material and Methods: Our study is a prospective study including 960 pregnant women and spanning \u0000from November 2017 to May 2019 in Ege University Endocrinology outpatient clinic.100 pregnant \u0000women with thyroid dysfunction out of 960 pregnant women were included in the study. Maternal \u0000age, gestational trimester, family history of the thyroid disorder, TSH, FT4, free triiodothyronine (FT3), \u0000anti-thyroid peroxidase antibody (Anti-TPO), anti-thyroglobulin antibody (Anti-TG), thyrotropin (TSH) \u0000receptor antibody (TRAb) were collected. The correlations between TSH, FT3 and FT4 were examined. \u0000Results: In the study, the mean age of pregnant patients was 29.33 ± 5.97. Anti-TPO was positive %18 and \u0000Anti-TG was positive (5%). 24 of 100 (24%) patients had nodules. 1 (8.3%) patient with hyperthyroidism \u0000was positive for TRAb. Age differences in patients with or without nodule were not statistically significant. \u00001 (1%) of the patient had Graves disease, 81 (81%) had subclinical hypothyroidism, 7 (7%) had clinical \u0000hypothyroidism, 11 (11%) had gestational thyrotoxicosis. The frequency of prematurity was determined \u0000in 7 patients (15.6%) by the data of 45 pregnant women who gave birth. \u0000Conclusion: TSH levels in pregnant patients with positivity for anti-TPO and anti-TG were significantly \u0000higher than pregnant patients with negativity for anti-TPO and anti-TG. In addition, the relationship \u0000between thyroid diseases and nodule frequency, autoimmunity, premature birth in pregnant women \u0000were not detected. More comprehensive study series are needed.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129510004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difficulty in Follow-Up of Papillary Thyroid Cancer Co-Existent with Hypopituitarism: Case Report and Review of the Literature","authors":"Ö. Topaloğlu, Güldeniz Gizem Açikgöz, Sakin Tekin, Barkın Malkoç, E. Kaymaz, G. Karadeniz Cakmak, T. Bayraktaroğlu","doi":"10.29058/mjwbs.1164665","DOIUrl":"https://doi.org/10.29058/mjwbs.1164665","url":null,"abstract":"Aim: We present an interesting case of papillary thyroid cancer co-existent with hypopituitarism. \u0000Case: Fortysix-year-old female was applied with a complaint of painful palpabl lump in the right side of the neck, difficulty swallowing, cough and dyspnea. The patient was diagnosed with type 2 diabetes mellitus 8 years ago, underwent craniotomy for nonfunctioning pituitary adenoma 15 years ago, and received gamma knife 10 years ago. She had been taking insulin glargine and lispro, prednisolone, and levothyroxine (LT4). Physical examination was unremarkable. Pituitary MRI revealed partial empty sella. A solid nodule of 33x27x30 mm with irregular borders and containing microcalcifications in the right thyroid lobe was detected on sonography. Fine needle aspiration cytology revealed “strongly suspicious features for malignancy”. Papillary thyroid carcinoma (PTC) was detected after right lobectomy and then complementary thyroidectomy. Follow-up sonography performed 14 months later than radioactive iodine (RAI) showed an avascular solid area of 30x14x15 mm in the right. We decided to monitor free thyroxine (fT4), thyroglobulin and anti-thyroglobulin levels. LT4 dose was adjusted to keep fT4 level closer to the upper limit of normal. No complications or recurrences were detected. \u0000Conclusion: Studies on the follow-up of PTC cases with hypopituitarism are limited. We performed RAI after total thyroidectomy, and treated the patient with LT4 by adjusting fT4 level.