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Toward Personalized Immunotherapeutic Drug Monitoring with Multiplexed Extended-Gate Field-Effect-Transistor Biosensors. 利用多路扩展门场效应晶体管生物传感器实现个性化免疫治疗药物监测。
IF 11.1
Small Science Pub Date : 2025-02-03 eCollection Date: 2025-05-01 DOI: 10.1002/smsc.202400515
Trang-Anh Nguyen-Le, Christin Neuber, Isli Cela, Željko Janićijević, Liliana Rodrigues Loureiro, Lydia Hoffmann, Anja Feldmann, Michael Bachmann, Larysa Baraban
{"title":"Toward Personalized Immunotherapeutic Drug Monitoring with Multiplexed Extended-Gate Field-Effect-Transistor Biosensors.","authors":"Trang-Anh Nguyen-Le, Christin Neuber, Isli Cela, Željko Janićijević, Liliana Rodrigues Loureiro, Lydia Hoffmann, Anja Feldmann, Michael Bachmann, Larysa Baraban","doi":"10.1002/smsc.202400515","DOIUrl":"10.1002/smsc.202400515","url":null,"abstract":"<p><p>The selection and optimization of therapies for cancer patients urgently need personalization. Portable point-of-care electronic biosensors emerge as a groundbreaking solution contributing to better decision-making in precision oncology. In this study, the innovative use of extended-gate field-effect-transistor (EG-FET) biosensors is showcased for monitoring the concentration and pharmacokinetics of immunotherapeutic drugs in vivo. Complementary positron emission tomography and radioactivity biodistribution studies in mice validate the EG-FET measurements. Herein, a novel indirect assay format is also introduced for detecting target modules (TMs) in an adapter chimeric antigen receptor T-cell therapy model, effectively addressing the current limitations of potentiometric measurements. In pharmacokinetic evaluations, the EG-FET biosensor performance aligns with standard radioactivity measurements, revealing the distinct lifespans of small-sized single-chain-fragment-variable-derived TMs (15 min) and larger IgG4-derived TMs (14 h). Advantageously, the EG-FET sensors exhibit exceptional sensitivity and fulfill the requirements for immunotherapeutic drug monitoring without complex radioactive labeling, which is indispensable. In these promising findings, the exploration of next-generation electronic biosensors as therapeutic monitoring tools is advocated for. With their cost, size, and response time advantages, these biosensors hold immense potential for advancing personalized oncology, transcending the conventional diagnostic roles typically highlighted in the literature.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 5","pages":"2400515"},"PeriodicalIF":11.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic Probing of Deep Brain Neuronal Activity Using Nanofibrous Smart Conducting Hydrogel-Based Brain-Machine Interface Probes. 利用纳米纤维智能导电水凝胶脑机接口探针慢性探测深部脑神经元活动。
IF 11.1
Small Science Pub Date : 2025-01-28 eCollection Date: 2025-05-01 DOI: 10.1002/smsc.202400463
Seyed Shahrooz Zargarian, Chiara Rinoldi, Yasamin Ziai, Anna Zakrzewska, Roberto Fiorelli, Małgorzata Gazińska, Martina Marinelli, Magdalena Majkowska, Paweł Hottowy, Bartosz Mindur, Rafał Czajkowski, Ewa Kublik, Paweł Nakielski, Massimiliano Lanzi, Leszek Kaczmarek, Filippo Pierini
{"title":"Chronic Probing of Deep Brain Neuronal Activity Using Nanofibrous Smart Conducting Hydrogel-Based Brain-Machine Interface Probes.","authors":"Seyed Shahrooz Zargarian, Chiara Rinoldi, Yasamin Ziai, Anna Zakrzewska, Roberto Fiorelli, Małgorzata Gazińska, Martina Marinelli, Magdalena Majkowska, Paweł Hottowy, Bartosz Mindur, Rafał Czajkowski, Ewa Kublik, Paweł Nakielski, Massimiliano Lanzi, Leszek Kaczmarek, Filippo Pierini","doi":"10.1002/smsc.202400463","DOIUrl":"10.1002/smsc.202400463","url":null,"abstract":"<p><p>The mechanical mismatch between microelectrode of brain-machine interfaces (BMIs) and soft brain tissue during electrophysiological investigations leads to inflammation, glial scarring, and compromising performance. Herein, a nanostructured, stimuli-responsive, conductive, and semi-interpenetrating polymer network hydrogel-based coated BMIs probe is introduced. The system interface is composed of a cross-linkable poly(<i>N</i>-isopropylacrylamide)-based copolymer and regioregular poly[3-(6-methoxyhexyl)thiophene] fabricated via electrospinning and integrated into a neural probe. The coating's nanofibrous architecture offers a rapid swelling