Highly stable Aza-BODIPY dyes for near-infrared-II PAI/FLI guided efficient tumor photothermal therapy

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2025-07-16 DOI:10.1016/j.dyepig.2025.113018

Yunjian Xu , Ke Xu , Zhen Wang , Yajie Zhang , Jia Chen , Menglong Zhao , Jianfeng Qiu

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Abstract

Fluorescence imaging (FLI) and photoacoustic imaging (PAI) in the near-infrared-II (NIR-II) window offer significant superiorities, including non-invasiveness and deep tissue penetration, which are beneficial for guiding highly efficient tumor photothermal therapy (PTT). Herein, utilizing photoinduced electron transfer (PET) and vibration relaxation effect, a NIR-II therapeutic agent based on aza-BODIPY dyes is rationally constructed by bonding diethylaminobenzene with strong electron supply capability, small spatial skeleton of conjugated aromatic rings, aza-BODIPY core, and triethylene glycol monomethyl ether (TGME). Aza NPs with enhanced loading rates is obtained for biological application by introducing TGME. Aza NPs with concentration-dependence linear NIR-II fluorescence and photoacoustic signals, excellent resistance to reactive oxygen nitrogen species exhibits a high photothermal conversion efficiency of 53.3 %. Finally, guided by the superior NIR-II FLI and PAI, HeLa tumors were effectively eliminated by the super photothermal conversion performance of Aza NPs. This work proposes that PET and vibration relaxation effect are very important theoretical guidance to construct aza-BODIPY-based NIR-II therapeutic agent for tumor PTT, which lays the foundation for the clinical application development of small-molecule organic nanomedicines. It also provides new ideas for the diagnosis and treatment of deep-located tumors through the NIR-II FLI & PAI guidance.

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高度稳定的Aza-BODIPY染料用于近红外ii PAI/FLI引导的高效肿瘤光热治疗

近红外- ii （NIR-II）窗口下的荧光成像（FLI）和光声成像（PAI）具有非侵入性、穿透组织深部等显著优势，有利于指导高效肿瘤光热治疗（PTT）。本研究利用光致电子转移（PET）和振动松弛效应，将电子供给能力强的二乙基氨基苯、共轭芳环的小空间骨架、aza-BODIPY核心与三甘醇单甲基醚（TGME）键合，合理构建了基于aza-BODIPY染料的NIR-II治疗剂。通过引入TGME，获得了具有增强负载率的Aza NPs，可用于生物应用。Aza NPs具有浓度依赖的线性NIR-II荧光和光声信号，对活性氧氮具有良好的抗性，光热转换效率高达53.3%。最后，在优越的NIR-II FLI和PAI的引导下，Aza NPs的超光热转化性能有效地消除了HeLa肿瘤。本研究提出PET和振动松弛效应是构建基于aza- bodipy的NIR-II肿瘤PTT治疗剂非常重要的理论指导，为小分子有机纳米药物的临床应用开发奠定基础。通过NIR-II FLI为深部肿瘤的诊断和治疗提供了新的思路。PAI指导。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.