Effects of Chronic Oral Monosodium Glutamate Consumption on Naloxane-Induced Morphine Withdrawal in Infant Rats

Mahluga Jafarova Demirkapu, B. Özen, Songül Özkula, Merve Yi̇ldi̇z, Hasan Temel, Sena Nur Kutluay, Mustafa Büyük, Melih Ki̇li̇nc, H. Yananlı
{"title":"Effects of Chronic Oral Monosodium Glutamate Consumption on Naloxane-Induced Morphine Withdrawal in Infant Rats","authors":"Mahluga Jafarova Demirkapu, B. Özen, Songül Özkula, Merve Yi̇ldi̇z, Hasan Temel, Sena Nur Kutluay, Mustafa Büyük, Melih Ki̇li̇nc, H. Yananlı","doi":"10.29058/mjwbs.1124034","DOIUrl":null,"url":null,"abstract":"Aim: The aim of this study was to investigate chronic oral monosodium glutamate (MSG) consumption effects on symptoms of withdrawal, locomotor activity, and anxiety in morphine withdrawal syndrome induced by naloxone in infant rats. \nMaterials and Methods: Twelve 21-day-old male Wistar rats used in the study. Infant rats were given unlimited access to saline (control group) or MSG (MSG group) added to drinking water for 32 days. Withdrawal was induced by naloxone in morphine-dependent rats. Evaluation of withdrawal symptoms and anxiety were performed simultaneously with locomotor activity measurements. \nResults: Withdrawal sings, such as jumping, wet dog shake, and weight loss; stereotypic, ambulatory, and vertical locomotor activity movements; central, peripheral, and total activities used in the assessment of anxiety in infant rats with naloxone-induced withdrawal syndrome that consumed oral MSG for 32 days were not different from the control group. \nConclusion: These findings obtained in our study indicate that chronic consumption of oral MSG in infant rats whose blood-brain barrier has not yet developed does not affect morphine dependence and naloxone-induced withdrawal. Further studies are needed to investigate the mechanism of action of orally administered MSG.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Journal of Western Black Sea","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29058/mjwbs.1124034","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Aim: The aim of this study was to investigate chronic oral monosodium glutamate (MSG) consumption effects on symptoms of withdrawal, locomotor activity, and anxiety in morphine withdrawal syndrome induced by naloxone in infant rats. Materials and Methods: Twelve 21-day-old male Wistar rats used in the study. Infant rats were given unlimited access to saline (control group) or MSG (MSG group) added to drinking water for 32 days. Withdrawal was induced by naloxone in morphine-dependent rats. Evaluation of withdrawal symptoms and anxiety were performed simultaneously with locomotor activity measurements. Results: Withdrawal sings, such as jumping, wet dog shake, and weight loss; stereotypic, ambulatory, and vertical locomotor activity movements; central, peripheral, and total activities used in the assessment of anxiety in infant rats with naloxone-induced withdrawal syndrome that consumed oral MSG for 32 days were not different from the control group. Conclusion: These findings obtained in our study indicate that chronic consumption of oral MSG in infant rats whose blood-brain barrier has not yet developed does not affect morphine dependence and naloxone-induced withdrawal. Further studies are needed to investigate the mechanism of action of orally administered MSG.
长期口服谷氨酸钠对幼鼠纳洛酮诱导的吗啡戒断的影响
目的:探讨长期口服谷氨酸钠(MSG)对纳洛酮所致吗啡戒断综合征幼鼠戒断症状、运动活动和焦虑的影响。材料与方法:选用12只21日龄雄性Wistar大鼠。在32天的时间里,幼龄大鼠无限制地饮用生理盐水(对照组)或添加味精(味精组)的饮用水。吗啡依赖大鼠被纳洛酮诱导戒断。戒断症状和焦虑的评估与运动活动测量同时进行。结果:戒断症状,如跳跃、湿狗摇、体重减轻;刻板、移动和垂直运动活动运动;服用口服味精32天的纳洛酮戒断综合征幼鼠的焦虑评估中使用的中枢、外周和总活动与对照组没有差异。结论:本研究结果表明,在血脑屏障尚未发育成熟的幼鼠中,长期口服味精对吗啡依赖和纳洛酮诱导的戒断没有影响。口服味精的作用机制有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信