response and faster shape recovery compared to bulk hydrogels. Moreover, the smart coating becomes more conductive at physiological temperatures, which improves signal transmission efficiency and enhances its stability during chronic use. Indeed, detecting acute neuronal deep brain signals in a mouse model demonstrates that the developed probe can record high-quality signals and action potentials, favorably modulating impedance and capacitance. Evaluation of in vivo neuronal activity and biocompatibility in chronic configuration shows the successful recording of deep brain signals and a lack of substantial inflammatory response in the long-term. The development of conducting fibrous hydrogel bio-interface demonstrates its potential to overcome the limitations of current neural probes, highlighting its promising properties as a candidate for long-term, high-quality detection of neuronal activities for deep brain applications such as BMIs.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 5","pages":"2400463"},"PeriodicalIF":11.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Yeast Complementation Assays Demonstrating the Importance of the Affinity Tag Position in Membrane Protein Purification, as Exemplified by HpUreI, the pH-Gated Urea Channel of Helicobacter pylori. 酵母互补实验证明了亲和标签位置在膜蛋白纯化中的重要性,如幽门螺杆菌ph门控尿素通道HpUreI。
IF 11.1
Small Science Pub Date : 2025-01-27 eCollection Date: 2025-05-01 DOI: 10.1002/smsc.202400571
Anna Stoib, Sahar Shojaei, Christine Siligan, Andreas Horner
{"title":"Yeast Complementation Assays Demonstrating the Importance of the Affinity Tag Position in Membrane Protein Purification, as Exemplified by <i>Hp</i>UreI, the pH-Gated Urea Channel of <i>Helicobacter pylori</i>.","authors":"Anna Stoib, Sahar Shojaei, Christine Siligan, Andreas Horner","doi":"10.1002/smsc.202400571","DOIUrl":"10.1002/smsc.202400571","url":null,"abstract":"<p><p>Affinity tags are a crucial component in protein purification. Despite several indications that they can influence protein structure and function, this influence is often unknown or disregarded. This unnecessarily introduces ambiguity in the interpretation of in vitro data. To illustrate that, urea and ammonia yeast complementation assays are used as a screening tool to assess functional differences in various affinity tag positions, compared to the WT protein, using <i>Hp</i>UreI, an acid-gated urea channel of <i>Helicobacter pylori</i>. Yeast complementation assays test the pH-dependent functionality of exogenous proteins expressed in deletion strains by observing growth. If the exogenous protein is able to replace the function of the deleted endogenous protein, yeast cells can demonstrate growth under specific assay conditions. The overall tag position and even a minor amount of residual N- or C-terminal amino acids following tag cleavage exert a solute-specific influence on <i>Hp</i>UreI functionality, suggesting a complex solute selectivity mechanism and underscores the necessity for in vivo characterization. This cost-effective yeast complementation assay can be adapted to test a broad range of solutes. It can be used as a preliminary screening tool for affinity tag positions or protein mutations before quantitative in vitro protein characterization.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 5","pages":"2400571"},"PeriodicalIF":11.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Volatile MoS2 Memristors with Lateral Silver Ion Migration for Artificial Neuron Applications. 具有银离子横向迁移的挥发性二硫化钼忆阻器在人工神经元中的应用。
IF 11.1
Small Science Pub Date : 2025-01-27 eCollection Date: 2025-05-01 DOI: 10.1002/smsc.202400523
Sofía Cruces, Mohit Dineshkumar Ganeriwala, Jimin Lee, Lukas Völkel, Dennis Braun, Annika Grundmann, Ke Ran, Enrique González Marín, Holger Kalisch, Michael Heuken, Andrei Vescan, Joachim Mayer, Andrés Godoy, Alwin Daus, Max Christian Lemme
