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Electrosynthesis of Hydrogen Peroxide at Industrial-Level Current Density in Flow-Cell System: Interfacial Microenvironment Regulation and Catalyst Design. 工业级电流密度下的过氧化氢电合成:界面微环境调节和催化剂设计。
IF 11.1
Small Science Pub Date : 2025-05-19 eCollection Date: 2025-06-01 DOI: 10.1002/smsc.202500017
Abdalazeez Ismail Mohamed Albashir, Yunlong Li, Jing Dou, Ke Qi, Wei Qi
{"title":"Electrosynthesis of Hydrogen Peroxide at Industrial-Level Current Density in Flow-Cell System: Interfacial Microenvironment Regulation and Catalyst Design.","authors":"Abdalazeez Ismail Mohamed Albashir, Yunlong Li, Jing Dou, Ke Qi, Wei Qi","doi":"10.1002/smsc.202500017","DOIUrl":"10.1002/smsc.202500017","url":null,"abstract":"<p><p>Electrosynthesis of hydrogen peroxide via two-electron oxygen reduction (2e<sup>-</sup> ORR) provides a green, sustainable, and cost-effective alternative to anthraquinone processes. However, scaling up from laboratory evaluations to practical applications remains challenging. Herein, an interfacial microenvironment regulation strategy using cetyltrimethylammonium bromide cationic surfactant is reported to boost the hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) production rate of commercial carbon black catalysts in alkaline flow-cell reactors. The modified interfacial microenvironment creates an ideal environment for H<sub>2</sub>O<sub>2</sub> production, resulting in a 1.40-fold improvement in 2e<sup>-</sup> ORR current density (from 227.0 to 320.0 mA cm<sup>-2</sup>) and a 1.58-fold improvement in H<sub>2</sub>O<sub>2</sub> production rate (from 137.0 to 217.8 mM L<sup>-1</sup> h<sup>-1</sup>). Additionally, a boron-doped mesoporous carbon catalyst is developed, demonstrating superior catalytic performance, achieving a 1.80-fold improvement in H<sub>2</sub>O<sub>2</sub> production rate (246.7 mM L<sup>-1</sup> h<sup>-1</sup>) comparing with commercial carbon black. These results highlight the potential of microenvironment regulation and catalyst design for developing highly efficient and scalable H<sub>2</sub>O<sub>2</sub> electrosynthesis system.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 6","pages":"2500017"},"PeriodicalIF":11.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atomic-Scale Dynamics at the Interface of Doped Liquid Gallium: Contrasting Effects of Gallium Oxide and Vacuum. 掺杂液体镓界面的原子尺度动力学:氧化镓和真空的对比效应。
IF 11.1
Small Science Pub Date : 2025-05-15 eCollection Date: 2025-06-01 DOI: 10.1002/smsc.202500153
Krista G Steenbergen, Stephanie Lambie, Charlie Ruffman, Nicola Gaston
{"title":"Atomic-Scale Dynamics at the Interface of Doped Liquid Gallium: Contrasting Effects of Gallium Oxide and Vacuum.","authors":"Krista G Steenbergen, Stephanie Lambie, Charlie Ruffman, Nicola Gaston","doi":"10.1002/smsc.202500153","DOIUrl":"10.1002/smsc.202500153","url":null,"abstract":"<p><p>Liquid gallium exhibits a unique, geometrically structured surface that directly influences the diffusion and coalescence of metal solutes at its surface. The complex interplay between different chemical species and gallium's unusual interfacial properties remains poorly understood, yet it plays a crucial role in controlling dopant dynamics, with applications spanning catalysis, nanoscale fabrication, flexible electronics, and liquid metal batteries. Herein, large-scale simulations with <i>ab</i> <i>initio</i>-trained machine learning force fields reveal strikingly different interactions of Ag, Au, Bi, Li, Pt, and Sn with liquid gallium interfaces, including both liquid-vacuum and liquid-gallium oxide boundaries. For example, Bi dopants migrate strongly toward vacuum interfaces but are repelled by the oxide interface, while Au is repelled by both interfaces. The results have direct implications for applications involving doped liquid gallium systems, including optimizing Bi surface patterning in plasmonic and catalytic applications or the use of Li in liquid metal batteries. More broadly, these findings underscore the critical role of interfaces in modulating dopant dynamics, offering new pathways for tuning the properties and functionalities of liquid metal technologies.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 6","pages":"2500153"},"PeriodicalIF":11.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chiroptical Activities of Low-Dimensional Lead-Free Chiral Halide Perovskites with White-Light Emission. 具有白光发射的低维无铅手性卤化物钙钛矿的热学活性。
