{"title":"Therapeutic Implications of Biomolecular Corona on Lipid Nanoparticle-Based Gene Delivery Systems.","authors":"Antonietta Greco, Claudia Corbo","doi":"10.1002/smsc.202500206","DOIUrl":null,"url":null,"abstract":"<p><p>Lipid nanoparticles (LNPs) are widely used in drug delivery due to their low toxicity, excellent biocompatibility, and ability to facilitate endosomal escape. A critical factor influencing the in vivo behavior of LNPs is the formation of a biomolecular corona (BC) on their surface. This layer of biomolecules affects key biological processes such as targeting, absorption, distribution, metabolism, and clearance. Gaining a deeper understanding of the BC formation mechanisms is essential for predicting and optimizing the therapeutic efficacy of LNPs. In this perspective, we present recent advances in the characterization, isolation, and functional implications of the BC. We explore how BC formation affects the stability, biodistribution, and targeting capacity of LNPs, and discuss how harnessing this phenomenon could offer a powerful strategy to improve the precision and effectiveness of targeted drug delivery.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 9","pages":"2500206"},"PeriodicalIF":8.3000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412465/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Small Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/smsc.202500206","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Lipid nanoparticles (LNPs) are widely used in drug delivery due to their low toxicity, excellent biocompatibility, and ability to facilitate endosomal escape. A critical factor influencing the in vivo behavior of LNPs is the formation of a biomolecular corona (BC) on their surface. This layer of biomolecules affects key biological processes such as targeting, absorption, distribution, metabolism, and clearance. Gaining a deeper understanding of the BC formation mechanisms is essential for predicting and optimizing the therapeutic efficacy of LNPs. In this perspective, we present recent advances in the characterization, isolation, and functional implications of the BC. We explore how BC formation affects the stability, biodistribution, and targeting capacity of LNPs, and discuss how harnessing this phenomenon could offer a powerful strategy to improve the precision and effectiveness of targeted drug delivery.
期刊介绍：
Small Science is a premium multidisciplinary open access journal dedicated to publishing impactful research from all areas of nanoscience and nanotechnology. It features interdisciplinary original research and focused review articles on relevant topics. The journal covers design, characterization, mechanism, technology, and application of micro-/nanoscale structures and systems in various fields including physics, chemistry, materials science, engineering, environmental science, life science, biology, and medicine. It welcomes innovative interdisciplinary research and its readership includes professionals from academia and industry in fields such as chemistry, physics, materials science, biology, engineering, and environmental and analytical science. Small Science is indexed and abstracted in CAS, DOAJ, Clarivate Analytics, ProQuest Central, Publicly Available Content Database, Science Database, SCOPUS, and Web of Science.
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