Small Science最新文献_第10页

Investigating the Dynamics of a Soft Crystalline Covalent Organic Framework during Benzene and Cyclohexane Adsorption by in situ Powder X-ray Diffraction. 用原位粉末x射线衍射研究软晶共价有机骨架在苯和环己烷吸附过程中的动力学。

IF 11.1

Small Science Pub Date : 2024-10-12 eCollection Date: 2024-12-01 DOI: 10.1002/smsc.202400277

Anna Mauri, Rebecca Vismara, Marco Moroni, Esther Roldán-Molina, Jorge A R Navarro, Simona Galli

{"title":"Investigating the Dynamics of a Soft Crystalline Covalent Organic Framework during Benzene and Cyclohexane Adsorption by in situ Powder X-ray Diffraction.","authors":"Anna Mauri, Rebecca Vismara, Marco Moroni, Esther Roldán-Molina, Jorge A R Navarro, Simona Galli","doi":"10.1002/smsc.202400277","DOIUrl":"https://doi.org/10.1002/smsc.202400277","url":null,"abstract":"Due to their similar boiling points, separation of benzene and cyclohexane mixtures is among the current challenging processes faced by the petrochemical industry. As recently assessed, the soft imine-based covalent organic framework [(TAM)(BDA)2] (COF-300; TAM = tetrakis(4-aminophenyl)methane, BDA = terephthaldehyde) possesses higher affinity for benzene than cyclohexane in both static conditions at 298 K and dynamic conditions in the range of 298-348 K. As shown in this contribution, in situ powder X-ray diffraction while dosing benzene and cyclohexane vapors in the range of 0.01-4.74 bar on the narrow-pore form of COF-300 confirmed the coherent switchability of its framework, unveiling the progressive formation of different intermediate- and large-pore forms. In addition, a basket of otherwise inaccessible key crystallochemical details-\"on/off\" structural-feature changes cooperating to adsorption, primary adsorption sites, and host-guest and guest-guest interactions-was successfully retrieved. Overall, these findings allowed to shed light on the framework dynamics underneath the previously observed selectivity toward benzene over cyclohexane, completing this case of study and providing relevant information for the design of new-generation adsorbents for this applicative context.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"4 12","pages":"2400277"},"PeriodicalIF":11.1,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasmonic Coupling for High-Sensitivity Detection of Low Molecular Weight Molecules. 等离子体耦合用于低分子量分子的高灵敏度检测。

IF 11.1

Small Science Pub Date : 2024-10-09 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400382

Alexa Guglielmelli, Rossella Zaffino, Giovanna Palermo, Liliana Valente, Dante Maria Aceti, Loredana Ricciardi, Arántzazu González-Campo, Raphael Pfattner, Núria Aliaga-Alcalde, Giuseppe Strangi

{"title":"Plasmonic Coupling for High-Sensitivity Detection of Low Molecular Weight Molecules.","authors":"Alexa Guglielmelli, Rossella Zaffino, Giovanna Palermo, Liliana Valente, Dante Maria Aceti, Loredana Ricciardi, Arántzazu González-Campo, Raphael Pfattner, Núria Aliaga-Alcalde, Giuseppe Strangi","doi":"10.1002/smsc.202400382","DOIUrl":"https://doi.org/10.1002/smsc.202400382","url":null,"abstract":"This article presents a novel plasmonic sensing platform designed for the detection of low molecular weight molecules, offering significant advancements in diagnostic applications. The platform features a periodic array of gold nanodisks on a 20 nm thin silica layer, supported by a 100 nm thick gold substrate. By leveraging the coupling between localized and propagating surface plasmon resonances, this design significantly enhances the sensitivity and specificity of molecular detection. Finite element method simulations are conducted to characterize the optical properties and reflectance response of the nanodisks array in the visible to near-infrared range. Ellipsometric analysis is performed to measure the reflectance of the sample at various angles. Additionally, scanning near-field optical microscopy in reflectance mode validates the design by revealing well-defined plasmonic hot spots and interference patterns consistent with the simulated results. The findings demonstrate the platform's effectiveness in amplifying optical signals, achieving a limit of detection of 50 μM for molecules with a molecular weight of less than 1 KDa. This high sensitivity and specificity highlight the potential of the proposed plasmonic platform to advance the development of highly sensitive sensors for low molecular weight molecules, making it a valuable tool for diagnostics and precise molecular detection.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 1","pages":"2400382"},"PeriodicalIF":11.1,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcoming the Blood-Brain Barrier: Multifunctional Nanomaterial-Based Strategies for Targeted Drug Delivery in Neurological Disorders. 克服血脑屏障：神经系统疾病靶向药物递送的多功能纳米材料策略。

