Small Science最新文献_第8页

Binding of Perfluoroalkyl Substances to Nanoplastic Protein Corona Is pH-Dependent and Attenuates Their Bioavailability and Toxicity. 全氟烷基物质与纳米塑料蛋白电晕的结合是ph依赖性的，并降低了它们的生物利用度和毒性。

IF 11.1

Small Science Pub Date : 2024-09-23 eCollection Date: 2024-12-01 DOI: 10.1002/smsc.202400255

Zongshan Zhao, Jiaqiang Yao, Haimei Li, Jing Lan, Yan Bao, Lining Zhao, Wansong Zong, Yanmin Long, Lei Feng, Henner Hollert, Xingchen Zhao

{"title":"Binding of Perfluoroalkyl Substances to Nanoplastic Protein Corona Is pH-Dependent and Attenuates Their Bioavailability and Toxicity.","authors":"Zongshan Zhao, Jiaqiang Yao, Haimei Li, Jing Lan, Yan Bao, Lining Zhao, Wansong Zong, Yanmin Long, Lei Feng, Henner Hollert, Xingchen Zhao","doi":"10.1002/smsc.202400255","DOIUrl":"https://doi.org/10.1002/smsc.202400255","url":null,"abstract":"There is a severe lack of understanding of the effects of micro/nanoplastics on human proteins and cells, especially in the presence of organic pollutants. Herein, both in vivo and in vitro assays are conducted to structurally evaluate blood protein complexed with perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) as well as their coronas formed on polystyrene nanoplastics (PNs). PFOS is bound to serum albumin (SA) about 4 times as firmly as PFOA, which is not influenced by protein corona formation onto PN surfaces. However, the small molecular binding dramatically suppresses SA-PN aggregation. Low pH weakens the protein interaction of PFOS while not PFOA, which is also independent of PN adsorption, but the interaction with SA is still stronger for PFOS than PFOA, indicating higher serum persistence and risks. The presence of PN suppresses the cellular uptake of the chemicals and attenuates cytotoxicity due to low bioavailability. Overall, these results provide fundamental information on the ternary interaction mode of protein, particle, and organic pollutants in physiological environments with varying pH, as well as the subsequent cellular responses.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"4 12","pages":"2400255"},"PeriodicalIF":11.1,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functionalized Amyloid-Like Protein Nanofilm-Mediated Synergistic Disulfidptosis and Photodynamic Therapy for Preventing Postoperative Recurrence of Colorectal Cancer. 功能化淀粉样蛋白纳米膜介导的协同双下垂和光动力治疗预防结直肠癌术后复发。

IF 11.1

Small Science Pub Date : 2024-09-23 eCollection Date: 2024-11-01 DOI: 10.1002/smsc.202400323

Man Zhang, Ke Li, Junhao Kou, Guozhi Lu, Ling Qiu, Chunzhao Yang, Yongchun Liu, Qi Xue, Peng Yang

{"title":"Functionalized Amyloid-Like Protein Nanofilm-Mediated Synergistic Disulfidptosis and Photodynamic Therapy for Preventing Postoperative Recurrence of Colorectal Cancer.","authors":"Man Zhang, Ke Li, Junhao Kou, Guozhi Lu, Ling Qiu, Chunzhao Yang, Yongchun Liu, Qi Xue, Peng Yang","doi":"10.1002/smsc.202400323","DOIUrl":"https://doi.org/10.1002/smsc.202400323","url":null,"abstract":"Colorectal cancer (CRC) has a postoperative recurrence rate of up to 50%. Local treatment at the surgical site offers a new strategy to prevent recurrence, minimizing systemic side effects. However, these treatments often face issues like poor stability, insufficient targeting, and significant local side effects. Research shows glucose starvation can induce disulfidptosis, a novel cell death pathway, in CRC cells, suitable for precise intervention in residual tumor cells postsurgery. This study develops a biocompatible 2D therapeutic platform using amyloid-like protein nanofilm technology for precise local synergistic intervention in disulfidptosis and photodynamic therapy (PDT) after CRC surgery. The nanofilm boasts excellent drug-loading capacity, enzyme activity retention, ultrathin dimensions, wet adhesion, and biocompatibility. A model simulating incomplete tumor resection post-CRC surgery shows that the GCI@nanofilm effectively inhibits recurrence through an enzyme-catalyzed cascade reaction inducing disulfidptosis and synergizing with PDT. In summary, GCI@nanofilm overcomes multiple challenges in local postsurgical intervention, providing a foundation for precise and efficient treatment of residual tumors.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"4 11","pages":"2400323"},"PeriodicalIF":11.1,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Central Role of Oxo Clusters in Zirconium-Based Esterification Catalysis. 氧簇在锆基酯化催化中的核心作用。

