Advanced Nanobiomed Research最新文献_第4页

Architected Microalgae-Based Matter via 3D Printing: Properties, Printing Techniques, and Applications 通过3D打印构建基于微藻的物质：属性，打印技术和应用

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-04-28 DOI: 10.1002/anbr.202500023

Yiwei Zou, Jiuhong Yi, Yunlu Dai, Iek Man Lei

{"title":"Architected Microalgae-Based Matter via 3D Printing: Properties, Printing Techniques, and Applications","authors":"Yiwei Zou, Jiuhong Yi, Yunlu Dai, Iek Man Lei","doi":"10.1002/anbr.202500023","DOIUrl":"10.1002/anbr.202500023","url":null,"abstract":"3D printing is a promising technology that enables the creation of intricate structures with tailorable properties, successfully transforming various fields, particularly in medical science, healthcare, and biomaterial technologies. Recent studies have recognized microalgae as sustainable, renewable, and cost-effective bioresources that can be utilized as bioinks for creating constructs with intriguing functionalities, such as oxygen-generating scaffolds for tissue engineering, engineered living materials, and bioremediation. This review discusses the properties and applications of microalgae, presents an overview of the current 3D printing technology, and provides a comprehensive review of the recent advancements in 3D-printed microalgae-based constructs for diverse applications. Finally, the challenges that must be overcome to ensure the widespread applicability of these materials are discussed. This review is expected to inspire future exploration of the innate properties and compositions of microalgae in developing materials with transformative potential in biomedical and biotechnological sectors.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 7","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Synovium-Based 3D Models in the Context of Human Disease and Inflammation 人类疾病和炎症背景下基于滑膜功能的3D模型

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-04-26 DOI: 10.1002/anbr.202500029

Amelia Heslington, Catharien M. U. Hilkens, Ana Marina Ferreira, Priscila Melo

{"title":"Functional Synovium-Based 3D Models in the Context of Human Disease and Inflammation","authors":"Amelia Heslington, Catharien M. U. Hilkens, Ana Marina Ferreira, Priscila Melo","doi":"10.1002/anbr.202500029","DOIUrl":"10.1002/anbr.202500029","url":null,"abstract":"The synovium plays a crucial role in joint function and is a primary site of pathology in inflammatory joint diseases, such as rheumatoid arthritis (RA). Immune-mediated inflammatory diseases (IMIDs), including RA, are becoming increasingly prevalent worldwide. However, the development of effective treatments remains hindered by the limitations of preclinical modeling techniques. Traditional methods, such as 2D in vitro monolayer cultures and animal models, often fail to replicate the complexity of human tissues. To address these challenges, tissue engineering (TE) and biofabrication strategies have emerged as promising alternatives. These approaches enable the creation of 3D in vitro models that better mimic physiological conditions. Techniques like 3D bioprinting allow researchers to replicate cellular interactions and the extracellular matrix, improving the accuracy of disease models. The application of 3D models in therapy development, drug screening, and personalized medicine has grown significantly. These platforms offer valuable insights into IMID pathophysiology by simulating relevant microenvironments. This review examines current synovium models used in IMID research and explores future directions in TE and 3D biofabrication. Additionally, the impact of inflammation on tissues and discuss the clinical potential of 3D disease models to address current disregarded aspects of coexistent diseases is highlighted.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 7","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing μ-X-Ray Fluorescence Spectroscopy as a Tool to Assess Extracellular Vesicle-Induced Biomineralization 利用μ- x射线荧光光谱作为评估细胞外囊泡诱导生物矿化的工具

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-04-24 DOI: 10.1002/anbr.202400184

Mathieu Y. Brunet, Adam McGuinness, Kenny Man, Marie-Christine Jones, Sophie C. Cox

