Investigation on Demographic Characteristics of Pregnant Patients with Thyroid Dysfunction- Ege University Sample

Medical Journal of Western Black Sea Pub Date : 2022-12-27 DOI:10.29058/mjwbs.1141211

M. Erdogan, G. Bayramova, Hatice Özişik, A. Suner

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Abstract

Aim: Thyroid diseases can cause maternal and fetal adversities, and proper diagnosis, follow-up and treatment during pregnancy requires special attention. In the evaluation of thyroid functions during pregnancy, free thyroxine (FT4) is used primarily with thyroid-stimulating hormone (TSH). Our aim is to investigate the prevalence and the effects of thyroid dysfunction during pregnancy. Material and Methods: Our study is a prospective study including 960 pregnant women and spanning from November 2017 to May 2019 in Ege University Endocrinology outpatient clinic.100 pregnant women with thyroid dysfunction out of 960 pregnant women were included in the study. Maternal age, gestational trimester, family history of the thyroid disorder, TSH, FT4, free triiodothyronine (FT3), anti-thyroid peroxidase antibody (Anti-TPO), anti-thyroglobulin antibody (Anti-TG), thyrotropin (TSH) receptor antibody (TRAb) were collected. The correlations between TSH, FT3 and FT4 were examined. Results: In the study, the mean age of pregnant patients was 29.33 ± 5.97. Anti-TPO was positive %18 and Anti-TG was positive (5%). 24 of 100 (24%) patients had nodules. 1 (8.3%) patient with hyperthyroidism was positive for TRAb. Age differences in patients with or without nodule were not statistically significant. 1 (1%) of the patient had Graves disease, 81 (81%) had subclinical hypothyroidism, 7 (7%) had clinical hypothyroidism, 11 (11%) had gestational thyrotoxicosis. The frequency of prematurity was determined in 7 patients (15.6%) by the data of 45 pregnant women who gave birth. Conclusion: TSH levels in pregnant patients with positivity for anti-TPO and anti-TG were significantly higher than pregnant patients with negativity for anti-TPO and anti-TG. In addition, the relationship between thyroid diseases and nodule frequency, autoimmunity, premature birth in pregnant women were not detected. More comprehensive study series are needed.

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妊娠甲状腺功能障碍患者人口学特征调查-埃格大学样本

目的:甲状腺疾病可引起母体和胎儿的不良反应，怀孕期间的正确诊断、随访和治疗需要特别注意。在评估妊娠期间甲状腺功能时，游离甲状腺素(FT4)主要与促甲状腺激素(TSH)一起使用。我们的目的是调查妊娠期间甲状腺功能障碍的患病率和影响。材料与方法:我们的研究是一项前瞻性研究，包括960名孕妇，时间为2017年11月至2019年5月，在Ege大学内分泌门诊。960名孕妇中有100名患有甲状腺功能障碍的孕妇参与了这项研究。采集产妇年龄、妊娠三个月、甲状腺疾病家族史、TSH、FT4、游离三碘甲状腺原氨酸(FT3)、抗甲状腺过氧化物酶抗体(Anti-TPO)、抗甲状腺球蛋白抗体(Anti-TG)、促甲状腺素(TSH)受体抗体(TRAb)。检测TSH、FT3和FT4之间的相关性。结果:本组孕妇平均年龄为29.33±5.97岁。抗tpo阳性(%18)，抗tg阳性(5%)。100例患者中有24例(24%)有结节。1例(8.3%)甲亢患者TRAb阳性。有无结节患者的年龄差异无统计学意义。其中格雷夫斯病1例(1%)，亚临床甲状腺功能减退81例(81%)，临床甲状腺功能减退7例(7%)，妊娠期甲状腺毒症11例(11%)。通过45例分娩孕妇的资料，确定了7例(15.6%)的早产频率。结论:抗tpo、抗tg阳性孕妇TSH水平明显高于抗tpo、抗tg阴性孕妇。此外，甲状腺疾病与孕妇结节频率、自身免疫、早产的关系未被发现。需要更全面的研究系列。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Medical Journal of Western Black Sea

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