IF 11.1

Small Science Pub Date : 2024-09-23 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400369

Jikson Pulparayil Mathew, Carlotta Seno, Mohit Jaiswal, Charlotte Simms, Nico Reichholf, Dietger Van den Eynden, Tatjana N Parac-Vogt, Jonathan De Roo

{"title":"The Central Role of Oxo Clusters in Zirconium-Based Esterification Catalysis.","authors":"Jikson Pulparayil Mathew, Carlotta Seno, Mohit Jaiswal, Charlotte Simms, Nico Reichholf, Dietger Van den Eynden, Tatjana N Parac-Vogt, Jonathan De Roo","doi":"10.1002/smsc.202400369","DOIUrl":"https://doi.org/10.1002/smsc.202400369","url":null,"abstract":"Oxo clusters are a unique link between oxide nanocrystals and Metal-Organic Frameworks (MOFs), representing the limit of downscaling each of the respective crystals. Herein, the superior catalytic activity of <math> <mrow> <mrow> <msub><mrow><mtext>Zr</mtext></mrow> <mrow><mn>12</mn></mrow> </msub> <msub><mi>O</mi> <mn>8</mn></msub> <msub><mrow><mo>(</mo> <mtext>OH</mtext> <mo>)</mo></mrow> <mn>8</mn></msub> <msub><mrow><mo>(</mo> <mtext>OOCR</mtext> <mo>)</mo></mrow> <mrow><mn>24</mn></mrow> </msub> </mrow> </mrow> </math> clusters, compared to zirconium MOF UiO-66 and <math> <mrow> <mrow> <msub><mrow><mtext>ZrO</mtext></mrow> <mn>2</mn></msub> </mrow> </mrow> </math> nanocrystals is shown. Focus is on esterification reactions given their general importance in consumer products and the challenge of converting large substrates. Oxo clusters have a higher surface-to-volume ratio than nanocrystals, rendering them more active. For large substrates, for example, oleic acid, MOF UiO-66 has negligible catalytic activity while clusters provide almost quantitative conversion, a fact we ascribe to limited diffusion of large substrates through the MOF pores. Clusters do not suffer from limited mass transfer and we also obtain high conversion in solvent-free reactions with sterically hindered alcohols (hexanol, 2-ethyl hexanol, benzyl alcohol, and neopentyl alcohol). The cluster catalyst can be recovered and shows identical activity when reused. The structural integrity of the cluster is confirmed using X-ray total scattering and pair distribution function analysis. Moreover, when homogeneous zirconium alkoxides are used as catalysts, the same oxo cluster is retrieved, showing that oxo clusters are the active catalytic species, even in previously assumed homogeneously catalyzed reactions.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 1","pages":"2400369"},"PeriodicalIF":11.1,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Boron-Doped Zinc Oxide Electron-Selective Contacts for Crystalline Silicon Solar Cells with Efficiency over 22.0. 效率超过22.0的晶体硅太阳能电池的掺硼氧化锌电子选择触点。

IF 11.1

Small Science Pub Date : 2024-09-22 eCollection Date: 2024-11-01 DOI: 10.1002/smsc.202400168