{"title":"Harnessing μ-X-Ray Fluorescence Spectroscopy as a Tool to Assess Extracellular Vesicle-Induced Biomineralization","authors":"Mathieu Y. Brunet, Adam McGuinness, Kenny Man, Marie-Christine Jones, Sophie C. Cox","doi":"10.1002/anbr.202400184","DOIUrl":"10.1002/anbr.202400184","url":null,"abstract":"\u0000Bone cell-derived extracellular vesicles (EVs) have been increasingly investigated as novel acellular strategies for bone regeneration due to their pro-regenerative potency. The evaluation of such bone repair enhancement strategies commonly lies in the assessment of cell-mediated mineral deposition, associated with destructive and nonhigh-throughput methods. Herein, a robust methodology is presented to assess the osteogenic potential of an EV therapy using μ-X-ray fluorescence spectroscopy (μ-XRF). Mineralizing osteoblast-derived EVs (MO-EVs) are isolated from conditioned media via ultracentrifugation and comprehensively characterized. Their pro-osteogenic potency is validated via alkaline phosphatase activity, alizarin red, and picrosirius red staining for the evaluation of calcium and matrix deposition, respectively. μ-XRF is first employed to quantify calcium and phosphorous levels as markers of minerals generating 2D elemental maps of the cultures. The in-depth downstream analysis of the elemental maps reveals that MO-EVs modulate mineralization in a time- and concentration-dependent manner as MO-EV concentration from 5 μg mL−1 significantly increases mineral coverage and increases calcium/phosphate levels in mineralized phases. Together, these results demonstrate the potential of μ-XRF, allowing the examination of elemental levels, mineral coverage, and chemical phases in a single process and thus, offering a new platform for the therapeutic screening of osteogenic technologies with a resolution accommodating biological workflows.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 6","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Cancer Cell Membrane-Based Nanoparticles and Cancer Cell-Derived Small Extracellular Vesicles as Drug Delivery Platforms 基于癌细胞膜的纳米颗粒和癌细胞来源的细胞外小泡作为药物传递平台的最新进展

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-04-19 DOI: 10.1002/anbr.202500008

Wei Zhang, Jingjing Wang, Long Ngo, Li Li, Yuling Wang

{"title":"Recent Advances in Cancer Cell Membrane-Based Nanoparticles and Cancer Cell-Derived Small Extracellular Vesicles as Drug Delivery Platforms","authors":"Wei Zhang, Jingjing Wang, Long Ngo, Li Li, Yuling Wang","doi":"10.1002/anbr.202500008","DOIUrl":"10.1002/anbr.202500008","url":null,"abstract":"Advances in nanotechnology have paved the way for innovative drug delivery systems that enhance the effectiveness of cancer treatment. Cancer cell membrane-based nanoparticles (CCM-NPs) and cancer cell-derived small extracellular vesicles (CsEVs) are emerging as promising drug delivery systems for cancer treatment due to their inherent properties such as low immunogenicity and natural targeting capabilities to cancer cells. However, a comprehensive comparison of the advantages, disadvantages, and similarities of these two platforms is lacking. This review summarizes the natural, engineered, and hybrid forms of CCM-NPs and CsEVs-based drug delivery platforms with a focus on comparison of these two platforms, considering key aspects including preparation methods, drug encapsulation strategies, delivery pathways, immune evasion, targeting ability, and their potential for clinical applications. By understanding the strengths and weaknesses of each approach, the aim is to pave the way for next-generation nanoscale drug delivery platforms and contribute to the development of more effective and personalized cancer therapies.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 6","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

“Spin-Rinse and Repeat”: Facile Processing to Improve Cytocompatibility of Poly(3,4-Ethyelenedioxythiophene): Polystyrene Sulfonate Composites for Bioelectronics “旋转冲洗和重复”：简单的处理，以提高细胞相容性的聚（3,4-乙炔二氧噻吩）：聚苯乙烯磺酸复合材料的生物电子学

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-04-13 DOI: 10.1002/anbr.202400149