IF 11.1

Small Science Pub Date : 2024-10-06 eCollection Date: 2024-12-01 DOI: 10.1002/smsc.202400232

Callan D McLoughlin, Sarah Nevins, Joshua B Stein, Mehrdad Khakbiz, Ki-Bum Lee

{"title":"Overcoming the Blood-Brain Barrier: Multifunctional Nanomaterial-Based Strategies for Targeted Drug Delivery in Neurological Disorders.","authors":"Callan D McLoughlin, Sarah Nevins, Joshua B Stein, Mehrdad Khakbiz, Ki-Bum Lee","doi":"10.1002/smsc.202400232","DOIUrl":"https://doi.org/10.1002/smsc.202400232","url":null,"abstract":"The development of effective therapies for neurological disorders is a growing area of research due to the increasing prevalence of these conditions. Some neurological disorders that are prevalent and remain difficult to treat are glioma, neurodegenerative disease, ischemic stroke, and traumatic brain injury. Subsequently, the therapeutic efficacy of small molecules, proteins, and oligonucleotides remains a challenge due to the presence of the blood-brain barrier (BBB), a highly selective semipermeable membrane. To this end, multifunctional nanomaterials have emerged as promising vehicles for targeted drug delivery to the brain, due to their ability to transport therapeutics across the BBB selectively. The design of advanced nanomaterial-based drug delivery systems capable of overcoming the BBB is influenced by many factors, such as fabrication technique and surface modification. This review explores the diverse range of nanomaterials, including polymer, lipid, gold, magnetic, and carbon-based nanostructures, capable of effectively passing the BBB. These materials cross the BBB via a variety of established transport mechanisms for targeted delivery of therapeutics to the brain. Moreover, the structure and function of the BBB are highlighted and the potential for nanotechnology to aid the treatment of neurological disorders based on their ability to undergo transcytosis into the brain is highlighted.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"4 12","pages":"2400232"},"PeriodicalIF":11.1,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid Metal Electrocatalyst with Ultralow Pt Loading for Ethanol Oxidation. 超低铂负载乙醇氧化用液态金属电催化剂。

IF 11.1

Small Science Pub Date : 2024-10-06 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400370

Muhammad Hamza Nazir, Tu C Le, Imtisal Zahid, Karma Zuraiqi, Mew P Aukarasereenont, Caiden J Parker, Pierre H A Vaillant, Fahad Jabbar, Chung Kim Nguyen, Mehmood Irfan, Mariam Ameen, Michelle J S Spencer, Andrew J Christofferson, Salvy P Russo, Ken Chiang, Nastaran Meftahi, Torben Daeneke, Dan Yang

{"title":"Liquid Metal Electrocatalyst with Ultralow Pt Loading for Ethanol Oxidation.","authors":"Muhammad Hamza Nazir, Tu C Le, Imtisal Zahid, Karma Zuraiqi, Mew P Aukarasereenont, Caiden J Parker, Pierre H A Vaillant, Fahad Jabbar, Chung Kim Nguyen, Mehmood Irfan, Mariam Ameen, Michelle J S Spencer, Andrew J Christofferson, Salvy P Russo, Ken Chiang, Nastaran Meftahi, Torben Daeneke, Dan Yang","doi":"10.1002/smsc.202400370","DOIUrl":"https://doi.org/10.1002/smsc.202400370","url":null,"abstract":"Developing efficient and durable electrocatalysts for ethanol electro-oxidation is crucial for enabling the application of direct ethanol fuel cell technology. Herein, it is demonstrated that Pt-Ga liquid metal-based nanodroplets can serve as an efficient electrocatalyst to drive ethanol oxidation. The mass activity of Pt is significantly improved by alloying with liquid gallium. Guided by machine learning neural networks, a low-concentration alkaline electrolyte is specifically formulated to allow electrodes with ultralow Pt loading to demonstrate remarkable activity toward ethanol oxidation with a mass activity as high as 13.47 A mg-1 Pt, which is more than 14 times higher than that of commercial Pt/C electrocatalysts (i.e., 0.76 A mg-1 Pt). Computational studies reveal that the superior activity is associated with the presence of Ga oxides adjacent to Pt on the catalyst surface which leads to energetically favorable pathways for the oxidation process. The findings reveal untapped opportunities in the realm of liquid metal catalysis and hold great promise for the future development of high-performance alcohol fuel cells.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 1","pages":"2400370"},"PeriodicalIF":11.1,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rational Doping Strategy to Build the First Solution-Processed p-n Homojunction Architecture toward Silicon Quantum Dot Photodetectors. 合理掺杂策略构建首个溶液处理p-n同质结结构的硅量子点光电探测器。