Zheng Li, Anzhi Xie, Qingxian Nong, Yiwei Sun, Haihuai Cai, Zhexi Chen, Jian He, Pingqi Gao

{"title":"Boron-Doped Zinc Oxide Electron-Selective Contacts for Crystalline Silicon Solar Cells with Efficiency over 22.0.","authors":"Zheng Li, Anzhi Xie, Qingxian Nong, Yiwei Sun, Haihuai Cai, Zhexi Chen, Jian He, Pingqi Gao","doi":"10.1002/smsc.202400168","DOIUrl":"https://doi.org/10.1002/smsc.202400168","url":null,"abstract":"The exploration of wide-bandgap metal compound films with excellent passivation and contact properties on crystalline silicon (c-Si) surface, as alternatives to traditional-doped Si thin films, holds significant promise for the future enhancement of c-Si solar cell efficiency. Herein, conductive boron-doped zinc oxide (ZnO:B) films are deposited by atomic layer deposition (ALD) process and investigated as electron-selective contacts, in combination with a thin SiO x passivating interlayer. This combination demonstrates a relative low contact resistivity of ≈2 mΩ cm2 and improved passivation quality. Further application of this SiO x /ZnO:B stack as a full-area electron-selective passivating contact in proof-of-concept n-type c-Si solar cells results in a satisfactory power conversion efficiency of over 22.0%. This electron-selective passivating contact structure, prepared via low-temperature, simplified, and the compositionally controlled ALD process, offers a promising pathway for the development of high-efficiency and low-cost c-Si solar cells.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"4 11","pages":"2400168"},"PeriodicalIF":11.1,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Organ Microphysiological Systems Targeting Specific Organs for Recapitulating Disease Phenotypes via Organ Crosstalk 针对特定器官的多器官微观生理系统，通过器官串联重现疾病表型

IF 12.7

Small Science Pub Date : 2024-09-19 DOI: 10.1002/smsc.202400314

Joeng Ju Kim, Mihyeon Bae, Dong-Woo Cho

{"title":"Multi-Organ Microphysiological Systems Targeting Specific Organs for Recapitulating Disease Phenotypes via Organ Crosstalk","authors":"Joeng Ju Kim, Mihyeon Bae, Dong-Woo Cho","doi":"10.1002/smsc.202400314","DOIUrl":"https://doi.org/10.1002/smsc.202400314","url":null,"abstract":"Various systemic metabolic diseases arise from prolonged crosstalk across multiple organs, triggering serious impairments in various physiological systems. These diseases are intricate systemic pathologies characterized by complex mechanisms and an unclear etiology, making the treatment challenging. Efforts have been made to develop in vitro models to understand these diseases and devise new treatments. However, there are limitations in reconstructing the causal relationships between diseases and interorgan crosstalk, including the tissue-specific microenvironment. Alternatively, multi-organ microphysiological systems (MOMPS) present new possibilities for capturing the complexity of systemic metabolic diseases by replicating human microphysiology and simulating diverse interorgan crosstalk. Controlled interactions and scalable representations of biological complexity in MOMPS offer a more accurate portrayal of organ interactions, enabling the identification of novel relationships between organ crosstalk, metabolism, and immunity. This, in turn, can yield valuable insights into disease mechanisms and drug development research and enhance the efficiency of preclinical studies. In this review, the examples and technical capabilities of MOMPS pathological modeling for various diseases are discussed, leveraging state-of-the-art biofabrication technology of MOMPS. It evaluates the current opportunities and challenges in this field.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"54 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultralow Lattice Thermal Conductivity of Zintl-Phase CaAgSb Induced by Interface and Superlattice Scattering 由界面和超晶格散射诱导的津特尔相 CaAgSb 的超低晶格导热率

IF 12.7

Small Science Pub Date : 2024-09-17 DOI: 10.1002/smsc.202400147

Wenhua Xue, Jie Chen, Honghao Yao, Jun Mao, Chen Chen, Yumei Wang, Qian Zhang

引用次数: 0

Transformative Impact of Nanocarrier-Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons 纳米载体介导的药物传输的变革性影响：克服生物障碍，拓展治疗领域