Joshua Killilea, Aaron Lee, Estelle A. Cuttaz, Giovanni Carlo Miceli, Leire L. Suquia, Josef A. Goding, Christopher A. R. Chapman, Rylie A. Green

{"title":"“Spin-Rinse and Repeat”: Facile Processing to Improve Cytocompatibility of Poly(3,4-Ethyelenedioxythiophene): Polystyrene Sulfonate Composites for Bioelectronics","authors":"Joshua Killilea, Aaron Lee, Estelle A. Cuttaz, Giovanni Carlo Miceli, Leire L. Suquia, Josef A. Goding, Christopher A. R. Chapman, Rylie A. Green","doi":"10.1002/anbr.202400149","DOIUrl":"10.1002/anbr.202400149","url":null,"abstract":"\u0000Conductive polymers, such as poly(3,4-ethyelenedioxythiophene):polystyrene sulfonate (PEDOT:PSS), offer exciting prospects in organic bioelectronic applications. Translation of commercially available formulations of PEDOT:PSS is hampered by leachable contaminants. Herein, a facile processing technique utilizing differences in polymer–solvent affinity and centrifugation of poor dispersions of PEDOT:PSS to remove leachable components is presented. 1H-nuclear magnetic resonance spectroscopy of the centrifugation supernatant identifies PSS as the most abundant impurity removed. To demonstrate versatility and applicability to bioelectronic applications, centrifuged PEDOT:PSS is blended with medical grade polyurethane. Bulk composite swelling and degradation are largely unaltered, and the electrochemical performance of the composite is not significantly compromised. Marked improvement in cytocompatibility is only observed in composites fabricated using centrifugation, indicating that soluble components such as PSS contribute significantly to cytotoxicity. Removal of excess PSS improves the ability of these polymer systems to act as drug delivery vehicles as evidenced by differences in chemotherapeutic efficacy of doxorubicin following electrophoretic release. It is demonstrated that excess PSS in commercial formulations can exert significant cytotoxicity, and its reduction can produce cytocompatible PEDOT:PSS materials for use across a wide spectrum of bioelectronic applications.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 5","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143925906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of the Micro-Ribonucleic Acid Profiles of Plant-Derived Extracellular Vesicles and their Potential Crosskingdom Regulation 植物源性细胞外囊泡微核糖核酸谱的鉴定及其潜在的交叉皮调控

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-03-30 DOI: 10.1002/anbr.202400193

Fei Wang, Junyao Deng, Shushan Mo, Jiacong Ai, Yingxian Xiao, Xiaohan Zhou, Zhenhua Li, Lanya Li

{"title":"Identification of the Micro-Ribonucleic Acid Profiles of Plant-Derived Extracellular Vesicles and their Potential Crosskingdom Regulation","authors":"Fei Wang, Junyao Deng, Shushan Mo, Jiacong Ai, Yingxian Xiao, Xiaohan Zhou, Zhenhua Li, Lanya Li","doi":"10.1002/anbr.202400193","DOIUrl":"10.1002/anbr.202400193","url":null,"abstract":"Plant-derived extracellular vesicles (pEVs) are nanosized vesicles that have comparable structure and properties to EVs derived from mammalian cells. Prior studies have confirmed that pEVs have remarkable efficacy in the treatment of human diseases, such as cancer. As critical regulators of gene expression, microRNAs (miRNAs) are abundant in pEVs. However, their potential functional roles and regulatory mechanisms in mediating crosskingdom regulation of mammalian cells by pEVs remain undefined. In particular, the similarities and differences in the miRNA profiles of various pEVs in gene regulation remain elusive. Herein, pEVs are isolated from grapefruit, ginger, lemon, and grape, and small RNA (sRNA) libraries are constructed to perform sRNA sequencing. Only 15 consistently expressed miRNAs are identified in these pEVs. Furthermore, the top 20 miRNAs of each pEV are highly expressed among total miRNAs, accounting for 79.93–87.12%. Through functional annotation analysis of the miRNA target genes, these miRNAs are found to be involved in regulating the progression of human cancer and viral infection. Taken together, this study demonstrates that the miRNAs contained in the pEVs play a critical role in mediating the potential crosskingdom regulatory effects against human genes and highlights their significant potential therapeutic applications in human diseases.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 5","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide-Doped Luminescence Nanothermometers 纳米医学应用路线图：掺杂镧系发光纳米温度计的纳米毒理学和体外指南