IF 11.1

Small Science Pub Date : 2024-10-06 eCollection Date: 2024-12-01 DOI: 10.1002/smsc.202400367

Batu Ghosh, Hiroyuki Yamada, Kazuhiro Nemoto, Wipakorn Jevasuwan, Naoki Fukata, Hon-Tao Sun, Naoto Shirahata

{"title":"Rational Doping Strategy to Build the First Solution-Processed p-n Homojunction Architecture toward Silicon Quantum Dot Photodetectors.","authors":"Batu Ghosh, Hiroyuki Yamada, Kazuhiro Nemoto, Wipakorn Jevasuwan, Naoki Fukata, Hon-Tao Sun, Naoto Shirahata","doi":"10.1002/smsc.202400367","DOIUrl":"https://doi.org/10.1002/smsc.202400367","url":null,"abstract":"Semiconductor p-n homojunction is a requisite building block of operating transistors and diodes which make up the modern electronic circuits and optoelectronic applications. However, it has been so far limited to bulk form of single crystals such as silicon (Si) or gallium arsenide. Herein, a brand-new method of constructing p-n homojunction architectures that breaks through the limitation is presented. Colloidal inks of p-type and n-type Si quantum dots (QDs) are synthesized by thermal disproportionation of (HSiO1.5) n doped with boron or phosphorus, followed by surface ligand engineering. Analysis combining UV photoelectron spectroscopy, electron spin resonance, and current-voltage characteristics confirms that an orthogonal solvent trick makes clean interfaces between n-type and p-type SiQD layers without disruption on film formation. The forward and reverse current-voltage characteristics of the diode, along with various spectroscopic characterizations, demonstrate the formation of the first p-n homojunction of SiQDs. The self-powered photodiode provides a tunable response specific to the wavelength.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"4 12","pages":"2400367"},"PeriodicalIF":11.1,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rigidity-Driven Structural Isomers in the NaCl-Ga₂S₃ System: Implications for Energy Storage. NaCl-Ga2S3体系中刚性驱动的结构异构体：对能量存储的影响。

IF 11.1

Small Science Pub Date : 2024-10-01 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400371

Maria Bokova, Mohammad Kassem, Takeshi Usuki, Andrey Tverjanovich, Anton Sokolov, Daniele Fontanari, Alex C Hannon, Chris J Benmore, Igor Alekseev, Shinji Kohara, Pascal Roussel, Maxim Khomenko, Koji Ohara, Yohei Onodera, Arnaud Cuisset, Eugene Bychkov

{"title":"Rigidity-Driven Structural Isomers in the NaCl-Ga2S3 System: Implications for Energy Storage.","authors":"Maria Bokova, Mohammad Kassem, Takeshi Usuki, Andrey Tverjanovich, Anton Sokolov, Daniele Fontanari, Alex C Hannon, Chris J Benmore, Igor Alekseev, Shinji Kohara, Pascal Roussel, Maxim Khomenko, Koji Ohara, Yohei Onodera, Arnaud Cuisset, Eugene Bychkov","doi":"10.1002/smsc.202400371","DOIUrl":"https://doi.org/10.1002/smsc.202400371","url":null,"abstract":"Alternative energy sources require the search for innovative materials with promising functionalities. Systems with unusual chemical properties represent an insufficiently explored domain, concealing unexpected features. Using diffraction and Raman spectroscopy over a wide temperature range, supported by first-principles simulations, a rare phenomenon is unveiled: phase-dependent chemical interactions between binary components in the NaCl-Ga2S3 system. In this unique occurrence, previously intact binary crystalline species transform upon melting into mixed liquid structural isomers, forming bonds with new partners. The chemical combinatorics appears to be fully reversible for stable crystals and liquids. Despite this, rapidly frozen glasses out of thermodynamic equilibrium remain in a metastable isomeric state, offering remarkable properties, particularly a high room-temperature Na+ conductivity, comparable to the best sodium halide superionic conductors and therefore encouraging for sodium solid-state batteries and energy applications. A rigidity paradigm is responsible for the observed phenomenon, as the extremely constrained Ga2S3 crystal lattice does not survive viscous flow, breaking up at a short-range level. The removal of rigidity constraints and dense packing leads to a significant increase in empty space, which is the origin of high sodium diffusivity. Broadly, the rigidity-driven structural isomerism opens up an inspiring path to the discovery of atypical materials.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 1","pages":"2400371"},"PeriodicalIF":11.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capture and Protection of Environmental DNA in a Metal-Organic Framework. 金属-有机框架中环境DNA的捕获与保护。