{"title":"Volatile MoS<sub>2</sub> Memristors with Lateral Silver Ion Migration for Artificial Neuron Applications.","authors":"Sofía Cruces, Mohit Dineshkumar Ganeriwala, Jimin Lee, Lukas Völkel, Dennis Braun, Annika Grundmann, Ke Ran, Enrique González Marín, Holger Kalisch, Michael Heuken, Andrei Vescan, Joachim Mayer, Andrés Godoy, Alwin Daus, Max Christian Lemme","doi":"10.1002/smsc.202400523","DOIUrl":"10.1002/smsc.202400523","url":null,"abstract":"<p><p>Layered 2D semiconductors have shown enhanced ion migration capabilities along their van der Waals (vdW) gaps and on their surfaces. This effect can be employed for resistive switching (RS) in devices for emerging memories, selectors, and neuromorphic computing. To date, all lateral molybdenum disulfide (MoS<sub>2</sub>)-based volatile RS devices with silver (Ag) ion migration have been demonstrated using exfoliated, single-crystal MoS<sub>2</sub> flakes requiring a forming step to enable RS. Herein, present volatile RS with multilayer MoS<sub>2</sub> grown by metal-organic chemical vapor deposition (MOCVD) with repeatable forming-free operation is presented. The devices show highly reproducible volatile RS with low operating voltages of ≈2 V and fast-switching times down to 130 ns considering their micrometer-scale dimensions. The switching mechanism is investigated based on Ag ion surface migration through transmission electron microscopy, electronic transport modeling, and density functional theory. Finally, a physics-based compact model is developed and the implementation of the volatile memristors as artificial neurons in neuromorphic systems is exploredd.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 5","pages":"2400523"},"PeriodicalIF":11.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting Nanotherapeutics for Highly Efficient Diagnosis and Treatment of Systemic Lupus Erythematosus through Regulation of Immune Response. 靶向纳米疗法通过调节免疫反应高效诊断和治疗系统性红斑狼疮。
IF 11.1
Small Science Pub Date : 2025-01-23 eCollection Date: 2025-05-01 DOI: 10.1002/smsc.202400521
Ting Liu, Zhiming Lin, Xi Zhang, Yu Yang, Guanning Huang, Yanzi Yu, Bin Xie, Lizhen He, Tianfeng Chen
{"title":"Targeting Nanotherapeutics for Highly Efficient Diagnosis and Treatment of Systemic Lupus Erythematosus through Regulation of Immune Response.","authors":"Ting Liu, Zhiming Lin, Xi Zhang, Yu Yang, Guanning Huang, Yanzi Yu, Bin Xie, Lizhen He, Tianfeng Chen","doi":"10.1002/smsc.202400521","DOIUrl":"10.1002/smsc.202400521","url":null,"abstract":"<p><p>Systemic lupus erythematosus (SLE) is characterized by the production of pathogenic autoantibodies, particularly antidouble-stranded (ds) DNA antibodies, which contribute to multiorgan damage (lupus nephritis, LN). Hence, there is an urgent need to recognize and eliminate SLE-specific anti-ds DNA antibodies to enhance the SLE treatment. Herein, mesoporous silica (MSNs) loaded with SeC and surface-modified ctDNA are constructed to effectively specific bind and eliminate pathogenic anti-dsDNA antibodies for treatment SLE in 125 plasm and enabling swift LN diagnosis in 36 kidney tissue from SLE patients. As expected, the clearance ratio of anti-dsDNA antibodies by nanotherapeutics is significantly greater compared to other products commonly used in clinical therapies and exhibits biocompatibility and safety in patients. Moreover, MSNs-DNA can also help visualize the distribution of anti-dsDNA antibodies in the lesions of the kidney. Importantly, the combination strategy (MSNs-DNA@SeC) can effectively remove antibodies and reduce UP production by the regulation of B cells and T cells in female MRL/lpr SLE model mice to alleviate related symptoms. Collectively, the resultant data not only presents a straightforward method for the systematic design of nanomedicine targeting SLE to enhance the effects on diagnosis and treatment, but also elucidates the potential mechanisms involving anti-dsDNA antibodies in the pathogenesis and progression of SLE.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 5","pages":"2400521"},"PeriodicalIF":11.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Passivation Mechanism in Highly Luminescent Nanocomposite-Based CH3NH3PbBr3 Perovskite Nanocrystals. 高发光纳米复合材料基CH3NH3PbBr3钙钛矿纳米晶体的钝化机理。
IF 11.1
Small Science Pub Date : 2025-01-22 eCollection Date: 2025-05-01 DOI: 10.1002/smsc.202400529
Jaume Noguera-Gómez, Víctor Sagra-Rodríguez, Vladimir S Chirvony, Miriam Minguez-Avellan, Mahesh Eledath-Changarath, Juan F Sánchez-Royo, Juan P Martínez-Pastor, Pablo P Boix, Rafael Abargues