IF 12.7

Small Science Pub Date : 2024-09-17 DOI: 10.1002/smsc.202400280

Minhye Kim, Myeongyeon Shin, Yaping Zhao, Mrinmoy Ghosh, Young-Ok Son

{"title":"Transformative Impact of Nanocarrier-Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons","authors":"Minhye Kim, Myeongyeon Shin, Yaping Zhao, Mrinmoy Ghosh, Young-Ok Son","doi":"10.1002/smsc.202400280","DOIUrl":"https://doi.org/10.1002/smsc.202400280","url":null,"abstract":"Advancing therapeutic progress is centered on developing drug delivery systems (DDS) that control therapeutic molecule release, ensuring precise targeting and optimal concentrations. Targeted DDS enhances treatment efficacy and minimizes off-target effects, but struggles with drug degradation. Over the last three decades, nanopharmaceuticals have evolved from laboratory concepts into clinical products, highlighting the profound impact of nanotechnology in medicine. Despite advancements, the effective delivery of therapeutics remains challenging because of biological barriers. Nanocarriers offer a solution with a small size, high surface-to-volume ratios, and customizable properties. These systems address physiological and biological challenges, such as shear stress, protein adsorption, and quick clearance. They allow targeted delivery to specific tissues, improve treatment outcomes, and reduce adverse effects. Nanocarriers exhibit controlled release, decreased degradation, and enhanced efficacy. Their size facilitates cell membrane penetration and intracellular delivery. Surface modifications increase affinity for specific cell types, allowing precise treatment delivery. This study also elucidates the potential integration of artificial intelligence with nanoscience to innovate future nanocarrier systems.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"11 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory or Reparative? Tuning Macrophage Polarization Using Anodized Anisotropic Nanoporous Titanium Implant Surfaces 炎症还是修复？利用阳极氧化各向异性纳米多孔钛种植体表面调节巨噬细胞极化

IF 12.7

Small Science Pub Date : 2024-09-17 DOI: 10.1002/smsc.202400211

Ho-Jin Moon, Karan Gulati, Tao Li, Corey Stephen Moran, Sašo Ivanovski

{"title":"Inflammatory or Reparative? Tuning Macrophage Polarization Using Anodized Anisotropic Nanoporous Titanium Implant Surfaces","authors":"Ho-Jin Moon, Karan Gulati, Tao Li, Corey Stephen Moran, Sašo Ivanovski","doi":"10.1002/smsc.202400211","DOIUrl":"https://doi.org/10.1002/smsc.202400211","url":null,"abstract":"Modulating macrophage phenotype based on implant surface characteristics, including topography and chemistry, has been employed to enhance osseointegration and long-term functional outcomes for titanium (Ti)-based implants. An excessive and/or prolonged M1 macrophage response can lead to damaging immune-inflammatory reactions, negatively influencing the fate of the implant, and hence, modulating these responses via nanoscale implant surface modification is an emerging paradigm. Herein, an anodized titanium implant surface based on single-step electrochemical anodization, with preserved underlying microfeatures and superimposed nanopores (50 and 70 nm), compared with irregular rough and microrough (machined-like) surfaces, is investigated for its effect on the functions of primary macrophages in vitro. Significantly reduced macrophage proliferation and increased tissue-reparative M2 phenotype polarization are confirmed for the nanopores, which are more pronounced for 70 nm diameter. Moreover, osteoclastogenesis is reduced while osteogenic differentiation of osteoblasts is enhanced for the nanopores (higher for 70 nm pores). Advanced nanoengineered Ti implants can enhance titanium implant tissue integration by modulating the inflammatory response at the implant–cell interface.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"14 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible Phototransistors on Paper: Scalable Fabrication of PEDOT:PSS Devices Using a Pen Plotter 纸上柔性光电晶体管：使用笔式绘图仪大规模制造 PEDOT:PSS 器件