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127654736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Travma Anestezisinde Hasta Güvenliği, Zonguldak’ta Sonbahar Sempozyumu-III, Bilimsel Program Ve Sözlü Bildirileri","authors":"Aslı Dönmez, H. Ayoğlu, Ö. Pişkin, Gamze Küçükosman, R. D. Okyay","doi":"10.29058/mjwbs.1201881","DOIUrl":"https://doi.org/10.29058/mjwbs.1201881","url":null,"abstract":"Zonguldak Bülent Ecevit Üniversitesi Merkez Farabi Kampüsü Sezai Karakoç Kültür Merkezi’nde, 12 Kasım 2022 tarihinde “Travma anestezisinde Hasta Güvenliği, Zonguldak’ta Sonbahar Sempozyumu-III “(https://www.zbeu-travmaanestezisi.org) gerçekleştirildi. \u0000Sempozyum oturumlarındaki sözlü bildirilerin özetlerinin sunulması amaçlanmıştır. Kongre süresince toplam 15 sözel bildiri sunulmuştur. Böylece, travma anestezisinde hasta güvenliği ve travma hastasının yönetiminde güncel yaklaşımların bilim dünyası ile paylaşılması sağlanmıştır.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127237553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Chronic Oral Monosodium Glutamate Consumption on Naloxane-Induced Morphine Withdrawal in Infant Rats","authors":"Mahluga Jafarova Demirkapu, B. Özen, Songül Özkula, Merve Yi̇ldi̇z, Hasan Temel, Sena Nur Kutluay, Mustafa Büyük, Melih Ki̇li̇nc, H. Yananlı","doi":"10.29058/mjwbs.1124034","DOIUrl":"https://doi.org/10.29058/mjwbs.1124034","url":null,"abstract":"Aim: The aim of this study was to investigate chronic oral monosodium glutamate (MSG) consumption effects on symptoms of withdrawal, locomotor activity, and anxiety in morphine withdrawal syndrome induced by naloxone in infant rats. \u0000Materials and Methods: Twelve 21-day-old male Wistar rats used in the study. Infant rats were given unlimited access to saline (control group) or MSG (MSG group) added to drinking water for 32 days. Withdrawal was induced by naloxone in morphine-dependent rats. Evaluation of withdrawal symptoms and anxiety were performed simultaneously with locomotor activity measurements. \u0000Results: Withdrawal sings, such as jumping, wet dog shake, and weight loss; stereotypic, ambulatory, and vertical locomotor activity movements; central, peripheral, and total activities used in the assessment of anxiety in infant rats with naloxone-induced withdrawal syndrome that consumed oral MSG for 32 days were not different from the control group. \u0000Conclusion: These findings obtained in our study indicate that chronic consumption of oral MSG in infant rats whose blood-brain barrier has not yet developed does not affect morphine dependence and naloxone-induced withdrawal. Further studies are needed to investigate the mechanism of action of orally administered MSG.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123428263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Mean Platelet Volume, Platelet Distribution Width, Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio and Lymphocyte/Monocyte Ratio in Patients with Differentiated Thyroid Cancer According to TSH Levels","authors":"Seher Çetinkaya Altuntaş, Ö. Topaloğlu","doi":"10.29058/mjwbs.1187429","DOIUrl":"https://doi.org/10.29058/mjwbs.1187429","url":null,"abstract":"Purpose: The standard treatment in differentiated thyroid cancer (DTC) is total thyroidectomy followed by lifelong levothyroxine (LT4) replacement. However, what should be the level of exogenous LT4 and TSH is still a matter of debate. \u0000Material and Method: 162 patients with a prospective diagnosis of non-metastatic DTC and 69 healthy volunteers were included. DTC patients were divided into 3 groups according to their TSH level. If TSH is less than 0.1μIU/mL, between 0.11-0.49 μIU/mL, 0.5-2μIU/mL, the groups were named as suppressed thyrotropin, moderately suppressed thyrotropin and low-normal thyrotropin group, respectively. \u0000Results: No statistical difference was observed between MPV, PDW, NLR, PLR, LMR when the DTC group and the healthy control group were compared. When the patients were divided into 3 groups according to their TSH levels, only PDW levels were found to be higher in the moderately suppressed group compared to the other groups (p","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127775071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fare ve Sıçanlarda Dişi Genital Kanalı Değerlendirmenin Kolay Bir Yolu: Vajinal Sitoloji","authors":"Zekiye Gülfem Yurtgezen, Deniz Erçeti̇n, Melike SAPMAZ METİN","doi":"10.29058/mjwbs.1172971","DOIUrl":"https://doi.org/10.29058/mjwbs.1172971","url":null,"abstract":"Dişi genital kanalın durumunu izlemek için kullanılan vajinal sitoloji yöntemi, zaman içinde farklı metodlar ortaya çıksa da, kolay ve pratik olması nedeniyle sıklıkla tercih edilmektedir. 