长期口服谷氨酸钠对幼鼠纳洛酮诱导的吗啡戒断的影响

Mahluga Jafarova Demirkapu, B. Özen, Songül Özkula, Merve Yi̇ldi̇z, Hasan Temel, Sena Nur Kutluay, Mustafa Büyük, Melih Ki̇li̇nc, H. Yananlı
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引用次数: 0

摘要

目的:探讨长期口服谷氨酸钠(MSG)对纳洛酮所致吗啡戒断综合征幼鼠戒断症状、运动活动和焦虑的影响。材料与方法:选用12只21日龄雄性Wistar大鼠。在32天的时间里,幼龄大鼠无限制地饮用生理盐水(对照组)或添加味精(味精组)的饮用水。吗啡依赖大鼠被纳洛酮诱导戒断。戒断症状和焦虑的评估与运动活动测量同时进行。结果:戒断症状,如跳跃、湿狗摇、体重减轻;刻板、移动和垂直运动活动运动;服用口服味精32天的纳洛酮戒断综合征幼鼠的焦虑评估中使用的中枢、外周和总活动与对照组没有差异。结论:本研究结果表明,在血脑屏障尚未发育成熟的幼鼠中,长期口服味精对吗啡依赖和纳洛酮诱导的戒断没有影响。口服味精的作用机制有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Chronic Oral Monosodium Glutamate Consumption on Naloxane-Induced Morphine Withdrawal in Infant Rats
Aim: The aim of this study was to investigate chronic oral monosodium glutamate (MSG) consumption effects on symptoms of withdrawal, locomotor activity, and anxiety in morphine withdrawal syndrome induced by naloxone in infant rats. Materials and Methods: Twelve 21-day-old male Wistar rats used in the study. Infant rats were given unlimited access to saline (control group) or MSG (MSG group) added to drinking water for 32 days. Withdrawal was induced by naloxone in morphine-dependent rats. Evaluation of withdrawal symptoms and anxiety were performed simultaneously with locomotor activity measurements. Results: Withdrawal sings, such as jumping, wet dog shake, and weight loss; stereotypic, ambulatory, and vertical locomotor activity movements; central, peripheral, and total activities used in the assessment of anxiety in infant rats with naloxone-induced withdrawal syndrome that consumed oral MSG for 32 days were not different from the control group. Conclusion: These findings obtained in our study indicate that chronic consumption of oral MSG in infant rats whose blood-brain barrier has not yet developed does not affect morphine dependence and naloxone-induced withdrawal. Further studies are needed to investigate the mechanism of action of orally administered MSG.
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