Dyes and PigmentsPub Date : 2025-09-17DOI: 10.1016/j.dyepig.2025.113251
Yasumasa Kanekiyo, Risaki Sato, Emi Sakai
{"title":"Pattern changes in cotton fabrics functionalized with lactate-responsive polymers","authors":"Yasumasa Kanekiyo, Risaki Sato, Emi Sakai","doi":"10.1016/j.dyepig.2025.113251","DOIUrl":"10.1016/j.dyepig.2025.113251","url":null,"abstract":"<div><div>This study explored the responses of cotton fabrics functionalized with lactate-responsive and non-responsive polymers, focusing on color and pattern changes. Circular samples, conjugated with lactate-responsive polymers and stained with indigotrisulfonate, showed distinct color shifts from blue to colorless as lactate concentration increased. This effect was linked to dye release triggered by lactate binding to boronic acid groups in the polymer. In contrast, samples with non-responsive polymers displayed minimal color changes. RGB analysis of photographs revealed significant R-value shifts in lactate-responsive samples, suggesting potential for semi-quantitative lactate detection via simple measurements. Additionally, facial pattern samples visualized the lactate response, transforming a smiling face into a crying face with rising lactate levels. Similar results were observed with another anionic dye, Acid Red 18. These findings demonstrate the promise of designing wearable lactate sensors that enable easy, burden-free monitoring.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113251"},"PeriodicalIF":4.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dyes and PigmentsPub Date : 2025-09-17DOI: 10.1016/j.dyepig.2025.113255
Chengda Wu , Yahong Jin
{"title":"Cr3+-activated Ca2GdZrSnGa3O12 garnet phosphors: structural reconstruction and crystal-field engineered broadband near-infrared emitters for LD/LED-driven light sources","authors":"Chengda Wu , Yahong Jin","doi":"10.1016/j.dyepig.2025.113255","DOIUrl":"10.1016/j.dyepig.2025.113255","url":null,"abstract":"<div><div>Broadband near-infrared (NIR) phosphor-converted light sources (pc-LSs) are indispensable for emerging technologies that exploit the 700–1100 nm biological transparency window, yet their performance is critically limited by the scarcity of phosphors that simultaneously deliver red-shifted emission, high quantum efficiency, and thermal robustness. Here, we report a Cr<sup>3+</sup>-activated garnet Ca<sub>2</sub>GdZrSnGa<sub>3</sub>O<sub>12</sub> engineered by Ca–Zr/Sn cooperative substitution and M<sup>5+</sup> charge compensation. The incorporation of Cr<sup>3+</sup> into host lattice with a weak-field octahedral environment produces broadband NIR emission (<sup>4</sup>T<sub>2</sub> → <sup>4</sup>A<sub>2</sub>) centered at 801 nm with bandwidth of 168 nm under 466 nm excitation. M<sup>5+</sup> cations codoping suppresses non-radiative pathways, elevating IQE to 51.58 % and retaining 81.58 % of the room-temperature intensity at 423 K. A low Huang-Rhys factor (<em>S</em> = 0.94) and enlarged activation energy (<em>E</em><sub><em>a</em></sub> = 0.25 eV) corroborate the suppressed electron–phonon coupling. Prototype phosphor-converted laser diode (pc-LD) and light-emitting diode (pc-LED) packages deliver optical output powers up to 381.2 mW@1500 mW mm<sup>−2</sup> and 51.2 mW@300 mA with photoelectric conversion efficiencies approaching 25.4 % and 4.48 %, respectively. These findings provide a materials-by-design route that reconciles the long-standing trade-off between spectral red-shift, quantum efficiency, and thermal robustness in Cr<sup>3+</sup>-activated NIR systems, and constitute a decisive advance toward compact, high-power NIR light engines for next-generation photonic applications.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113255"},"PeriodicalIF":4.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dyes and PigmentsPub Date : 2025-09-17DOI: 10.1016/j.dyepig.2025.113253
Fen Wang , Shibo Chen , Jiaming Liu , Qingqing Han , Xiongwei Ma , Zhuang He , Juan Yu , Xiaohong Cheng