1917’de Stockard ve Papanicolaou’nun kobay vajinal lümen epitel hücrelerinin ovulasyon döngüsünün durumuna göre değişiklik gösterdiğini keşfetmelerinin ardından östrus siklusu takibi, dişi genital sistem çalışmalarının vazgeçilmez bir parçası olmuştur. Vajinal sitolojiyi göstermek için smear örneklerinin alınma zamanı ve yöntemi, uygulayıcının tecrübesi gibi çeşitli faktörler sonuçların doğruluğu üzerine etkilidir. Östrus siklusu, sıçan ve farelerde temel olarak dört faz gösterir: proöstrus, östrus, metöstrus ve diöstrus. Her fazın hücre tipi ve yoğunluğu farklıdır. Bu derlemede; fare ve sıçandan smear alma yöntemleri ve östrus siklus fazlarının özelliklerinin yanı sıra, elde edilen verilerin deneysel çalışmalarda kullanım alanlarına yönelik literatür bilgileri yer almaktadır. Ayrıca bu çalışma, dişi üreme sistemindeki dinamik değişikliklerin takibi, deneysel çalışmaların doğru planlanması ve sonuçların değerlendirilmesi yönünden dikkat edilmesi gereken noktaları belirtmesi ile dişi deneklerle çalışacak araştırmacılara kapsamlı bir bakış açısı sağlamayı hedeflemektedir.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128211620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yumuşak Doku Sarkomlarında Adjuvan Tedavi (Tek Merkez Deneyimi)","authors":"Metin Pehlivan, Ayça Iribaş, Bilge Bilgiç, Mert Başaran, Meltem Ekenel","doi":"10.29058/mjwbs.1061890","DOIUrl":"https://doi.org/10.29058/mjwbs.1061890","url":null,"abstract":"Amaç: Yumuşak doku sarkomları, malignitelerin yaklaşık %1’ini oluşturan, 50’den fazla histolojik alt \u0000grubu olan bir kanser türüdür. Adjuvan kemoterapi alan hastaların hastalıksız sağkalımlarının uzadığını \u0000birçok çalışma ve metaanaliz gösterse de, genel sağkalıma ilişkin çalışmalar arasında fark vardır. \u0000Çalışmamızın amacı, merkezimizde yumuşak doku sarkomu nedeniyle adjuvan kemoterapi uygulanan \u0000hastaların klinik seyirlerini incelemektir. \u0000Gereç ve Yöntemler: Çalışma retrospektif olarak planlanmıştır. İstanbul Üniversitesi Onkoloji Enstitüsü \u0000Tıbbi Onkoloji polikliniğinde; lokal, lokal ileri olup opere olan veya metastatik olup hem lokal cerrahi \u0000hem de metastazektomi yapılan ve sonrasında adjuvan tedavi almış 18 yaşın üstündeki yumuşak doku \u0000sarkomu hastaları alınmış ve adjuvan kemoterapinin hastalığın seyrine olan etkisi incelenmiştir. \u0000Bulgular: 40 hasta çalışmaya dahil edildi. Hastalar medyan 53 ay (5-155) takip edildi. Hastaların \u0000%55’i Evre 1 (%10 Evre 1A, %45 Evre 1B), %15 Evre 3 (%5 Evre 3A, %10 Evre 3B), %30 Evre 4’tür. \u0000Hastalara medyan dört kür adjuvan kemoterapi verildi ve hastaların %80’i Adriamisin - İfosfamid aldı. \u0000Hastaların yarısında hastalık nüks ederken, nüks eden hastalarda hastalıksız sağkalım medyan 12 \u0000aydır. Hastaların medyan toplam sağkalımı 39 aydır. \u0000Sonuç: Yaptığımız çalışmanın sonucunda adjuvan tedavinin hem hastalıksız hem de total sağkalımı \u0000katkısı sağlayabileceğini ve bu katkının hem ekstremite hem de ekstremite dışı yumuşak doku \u0000sarkomlarında olabileceğini düşünüyoruz ama kesin bir kanıya varmak için daha geniş hasta sayıları ile \u0000yapılacak prospektif çalışmaların daha yararlı olabileceğini düşünüyoruz.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129262766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}