Small Science最新文献_第2页

Stem-Cell-Based Small-Diameter Blood Vessels with 3D Printing 基于干细胞的三维打印小直径血管

IF 12.7

Small Science Pub Date : 2024-09-10 DOI: 10.1002/smsc.202400261

Yifan Wang, Xinhuan Wang, Jun Chen, Gordon Wallace, Qi Gu

{"title":"Stem-Cell-Based Small-Diameter Blood Vessels with 3D Printing","authors":"Yifan Wang, Xinhuan Wang, Jun Chen, Gordon Wallace, Qi Gu","doi":"10.1002/smsc.202400261","DOIUrl":"https://doi.org/10.1002/smsc.202400261","url":null,"abstract":"Cardiovascular disease has emerged as the leading cause of death worldwide. Since coronary arteries, carotid arteries, and other blood vessels are prone to narrowing, small-diameter artificial blood channels offer a crucial solution for restoring blood flow. Ideal grafts must emulate the structure of natural blood vessels, possess adequate mechanical strength, ensure long-term patency, and incorporate functional cells with minimal immunogenicity. Enhanced cell sources and engineering methods are vital for the creation of functional small-diameter blood vessels (SDBVs). Among potential cell sources, stem cells stand out due to their ability to differentiate into multiple cell types, self-renew, and exhibit low immunogenicity. Additionally, three-dimensionally (3D) printed vascular stents have attracted widespread attention for their precision and controllable bioink application. The need for tissue-engineered blood vessels is currently rising, and innovative design concepts integrating stem cells and 3D printing present promising solutions. Herein, the construction requirements of vascular grafts are reviewed, current status of using stem cells as a cell source and 3D printing as an engineering strategy is described, and prospects and challenges for the development of SDBVs in the medical field are discussed.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"11 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photo-Curable Stretchable High-k Polymer/TiO2 Nanosheet Hybrid Dielectrics for Field-Effect Transistors 用于场效应晶体管的光固化可拉伸高 k 值聚合物/二氧化钛纳米片混合电介质

IF 12.7

Small Science Pub Date : 2024-09-10 DOI: 10.1002/smsc.202400197

Qun-Gao Chen, Xingke Cai, Chu-Chen Chueh, Wen-Ya Lee

{"title":"Photo-Curable Stretchable High-k Polymer/TiO2 Nanosheet Hybrid Dielectrics for Field-Effect Transistors","authors":"Qun-Gao Chen, Xingke Cai, Chu-Chen Chueh, Wen-Ya Lee","doi":"10.1002/smsc.202400197","DOIUrl":"https://doi.org/10.1002/smsc.202400197","url":null,"abstract":"Elastomeric polymer materials are of interest due to their stretchability, low-temperature processing, and scalability. In addition, the incorporation of 2D materials can further enhance the dielectric properties and capacitance of elastic polymer materials, thereby reducing the driving voltage and energy consumption. In this study, titanium dioxide (TiO2) nanosheets are cross-linked with nitrile butadiene rubber using thiol-ene click chemistry, which leads to the preparation of nanocomposite dielectric films with stretchability and high dielectric constant. Furthermore, by controlling the doping amount of the nanosheets, it is observed that the capacitance of the nanocomposite films increases from 25.61 to 684.67 nF cm−2, and the dielectric constant increases from 14.96 to 161.98. Finally, the stretchable nanocomposite films exhibit good insulating properties even at 50% strain. In this study, insight is provided into the potential of in situ cross-linking between elastic polymer materials and 2D materials to produce high-k dielectric materials with both stretchability and high insulating properties.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"68 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal Oxide vs Organic Semiconductor Charge Extraction Layers for Halide Perovskite Indoor Photovoltaics 用于卤化物过氧化物室内光伏的金属氧化物与有机半导体电荷提取层对比

IF 12.7

Small Science Pub Date : 2024-09-10 DOI: 10.1002/smsc.202400292

Shaoyang Wang, Tim Kodalle, Sam Millar, Carolin M. Sutter-Fella, Lethy Krishnan Jagadamma