{"title":"Bent-core hexacatenar liquid crystals with diphenylmethane or benzophenone core and salicylaldimine arms: Self-assembly and dual-modality fluorescence probe","authors":"Fen Wang , Shibo Chen , Jiaming Liu , Qingqing Han , Xiongwei Ma , Zhuang He , Juan Yu , Xiaohong Cheng","doi":"10.1016/j.dyepig.2025.113253","DOIUrl":"10.1016/j.dyepig.2025.113253","url":null,"abstract":"<div><div>This study investigates two novel bent-core salicylaldimine hexacatenar liquid crystals, <strong>SDM</strong> and <strong>SBP</strong>, focusing on their self-assembly modes and multifunctionality, which are modulated through the structural differentiation of their central cores. The diphenylmethane core in <strong>SDM</strong> enables the formation of a rectangular columnar phase (Col<sub>rec</sub>/<em>p</em>2<em>mm</em>) through tilted stacking of dimer formed by two molecules, while <strong>SBP</strong> with a benzophenone core, forms a highly symmetric square columnar phase (Col<sub>squ</sub>/<em>p</em>4<em>mm</em>) with a broader liquid crystal phase range and enhanced thermal stability due to the strong polarity and dipole-dipole interactions between molecules. Moreover, <strong>SDM</strong> and <strong>SBP</strong> can form organogels in <em>N</em>, <em>N</em>-dimethylformamide (DMF) and <em>n</em>-hexane, respectively. Photophysical investigations reveal that both compounds exhibit characteristics of excited state intramolecular proton transfer (ESIPT), significant Stokes shifts, and aggregation-induced emission (AIE) effects. Furthermore, <strong>SDM</strong> can serve as a dual-channel fluorescent probe that enables and simultaneous recognition of Cu<sup>2+</sup> and Zn<sup>2+</sup> to achieve an “on-off” dual-modality response, overcoming the limitations of traditional Schiff base-based single-ion probes.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113253"},"PeriodicalIF":4.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dyes and PigmentsPub Date : 2025-09-17DOI: 10.1016/j.dyepig.2025.113240
Juan Tricas-Ranchal, Antonio Molina, Ana Sanchez-Cano, Elvira Orduna-Hospital, Justiniano Aporta
{"title":"A physically grounded model for predicting subtractive colour mixing: towards a perception-independent framework","authors":"Juan Tricas-Ranchal, Antonio Molina, Ana Sanchez-Cano, Elvira Orduna-Hospital, Justiniano Aporta","doi":"10.1016/j.dyepig.2025.113240","DOIUrl":"10.1016/j.dyepig.2025.113240","url":null,"abstract":"<div><div>This work develops a physically grounded model for predicting pigment mixture colours that operates independently of visual perception. The central objective is to identify intrinsic, measurable parameters that enable accurate and linear predictions of colour outcomes, validated through a dataset of 8421 manually prepared samples, including 43 base pigments and their binary mixtures, both inter-pigment and pigment-white.</div><div>To achieve this, three interconnected goals are pursued. First, the construction of a high-resolution reflectance database, <span><math><mrow><mi>ρ</mi><mrow><mo>(</mo><mi>λ</mi><mo>)</mo></mrow></mrow></math></span>, and the generation of a corresponding set of colour coordinates using newly defined physical parameters. Second, the formulation of a novel, perception-independent colour space, termed the General Sample Plane (GSP), in which each pigment sample <em>G</em> is uniquely represented by the triplet <span><math><mrow><mo>(</mo><mrow><mi>G</mi><mo>,</mo><msub><mi>M</mi><mi>x</mi></msub><mrow><mo>(</mo><mi>G</mi><mo>)</mo></mrow><mo>,</mo><msub><mi>M</mi><mi>y</mi></msub><mrow><mo>(</mo><mi>G</mi><mo>)</mo></mrow></mrow><mo>)</mo></mrow></math></span>. This framework is further extended into three dimensions as the General Sample Volume (GSV). Unlike conventional perceptual models, the GSP and GSV are constructed from optical properties alone, with no reliance on observer-based colour metrics. Third, the predictive validity of this coordinate system is evaluated by analysing the linearity of trajectories traced by pigment mixtures and their respective whitening stages in the GSP. The results confirm that mixtures of two components, both pigment-pigment and pigment-white, describe highly linear paths in