纤维肌痛患者维生素D水平的评价及其与功能状态的关系

E. Aktunc, Şenay ÖZDOLAP ÇOBAN, Tuğçe Köksal, S. Sarıkaya
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引用次数: 1

摘要

目的:纤维肌痛综合征是一种常见的肌肉骨骼疾病,其特征是慢性广泛性疼痛,多个压痛点,关节僵硬和全身症状,没有任何潜在的器质性疾病。本研究的最初目的是确定纤维肌痛患者的维生素D水平,并将这些值与健康受试者的维生素D水平进行比较。然后,评估功能状态、疾病的临床严重程度和维生素D水平之间的相关性。材料与方法:本病例对照研究纳入137例女性纤维肌痛患者和109例健康女性对照者。通过视觉模拟量表评估疼痛的严重程度,并通过纤维肌痛影响问卷评估患者组的功能影响。比较各组之间的维生素D水平,并确定维生素D水平与问卷得分之间的相关性。结果:各组间维生素D和甲状旁激素水平差异无统计学意义(p=0.858, p=0.790)。纤维肌痛影响问卷的平均得分和视觉模拟量表的中位数在维生素D缺乏、维生素D不足和维生素D充足的患者中没有显著差异(p=0.548, p=0.952)。此外,维生素D水平与纤维肌痛影响问卷评分之间无显著相关性(Spearman’s rho=0.056, p=0.513)。结论:本研究未发现纤维肌痛患者与健康人群维生素D水平有显著差异。此外,在纤维肌痛患者中,维生素D水平与功能状态或疾病严重程度之间没有相关性
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Vitamin D Levels in Fibromyalgia Patients and the Relation to Functional Status
Aim: Fibromyalgia syndrome is a common musculoskeletal disorder, characterized by chronic widespread pain, multiple tender points, joint stiffness, and systemic symptoms without any underlying organic disease. The initial aim of the present study was to determine the vitamin D levels in patients with fibromyalgia and compare these values to those found in healthy subjects. Then, correlations between functional status, clinical severity of the disease, and vitamin D levels were assessed. Material and Methods: This case-control study included 137 female fibromyalgia patients and 109 healthy female counterparts. The severity of pain was assessed by a visual analogue scale and the functional impact was evaluated through the Fibromyalgia Impact Questionnaire in the patient group. Vitamin D levels were compared between groups, and the correlation between vitamin D levels and questionnaire scores was determined. Results: Vitamin D and parathormone levels did not differ significantly between groups (p=0.858, p=0.790 respectively). The mean Fibromyalgia Impact Questionnaire scores and the medians for the visual analogue scale did not differ significantly among vitamin D deficient, insufficient, and sufficient patients (p=0.548 , p=0.952 respectively). In addition, no significant correlation between vitamin D levels and the Fibromyalgia Impact Questionnaire score was found(Spearman’s rho=0.056, p=0.513). Conclusion: This study did not show any significant differences between the vitamin D levels of fibromyalgia patients and those of healthy subjects. Further, in fibromyalgia patients, there was no correlation between vitamin D levels and functional status or disease severity
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