{"title":"Passivation Mechanism in Highly Luminescent Nanocomposite-Based CH<sub>3</sub>NH<sub>3</sub>PbBr<sub>3</sub> Perovskite Nanocrystals.","authors":"Jaume Noguera-Gómez, Víctor Sagra-Rodríguez, Vladimir S Chirvony, Miriam Minguez-Avellan, Mahesh Eledath-Changarath, Juan F Sánchez-Royo, Juan P Martínez-Pastor, Pablo P Boix, Rafael Abargues","doi":"10.1002/smsc.202400529","DOIUrl":"10.1002/smsc.202400529","url":null,"abstract":"<p><p>Water exposure significantly impacts the structure and photoluminescence (PL) of metal halide perovskites. However, humid conditions can enable the in situ synthesis of methylammonium lead bromide (MAPbBr<sub>3</sub>) perovskite nanocrystals (NCs) within a nickel acetate matrix, achieving PL quantum yields (PLQY) of up to 80%. The water-driven formation and transformation of MAPbBr<sub>3</sub> is presented, highlighting the crucial role of acetate. Comprehensive optical and structural analyses reveal that low relative humidity (RH < 20%) favors the formation of non-emissive MA<sub>4</sub>PbBr<sub>6</sub> (0D) and hydroxide species (PbBrOH, OH<sup>-</sup>) . Exposure to higher RH induces a structural reorganization from 0D MA<sub>4</sub>PbBr<sub>6</sub> to 3D MAPbBr<sub>3</sub> via a MABr-stripping mechanism, forming NCs with enhanced PLQY. Removing ambient humidity quenches PL, a process that is reversible due to hydroxide-mediated reactions controlled by dual acid-base nature of the acetic acid/acetate system. Unlike previous reports, the findings reveal that hydroxide ions reversibly bind to NCs, passivating traps and improving stability. Acetate's basicity plays a critical role in generating OH<sup>-</sup>, promoting the passivation, stability, and enhanced optical properties of the perovskite nanocomposites.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 5","pages":"2400529"},"PeriodicalIF":11.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-Power Optoelectronic Synaptic Transistors with Multimodal Neuromorphic Computation and Retinal-Inspired Multiband Optical Binary Communication. 具有多模态神经形态计算和视网膜启发的多波段光二进制通信的低功耗光电突触晶体管。
IF 11.1
Small Science Pub Date : 2025-01-21 eCollection Date: 2025-05-01 DOI: 10.1002/smsc.202400511
Bo Huang, Linfeng Lan, Jiayi Pan, Fuzheng Qi, Jing Li, Churou Wang, Yaping Li, Dechun Zeng, Jiale Huang, Jintao Xu, Junbiao Peng
{"title":"Low-Power Optoelectronic Synaptic Transistors with Multimodal Neuromorphic Computation and Retinal-Inspired Multiband Optical Binary Communication.","authors":"Bo Huang, Linfeng Lan, Jiayi Pan, Fuzheng Qi, Jing Li, Churou Wang, Yaping Li, Dechun Zeng, Jiale Huang, Jintao Xu, Junbiao Peng","doi":"10.1002/smsc.202400511","DOIUrl":"10.1002/smsc.202400511","url":null,"abstract":"<p><p>Biomimetic neuromorphic optoelectronics exude tempting attraction in multimodal interaction and visual applications because of their capability of integrating sensing, memorizing, and processing in a single device. Herein, a natural dextran film that is intrinsically green and transparent is employed as the dielectric of the optoelectronic synaptic transistors (OSTs). The resulting dextran-OSTs that operate at an ultralow energy consumption (15.89 aJ) exhibit multimodal neuromorphic computation ability with excellent synaptic plasticity, including pair-pulse facilitation (PPF, as high as 494%), spike voltage/frequency/duration/number-dependent plasticity, and a high recognition accuracy of 89.95% by handwritten digital datasets. Furthermore, the device exhibits visual self-adaptation ability and audiovisual fusion effect, showcasing the immense potential in self-adaptation and synergy sensing. More importantly, the dextran-OSTs can significantly advance the capabilities of binary optical information processing and memorizing. This demonstrates the great advantages of dextran-OSTs in multimodal neuromorphic computation, visual self-adaptation, synergy sensing, and multiband optical communication.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 5","pages":"2400511"},"PeriodicalIF":11.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to "Hierarchical Microcarriers Loaded with Peptide Dendrimer-Grafted Methotrexate for Rheumatoid Arthritis Treatment". 修正“类风湿性关节炎的分级微载体装载肽树状分子移植的甲氨蝶呤”。
IF 11.1
Small Science Pub Date : 2025-01-08 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400614
Yang Li, Haofang Zhu, Rui Liu, Yuanjin Zhao, Lingyun Sun