this space (reaching R<sup>2</sup> > 0.99), with minimal chromatic distortion even across broad spectral domains. Additionally, quantitative evaluation of interpolation accuracy, based on excluded intermediate mixtures, showed low ΔE values (ΔE ≤ 1.0) in the GSP space, where ΔE represents the Euclidean distance between predicted and measured coordinates, confirming the model's reliable predictive performance. The model offers a scalable, quantitative basis for physically consistent colour prediction in subtractive systems, with potential applications in pigment formulation, digital calibration, and optical modelling of coloured materials.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113240"},"PeriodicalIF":4.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dyes and PigmentsPub Date : 2025-09-16DOI: 10.1016/j.dyepig.2025.113249
Weiwei Yu , Peng Ji , Guangnan Xing , Lingxiao Xiong , Zhiguang Song , Guodong Feng
{"title":"A dual-modality fluorescent probe for peroxynitrite based on TICT-AIE synergy: Environmental responsiveness and biological imaging","authors":"Weiwei Yu , Peng Ji , Guangnan Xing , Lingxiao Xiong , Zhiguang Song , Guodong Feng","doi":"10.1016/j.dyepig.2025.113249","DOIUrl":"10.1016/j.dyepig.2025.113249","url":null,"abstract":"<div><div>Peroxynitrite (ONOO<sup>−</sup>) is a highly reactive nitrogen species implicated in diverse physiological and pathological processes, yet its transient nature poses significant challenges for real-time monitoring. Herein, we report a novel environment-adaptive fluorescent probe, TBN-BPE, that exhibits dual-mode fluorescence response to ONOO<sup>−</sup> based on the interplay between twisted intramolecular charge transfer (TICT) and aggregation-induced emission (AIE) mechanisms. Structurally, TBN-BPE integrates a triphenylamine donor, a benzothiazole acceptor, and a boronate ester recognition unit, enabling selective cyclization upon ONOO<sup>−</sup> exposure. In DMSO-rich media, ONOO<sup>−</sup> treatment induces a “turn-on” fluorescence response via TICT suppression and enhanced radiative decay. In contrast, under water-rich conditions, ONOO<sup>−</sup> promotes aggregation and π–π stacking, resulting in fluorescence quenching and a hypsochromic shift. The probe exhibits high selectivity for ONOO<sup>−</sup> over competing reactive species, with detection limits of 71 nM and 77 nM under water-poor and water-rich conditions, respectively. Practical utility is demonstrated through quantitative detection in spiked human saliva samples and dual-channel fluorescence imaging of exogenous and endogenous ONOO<sup>−</sup> in A549 cells. This work introduces a versatile probe design strategy for responsive and context-aware imaging of reactive nitrogen species in complex biological environments.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113249"},"PeriodicalIF":4.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dyes and PigmentsPub Date : 2025-09-16DOI: 10.1016/j.dyepig.2025.113247
Jia-Ming Jin , Chengxiang Shi , Xiao-Long Liu , Longjiang Xing , Ji-Hua Tan , Sheng Hu , Xiaofeng Tan , Wen-Cheng Chen , Yanping Huo
{"title":"Donor-acceptor steric shielding of multi-resonance emitters for suppressed exciton quenching","authors":"Jia-Ming Jin , Chengxiang Shi , Xiao-Long Liu , Longjiang Xing , Ji-Hua Tan , Sheng Hu , Xiaofeng Tan , Wen-Cheng Chen , Yanping Huo","doi":"10.1016/j.dyepig.2025.113247","DOIUrl":"10.1016/j.dyepig.2025.113247","url":null,"abstract":"<div><div>We report a multi-resonance thermally activated delayed fluorescence emitter equipped with a donor–acceptor configured, sterically wrapped subunit. In the present work, TCZA-BNCz was successfully synthesized by introducing the Donor-Acceptor Steric Shielding moiety TCZA into the MR core BNCz. Due to the long-range charge transport characteristic of the D-A type TCZA group, the reverse intersystem crossing (RISC) is significantly enhanced. Moreover, the steric shielding effect leads to an inhibition of aggregation-caused quenching (ACQ). This enables the doped film to maintain a photoluminescence quantum yield (PLQY) of over 90 % even at a high doping concentration (15 wt.%), while achieving a <em>k</em><sub>RISC</sub> of 1.74 × 10<sup>5</sup> s<sup>−1</sup>. The strategy effectively inhibiting aggregation-caused quenching and facilitating efficient RISC process. The OLED devices achieve high external quantum efficiency of 27.9 % at 15 wt.% doping concentration.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113247"},"PeriodicalIF":4.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dyes and PigmentsPub Date : 2025-09-16DOI: 10.1016/j.dyepig.2025.113245