IF 11.1
Small Science Pub Date : 2025-05-15 eCollection Date: 2025-06-01 DOI: 10.1002/smsc.202500034
Min-Han Tsai, Chia-Hsiang Chuang, Pei-Hsuan Lo, Wei-Yun Zeng, Chun-Yao Huang, Lan-Sheng Yang, Yu-Chiang Chao
{"title":"Chiroptical Activities of Low-Dimensional Lead-Free Chiral Halide Perovskites with White-Light Emission.","authors":"Min-Han Tsai, Chia-Hsiang Chuang, Pei-Hsuan Lo, Wei-Yun Zeng, Chun-Yao Huang, Lan-Sheng Yang, Yu-Chiang Chao","doi":"10.1002/smsc.202500034","DOIUrl":"10.1002/smsc.202500034","url":null,"abstract":"<p><p>Chiral halide perovskites have attracted considerable attention due to their intrinsic chirality-induced circular dichroism (CD), circularly polarized luminescence (CPL), and spin selectivity. However, chiroptical activities of low-dimensional lead-free chiral halide perovskites are hardly observed, especially for those with white-light emission. Herein, lead-free halide perovskites with different ratios of 0D Cs<sub>3</sub>Cu<sub>2</sub>I<sub>5</sub> and 1D CsCu<sub>2</sub>I<sub>3</sub> are realized. Chiroptical activities are introduced into these films by post-treatment with r-/s-methylbenzylammonium iodide to realize lead-free chiral halide perovskites. The absorption, photoluminescence, photoluminescence excitation, CD, and CPL spectra of these films are investigated. The Commission Internationale de L'Eclairage chromaticity coordinates (0.33, 0.33) are obtained when the excitation wavelength is 300 nm. Large Stokes shifts and broadband emission are observed and attributed to the presence of self-trapped excitons. At room temperature, intrinsic chirality-induced CD signals are observed without the application of an external magnetic field, indicating the presence of chirality in the low-dimensional lead-free chiral halide perovskites. Room-temperature CPL is also observed from the low-dimensional lead-free chiral halide perovskites, but only from the Cs<sub>3</sub>Cu<sub>2</sub>I<sub>5</sub> component. This is attributed to the fact that CsCu<sub>2</sub>I<sub>3</sub> does not produce CPL and spin-polarized excitons do not transfer from Cs<sub>3</sub>Cu<sub>2</sub>I<sub>5</sub> to CsCu<sub>2</sub>I<sub>3</sub>.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 6","pages":"2500034"},"PeriodicalIF":11.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stable Na Deposition/Dissolution Enabled by 3D Bimetallic Carbon Fibers with Artificial Solid Electrolyte Interface. 具有人工固体电解质界面的三维双金属碳纤维实现稳定的Na沉积/溶解。
IF 11.1
Small Science Pub Date : 2025-04-29 eCollection Date: 2025-06-01 DOI: 10.1002/smsc.202400655
Sandro Schöner, Dana Schmidt, Leonie Wildersinn, Stephanie E Wolf, Sebastian Speer, Beatrice Wolff, Arseniy Bokov, Pengfei Cao, Anna Windmüller, Xiaoxuan Chen, Chih-Long Tsai, Fabian Jeschull, Hermann Tempel, Shicheng Yu, Rüdiger-A Eichel
{"title":"Stable Na Deposition/Dissolution Enabled by 3D Bimetallic Carbon Fibers with Artificial Solid Electrolyte Interface.","authors":"Sandro Schöner, Dana Schmidt, Leonie Wildersinn, Stephanie E Wolf, Sebastian Speer, Beatrice Wolff, Arseniy Bokov, Pengfei Cao, Anna Windmüller, Xiaoxuan Chen, Chih-Long Tsai, Fabian Jeschull, Hermann Tempel, Shicheng Yu, Rüdiger-A Eichel","doi":"10.1002/smsc.202400655","DOIUrl":"10.1002/smsc.202400655","url":null,"abstract":"<p><p>3D bimetallic carbon nanofibers (CNFs) are promising interlayers for regulating Na deposition/dissolution on the Na metal or directly on current collectors like Cu. However, uncontrollable solid electrolyte interface (SEI) growth on the interlayer during the repeated Na plating/stripping process leads to low initial Coulombic efficiency (CE), impeding the practical applications of such a protective layer in Na metal batteries. Herein, an artificial SEI-coated interlayer decorated with sodiophilic Ag and sodiophobic Cu on CNF is applied on Cu foil to regulate the Na deposition/dissolution behavior. The artificial SEI, consisting of organic components like RCO<sub>2</sub>Na/RCONa and inorganic reactants Na<sub>2</sub>CO<sub>3</sub>/Na<sub>x</sub>O<sub>y</sub>, minimizes irreversible electrolyte decomposition at the interlayer. The sodiophobic-sodiophilic bimetallic CNF interlayer is lightweight, porous, and mechanically robust. It can guide Na deposition toward the sodiophilic Ag-rich region of the CNF matrix and cluster in the open pores facing the current collector, effectively preventing Na dendrite formation. The interlayer features with artificial SEI synergistically enhance the stability of Na deposition/dissolution on Cu foil, resulting in a high average CE of over 99.5% for 600 cycles spanning 6500 h. Furthermore, post-analysis confirms the high electrochemical stability of the artificial SEI of the interlayer during cycling.