Small Science最新文献

Correction to "Nanoengineered Shape-Memory Hemostat". 更正“纳米工程形状记忆止血器”。

IF 11.1

Small Science Pub Date : 2025-06-12 eCollection Date: 2025-07-01 DOI: 10.1002/smsc.202500274

引用次数: 0

Recoil Cavity Formation and Collapse for Drop Impact on Sieves. 落锤冲击筛网时的反冲空腔形成与坍塌。

IF 11.1

Small Science Pub Date : 2025-06-06 eCollection Date: 2025-07-01 DOI: 10.1002/smsc.202400586

Chandantaru Dey Modak, Prosenjit Sen

{"title":"Recoil Cavity Formation and Collapse for Drop Impact on Sieves.","authors":"Chandantaru Dey Modak, Prosenjit Sen","doi":"10.1002/smsc.202400586","DOIUrl":"10.1002/smsc.202400586","url":null,"abstract":"The principle underpinning most printing technologies rely on is the formation and subsequent collapse of cavities to generate high-speed jets or droplets. Traditional methods, such as the Worthington jet or bubble-based cavity, utilize the collapse mechanism to give rise to a high-speed liquid jet. In contrast to known cavity collapse processes, a distinct phenomenon occurring during droplet impact on a superhydrophobic sieve is reported. Herein, the collapse of the impact cavity causes an air jet to rise through the sieve pore to form a \"recoil cavity.\" Subsequently, the recoil cavity collapses to eject a jet (droplets). The notable discovery is the emergence of the recoil cavity as a result of the impact cavity's collapse, which has been absent on any other surfaces. The present research explores the underlying mechanism and develops a model of the phenomenon. It is found that the process follows the principle of energy conservation, with a threshold energy flux ratio between impact and recoil driving the ejection of a single drop. These findings provide valuable insights for understanding drop impact printing techniques, which can be applied across various fields, including electronics, biology, and structural printing.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 7","pages":"2400586"},"PeriodicalIF":11.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MXene-Integrated Contact Lens: A Breakthrough in Wearable Eye Protection and Healthcare. mxene集成隐形眼镜：可穿戴式护眼和医疗保健的突破。

IF 11.1

Small Science Pub Date : 2025-06-03 eCollection Date: 2025-07-01 DOI: 10.1002/smsc.202400628

Lunjie Hu, Saman Azhari, Hanzhe Zhang, Yuki Matsunaga, Jun Hirotani, Atsushige Ashimori, Kazuhiro Kimura, Takeo Miyake

{"title":"MXene-Integrated Contact Lens: A Breakthrough in Wearable Eye Protection and Healthcare.","authors":"Lunjie Hu, Saman Azhari, Hanzhe Zhang, Yuki Matsunaga, Jun Hirotani, Atsushige Ashimori, Kazuhiro Kimura, Takeo Miyake","doi":"10.1002/smsc.202400628","DOIUrl":"10.1002/smsc.202400628","url":null,"abstract":"Smart contact lenses with electronic circuits are rapidly advancing for health monitoring and sensing applications, but concerns over electromagnetic (EM) radiation exposure remain. As these devices are near commercialization, protecting the eyes from such radiation is crucial. MXenes (M n+1X n T x , where M is a transition metal, X is carbon and/or nitrogen, and T x denotes the functional groups [e.g., -OH, -F, =O, etc.]), a class of 2D transition metal carbides/nitrides, offer exceptional properties such as high conductivity, biocompatibility, and strong EM shielding, making them ideal for preventing radiation-induced eye diseases like cataracts. Herein, an MXene-coated contact lens platform that effectively reduces EM radiation exposure while maintaining over 80% visible light transmission, 90% cell viability, and robust shielding capabilities is presented. This approach achieves stable integration of MXene nanosheets on soft contact lenses and mitigates their oxidation degradation. The lens also enhances dehydration protection and demonstrates safety by showing no signs of inflammation or adverse effects in rabbit eyes. These findings highlight MXene-coated contact lenses as a promising solution for next-generation wearable technologies and healthcare applications.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 7","pages":"2400628"},"PeriodicalIF":11.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-Time and Site-Specific Perturbation of Dynamic Subcellular Compartments Using Femtosecond Pulses. 利用飞秒脉冲对动态亚细胞室进行实时和定点扰动。

IF 11.1

Small Science Pub Date : 2025-05-22 eCollection Date: 2025-07-01 DOI: 10.1002/smsc.202500166