Alexey A. Kalinin , Alexey A. Shustikov , Danil Petrov , Guzel M. Fazleeva , Anastasiya V. Sharipova , Adel I. Gaysin , Andrey E. Simanchuk , Alexey B. Dobrynin , Artemiy G. Shmelev , Olga B. Babaeva , Sirina M. Sharipova , Tatyana A. Vakhonina , Ayrat R. Khamatgalimov , Sergey L. Mikerin , Marina Yu Balakina
{"title":"Dipole fused (azinylmethylene)malononitrile-based chromophores with TBDPS group: increase of nonlinear optical performance of polymer films at high dopant content","authors":"Alexey A. Kalinin , Alexey A. Shustikov , Danil Petrov , Guzel M. Fazleeva , Anastasiya V. Sharipova , Adel I. Gaysin , Andrey E. Simanchuk , Alexey B. Dobrynin , Artemiy G. Shmelev , Olga B. Babaeva , Sirina M. Sharipova , Tatyana A. Vakhonina , Ayrat R. Khamatgalimov , Sergey L. Mikerin , Marina Yu Balakina","doi":"10.1016/j.dyepig.2025.113245","DOIUrl":"10.1016/j.dyepig.2025.113245","url":null,"abstract":"<div><div>Dipole azinylmethylenemalononitrile-based chromophores with various fused azine (quinoline, quinoxaline and pyrido[2,3-b]pyrazine) moieties and bulky TBDPS-ethyl group in aniline donor fragment have been synthesized. Nonlinear optical (NLO) activity of poled PMMA films doped with such dyes has been investigated by second harmonic generation technique with in two approaches. Composite materials exhibit the growth of NLO performance at increasing dyes load from 25 wt% to 35 wt%. Polymer films doped with quinoxalin(on)ylmethylenemalononitrile-based chromophores demonstrate enhanced values of NLO coefficients, d<sub>33</sub>, up to 85 p.m./V.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113245"},"PeriodicalIF":4.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dyes and PigmentsPub Date : 2025-09-16DOI: 10.1016/j.dyepig.2025.113243
Daniel Ziental , Mikolaj Czajkowski , Aleksandra Majchrzak-Celińska , Violetta Krajka-Kuźniak , Jolanta Długaszewska , Lukasz Sobotta
{"title":"Ultrasound responsive violacein loaded liposomes for sonodynamic therapy","authors":"Daniel Ziental , Mikolaj Czajkowski , Aleksandra Majchrzak-Celińska , Violetta Krajka-Kuźniak , Jolanta Długaszewska , Lukasz Sobotta","doi":"10.1016/j.dyepig.2025.113243","DOIUrl":"10.1016/j.dyepig.2025.113243","url":null,"abstract":"<div><div>Violacein is a bisindole compound with interesting anticancer and antimicrobial properties, but poor water solubility limiting its clinical application. The aim of this study was to evaluate the utility of free, and liposome-encapsulated violacein as a novel sonosensitizer for sonodynamic therapy (SDT) against melanoma cells and various strains of microorganisms. For this purpose, liposomes consisting of EggPC, cholesterol, and DOTAP were created. This approach enabled higher and more stable concentrations of violacein, enhancing its synergy with ultrasounds against melanoma cell lines MICH-2 (primary) and HTB-140 (metastatic). The combination of violacein and SDT resulted in a reduction of cell viability by over 90 %. A significant increase in oxidative stress was also observed in treated cells. In studies on a broad panel of microorganisms, the results were more variable, with activity strongly dependent on the specific strain. Notably, potent bactericidal and fungicidal effects were observed against <em>Vibrio vulnificus</em> and <em>Candida auris</em> in both planktonic and biofilm forms. Overall, our study provides evidence that violacein, and in particular liposomal form of this compound, when used in combination with ultrasounds, exerts strong anticancer and antimicrobial effects, which deserves further investigation.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113243"},"PeriodicalIF":4.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dyes and PigmentsPub Date : 2025-09-15DOI: 10.1016/j.dyepig.2025.113246