IF 12.7

Small Science Pub Date : 2024-09-16 DOI: 10.1002/smsc.202400063

Yigit Sozen, Gülsüm Ersu, Thomas Pucher, Jorge Quereda, Andres Castellanos-Gomez

{"title":"Flexible Phototransistors on Paper: Scalable Fabrication of PEDOT:PSS Devices Using a Pen Plotter","authors":"Yigit Sozen, Gülsüm Ersu, Thomas Pucher, Jorge Quereda, Andres Castellanos-Gomez","doi":"10.1002/smsc.202400063","DOIUrl":"https://doi.org/10.1002/smsc.202400063","url":null,"abstract":"Phototransistors are used in plenty of diverse applications such as optical communication systems, light sensors, imaging devices, and biomedical instruments for detecting and amplifying light signals. Herein, an approach for the large-scale production of low-cost and flexible phototransistors by integrating the inks of PEDOT:PSS, and graphite with paper, which serves as an ionic conductor material to gate the PEDOT:PSS channel, is proposed. The fabrication of the devices is carried out by sequentially depositing the PEDOT:PSS channel and graphite electrodes onto paper using a benchtop XY plotter. To characterize device-to-device variability, 200 devices are fabricated and their electrical and optical properties are statistically analyzed. By performing a detailed characterization on the optical properties under varying wavelength, power, and bias conditions, it is found that devices exhibit good photoresponse across a wide spectrum range. Moreover, devices maintain their photoactive characteristics even when subjected to high mechanical tensile strain, indicating the suitability of these paper-supported devices for flexible electronic applications. Time and photocurrent magnitude can be tuned via gate voltages applied through the graphite-based back-gate configuration.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"16 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tunneling Mechanisms of Quinones in Photosynthetic Reaction Center–Light Harvesting 1 Supercomplexes 光合作用反应中心-光收集 1 超级复合物中醌的隧道机制

IF 12.7

Small Science Pub Date : 2024-09-15 DOI: 10.1002/smsc.202400188

Ruichao Mao, Jianping Guo, Lihua Bie, Lu-Ning Liu, Jun Gao

{"title":"Tunneling Mechanisms of Quinones in Photosynthetic Reaction Center–Light Harvesting 1 Supercomplexes","authors":"Ruichao Mao, Jianping Guo, Lihua Bie, Lu-Ning Liu, Jun Gao","doi":"10.1002/smsc.202400188","DOIUrl":"https://doi.org/10.1002/smsc.202400188","url":null,"abstract":"In photosynthesis, light energy is absorbed and transferred to the reaction center, ultimately leading to the reduction of quinone molecules through the electron transfer chain. The oxidation and reduction of quinones generate an electrochemical potential difference used for adenosine triphosphate synthesis. The trafficking of quinone/quinol molecules between electron transport components has been a long-standing question. Here, an atomic-level investigation into the molecular mechanism of quinol dissociation in the photosynthetic reaction center–light-harvesting complex 1 (RC–LH1) supercomplexes from Rhodopseudomonas palustris, using classical molecular dynamics (MD) simulations combined with self-random acceleration MD-MD simulations and umbrella sampling methods, is conducted. Results reveal a significant increase in the mobility of quinone molecules upon reduction within RC–LH1, which is accompanied by conformational modifications in the local protein environment. Quinol molecules have a tendency to escape from RC–LH1 in a tail-first mode, exhibiting channel selectivity, with distinct preferred dissociation pathways in the closed and open LH1 rings. Furthermore, comparative analysis of free energy profiles indicates that alternations in the protein environment accelerate the dissociation of quinol molecules through the open LH1 ring. In particular, aromatic amino acids form π-stacking interactions with the quinol headgroup, resembling the key components in a conveyor belt system. This study provides insights into the molecular mechanisms that govern quinone/quinol exchange in bacterial photosynthesis and lays the framework for tuning electron flow and energy conversion to improve metabolic performance.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"47 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0