Seohee Ma, Bin Dong, Matthew G Clark, R Michael Everly, Shivam Mahapatra, Chi Zhang

{"title":"Real-Time and Site-Specific Perturbation of Dynamic Subcellular Compartments Using Femtosecond Pulses.","authors":"Seohee Ma, Bin Dong, Matthew G Clark, R Michael Everly, Shivam Mahapatra, Chi Zhang","doi":"10.1002/smsc.202500166","DOIUrl":"10.1002/smsc.202500166","url":null,"abstract":"Understanding laser interactions with subcellular compartments is crucial for advancing optical microscopy, phototherapy, and optogenetics. While continuous-wave lasers rely on linear absorption, femtosecond (fs) lasers enable nonlinear multiphoton absorption confined to the laser focus, offering high axial precision. However, current fs laser delivery methods lack the ability to target dynamic molecular entities and automate target selection, making them incapable of performing real-time perturbation of mobile or complexly distributed biomolecules. Additionally, existing technologies separate fs pulse delivery and imaging, preventing simultaneous recording of cellular responses. To overcome these challenges, this study introduces fs real-time precision opto-control (fs-RPOC), which integrates a laser scanning microscope with a closed-loop feedback mechanism for automated, chemically selective subcellular perturbation. Fs-RPOC achieves superior spatial precision and fast response time, enabling single- and sub-organelle microsurgery of dynamic targets and localized molecular modulation. By applying a pulse-picking method, fs-RPOC independently controls laser average and peak power at any desired subcellular compartment. Targeting mitochondria, fs-RPOC reveals site-specific molecular responses resulting from fs-laser-induced reactive oxygen species formation, H2O2 diffusion, and low-density plasma generation. These findings offer new insights into fs laser interactions with subcellular compartments and demonstrate fs-RPOC's potential for precise molecular and organelle regulation.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 7","pages":"2500166"},"PeriodicalIF":11.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Columns to Networks: Search toward the Elusive Single Gyroid with π-Shaped Polyphilic Liquid Crystalline Block Molecules. 从圆柱到网络：寻找π型多亲液晶块分子难以捉摸的单陀螺。

IF 11.1

Small Science Pub Date : 2025-05-22 eCollection Date: 2025-07-01 DOI: 10.1002/smsc.202500157

Silvio Poppe, Changlong Chen, Yu Cao, Feng Liu, Carsten Tschierske

{"title":"From Columns to Networks: Search toward the Elusive Single Gyroid with π-Shaped Polyphilic Liquid Crystalline Block Molecules.","authors":"Silvio Poppe, Changlong Chen, Yu Cao, Feng Liu, Carsten Tschierske","doi":"10.1002/smsc.202500157","DOIUrl":"10.1002/smsc.202500157","url":null,"abstract":"Polyphilic block molecules form a wide range of new liquid crystalline (LC) phases with complex morphologies on a nanometer scale. Herein the soft self-assembly of π-shaped p-terphenyl-based bolapolyphiles having two adjacent aliphatic side chains at the central benzene ring (catechol dialkyl ethers) is reported with a focus on the design of single-network structures. Depending on the length of the side chains and temperature a series of polygonal honeycombs, a zeolite-like LC, a lamellar phase, and two segmented network phases with cubic symmetry is found. In these networks self-assembled glycerol spheres, forming the junctions, are interconnected by coaxial p-terphenyl bundles. Upon side-chain elongation, a double-gyroid phase with three-way junctions is replaced by the single diamond having a four-way junction network. However, the single gyroid supposed to be formed by further side-chain expansion could not be observed; instead, the LC self-assembly breaks down completely. It is hypothesized that the formation of single-network phases by bottom-up self-assembly in soft matter systems requires a minimum junction valence of at least 4 to stabilize the networks.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 7","pages":"2500157"},"PeriodicalIF":11.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Programming-Assisted Imaging of Cellular Nitric Oxide Efflux Gradients and Directionality via Carbon Nanotube Sensors". 修正“通过碳纳米管传感器的细胞一氧化氮外排梯度和方向性的编程辅助成像”。

IF 11.1

Small Science Pub Date : 2025-05-21 eCollection Date: 2025-07-01 DOI: 10.1002/smsc.202500263

引用次数: 0

Fluorescent Antibiotics: Bridging Diagnostic and Therapy in the Fight against Bacterial Infections. 荧光抗生素：在对抗细菌感染的斗争中架起诊断和治疗的桥梁。