{"title":"Metal Oxide vs Organic Semiconductor Charge Extraction Layers for Halide Perovskite Indoor Photovoltaics","authors":"Shaoyang Wang, Tim Kodalle, Sam Millar, Carolin M. Sutter-Fella, Lethy Krishnan Jagadamma","doi":"10.1002/smsc.202400292","DOIUrl":"https://doi.org/10.1002/smsc.202400292","url":null,"abstract":"Halide perovskite indoor photovoltaics (PVs) are highly promising to autonomously power the billions of microelectronic sensors in the emerging and disruptive technology of the Internet of Things (IoT). However, how the wide range of different types of hole extraction layers (HELs) impacts the indoor light harvesting of perovskite solar cells is still elusive, which hinders the material selection and industrial-scale fabrication of indoor perovskite photovoltaics. In the present study, new insights are provided regarding the judicial selection of HELs at the buried interface of halide perovskite indoor photovoltaics. This study unravels the detrimental and severe light-soaking effect of metal oxide transport layer-based PV devices under the indoor lighting effect for the first time, which then necessitates the interface passivation/engineering for their reliant performance. This is not a stringent criterion under 1 sun illumination. By systematically investigating the charge carrier dynamics and sequence of measurements from dark, light-soaked, interlayer-passivated device, the bulk and interface defects are decoupled and reveal the gradual defect passivation from shallow to deep level traps. Thus, the present study puts forward a useful design strategy to overcome the deleterious effect of metal oxide HELs and employ them in halide perovskite indoor PVs.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"79 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vanadium Carbide Quantum Dots Exert Efficient Anti-Inflammatory Effects in Lipopolysaccharide-Induced BV2 Microglia and Mice 碳化钒量子点在脂多糖诱导的 BV2 小胶质细胞和小鼠体内发挥高效抗炎作用

IF 12.7

Small Science Pub Date : 2024-09-10 DOI: 10.1002/smsc.202300334

Zhijun He, Qiqi Yang, Xiaoqian Li, Zi Wang, Shengwu Wen, Ming-Jie Dong, Weiyun Zhang, Youcong Gong, Zijia Zhou, Qiong Liu, Haifeng Dong

{"title":"Vanadium Carbide Quantum Dots Exert Efficient Anti-Inflammatory Effects in Lipopolysaccharide-Induced BV2 Microglia and Mice","authors":"Zhijun He, Qiqi Yang, Xiaoqian Li, Zi Wang, Shengwu Wen, Ming-Jie Dong, Weiyun Zhang, Youcong Gong, Zijia Zhou, Qiong Liu, Haifeng Dong","doi":"10.1002/smsc.202300334","DOIUrl":"https://doi.org/10.1002/smsc.202300334","url":null,"abstract":"The regulation of glial cell activation is a critical step for the treatment or prevention of neuroinflammation-based brain diseases. However, the development of therapeutic drugs that pass the blood–brain barrier (BBB) and inhibit the glia cell activation remains a significant challenge. Herein, an ultrasmall 2D vanadium carbide quantum dots (V2C QDs) that are capable of crossing the BBB are prepared, and the admirable anti-neuroinflammatory effects are presented. The prepared 2D V2C QDs with an average size of 2.54 nm show good hydrophilicity, physiological stability, and effective BBB-crossing ability. The biological effect of V2C QDs on inflammatory reactions demonstrates fascinating results in preventing the impairment of learning and memory in BALB/c mice stimulated by lipopolysaccharide. Investigation of molecular mechanism reveals that V2C QDs not only inhibit the toll-like receptor 4/myeloid differentiation factor 88-mediated nuclear factor kappa B and mitogen-activated protein kinase pathways, but also prevent eukaryotic translation initiation factor 2α/activating transcription factor 4/C/EBP homologous protein-signaling pathway and reduce oxidative stress via activating the NF-E2-related factor-2/heme oxygenase-1-signaling pathway, leading to greatly inhibited activation of microglia and astrocytes and weakened production of inflammatory cytokines. In summary, V2C QDs exert potent anti-inflammatory effects through multiple pathways, thus offer great potential for the treatment of neurodegenerative diseases.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"45 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Approach to Single-Step Fabrication of TiOx-CeOx Nanoparticles 单步制备 TiOx-CeOx 纳米粒子的新方法