IF 11.1

Small Science Pub Date : 2024-10-01 eCollection Date: 2024-12-01 DOI: 10.1002/smsc.202400432

Laura I FitzGerald, Erin E Hahn, Mark Wallace, Sarah A Stephenson, Oliver F Berry, Cara M Doherty

{"title":"Capture and Protection of Environmental DNA in a Metal-Organic Framework.","authors":"Laura I FitzGerald, Erin E Hahn, Mark Wallace, Sarah A Stephenson, Oliver F Berry, Cara M Doherty","doi":"10.1002/smsc.202400432","DOIUrl":"https://doi.org/10.1002/smsc.202400432","url":null,"abstract":"Environmental DNA (eDNA) is released by organisms into their surroundings, enabling non-invasive species detection and biodiversity assessments without the need for direct observation. However, collection poses challenges due to the generally low abundance of eDNA and the presence of degradation agents, including enzymes, UV radiation, and microorganisms, rendering samples unstable. Active filtration, which is frequently used to capture eDNA in water, can be time-consuming and cumbersome in field conditions. Herein, a filter-free one-pot procedure for capturing eDNA with the metal-organic framework (MOF), zeolitic imidazolate framework 8 (ZIF-8), is examined. The method is evaluated on 15 mL water samples from diverse sources (aquarium, river, and sea). ZIF-8 forms in all with high capture efficiency (>98%) using spiked salmon DNA to represent eDNA. The DNA is resistant to degradation by endonucleases and UV light. In addition, it remains stable over time as a species-specific salmon quantitative polymerase chain reaction detected genomic DNA in all samples captured with the MOF to a maximum of 28 days at 37 °C while the untreated control samples were below the assay detection limit by day 6. These results highlight the efficacy of ZIF-8 capture in overcoming challenges associated with the preservation of eDNA obtained from aquatic environments.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"4 12","pages":"2400432"},"PeriodicalIF":11.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Oxygen-Reaction Electrocatalysis and Corrosion Resistance of CoCrFeNi Thin Films by Tuned Microstructure and Surface Oxidation. 调整微观结构和表面氧化增强CoCrFeNi薄膜的氧反应电催化和耐蚀性。

IF 11.1

Small Science Pub Date : 2024-09-29 eCollection Date: 2024-11-01 DOI: 10.1002/smsc.202400296

Clara Linder, Robert Boyd, Grzegorz Greczynski, Mikhail Vagin, Daniel Lundin, Karin Törne, Per Eklund, Emma M Björk

{"title":"Enhanced Oxygen-Reaction Electrocatalysis and Corrosion Resistance of CoCrFeNi Thin Films by Tuned Microstructure and Surface Oxidation.","authors":"Clara Linder, Robert Boyd, Grzegorz Greczynski, Mikhail Vagin, Daniel Lundin, Karin Törne, Per Eklund, Emma M Björk","doi":"10.1002/smsc.202400296","DOIUrl":"https://doi.org/10.1002/smsc.202400296","url":null,"abstract":"Oxygen electrocatalysts play a key role in renewable and fossil-free energy production. Bifunctional catalysts active for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) allow use of the same material system for both energy production (ORR) and fuel generation (OER). However, optimizing the performance of bifunctional catalysts requires in depth understanding of the catalyst structure, its surface chemistry in terms of active sites and the underlying catalytic mechanism. Here, the catalytic performance of CoCrFeNi thin films is investigated, synthesized using high-power impulse magnetron sputtering, as bifunctional oxygen electrocatalysts. The film crystal structure and morphology, and thereby the catalytic performance, can be tuned by the ion acceleration (bias) to the substrate. To further enhance the catalytic activity, anodization is used to electrochemically modify the films, forming a thicker oxide layer enriched in Co and Ni cations which significantly improves the ORR performance. Anodization improves the catalyst stability during OER, with an OER potential of 1.45 V versus the reversible hydrogen electrode (RHE) at 10 mA cm-2 for more than 24 h. While the corrosion resistance is high both before and after anodization, in terms of catalytic activity the anodized films outperformed the as-deposited ones. This makes anodized films excellent electrocatalyst candidates in corrosive alkaline environments such as fuel cells and electrolyzers.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"4 11","pages":"2400296"},"PeriodicalIF":11.1,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimal Biofunctionalization of Gold Nanoislands for Electrochemical Detection of Soluble Programmed Death Ligand 1. 水溶性程序性死亡配体电化学检测中金纳米岛的最佳生物功能化研究