IF 11.1

Small Science Pub Date : 2025-05-20 eCollection Date: 2025-07-01 DOI: 10.1002/smsc.202500138

Tan Phuoc Ton, Richard Bright, Vi Khanh Truong, Krasimir Vasilev

{"title":"Fluorescent Antibiotics: Bridging Diagnostic and Therapy in the Fight against Bacterial Infections.","authors":"Tan Phuoc Ton, Richard Bright, Vi Khanh Truong, Krasimir Vasilev","doi":"10.1002/smsc.202500138","DOIUrl":"10.1002/smsc.202500138","url":null,"abstract":"Infections caused by pathogenic bacteria pose a significant threat to human health. Fluorescent antibiotics present an innovative material class that combines diagnostic capabilities with therapeutic effects. Fluorescent antibiotics offer a transformative strategy by combining precise visualization of bacterial activity with targeted antimicrobial action, addressing key challenges like drug resistance and rapid pathogen detection in diagnostics and treatment. This review highlights recent advances in the development of fluorescent antibiotics, focusing on chemical strategies such as click chemistry, amide bond formation, solid-phase peptide synthesis, and epoxy-amine addition. Also, the practical applications of these fluorescent probes, ranging from imaging, rapid detection, and real-time visual tracking of pathogenic bacteria to the detailed study of molecular dynamics at the cellular level are discussed. The opportunity to combine detection and treatment of infectious diseases underscores the significant promise of these probes, particularly in the face of escalating antimicrobial resistance. However, despite the promise, most studies are confined to laboratory settings. To move forward, continued innovation and rigorous clinical validation will be essential to translating these promising molecular tools from laboratory research to impactful clinical applications.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 7","pages":"2500138"},"PeriodicalIF":11.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrosynthesis of Hydrogen Peroxide at Industrial-Level Current Density in Flow-Cell System: Interfacial Microenvironment Regulation and Catalyst Design. 工业级电流密度下的过氧化氢电合成：界面微环境调节和催化剂设计。

IF 11.1

Small Science Pub Date : 2025-05-19 eCollection Date: 2025-06-01 DOI: 10.1002/smsc.202500017

Abdalazeez Ismail Mohamed Albashir, Yunlong Li, Jing Dou, Ke Qi, Wei Qi

{"title":"Electrosynthesis of Hydrogen Peroxide at Industrial-Level Current Density in Flow-Cell System: Interfacial Microenvironment Regulation and Catalyst Design.","authors":"Abdalazeez Ismail Mohamed Albashir, Yunlong Li, Jing Dou, Ke Qi, Wei Qi","doi":"10.1002/smsc.202500017","DOIUrl":"10.1002/smsc.202500017","url":null,"abstract":"Electrosynthesis of hydrogen peroxide via two-electron oxygen reduction (2e- ORR) provides a green, sustainable, and cost-effective alternative to anthraquinone processes. However, scaling up from laboratory evaluations to practical applications remains challenging. Herein, an interfacial microenvironment regulation strategy using cetyltrimethylammonium bromide cationic surfactant is reported to boost the hydrogen peroxide (H2O2) production rate of commercial carbon black catalysts in alkaline flow-cell reactors. The modified interfacial microenvironment creates an ideal environment for H2O2 production, resulting in a 1.40-fold improvement in 2e- ORR current density (from 227.0 to 320.0 mA cm-2) and a 1.58-fold improvement in H2O2 production rate (from 137.0 to 217.8 mM L-1 h-1). Additionally, a boron-doped mesoporous carbon catalyst is developed, demonstrating superior catalytic performance, achieving a 1.80-fold improvement in H2O2 production rate (246.7 mM L-1 h-1) comparing with commercial carbon black. These results highlight the potential of microenvironment regulation and catalyst design for developing highly efficient and scalable H2O2 electrosynthesis system.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 6","pages":"2500017"},"PeriodicalIF":11.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold Nanoparticle Adsorption and Uptake are Directed by Particle Capping Agent. 颗粒封盖剂对金纳米颗粒的吸附和吸收具有指导作用。

IF 11.1

Small Science Pub Date : 2025-05-19 eCollection Date: 2025-07-01 DOI: 10.1002/smsc.202500060