IF 12.7

Small Science Pub Date : 2024-09-09 DOI: 10.1002/smsc.202400305

Marie Elis, Tim Tjardts, Josiah Ngenev Shondo, Ainura Aliyeva, Alexander Vahl, Ulrich Schürmann, Thomas Strunskus, Franz Faupel, Cenk Aktas, Lorenz Kienle, Salih Veziroglu

{"title":"A New Approach to Single-Step Fabrication of TiOx-CeOx Nanoparticles","authors":"Marie Elis, Tim Tjardts, Josiah Ngenev Shondo, Ainura Aliyeva, Alexander Vahl, Ulrich Schürmann, Thomas Strunskus, Franz Faupel, Cenk Aktas, Lorenz Kienle, Salih Veziroglu","doi":"10.1002/smsc.202400305","DOIUrl":"https://doi.org/10.1002/smsc.202400305","url":null,"abstract":"Mixed metal oxide (MMO) nanoparticles (NPs) are hybrids consisting of two or more nanoscale metal oxides. Advantages of MMO NPs over single metal oxides include improved catalytic activity, enhanced electrical and magnetic properties, and increased thermal stability due to the synergy of the different oxide components. This study presents a novel fabrication route for TiO2-CeO2 NPs enriched with oxygen vacancies using a Haberland-type gas aggregation cluster source. The NPs, deposited from different segmented Ti/Ce targets under varying O2 addition, were examined with respect to final composition, morphology, and Ti, Ce surface oxidation states. Particle formation mechanisms are proposed for the observed morphologies. Additionally, available O2 during deposition and its impact on the formation of defective sites were investigated. Defective sites in TiO2-CeO2 NPs were analyzed using transfer to X-ray photoelectron spectroscopy and transmission electron microscopy without contact to ambient oxygen. The incorporation of Ce to the target exhibits synergistic effects on the synthesis process. Segmented Ti/Ce targets enable the deposition of a broad range of mixed oxide NPs with diverse compositions and morphologies at considerably enhanced deposition rates, which is vital for practical applications. The presented fabrication approach is expected to be applicable for a broad variety of MMO NPs.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"393 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanocomposite Hydrogels: A Promising Approach for the Treatment of Degenerative Joint Diseases 纳米复合水凝胶：治疗退行性关节疾病的有效方法

IF 12.7

Small Science Pub Date : 2024-09-03 DOI: 10.1002/smsc.202400236

Qizhu Chen, Zitian Zheng, Mian Lin, Zhengyu Guo, Hongjie Huang, Qingyun Xue, Shengdan Jiang, Jianquan Wang, Aimin Wu

{"title":"Nanocomposite Hydrogels: A Promising Approach for the Treatment of Degenerative Joint Diseases","authors":"Qizhu Chen, Zitian Zheng, Mian Lin, Zhengyu Guo, Hongjie Huang, Qingyun Xue, Shengdan Jiang, Jianquan Wang, Aimin Wu","doi":"10.1002/smsc.202400236","DOIUrl":"https://doi.org/10.1002/smsc.202400236","url":null,"abstract":"Degenerative joint diseases, as a global public health issue, impose significant burdens on patients’ lives and substantial economic costs on society. Currently, the primary modalities include physical therapy, pharmaceutical intervention, and surgical procedures. None of these approaches can alter the course of this degenerative process. Due to their commendable biocompatibility, biodegradability, and heightened efficacy in drug delivery, hydrogels present themselves as a novel noninvasive remedy for degenerative joint ailments. However, the clinical application of hydrogels still faces some challenges, including the uncontrolled discharge of encapsulated medications, the absence of adequate mechanical reinforcement for destabilized joints, and adaptability to fluctuating microenvironments. Recently, nanocomposite hydrogels, formed by introducing nanomaterials into hydrogels by physical or chemical means, can improve the limitations of hydrogels and extend their potential for biological applications in degenerative joint diseases. In this study, the pathologic features of degenerative joint diseases and the multiple applications of different types of nanocomposite hydrogels in targeting these different pathologic features are briefly described. It also concludes with an outlook on the use of nanocomposite hydrogels in clinical settings and discusses their challenges and limitations.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"393 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiaging Metabolite-Based Polymeric Microparticles for Intracellular Drug Delivery and Bone Regeneration 用于细胞内给药和骨再生的抗衰老代谢产物基聚合物微粒