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 6","pages":"2400655"},"PeriodicalIF":11.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to "Exploiting the Warburg Effect: Co-Delivery of Metformin and FOXK2 siRNA for Ovarian Cancer Therapy". 对“利用Warburg效应:二甲双胍和FOXK2 siRNA共同递送用于卵巢癌治疗”的修正。
IF 11.1
Small Science Pub Date : 2025-04-27 eCollection Date: 2025-06-01 DOI: 10.1002/smsc.202500197
{"title":"Correction to \"Exploiting the Warburg Effect: Co-Delivery of Metformin and FOXK2 siRNA for Ovarian Cancer Therapy\".","authors":"","doi":"10.1002/smsc.202500197","DOIUrl":"https://doi.org/10.1002/smsc.202500197","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1002/smsc.202300192.].</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 6","pages":"2500197"},"PeriodicalIF":11.1,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robust Laser-Induced Graphene-Boron-Doped Diamond Nanowall Hybrid Nanostructures with Enhanced Field Electron Emission Performance for Microplasma Illumination Devices. 用于微等离子体照明器件的增强场电子发射性能的激光诱导石墨烯-硼掺杂金刚石纳米壁杂化纳米结构。
IF 11.1
Small Science Pub Date : 2025-04-21 eCollection Date: 2025-06-01 DOI: 10.1002/smsc.202400430
Mohsen Khodadadiyazdi, Mateusz Ficek, Maria Brzhezinskaya, Shradha Suman, Salila Kumar Sethy, Kamatchi Jothiramalingam Sankaran, Bartłomiej Dec, Mattia Pierpaoli, Sujit Deshmukh, Miroslaw Sawczak, William A Goddard, Robert Bogdanowicz
{"title":"Robust Laser-Induced Graphene-Boron-Doped Diamond Nanowall Hybrid Nanostructures with Enhanced Field Electron Emission Performance for Microplasma Illumination Devices.","authors":"Mohsen Khodadadiyazdi, Mateusz Ficek, Maria Brzhezinskaya, Shradha Suman, Salila Kumar Sethy, Kamatchi Jothiramalingam Sankaran, Bartłomiej Dec, Mattia Pierpaoli, Sujit Deshmukh, Miroslaw Sawczak, William A Goddard, Robert Bogdanowicz","doi":"10.1002/smsc.202400430","DOIUrl":"10.1002/smsc.202400430","url":null,"abstract":"<p><p>This investigation introduces a scalable fabrication method for laser-induced graphene (LIG)-boron-doped diamond nanowall (BDNW) hybrid nanostructures, designed for field electron emission (FEE) cathode materials in microplasma illumination (μPI) devices. The two-step process involves fabricating BDNWs via microwave plasma-enhanced chemical vapor deposition, followed by drop-casting BDNW dispersion onto polyimide foils to create LIG-BDNW hybrid nanostructures. Topographic studies reveal that BDNWs on LIG boosts surface area and prevent graphene restacking. High-resolution transmission electron microscopy confirms precise BDNW decoration, creating sharp edges and high porosity. The effects of boron and nitrogen dopants, highlighted by Raman spectroscopy, are corroborated by near-edge X-ray absorption fire structure and X-ray photoelectron spectroscopies. The hybrid nanostructures exhibit high electrical conductivity and superior FEE properties, with a low turn-on field of 2.9 V μm<sup>-1</sup>, a large FEE current density of 3.0 mA cm<sup>-2</sup> at an applied field of 7.9 V μm<sup>-1</sup>, and a field-enhancement factor of 5,480. The hybrid nanostructures demonstrate an exceptionally low breakdown voltage of 320 V and a plasma current density of 9.48 mA cm<sup>-1</sup> at an applied voltage of 550 V. Ab-initio calculations of the electronic structure further support the experimental findings of these diamond-graphene hybrids, underscoring their potential in advanced electronic applications.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 6","pages":"2400430"},"PeriodicalIF":11.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supercooling of Alaskan Beetle Larvae as a Winter Survival Strategy. 阿拉斯加甲虫幼虫的过冷过冬生存策略。
IF 11.1
Small Science Pub Date : 2025-04-21 eCollection Date: 2025-06-01 DOI: 10.1002/smsc.202500058
