Comparison of Mean Platelet Volume, Platelet Distribution Width, Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio and Lymphocyte/Monocyte Ratio in Patients with Differentiated Thyroid Cancer According to TSH Levels

Abstract

Purpose: The standard treatment in differentiated thyroid cancer (DTC) is total thyroidectomy followed by lifelong levothyroxine (LT4) replacement. However, what should be the level of exogenous LT4 and TSH is still a matter of debate. Material and Method: 162 patients with a prospective diagnosis of non-metastatic DTC and 69 healthy volunteers were included. DTC patients were divided into 3 groups according to their TSH level. If TSH is less than 0.1μIU/mL, between 0.11-0.49 μIU/mL, 0.5-2μIU/mL, the groups were named as suppressed thyrotropin, moderately suppressed thyrotropin and low-normal thyrotropin group, respectively. Results: No statistical difference was observed between MPV, PDW, NLR, PLR, LMR when the DTC group and the healthy control group were compared. When the patients were divided into 3 groups according to their TSH levels, only PDW levels were found to be higher in the moderately suppressed group compared to the other groups (p