{"title":"Correction to \"Hierarchical Microcarriers Loaded with Peptide Dendrimer-Grafted Methotrexate for Rheumatoid Arthritis Treatment\".","authors":"Yang Li, Haofang Zhu, Rui Liu, Yuanjin Zhao, Lingyun Sun","doi":"10.1002/smsc.202400614","DOIUrl":"https://doi.org/10.1002/smsc.202400614","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1002/smsc.202300097.].</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400614"},"PeriodicalIF":11.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulating Adsorption Behaviors in Crystalline Porous Materials by External Electric Fields. 外加电场调节晶体多孔材料的吸附行为。
IF 11.1
Small Science Pub Date : 2025-01-03 eCollection Date: 2025-05-01 DOI: 10.1002/smsc.202400391
Yang Yang, Tianyi Zhang, Tianqi Wang, Teng Zhou, Youssef Belmabkhout, Qinfen Gu, Jin Shang
{"title":"Regulating Adsorption Behaviors in Crystalline Porous Materials by External Electric Fields.","authors":"Yang Yang, Tianyi Zhang, Tianqi Wang, Teng Zhou, Youssef Belmabkhout, Qinfen Gu, Jin Shang","doi":"10.1002/smsc.202400391","DOIUrl":"10.1002/smsc.202400391","url":null,"abstract":"<p><p>The regulation of adsorption behaviors in crystalline porous materials (CPMs) using external electric fields (E-fields) is an emerging field. CPMs are highly valued for their large surface area, well-ordered pore structures, and chemical versatility, making them ideal for applications in adsorption/separation, catalysis, and biomedicine. In this review, the mechanisms underlying the E-field-induced structural and functional modifications in CPMs, such as phase transitions, framework distortions, and alterations in pore accessibility and selectivity, are delved into. Through a comprehensive analysis, the adsorption behaviors influenced by E-field regulation are classified into three main categories: selective molecular adsorption, selective ion adsorption, and the diffusion/transportation of molecules and ions. Furthermore, in this review, the current landscape of research in this area, highlighting the challenges and future directions for developing E-field-regulated adsorbents is critically assessed. In this work, it is aimed to summarize recent advances and identify gaps in the understanding of E-field effects on CPMs, providing a foundation for the rational development of next-generation materials with E-field modulated functionalities.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 5","pages":"2400391"},"PeriodicalIF":11.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydrothermally Synthesized SnS2 Anode Materials with Selectively Tuned Crystallinity. 选择性调谐结晶度的水热合成SnS2负极材料。
IF 11.1
Small Science Pub Date : 2024-12-23 eCollection Date: 2025-05-01 DOI: 10.1002/smsc.202400516
Akzhan Bekzhanov, Nurgul Daniyeva, Qixiang Jiang, Yuri Surace, Freddy Kleitz, Damian Cupid
{"title":"Hydrothermally Synthesized SnS<sub>2</sub> Anode Materials with Selectively Tuned Crystallinity.","authors":"Akzhan Bekzhanov, Nurgul Daniyeva, Qixiang Jiang, Yuri Surace, Freddy Kleitz, Damian Cupid","doi":"10.1002/smsc.202400516","DOIUrl":"10.1002/smsc.202400516","url":null,"abstract":"<p><p>SnS<sub>2</sub>-based anode active materials for lithium-ion battery applications are synthesized with varying degrees of crystallinity via a hydrothermal method, and their electrochemical performance properties are assessed. Different ratios of tin chloride and thioacetamide precursors are used and studied to control the crystallization. In situ electrochemical impedance spectroscopy and galvanostatic intermittent titration technique experiments are used to study the lithium-ion diffusion kinetics into the crystal structures and the conversion reaction mechanisms for discharge up to <i>x</i> ≈ 2.08 moles of lithiation per SnS<sub>2</sub>, equivalent to a discharge capacity of 300 mAh g<sup>-1</sup>. Transmission electron microscopy reveals the presence of amorphous and crystalline domains, as well as the existence of additional Sn<sub>2</sub>S<sub>3</sub> layers on one of the samples. The highest specific reversible capacity during cycling and rate performance are 598 mAh g<sup>-1</sup> after 100 cycles and 605 mAh g<sup>-1</sup> after rate capability test, which are obtained for the samples prepared with the 1:4 tin chloride to thioacetamide ratio.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 5","pages":"2400516"},"PeriodicalIF":11.1,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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