Chris J Benmore, Leighanne C Gallington, Henry Vu, John G Duman, Brian M Barnes, Todd L Sformo
{"title":"Supercooling of Alaskan Beetle Larvae as a Winter Survival Strategy.","authors":"Chris J Benmore, Leighanne C Gallington, Henry Vu, John G Duman, Brian M Barnes, Todd L Sformo","doi":"10.1002/smsc.202500058","DOIUrl":"10.1002/smsc.202500058","url":null,"abstract":"<p><p>Insects are able to survive subfreezing temperatures by either limiting ice crystal formation in their bodies or through freeze avoidance. Beetle larvae are able to avoid freezing in winter by dehydrating in the fall months and replacing their body water content with high concentrations of glycerol. This enables the body fluid of the insect to supercool, and even vitrify, recovering unharmed when the temperature warms in the spring. Using nondestructive, high-energy X-ray synchrotron diffraction experiments, direct insight into how cryopreservation occurs at the atomic level within the beetle larvae has been obtained. The results shed light on the molecular-level interactions associated with the mechanism responsible for surviving freezing temperatures. The molecular models of severely dehydrated Alaskan beetle larvae, based on glycerol-water mixtures, yield a total of 4.2 ± 1.2 intermolecular hydrogen bonds per glycerol molecule at 275 K, in good agreement with existing molecular dynamics simulations. Most importantly, they show that if just over half the body fluid content is water, the water clusters are too small to form ice crystals that cause cellular damage.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 6","pages":"2500058"},"PeriodicalIF":11.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Importance of Particle Shape: Effect of Nonspherical Particles and Their Stabilized Pickering Emulsions on Immunization Efficacy. 颗粒形状的重要性:非球形颗粒及其稳定酸洗乳剂对免疫效果的影响。
IF 11.1
Small Science Pub Date : 2025-04-20 eCollection Date: 2025-06-01 DOI: 10.1002/smsc.202400527
Yanan Li, Jie Teng, Qiuting Chen, Qingze Fan, Hiroyuki Oku, Guanghui Ma, Jie Wu
{"title":"The Importance of Particle Shape: Effect of Nonspherical Particles and Their Stabilized Pickering Emulsions on Immunization Efficacy.","authors":"Yanan Li, Jie Teng, Qiuting Chen, Qingze Fan, Hiroyuki Oku, Guanghui Ma, Jie Wu","doi":"10.1002/smsc.202400527","DOIUrl":"10.1002/smsc.202400527","url":null,"abstract":"<p><p>Adjuvants based on spherical particles and stabilized Pickering emulsions represent a significant area of research in the adjuvant field. However, the immune effects of adjuvants containing nonspherical particles and their stabilized Pickering emulsions remain largely unexplored. Particle shape plays a critical role in influencing particle-cell interactions and antigen storage efficiency. In this study, it is aimed to synthesize nonspherical particles with diverse morphologies and sizes and successfully utilize one type to stabilize Pickering emulsions. In this research, their immunological effects are further evaluated by examining the activation of antigen-presenting cells (APCs) and their impact on both cellular and humoral immunity. In these findings, it is demonstrated that nonspherical particles extend the in vivo residence time of vaccines and enhance APCs activation, thereby improving cellular immunity. Additionally, Pickering emulsions stabilized by nonspherical particles exhibit superior flexibility, higher antigen uptake by APCs, and more robust APCs activation compared to those stabilized by spherical particles. These advantages ultimately result in enhanced humoral and cellular immune responses.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 6","pages":"2400527"},"PeriodicalIF":11.1,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental and Computational Study of Injectable Iron(III)/Ultrashort Peptide Hydrogels: A Candidate for Ferroptosis-Induced Treatment of Bacterial Infections. 可注射铁(III)/超短肽水凝胶的实验和计算研究:一个候选的铁中毒诱导的细菌感染治疗。
IF 11.1
Small Science Pub Date : 2025-04-17 eCollection Date: 2025-06-01 DOI: 10.1002/smsc.202400618
Capucine Loth, Florent Barbault, Cécile Guégan, Flora Lemaire, Christophe Contal, Alain Carvalho, Sophie Hellé, Marie Champion, Halima Kerdjoudj, Delphine Chan-Seng, Lydie Ploux, Fouzia Boulmedais
