Small Science最新文献_第2页

Antiaging Metabolite-Based Polymeric Microparticles for Intracellular Drug Delivery and Bone Regeneration 用于细胞内给药和骨再生的抗衰老代谢产物基聚合物微粒

IF 12.7

Small Science Pub Date : 2024-09-03 DOI: 10.1002/smsc.202400201

Zhuozhi Wang, Jue Hu, Jeffrey S. Marschall, Ling Yang, Erliang Zeng, Shaoping Zhang, Hongli Sun

{"title":"Antiaging Metabolite-Based Polymeric Microparticles for Intracellular Drug Delivery and Bone Regeneration","authors":"Zhuozhi Wang, Jue Hu, Jeffrey S. Marschall, Ling Yang, Erliang Zeng, Shaoping Zhang, Hongli Sun","doi":"10.1002/smsc.202400201","DOIUrl":"https://doi.org/10.1002/smsc.202400201","url":null,"abstract":"α-ketoglutarate (AKG), a key component of the tricarboxylic acid cycle, has attracted attention for its antiaging properties. In the recent study, it is indicated that locally delivered cell-permeable AKG significantly promotes osteogenic differentiation and mouse bone regeneration. However, the cytotoxicity and rapid hydrolysis of the metabolite limit its application. In this study, novel AKG-based polymeric microparticles (PAKG MPs) are synthesized for sustained release. In vitro data suggest that the chemical components, hydrophilicity, and size of the MPs can significantly affect their cytotoxicity and pro-osteogenic activity. Excitingly, these biodegradable PAKG MPs are highly phagocytosable for nonphagocytic pre-osteoblasts MC3T3-E1 and primary bone marrow mesenchymal stem cells, significantly promoting their osteoblastic differentiation. RNA-Sequencing (RNA-Seq) data suggest that PAKG MPs strongly activate Wnt/β-catenin and PI3K–Akt pathways for osteogenic differentiation. Moreover, PAKG enables poly(L-lactic acid) and poly(lactic-co-glycolic acid) MPs (PLGA MPs) for efficient phagocytosis. In this data, it is indicated that PLGA–PAKG-MPs-mediated intracellular drug delivery can significantly promote stronger osteoblastic differentiation compared to PLGA-MPs-delivered phenamil. Notably, PAKG MPs significantly improve large bone regeneration in a mouse cranial bone defect model. Thus, the novel PAKG-based MPs show great promise to improve osteogenic differentiation and bone regeneration and enable efficient intracellular drug delivery for broad regenerative medicine.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":12.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stretchable Ag2Se Thermoelectric Fabric with Simple and Nonthermal Fabrication for Wearable Electronics 用于可穿戴电子设备的可伸缩 Ag2Se 热电织物，其制造工艺简单且无需加热

IF 12.7

Small Science Pub Date : 2024-09-01 DOI: 10.1002/smsc.202400230

Chaebeen Kwon, Sanghyeon Lee, Chihyeong Won, Kyu Hyoung Lee, Byeonggwan Kim, Sungjoon Cho, Taeyoon Lee

{"title":"Stretchable Ag2Se Thermoelectric Fabric with Simple and Nonthermal Fabrication for Wearable Electronics","authors":"Chaebeen Kwon, Sanghyeon Lee, Chihyeong Won, Kyu Hyoung Lee, Byeonggwan Kim, Sungjoon Cho, Taeyoon Lee","doi":"10.1002/smsc.202400230","DOIUrl":"https://doi.org/10.1002/smsc.202400230","url":null,"abstract":"As the field of wearable electronics continues to expand, the integration of inorganic thermoelectric (TE) materials into fabrics has emerged as a promising development due to their excellent TE properties. However, conventional thermal methods for fabricating TE fabrics are unsuitable for wearable applications because of their high temperatures, resulting in rigid TE materials. Herein, a nonthermally fabricated silver selenide (Ag2Se) TE fabric is developed that can be effectively integrated into wearable applications. Ag2Se nanoparticles are densely formed within the fabric through a simple in situ chemical reduction process, resulting in remarkable electrical stability even after 10 000 cycles of mechanical deformation, such as stretching and compression. Notably, the fabricated Ag2Se TE fabric exhibits superior stretchability, stretching ≈1.36 times more than the thermally treated Ag2Se TE fabrics, while retaining its excellent electrical conductivity. Moreover, the TE unit exhibits 9.80 μW m−1 K−2 power factor, 134.45 S cm−1 electrical conductivity, and −26.98 μV K−1 Seebeck coefficient at 370 K. A haptic sensing glove based on the Ag2Se TE fabric as a sensor for detecting potential hazards is demonstrated. The glove effectively distinguishes between simple touch, physical pain, and high-temperature hazards, ensuring user safety and prompt response.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":12.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protic Stabilization Engenders High Energy Density and Long Cycle Life in Polyaniline–Zinc Supercapacitors 聚苯胺锌超级电容器中的原态稳定可实现高能量密度和长循环寿命