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-03-27 DOI: 10.1002/anbr.202500003

Simona Premcheska, Andre G. Skirtach, Anna M. Kaczmarek

引用次数: 0

Memory Effect of Bacteria-Killing Properties of Piezo-Catalysts Nanomaterials through Defect Engineering 基于缺陷工程的纳米压电催化剂杀菌性能记忆效应研究

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-03-27 DOI: 10.1002/anbr.202300144

Omid Amiri, Karzan A. Qurbani, Karukh A. Babakr, Peshang Kh. Omer, L. Jay Guo, Hastyar Hama Rashid Najmuldeen, Martin Bertau, Peshawa H. Mahmood, Sangar S. Ahmed, Mohammed A. Jamal

{"title":"Memory Effect of Bacteria-Killing Properties of Piezo-Catalysts Nanomaterials through Defect Engineering","authors":"Omid Amiri, Karzan A. Qurbani, Karukh A. Babakr, Peshang Kh. Omer, L. Jay Guo, Hastyar Hama Rashid Najmuldeen, Martin Bertau, Peshawa H. Mahmood, Sangar S. Ahmed, Mohammed A. Jamal","doi":"10.1002/anbr.202300144","DOIUrl":"10.1002/anbr.202300144","url":null,"abstract":"This study investigates the effects of piezo-catalysts on sterilizing surfaces. The memory effects in three piezo-catalysts, ZnO, CuO, and SiO2 are discovered, which are produced by a calcination process. After applying mechanical force to these materials, they retain an antibacterial effect for a period of days. With this discovery, it is possible to combat antibiotic-resistant bacteria by using piezo materials on hospital floors or operating rooms that can kill bacteria just by walking on them. The results show that ZnO, CuO, and SiO2 are capable of killing bacteria even after being subjected to mechanical force for 9 days. The memory effect duration can be influenced by a variety of factors, including the calcination temperature, the storage condition after ultrasonication, the drying temperature after ultrasonication, and the solvent in which the piezo-catalyst is ultrasonicated. When ZnO, CuO, and SiO2 are kept under a vacuum in a dark environment, the piezo effect remains almost constant for 11 days after sonication.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 7","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Induction of Cell Death by Combined Treatment with Photosensitizer-Chitosan Nanoparticles and the Ferroptosis Inducer RSL3 in Breast Cancer Cell Lines 光敏剂-壳聚糖纳米颗粒与铁下垂诱导剂RSL3联合作用诱导乳腺癌细胞死亡

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-03-23 DOI: 10.1002/anbr.202400208

Marek Feith, Saikat Das Sajib, Anne Grethe Myrann, Anders Høgset, Pablo Garrido, Alfredo Martinez, Erik Knutsen, Kirsten Sandvig, Tore Skotland, Gunhild Mari Mælandsmo, Tore-Geir Iversen

