Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide-Doped Luminescence Nanothermometers

IF 4.4 Q2 ENGINEERING, BIOMEDICAL

Advanced Nanobiomed Research Pub Date : 2025-03-27 DOI:10.1002/anbr.202500003

Simona Premcheska, Andre G. Skirtach, Anna M. Kaczmarek

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Abstract

Lanthanide-based luminescence nanothermometry has demonstrated unprecedented advantages in the development of nanotheranostic platforms for potential medical applications, yet despite exponential research progress and great enthusiasm across various related disciplines, a swift bench-to-bedside translation seems to be still out of reach. This is predominantly related to fundamental research issues at the preclinical stage, such as complex nanomaterials design, incomplete optimization, fragmented characterization, and insufficient validation of nanothermometer performance in physiological environments. The main impediments currently are important biophysicochemical issues that must be addressed comprehensively, first and foremost in available in vitro systems, before going on to in vivo investigations. This review outlines a critical perspective, as well as a route of suggestions and underexplored aspects to address and significantly minimize the existing translational gap.

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纳米医学应用路线图：掺杂镧系发光纳米温度计的纳米毒理学和体外指南

基于镧系元素的发光纳米热测量在纳米治疗平台的发展中显示出了前所未有的优势，这些平台具有潜在的医疗应用，然而，尽管各种相关学科的研究取得了指数级的进展和巨大的热情，但从实验室到病床的快速转化似乎仍然遥不可及。这主要与临床前阶段的基础研究问题有关，例如复杂的纳米材料设计，不完整的优化，碎片化的表征，以及在生理环境中纳米温度计性能的不充分验证。目前的主要障碍是重要的生物物理化学问题，在进行体内研究之前，必须首先在体外系统中全面解决这些问题。这篇综述概述了一个批判性的观点，以及解决和显著减少现有翻译差距的建议和未被探索的方面。

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来源期刊

Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-

CiteScore

5.00

自引率

5.90%

发文量

审稿时长

21 weeks

期刊介绍： Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.