IF 12.7

Small Science Pub Date : 2024-09-01 DOI: 10.1002/smsc.202400295

Chanho Shin, Eun Hye Lee, Hyeong Ju Eun, Jinwook Jung, Jong H. Kim, Tse Nga Ng

引用次数: 0

Engineering Conductive Hydrogels with Tissue-like Properties: A 3D Bioprinting and Enzymatic Polymerization Approach 具有类组织特性的导电水凝胶工程：三维生物打印和酶促聚合方法

IF 12.7

Small Science Pub Date : 2024-09-01 DOI: 10.1002/smsc.202400290

Changbai Li, Sajjad Naeimipour, Fatemeh Rasti Boroojeni, Tobias Abrahamsson, Xenofon Strakosas, Yangpeiqi Yi, Rebecka Rilemark, Caroline Lindholm, Venkata K. Perla, Chiara Musumeci, Yuyang Li, Hanne Biesmans, Marios Savvakis, Eva Olsson, Klas Tybrandt, Mary J. Donahue, Jennifer Y. Gerasimov, Robert Selegård, Magnus Berggren, Daniel Aili, Daniel T. Simon

{"title":"Engineering Conductive Hydrogels with Tissue-like Properties: A 3D Bioprinting and Enzymatic Polymerization Approach","authors":"Changbai Li, Sajjad Naeimipour, Fatemeh Rasti Boroojeni, Tobias Abrahamsson, Xenofon Strakosas, Yangpeiqi Yi, Rebecka Rilemark, Caroline Lindholm, Venkata K. Perla, Chiara Musumeci, Yuyang Li, Hanne Biesmans, Marios Savvakis, Eva Olsson, Klas Tybrandt, Mary J. Donahue, Jennifer Y. Gerasimov, Robert Selegård, Magnus Berggren, Daniel Aili, Daniel T. Simon","doi":"10.1002/smsc.202400290","DOIUrl":"https://doi.org/10.1002/smsc.202400290","url":null,"abstract":"Hydrogels are promising materials for medical devices interfacing with neural tissues due to their similar mechanical properties. Traditional hydrogel-based bio-interfaces lack sufficient electrical conductivity, relying on low ionic conductivity, which limits signal transduction distance. Conducting polymer hydrogels offer enhanced ionic and electronic conductivities and biocompatibility but often face challenges in processability and require aggressive polymerization methods. Herein, we demonstrate in situ enzymatic polymerization of π-conjugated monomers in a hyaluronan (HA)-based hydrogel bioink to create cell-compatible, electrically conductive hydrogel structures. These structures were fabricated using 3D bioprinting of HA-based bioinks loaded with conjugated monomers, followed by enzymatic polymerization via horseradish peroxidase. This process increased the hydrogels’ stiffness from about 0.6 to 1.5 kPa and modified their electroactivity. The components and polymerization process were well-tolerated by human primary dermal fibroblasts and PC12 cells. This work presents a novel method to fabricate cytocompatible and conductive hydrogels suitable for bioprinting. These hybrid materials combine tissue-like mechanical properties with mixed ionic and electronic conductivity, providing new ways to use electricity to influence cell behavior in a native-like microenvironment.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":12.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Selective Extraction: A Novel Approach for Scandium, Thorium, and Uranium Ion Capture 推进选择性萃取：钪、钍和铀离子捕获的新方法