{"title":"Induction of Cell Death by Combined Treatment with Photosensitizer-Chitosan Nanoparticles and the Ferroptosis Inducer RSL3 in Breast Cancer Cell Lines","authors":"Marek Feith, Saikat Das Sajib, Anne Grethe Myrann, Anders Høgset, Pablo Garrido, Alfredo Martinez, Erik Knutsen, Kirsten Sandvig, Tore Skotland, Gunhild Mari Mælandsmo, Tore-Geir Iversen","doi":"10.1002/anbr.202400208","DOIUrl":"10.1002/anbr.202400208","url":null,"abstract":"\u0000Breast cancer, a prevalent malignancy worldwide, includes the triple-negative subtype (TNBC) characterized by poor treatment outcomes. TNBC has been shown to be sensitive to ferroptotic cell death, an iron-dependent cell death mechanism involving reactive oxygen species (ROS) and lipid peroxidation. Herein, biodegradable tetraphenylchlorin-conjugated chitosan nanoparticles (TPC-CS NPs) in combination with the free ferroptosis inducer RSL3 is used in MCF7 (hormone receptor-positive, epithelial) and MDA-MB-231 (hormone receptor-negative, mesenchymal-like) breast cancer cell lines. The results show that RSL3 treatment has no cytotoxic effect in MCF7 and there is no enhanced sensitivity when combined with TPC-CS NPs, while the combination sensitizes MDA-MB-231 cells. Western blot analysis reveals that the combined treatment decreases and differently affects GPX4 levels and the ratio between the two GPX isoforms in the two cell lines. In MDA-MB-231 cells, the combined treatment shows enhanced effects on lipid peroxidation, mitochondrial potential, and basal and maximal respiration, as compared to single treatments. Finally, ferroptosis expression signatures distinguish breast cancer cell lines with an increasing score in mesenchymal-like cells. Moreover, the signatures correlate with breast cancer subtypes, exhibiting the highest scores in subtypes rich in mesenchymal-like cells, particularly basal-like and claudin-low tumors, suggesting their susceptibility to ferroptosis induction.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 5","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrophilic Particles Exit While Hydrophobic Particles Persist Following In Vivo Biodegradation of Nanoparticle-Laden Polymeric Devices 携带纳米粒子的聚合物装置在体内生物降解后，亲水粒子退出，而疏水粒子继续存在

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-03-19 DOI: 10.1002/anbr.202500005

Kendell M. Pawelec, Jeremy M. L. Hix, Matti Kiupel, Peter J. Bonitatibus Jr., Erik M. Shapiro

{"title":"Hydrophilic Particles Exit While Hydrophobic Particles Persist Following In Vivo Biodegradation of Nanoparticle-Laden Polymeric Devices","authors":"Kendell M. Pawelec, Jeremy M. L. Hix, Matti Kiupel, Peter J. Bonitatibus Jr., Erik M. Shapiro","doi":"10.1002/anbr.202500005","DOIUrl":"10.1002/anbr.202500005","url":null,"abstract":"\u0000Longitudinally monitoring biomedical devices postimplantation can improve patient outcomes by allowing targeted intervention during healing. Most polymeric devices are not visible via biomedical imaging technologies. Incorporation of nanoparticle contrast agents into polymer matrices creates imageable devices, but understanding and controlling nanoparticle clearance from the implant site after polymer degradation is needed for clinical translation. To achieve homogeneous distribution throughout biomedical devices, nanoparticle surface chemistry, particularly hydrophobicity, is often manipulated to generate stable suspensions during manufacture. As nanoparticle surface chemistry is a key parameter determining blood circulation, the effects of nanoparticle hydrophilicity on tissue clearance of nanoparticles from implant sites following polymeric device degradation are investigated. Hydrophilic and hydrophobic radiopaque tantalum oxide (TaOx) nanoparticles are incorporated at 10 wt% tantalum into gelatin phantoms. In vitro, the diffusion coefficient of released hydrophilic nanoparticles after phantom degradation is significantly greater than hydrophobic nanoparticles, 1.29 ± 0.26 × 10−5 and 0.40 ± 0.16 × 10−5 cm2 s−1, respectively. After subcutaneous implantation in mouse and subsequent phantom degradation, hydrophilic nanoparticles clear skin and muscle tissue within 24 h, whereas hydrophobic nanoparticles remained at the implant site >14 days without change in radiopacity. This clearly demonstrates that nanoparticle surface chemistry must be balanced for initial device manufacturing and final excretion.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 6","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0