IF 12.7

Small Science Pub Date : 2024-09-03 DOI: 10.1002/smsc.202400201

Zhuozhi Wang, Jue Hu, Jeffrey S. Marschall, Ling Yang, Erliang Zeng, Shaoping Zhang, Hongli Sun

{"title":"Antiaging Metabolite-Based Polymeric Microparticles for Intracellular Drug Delivery and Bone Regeneration","authors":"Zhuozhi Wang, Jue Hu, Jeffrey S. Marschall, Ling Yang, Erliang Zeng, Shaoping Zhang, Hongli Sun","doi":"10.1002/smsc.202400201","DOIUrl":"https://doi.org/10.1002/smsc.202400201","url":null,"abstract":"α-ketoglutarate (AKG), a key component of the tricarboxylic acid cycle, has attracted attention for its antiaging properties. In the recent study, it is indicated that locally delivered cell-permeable AKG significantly promotes osteogenic differentiation and mouse bone regeneration. However, the cytotoxicity and rapid hydrolysis of the metabolite limit its application. In this study, novel AKG-based polymeric microparticles (PAKG MPs) are synthesized for sustained release. In vitro data suggest that the chemical components, hydrophilicity, and size of the MPs can significantly affect their cytotoxicity and pro-osteogenic activity. Excitingly, these biodegradable PAKG MPs are highly phagocytosable for nonphagocytic pre-osteoblasts MC3T3-E1 and primary bone marrow mesenchymal stem cells, significantly promoting their osteoblastic differentiation. RNA-Sequencing (RNA-Seq) data suggest that PAKG MPs strongly activate Wnt/β-catenin and PI3K–Akt pathways for osteogenic differentiation. Moreover, PAKG enables poly(L-lactic acid) and poly(lactic-co-glycolic acid) MPs (PLGA MPs) for efficient phagocytosis. In this data, it is indicated that PLGA–PAKG-MPs-mediated intracellular drug delivery can significantly promote stronger osteoblastic differentiation compared to PLGA-MPs-delivered phenamil. Notably, PAKG MPs significantly improve large bone regeneration in a mouse cranial bone defect model. Thus, the novel PAKG-based MPs show great promise to improve osteogenic differentiation and bone regeneration and enable efficient intracellular drug delivery for broad regenerative medicine.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"9 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stretchable Ag2Se Thermoelectric Fabric with Simple and Nonthermal Fabrication for Wearable Electronics 用于可穿戴电子设备的可伸缩 Ag2Se 热电织物，其制造工艺简单且无需加热

IF 12.7

Small Science Pub Date : 2024-09-01 DOI: 10.1002/smsc.202400230

Chaebeen Kwon, Sanghyeon Lee, Chihyeong Won, Kyu Hyoung Lee, Byeonggwan Kim, Sungjoon Cho, Taeyoon Lee

{"title":"Stretchable Ag2Se Thermoelectric Fabric with Simple and Nonthermal Fabrication for Wearable Electronics","authors":"Chaebeen Kwon, Sanghyeon Lee, Chihyeong Won, Kyu Hyoung Lee, Byeonggwan Kim, Sungjoon Cho, Taeyoon Lee","doi":"10.1002/smsc.202400230","DOIUrl":"https://doi.org/10.1002/smsc.202400230","url":null,"abstract":"As the field of wearable electronics continues to expand, the integration of inorganic thermoelectric (TE) materials into fabrics has emerged as a promising development due to their excellent TE properties. However, conventional thermal methods for fabricating TE fabrics are unsuitable for wearable applications because of their high temperatures, resulting in rigid TE materials. Herein, a nonthermally fabricated silver selenide (Ag2Se) TE fabric is developed that can be effectively integrated into wearable applications. Ag2Se nanoparticles are densely formed within the fabric through a simple in situ chemical reduction process, resulting in remarkable electrical stability even after 10 000 cycles of mechanical deformation, such as stretching and compression. Notably, the fabricated Ag2Se TE fabric exhibits superior stretchability, stretching ≈1.36 times more than the thermally treated Ag2Se TE fabrics, while retaining its excellent electrical conductivity. Moreover, the TE unit exhibits 9.80 μW m−1 K−2 power factor, 134.45 S cm−1 electrical conductivity, and −26.98 μV K−1 Seebeck coefficient at 370 K. A haptic sensing glove based on the Ag2Se TE fabric as a sensor for detecting potential hazards is demonstrated. The glove effectively distinguishes between simple touch, physical pain, and high-temperature hazards, ensuring user safety and prompt response.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"45 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protic Stabilization Engenders High Energy Density and Long Cycle Life in Polyaniline–Zinc Supercapacitors 聚苯胺锌超级电容器中的原态稳定可实现高能量密度和长循环寿命