IF 12.7

Small Science Pub Date : 2024-08-28 DOI: 10.1002/smsc.202400171

Iryna Protsak, Martin Stockhausen, Aaron Brewer, Martin Owton, Thilo Hofmann, Freddy Kleitz

{"title":"Advancing Selective Extraction: A Novel Approach for Scandium, Thorium, and Uranium Ion Capture","authors":"Iryna Protsak, Martin Stockhausen, Aaron Brewer, Martin Owton, Thilo Hofmann, Freddy Kleitz","doi":"10.1002/smsc.202400171","DOIUrl":"https://doi.org/10.1002/smsc.202400171","url":null,"abstract":"The potential use of thorium (Th) and uranium (U) as nuclear fuels underscores the importance of developing materials for their sustainable recovery. The production of Th and U requires the separation of these elements from rare-earth elements (REEs) as they often coexist in various feedstocks. Equally crucial is efficiently isolating scandium (Sc) from REEs, considering its high-value status and pivotal role in advanced alloy technologies. This study introduces a new selective ligand-functionalized silica sorbent for extracting Sc, other REEs, Th, and U from solutions with varying pH and elemental compositions. The functionalized sorbent exhibits exceptional selectivity for Sc ions at pH 4 across solutions containing 3–20 elements. It also shows excellent selectivity for Th at pH 2 in 18- and 20-element solutions and substantial selectivity for U in 18- and 20-element solutions at pH 4. Additionally, it efficiently adsorbs neodymium (Nd), dysprosium (Dy), and lanthanum (La) in Sc-free solutions with a given preference for Nd. The ligand-functionalized sorbent successfully undergoes ten cycles of reuse which along with its enhanced recovery performance toward targeted elements highlights its industrial application potential.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":12.7,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking the Perfluorooctane Sulfonate Chain: Piezocatalytic Decomposition of PFOS Using BaTiO3 Nanoparticles 打破全氟辛烷磺酸链：使用 BaTiO3 纳米粒子压电催化分解全氟辛烷磺酸

IF 12.7

Small Science Pub Date : 2024-08-28 DOI: 10.1002/smsc.202400337

Andrea Veciana, Sarah Steiner, Qiao Tang, Vitaly Pustovalov, Joaquin Llacer-Wintle, Jiang Wu, Xiang-Zhong Chen, Trust Manyiwa, Venecio U. Ultra, Beltzane Garcia-Cirera, Josep Puigmartí-Luis, Carlos Franco, David J. Janssen, Laura Nyström, Samy Boulos, Salvador Pané

{"title":"Breaking the Perfluorooctane Sulfonate Chain: Piezocatalytic Decomposition of PFOS Using BaTiO3 Nanoparticles","authors":"Andrea Veciana, Sarah Steiner, Qiao Tang, Vitaly Pustovalov, Joaquin Llacer-Wintle, Jiang Wu, Xiang-Zhong Chen, Trust Manyiwa, Venecio U. Ultra, Beltzane Garcia-Cirera, Josep Puigmartí-Luis, Carlos Franco, David J. Janssen, Laura Nyström, Samy Boulos, Salvador Pané","doi":"10.1002/smsc.202400337","DOIUrl":"https://doi.org/10.1002/smsc.202400337","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFAS) pose significant environmental and health risks due to their ubiquitous presence and persistence in water systems. Herein, the efficacy of piezocatalysis using barium titanate nanoparticles under ultrasound irradiation for the degradation and defluorination of perfluorooctane sulfonate (PFOS) in water is investigated. The research demonstrates a substantial 90.5% degradation and 29% defluorination of PFOS after 6 h of treatment, highlighting the potential of piezocatalysis as a promising approach for PFAS degradation. Additionally, the quantification of degradation products elucidates the transformation pathways of PFOS, suggesting a stepwise chain-shortening mechanism. The findings underscore the importance of continued research in optimizing piezocatalytic processes and exploring synergistic approaches with other advanced oxidation methods to effectively address PFAS contamination challenges. These efforts are essential for advancing sustainable water treatment strategies and mitigating the environmental and health hazards associated with PFAS contamination.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":12.7,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Pattern of Copper Release in Copper-Based Nanoparticles Regulates Tumor Proliferation and Invasiveness in 3D Culture Models 铜基纳米颗粒中的铜释放模式可调节三维培养模型中肿瘤的增殖和侵袭性

