{"title":"妊娠甲状腺功能障碍患者人口学特征调查-埃格大学样本","authors":"M. Erdogan, G. Bayramova, Hatice Özişik, A. Suner","doi":"10.29058/mjwbs.1141211","DOIUrl":null,"url":null,"abstract":"Aim: Thyroid diseases can cause maternal and fetal adversities, and proper diagnosis, follow-up and \ntreatment during pregnancy requires special attention. In the evaluation of thyroid functions during \npregnancy, free thyroxine (FT4) is used primarily with thyroid-stimulating hormone (TSH). Our aim is to \ninvestigate the prevalence and the effects of thyroid dysfunction during pregnancy. \nMaterial and Methods: Our study is a prospective study including 960 pregnant women and spanning \nfrom November 2017 to May 2019 in Ege University Endocrinology outpatient clinic.100 pregnant \nwomen with thyroid dysfunction out of 960 pregnant women were included in the study. Maternal \nage, gestational trimester, family history of the thyroid disorder, TSH, FT4, free triiodothyronine (FT3), \nanti-thyroid peroxidase antibody (Anti-TPO), anti-thyroglobulin antibody (Anti-TG), thyrotropin (TSH) \nreceptor antibody (TRAb) were collected. The correlations between TSH, FT3 and FT4 were examined. \nResults: In the study, the mean age of pregnant patients was 29.33 ± 5.97. Anti-TPO was positive %18 and \nAnti-TG was positive (5%). 24 of 100 (24%) patients had nodules. 1 (8.3%) patient with hyperthyroidism \nwas positive for TRAb. Age differences in patients with or without nodule were not statistically significant. \n1 (1%) of the patient had Graves disease, 81 (81%) had subclinical hypothyroidism, 7 (7%) had clinical \nhypothyroidism, 11 (11%) had gestational thyrotoxicosis. The frequency of prematurity was determined \nin 7 patients (15.6%) by the data of 45 pregnant women who gave birth. \nConclusion: TSH levels in pregnant patients with positivity for anti-TPO and anti-TG were significantly \nhigher than pregnant patients with negativity for anti-TPO and anti-TG. In addition, the relationship \nbetween thyroid diseases and nodule frequency, autoimmunity, premature birth in pregnant women \nwere not detected. More comprehensive study series are needed.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigation on Demographic Characteristics of Pregnant Patients with Thyroid Dysfunction- Ege University Sample\",\"authors\":\"M. Erdogan, G. Bayramova, Hatice Özişik, A. Suner\",\"doi\":\"10.29058/mjwbs.1141211\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim: Thyroid diseases can cause maternal and fetal adversities, and proper diagnosis, follow-up and \\ntreatment during pregnancy requires special attention. In the evaluation of thyroid functions during \\npregnancy, free thyroxine (FT4) is used primarily with thyroid-stimulating hormone (TSH). Our aim is to \\ninvestigate the prevalence and the effects of thyroid dysfunction during pregnancy. \\nMaterial and Methods: Our study is a prospective study including 960 pregnant women and spanning \\nfrom November 2017 to May 2019 in Ege University Endocrinology outpatient clinic.100 pregnant \\nwomen with thyroid dysfunction out of 960 pregnant women were included in the study. Maternal \\nage, gestational trimester, family history of the thyroid disorder, TSH, FT4, free triiodothyronine (FT3), \\nanti-thyroid peroxidase antibody (Anti-TPO), anti-thyroglobulin antibody (Anti-TG), thyrotropin (TSH) \\nreceptor antibody (TRAb) were collected. The correlations between TSH, FT3 and FT4 were examined. \\nResults: In the study, the mean age of pregnant patients was 29.33 ± 5.97. Anti-TPO was positive %18 and \\nAnti-TG was positive (5%). 24 of 100 (24%) patients had nodules. 1 (8.3%) patient with hyperthyroidism \\nwas positive for TRAb. Age differences in patients with or without nodule were not statistically significant. \\n1 (1%) of the patient had Graves disease, 81 (81%) had subclinical hypothyroidism, 7 (7%) had clinical \\nhypothyroidism, 11 (11%) had gestational thyrotoxicosis. The frequency of prematurity was determined \\nin 7 patients (15.6%) by the data of 45 pregnant women who gave birth. \\nConclusion: TSH levels in pregnant patients with positivity for anti-TPO and anti-TG were significantly \\nhigher than pregnant patients with negativity for anti-TPO and anti-TG. In addition, the relationship \\nbetween thyroid diseases and nodule frequency, autoimmunity, premature birth in pregnant women \\nwere not detected. More comprehensive study series are needed.\",\"PeriodicalId\":309460,\"journal\":{\"name\":\"Medical Journal of Western Black Sea\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical Journal of Western Black Sea\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29058/mjwbs.1141211\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Journal of Western Black Sea","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29058/mjwbs.1141211","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Investigation on Demographic Characteristics of Pregnant Patients with Thyroid Dysfunction- Ege University Sample
Aim: Thyroid diseases can cause maternal and fetal adversities, and proper diagnosis, follow-up and
treatment during pregnancy requires special attention. In the evaluation of thyroid functions during
pregnancy, free thyroxine (FT4) is used primarily with thyroid-stimulating hormone (TSH). Our aim is to
investigate the prevalence and the effects of thyroid dysfunction during pregnancy.
Material and Methods: Our study is a prospective study including 960 pregnant women and spanning
from November 2017 to May 2019 in Ege University Endocrinology outpatient clinic.100 pregnant
women with thyroid dysfunction out of 960 pregnant women were included in the study. Maternal
age, gestational trimester, family history of the thyroid disorder, TSH, FT4, free triiodothyronine (FT3),
anti-thyroid peroxidase antibody (Anti-TPO), anti-thyroglobulin antibody (Anti-TG), thyrotropin (TSH)
receptor antibody (TRAb) were collected. The correlations between TSH, FT3 and FT4 were examined.
Results: In the study, the mean age of pregnant patients was 29.33 ± 5.97. Anti-TPO was positive %18 and
Anti-TG was positive (5%). 24 of 100 (24%) patients had nodules. 1 (8.3%) patient with hyperthyroidism
was positive for TRAb. Age differences in patients with or without nodule were not statistically significant.
1 (1%) of the patient had Graves disease, 81 (81%) had subclinical hypothyroidism, 7 (7%) had clinical
hypothyroidism, 11 (11%) had gestational thyrotoxicosis. The frequency of prematurity was determined
in 7 patients (15.6%) by the data of 45 pregnant women who gave birth.
Conclusion: TSH levels in pregnant patients with positivity for anti-TPO and anti-TG were significantly
higher than pregnant patients with negativity for anti-TPO and anti-TG. In addition, the relationship
between thyroid diseases and nodule frequency, autoimmunity, premature birth in pregnant women
were not detected. More comprehensive study series are needed.