IF 12.7

Small Science Pub Date : 2024-09-01 DOI: 10.1002/smsc.202400295

Chanho Shin, Eun Hye Lee, Hyeong Ju Eun, Jinwook Jung, Jong H. Kim, Tse Nga Ng

引用次数: 0

Engineering Conductive Hydrogels with Tissue-like Properties: A 3D Bioprinting and Enzymatic Polymerization Approach 具有类组织特性的导电水凝胶工程：三维生物打印和酶促聚合方法

IF 12.7

Small Science Pub Date : 2024-09-01 DOI: 10.1002/smsc.202400290

Changbai Li, Sajjad Naeimipour, Fatemeh Rasti Boroojeni, Tobias Abrahamsson, Xenofon Strakosas, Yangpeiqi Yi, Rebecka Rilemark, Caroline Lindholm, Venkata K. Perla, Chiara Musumeci, Yuyang Li, Hanne Biesmans, Marios Savvakis, Eva Olsson, Klas Tybrandt, Mary J. Donahue, Jennifer Y. Gerasimov, Robert Selegård, Magnus Berggren, Daniel Aili, Daniel T. Simon

{"title":"Engineering Conductive Hydrogels with Tissue-like Properties: A 3D Bioprinting and Enzymatic Polymerization Approach","authors":"Changbai Li, Sajjad Naeimipour, Fatemeh Rasti Boroojeni, Tobias Abrahamsson, Xenofon Strakosas, Yangpeiqi Yi, Rebecka Rilemark, Caroline Lindholm, Venkata K. Perla, Chiara Musumeci, Yuyang Li, Hanne Biesmans, Marios Savvakis, Eva Olsson, Klas Tybrandt, Mary J. Donahue, Jennifer Y. Gerasimov, Robert Selegård, Magnus Berggren, Daniel Aili, Daniel T. Simon","doi":"10.1002/smsc.202400290","DOIUrl":"https://doi.org/10.1002/smsc.202400290","url":null,"abstract":"Hydrogels are promising materials for medical devices interfacing with neural tissues due to their similar mechanical properties. Traditional hydrogel-based bio-interfaces lack sufficient electrical conductivity, relying on low ionic conductivity, which limits signal transduction distance. Conducting polymer hydrogels offer enhanced ionic and electronic conductivities and biocompatibility but often face challenges in processability and require aggressive polymerization methods. Herein, we demonstrate in situ enzymatic polymerization of π-conjugated monomers in a hyaluronan (HA)-based hydrogel bioink to create cell-compatible, electrically conductive hydrogel structures. These structures were fabricated using 3D bioprinting of HA-based bioinks loaded with conjugated monomers, followed by enzymatic polymerization via horseradish peroxidase. This process increased the hydrogels’ stiffness from about 0.6 to 1.5 kPa and modified their electroactivity. The components and polymerization process were well-tolerated by human primary dermal fibroblasts and PC12 cells. This work presents a novel method to fabricate cytocompatible and conductive hydrogels suitable for bioprinting. These hybrid materials combine tissue-like mechanical properties with mixed ionic and electronic conductivity, providing new ways to use electricity to influence cell behavior in a native-like microenvironment.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"9 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0