IF 12.7

Small Science Pub Date : 2024-08-27 DOI: 10.1002/smsc.202400206

Jose I. Garcia-Peiro, Paula Guerrero-López, Felipe Hornos, Jose L. Hueso, J. Manuel Garcia-Aznar, Jesus Santamaria

{"title":"The Pattern of Copper Release in Copper-Based Nanoparticles Regulates Tumor Proliferation and Invasiveness in 3D Culture Models","authors":"Jose I. Garcia-Peiro, Paula Guerrero-López, Felipe Hornos, Jose L. Hueso, J. Manuel Garcia-Aznar, Jesus Santamaria","doi":"10.1002/smsc.202400206","DOIUrl":"https://doi.org/10.1002/smsc.202400206","url":null,"abstract":"Cancer is a leading cause of death worldwide. Glioblastoma (GBM) is a major challenge in oncology due to its highly invasive nature and limited treatment options. GBM's aggressive migration beyond tumor margins and rapid tumor growth hinders success in patient treatment. Localized therapeutic delivery, such as the use of transition metals like copper, is highlighted as a novel therapeutic agent for many potential biomedical applications. Herein, it is aimed to study the effects of Cu release on the proliferation and invasiveness of cancer cells. To this end, novel copper-based nanostructures with different release patterns are designed. Using a complex 3D cell culture model to mimic the tumor microenvironment, it is shown that different patterns of copper ion release have a strong impact on GBM progression and invasiveness. The findings highlight the importance of optimizing localized copper release patterns to tailor different tumor treatment strategies. They also show the potential and suitability of 3D microchips as instruments to study the behavior of tumor spheroids. In spite of their limitations, these 3D microdevices enable a controlled and close monitoring of the influence of environmental factors (such as the presence of Cu ions) on the proliferation and invasiveness of the cells, with a better approach to reality compared to 2D models and with a more controlled environment, compared to an in vivo model.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":12.7,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic Functional Nanocomplexes for Photothermal Cancer Chemoimmunotheranostics 用于光热癌症化疗免疫疗法的仿生功能纳米复合物

IF 12.7

Small Science Pub Date : 2024-08-19 DOI: 10.1002/smsc.202400324

Nina Sang, Yun Qi, Shun Nishimura, Eijiro Miyako

{"title":"Biomimetic Functional Nanocomplexes for Photothermal Cancer Chemoimmunotheranostics","authors":"Nina Sang, Yun Qi, Shun Nishimura, Eijiro Miyako","doi":"10.1002/smsc.202400324","DOIUrl":"https://doi.org/10.1002/smsc.202400324","url":null,"abstract":"This study presents a novel multimodal cancer theranostic platform developed using tumor cell-coated biomimetic carbon nanohorn (CNH) complexes that encapsulate the anticancer drug paclitaxel (PTX). This platform combines photothermal therapy, chemotherapy, and immunotherapy to fight against malignant colorectal cancer. These engineered nanocomplexes are designed to deliver sufficient PTX molecules into a targeted solid tumor in a light-controllable manner while inducing significant photothermal and antitumor immune responses. The outstanding photothermal conversion property of the CNHs under near-infrared light enables effective cancer cell ablation and awakening of cytotoxic immune responses. Tumor cell membrane-coated CNHs show improved water dispersibility, immune evasion, and targeting capabilities alongside enhanced immune activation against tumors. The efficacy of the biomimetic functional CNH nanocomplexes is demonstrated through excellent tumor-targeting, controlled drug-releasing behavior, and induction of cancer cell death, contributing to a robust antitumor response. This study provides a promising approach to cancer treatment by integrating multiple therapeutic modalities into a single platform, potentially enhancing treatment efficacy to combat intractable cancer.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":12.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanosized Porphyrinic Metal–Organic Frameworks for the Construction of Transparent Membranes as a Multiresponsive Optical Gas Sensor 构建透明膜的纳米级卟啉金属有机框架，用作多反应光学气体传感器