IF 11.1

Small Science Pub Date : 2024-09-26 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400411

Zahra Lotfibakalani, Borui Liu, Monalisha Ghosh Dastidar, Thành Trân-Phú, Krishnan Murugappan, Parisa Moazzam, David R Nisbet, Antonio Tricoli

{"title":"Optimal Biofunctionalization of Gold Nanoislands for Electrochemical Detection of Soluble Programmed Death Ligand 1.","authors":"Zahra Lotfibakalani, Borui Liu, Monalisha Ghosh Dastidar, Thành Trân-Phú, Krishnan Murugappan, Parisa Moazzam, David R Nisbet, Antonio Tricoli","doi":"10.1002/smsc.202400411","DOIUrl":"https://doi.org/10.1002/smsc.202400411","url":null,"abstract":"Soluble programmed death ligand-1 (sPD-L1), a pivotal immune checkpoint protein, serves as a biomarker for evaluating the efficacy of cancer therapies. Aptamers, as highly stable and specific recognition elements, play an essential role in emerging point-of-care diagnostic technologies. Yet, crucial advancements rely on engineering the intricate interaction between aptamers and sensor substrates to achieve specificity and signal enhancement. Here, a comprehensive physicochemical characterization and performance optimization of a sPD-L1 aptamer-based biosensor by a complementary set of state-of-the-art methodologies is presented, including atomic force microscopy-based infrared spectroscopy and high-resolution transmission electron microscopy, providing critical insights on the surface coverage and binding mechanism. The optimal nanoaptasensors detect sPD-L1 across a wide concentration range (from am to μm) with a detection limit of 0.76 am in both buffer and mouse serum samples. These findings, demonstrating superior selectivity, reproducibility, and stability, pave the way for engineering miniaturized point-of-care and portable biosensors for cancer diagnostics.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 1","pages":"2400411"},"PeriodicalIF":11.1,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in the Design and Structural/Functional Regulations of Biomolecule-Reinforced Graphene Materials for Bone Tissue Engineering Applications. 骨组织工程应用生物分子增强石墨烯材料的设计和结构/功能调控研究进展。

IF 11.1

Small Science Pub Date : 2024-09-26 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400414

Dagang Li, Jinze Zhao, Yuan Wang, Jialu Wang, Zhenjuan Sun, Fuxin Wei, Gang Wei, Zhengang Sun

{"title":"Recent Advances in the Design and Structural/Functional Regulations of Biomolecule-Reinforced Graphene Materials for Bone Tissue Engineering Applications.","authors":"Dagang Li, Jinze Zhao, Yuan Wang, Jialu Wang, Zhenjuan Sun, Fuxin Wei, Gang Wei, Zhengang Sun","doi":"10.1002/smsc.202400414","DOIUrl":"https://doi.org/10.1002/smsc.202400414","url":null,"abstract":"Biomolecule-reinforced graphene materials (Bio-RGMs) have emerged as versatile matrices for biomedical and tissue engineering applications, owing to the combination of graphene-based materials (GMs) with biomolecular components and their synergistic effects. In this review, an overview of the design, synthesis, structural/functional regulation, and bone engineering applications of various Bio-RGMs is provided. Both covalent and noncovalent methods for conjugating biomolecules onto GMs, followed by an exploration of the structural diversity of Bio-RGMs, ranging from 1D nanofibers to 2D membranes and 3D scaffolds/hydrogels/aerogels are discussed. Techniques such as electrospinning, self-assembly, freeze-drying, 3D printing, and templated synthesis are highlighted for their roles in designing and fabricating Bio-RGM architectures. Additionally, specific properties and functions endowed to Bio-RGMs by biomolecule conjugation, including biocompatibility, cytotoxicity, antibacterial activity, drug delivery ability, and fluorescent sensing are examined. Finally, recent advance is showcased in fabricating Bio-RGMs for the bone tissue engineering applications of bone repair, regeneration, grafting, drug/cell delivery, and tumor inhibition, and further, the potential of Bio-RGMs for preclinical applications is analyzed. It is believed that this review will deepen readers' understanding of biomolecule-GM interactions and inspire the development of innovative Bio-RGMs for advanced biomedical and tissue engineering applications.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 1","pages":"2400414"},"PeriodicalIF":11.1,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0