Xiaoyu Zhang , Zhengkuan Tan , Zhihong Gong , Chunmei Jian , Haichang Ding , Yuling Zeng , Congbin Fan , Gang Liu , Shouzhi Pu
{"title":"Visualizing hydrogen sulfide in food spoilage and live models: development of a near-infrared fluorescent probe for cellular and zebrafish imaging","authors":"Xiaoyu Zhang , Zhengkuan Tan , Zhihong Gong , Chunmei Jian , Haichang Ding , Yuling Zeng , Congbin Fan , Gang Liu , Shouzhi Pu","doi":"10.1016/j.dyepig.2025.113246","DOIUrl":"10.1016/j.dyepig.2025.113246","url":null,"abstract":"<div><div>Hydrogen sulfide (H<sub>2</sub>S) is a crucial signaling molecule in diverse physiological processes, meanwhile, it is a reliable indicator for monitoring food freshness. Herein, we developed a near-infrared (NIR) turn-on fluorescent probe (<strong>TPAY-HS</strong>) for highly effective detecting H<sub>2</sub>S. <strong>TPAY-HS</strong> was synthesized by connecting a twisted triphenylamine donor and a quinoline-based acceptor, with 2,4-dinitrosulfonyl (DNBS) as the H<sub>2</sub>S-responsive unit. In native state, DNBS quenched the fluorescence via photoinduced electron transfer (PET) mechanism. Upon recognition of H<sub>2</sub>S, DNBS was cleaved, resulting in the PET effect disappeared and activated an intramolecular charge transfer (ICT) process, thereby enabling the fluorescence \"turn-on\" response. Importantly, <strong>TPAY-HS</strong> can effectively monitor H<sub>2</sub>S production during food spoilage using a smartphone-based detection strip under UV light. Moreover, <strong>TPAY-HS</strong> has successfully imaged H<sub>2</sub>S in HeLa cells and zebrafish. These findings demonstrate that <strong>TPAY-HS</strong> can as a versatile tool with promising applications in food safety monitoring and biomedical research.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113246"},"PeriodicalIF":4.2,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dyes and PigmentsPub Date : 2025-09-13DOI: 10.1016/j.dyepig.2025.113242
Zehua Lu , Yuru Yao , Yunquan Zheng , Jianmin Yang , Xianai Shi , Chengqun Chen
{"title":"Photodynamic anticancer activity of Arthrospira phycocyanobilin enhanced by metal cobalt ion coordination","authors":"Zehua Lu , Yuru Yao , Yunquan Zheng , Jianmin Yang , Xianai Shi , Chengqun Chen","doi":"10.1016/j.dyepig.2025.113242","DOIUrl":"10.1016/j.dyepig.2025.113242","url":null,"abstract":"<div><div>Our previous research has demonstrated that <em>Arthrospira</em> phycocyanobilin (PCB) is a natural anticancer photosensitizer (PS) with a linear tetrapyrrole structure. Natural sources of PSs are harmless to the human body and exhibit relatively low cytotoxicity compared to clinical PSs. The challenge has always been to enhance their activity while maintaining their biocompatibility, which is crucial for the development of natural anticancer PSs. This study shows that the central coordination of transition metal ion Co<sup>2+</sup> in linear tetrapyrroles increases the quantum yield of reactive oxygen species (ROS) and improves the photodynamic anticancer activity of PCB following light exposure. The ROS quantum yield of Co-PCB is 0.5109, which is 2.45 times higher than that of PCB (0.1481). Co-PCB exhibited approximately 4.48 times the photodynamic anticancer activity of PCB on HeLa cells (IC<sub>50</sub>: 10.69 ± 0.50 μM vs. 47.91 ± 0.91 μM). Zn-phthalocyanine (ZnPc) is a representative second-generation PS. Co-PCB exhibits greater biosafety, while its anticancer therapeutic index is 55.14 % higher than that of ZnPc. Co-PCB has the potential to be used in photodynamic anticancer therapy. Furthermore, it could be used as a basis for developing and applying other natural linear tetrapyrrole compounds to improved their activity while maintaining biocompatibility.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113242"},"PeriodicalIF":4.2,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}