IF 12.7

Small Science Pub Date : 2024-08-19 DOI: 10.1002/smsc.202400210

Francisco G. Moscoso, Juan J. Romero-Guerrero, David Rodriguez-Lucena, José María Pedrosa, Carolina Carrillo-Carrión

{"title":"Nanosized Porphyrinic Metal–Organic Frameworks for the Construction of Transparent Membranes as a Multiresponsive Optical Gas Sensor","authors":"Francisco G. Moscoso, Juan J. Romero-Guerrero, David Rodriguez-Lucena, José María Pedrosa, Carolina Carrillo-Carrión","doi":"10.1002/smsc.202400210","DOIUrl":"https://doi.org/10.1002/smsc.202400210","url":null,"abstract":"The well-known and excellent colorimetric sensing capacity of porphyrins, along with the exceptional structural properties of metal–organic frameworks (MOFs), make porphyrin-based MOFs, such as PCN-222, ideal candidates for the construction of a chemical sensor based on absorbance. However, to the best of authors’ knowledge, no high-quality porphyrin-based MOF gas sensors have been developed to date, most likely due to the difficulties in: 1) preparing nanosized porphyrin-MOFs to minimize scattering in absorbance measurements; and 2) incorporating MOFs into transparent membranes for practical use. Herein, a simple and fast microwave-assisted method for preparing high-quality nanosized PCN-222 crystals and their metalated derivatives PCN-222(M) is reported to finely tune the sensing response. Next, the successful dispersion of these PCN-222(M) nanoparticles into poly(dimethylsiloxane) to create flexible and transparent membranes is demonstrated. This integration yields a multiresponsive optical gas sensor exhibiting excellent sensitivity and the ability to discriminate between various volatile organic compounds via pattern recognition identification.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":12.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel DNA-Based Dual-Mode Data Storage System with Interrelated Concise and Detailed Data 基于 DNA 的新型双模式数据存储系统，提供相互关联的简明和详细数据

IF 12.7

Small Science Pub Date : 2024-08-19 DOI: 10.1002/smsc.202400094

Ben Pei, Yongsen Zhou, Yu Yang, Jiaxiang Ma, Rangli Cao, Wen Huang, Liliang Ouyang, Shengli Mi, Zhuo Xiong

{"title":"A Novel DNA-Based Dual-Mode Data Storage System with Interrelated Concise and Detailed Data","authors":"Ben Pei, Yongsen Zhou, Yu Yang, Jiaxiang Ma, Rangli Cao, Wen Huang, Liliang Ouyang, Shengli Mi, Zhuo Xiong","doi":"10.1002/smsc.202400094","DOIUrl":"https://doi.org/10.1002/smsc.202400094","url":null,"abstract":"DNA has emerged as a promising storage medium to meet the soaring need for archival data storage because of its exceptional storage density and stability. However, current DNA-based data storage systems are incompetent of achieving high-quality random multiplexed access and frequently accessed data storage, which impedes its practical applications. Here, a dual-mode storage system is proposed that combines DNA-based archival data and nanodot-based active data. This novel data-storage system is constructed by writing the active and archival data on the same substrate through a facile two-step process involving scanning probe lithography (SPL), DNA synthesis, and chemical immobilization. The data files are categorized and stored orderly in different microregions of the substrate to achieve efficient random access. On each microregion, the nanodot array stores not only the concise information for the archival DNA data but also contains the corresponding primer sequence. Such interrelation between active and archival data allows for facilely data reading by efficient microscopic modalities and in situ polymerase chain reaction (PCR). Facilitated by the integration of nanodot and DNA, this novel dual-mode storage system demonstrates efficient data access and the potential of excellent storing capacity, paving the way for the advancement of DNA-based data storage.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":12.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0