Rashad Kariuki, Rowan Penman, Alexander D Newbold, Kalpani A Mirihana, Pierre H A Vaillant, Tilly P Shepherd, Nastaran Meftahi, Gary Bryant, Kislon Voïtchovsky, Claudia Contini, Andrew Hung, Kevion K Darmawan, Charlotte E Conn, Saffron J Bryant, Andrew J Christofferson, Aaron Elbourne

{"title":"Gold Nanoparticle Adsorption and Uptake are Directed by Particle Capping Agent.","authors":"Rashad Kariuki, Rowan Penman, Alexander D Newbold, Kalpani A Mirihana, Pierre H A Vaillant, Tilly P Shepherd, Nastaran Meftahi, Gary Bryant, Kislon Voïtchovsky, Claudia Contini, Andrew Hung, Kevion K Darmawan, Charlotte E Conn, Saffron J Bryant, Andrew J Christofferson, Aaron Elbourne","doi":"10.1002/smsc.202500060","DOIUrl":"10.1002/smsc.202500060","url":null,"abstract":"Nanomaterials are revolutionizing the development of novel therapies, with applications ranging from drug delivery and diagnostics to controlling specific biological processes. However, the specific interactions that govern nanomaterial behavior in biological systems remain difficult to elucidate due to the complex dynamic nature of the lipid bilayer environment. Here, a combination of atomic force microscopy and molecular dynamics simulations is used to discover the precise mechanisms by which various ligand-capped 5 nm gold nanoparticles (AuNPs) interact with supported lipid bilayers of pure fluid phospholipids (1,2-di(9Z-octadecenoyl)-sn-glycero-3-phosphocholine (DOPC)). When the ligand capping agent is altered, differences in adsorption and bilayer disruption as a function of capping agent size and charge are observed. Weakly physiosorbed ligands enable the absorption of the AuNP into the bilayer's hydrophobic core, whereas more strongly adsorbed ligands inhibit the complete insertion of the AuNP. However, ligand-dependent headgroup interactions can lead to interfacial adhesion or inhibition of adsorption. These results reveal that the interaction of AuNPs with biological membranes varies depending on the specific capping agent. Notably, the mechanisms may involve cooperative (or synergistic) effects with membrane components, highlighting the importance of understanding these interactions at molecular resolution.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 7","pages":"2500060"},"PeriodicalIF":11.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved Charge Carrier Dynamics by Unconventional Doping Strategy for BiVO₄ Photoanode. 采用非常规掺杂策略改善BiVO4光阳极的载流子动力学。

IF 11.1

Small Science Pub Date : 2025-05-19 eCollection Date: 2025-07-01 DOI: 10.1002/smsc.202500051

Jiseok Kwon, Heechae Choi, Seunggun Choi, Jooheon Sun, Hyuksu Han, Ungyu Paik, Junghyun Choi, Taeseup Song

{"title":"Improved Charge Carrier Dynamics by Unconventional Doping Strategy for BiVO4 Photoanode.","authors":"Jiseok Kwon, Heechae Choi, Seunggun Choi, Jooheon Sun, Hyuksu Han, Ungyu Paik, Junghyun Choi, Taeseup Song","doi":"10.1002/smsc.202500051","DOIUrl":"10.1002/smsc.202500051","url":null,"abstract":"Bismuth vanadate (BiVO4) is one of the promising photoanodes for solar fuel production, but it faces the challenge of poor charge separation due to its sluggish charge transport and short diffusion length. The ability to regulate charge separation is pivotal for obtaining high efficiency of BiVO4. Herein, an unconventional acceptor doping strategy is proposed for the first time, demonstrating its effectiveness in enhancing charge carrier dynamics. Introducing the Al3+ ions into BiVO4 induced a decrease in carrier concentration but an increase in the diffusion length and carrier lifetime due to the reduced chance of encountering an electron-hole pair. Furthermore, decreasing carrier concentration leads to a widened space charge layer, enabling facile charge transport and separation. The optimized 0.5 at% Al-doped BiVO4 (Al:BVO_0.5) exhibited ≈3.5 and 2.6 order of magnitude increase in diffusion length and in carrier lifetime, respectively, compared to pristine BiVO4, achieving a photocurrent density of 3.02 mA cm-2 at 1.23 V RHE (V versus reversible hydrogen electrode) under AM 1.5 G illumination. This research provides a new understanding of semiconductor physics and design principles for more efficient photoanodes.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 7","pages":"2500051"},"PeriodicalIF":11.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0