{"title":"Experimental and Computational Study of Injectable Iron(III)/Ultrashort Peptide Hydrogels: A Candidate for Ferroptosis-Induced Treatment of Bacterial Infections.","authors":"Capucine Loth, Florent Barbault, Cécile Guégan, Flora Lemaire, Christophe Contal, Alain Carvalho, Sophie Hellé, Marie Champion, Halima Kerdjoudj, Delphine Chan-Seng, Lydie Ploux, Fouzia Boulmedais","doi":"10.1002/smsc.202400618","DOIUrl":"10.1002/smsc.202400618","url":null,"abstract":"<p><p>Injectable hydrogels are promising candidates as local drug delivery platforms for the treatment of infected wounds. Self-assembled small peptide hydrogels are of interest due to their high biocompatibility, degradability, and ease of synthesis. This study describes the formation of an injectable hydrogel based on the self-assembly of Fmoc-FFpY (Fmoc: fluorenylmethoxycarbonyl, F: phenylalanine, pY: tyrosine phosphate) triggered by electrostatic interactions in the presence of Fe<sup>3+</sup> ions. Stabilized by H bonding and π-π stacking, the hydrogels exhibit high mechanical stiffness with a <i>G</i>' (storage modulus) of ≈8000 Pa and a self-recovery up to <i>G</i>' ≈100 Pa. Peptide self-assembly yields β-sheets twisted into fibrillar helices of 12 nm in diameter and pitch. Molecular dynamics simulations confirm 1) the aggregation of Fmoc-FFpY in the presence of Fe<sup>3+</sup> and the adopted secondary structure and show that 2) the aggregated Fmoc-FFpY/Fe<sup>3+</sup> disrupts the bacterial membrane of <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>, favoring the passive entry of Fe<sup>3+</sup> into the pathogen. In full agreement with the simulations, the hydrogels exhibit antibacterial activity against both bacteria, likely due to the increased Fe<sup>3+</sup> entry into the cell, resulting in enhanced production of reactive oxygen species. This work paves the way for ferroptosis-inducing treatment of bacterial infections using injectable ultrashort peptides.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 6","pages":"2400618"},"PeriodicalIF":11.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Record-Breaking Far-Red Silicon Quantum Dots LEDs Enabled by Solvent Engineering: Toward Superseding Perovskite Quantum Dots. 溶剂工程实现的破纪录远红硅量子点led:迈向取代钙钛矿量子点。
IF 11.1
Small Science Pub Date : 2025-04-16 eCollection Date: 2025-06-01 DOI: 10.1002/smsc.202400647
Li Wang, Yuto Wada, Honoka Ueda, Temmaru Hirota, Kota Sumida, Yuito Oba, Ken-Ichi Saitow
{"title":"Record-Breaking Far-Red Silicon Quantum Dots LEDs Enabled by Solvent Engineering: Toward Superseding Perovskite Quantum Dots.","authors":"Li Wang, Yuto Wada, Honoka Ueda, Temmaru Hirota, Kota Sumida, Yuito Oba, Ken-Ichi Saitow","doi":"10.1002/smsc.202400647","DOIUrl":"10.1002/smsc.202400647","url":null,"abstract":"<p><p>Most quantum dots (QDs) contain either toxic elements, which are health and environmental hazards, or costly precious metals. In contrast, as nanocrystals consisting mainly of an earth-abundant, light element, silicon QDs (SiQDs) have attracted attention as cost-effective biomedical, display, and solid-state lighting materials. However, unlike heavy-metal or perovskite QDs, SiQDs have not yet been used to create high-performance optoelectronics or long-lifetime light-emitting diodes (LEDs). Herein, the fabrication via solvent engineering of SiQD LEDs with record-breaking external quantum efficiency (16.5%) and lifetimes up to 733 times longer than the previous record is reported. Furthermore, the far-red (750 nm) luminance is comparable to that of state-of-the-art perovskite QD LEDs. Dispersing the SiQDs in octane yields particularly efficient LEDs owing to negligible SiQD aggregation, and Joule heating minimization realizes long-term stability (lifetime >200 h). Thus, solvent engineering is harnessed to break four QD LED performance records-for efficiency, luminance, voltage, and operational lifetime-using a more sustainable QD material, and the mechanisms underlying these performance improvements are unveiled. Thus, a new solvent-engineering approach for developing efficient, stable, and sustainable far-red SiQD LEDs, which are valuable light sources for applications including plant growth acceleration and photodynamic therapy, is highlighted.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 6","pages":"2400647"},"PeriodicalIF":11.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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