Small Science最新文献_第3页

Kinetic Monte Carlo Modeling of Helium Bubble Nucleation onto Oxides in the Fe-Ti-Y-O System. Fe-Ti-Y-O体系中氦泡在氧化物上成核的动力学蒙特卡罗模拟。

IF 11.1

Small Science Pub Date : 2024-12-23 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400462

Chris Nellis, Céline Hin

引用次数: 0

Intercalating Graphite-Based Na-Ion Battery Anodes with Integrated Magnetite. 集成磁铁矿嵌入石墨基钠离子电池阳极。

IF 11.1

Small Science Pub Date : 2024-12-19 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400405

Rukshan Karunarathna, Harsha Ranasinghe Arachchige, Shadeepa Karunarathne, W Parakrama Sanjeewa Lakshitha Wijesinghe, Chanaka Sandaruwan, M M M Prasanga Gayanath Mantilaka, Yasun Y Kannangara, Amr M Abdelkader

{"title":"Intercalating Graphite-Based Na-Ion Battery Anodes with Integrated Magnetite.","authors":"Rukshan Karunarathna, Harsha Ranasinghe Arachchige, Shadeepa Karunarathne, W Parakrama Sanjeewa Lakshitha Wijesinghe, Chanaka Sandaruwan, M M M Prasanga Gayanath Mantilaka, Yasun Y Kannangara, Amr M Abdelkader","doi":"10.1002/smsc.202400405","DOIUrl":"https://doi.org/10.1002/smsc.202400405","url":null,"abstract":"Graphite is known as the most successful anode material found for Li-ion batteries. However, unfortunately, graphite delivers an ordinary capacity as anode material for the next-generation Na-ion batteries (SIBs) due to difficulties in intercalating larger Na+ ions in between the layers of graphene due to incompatible d-spacing. The methodologies investigated in deriving suitable anode structures for SIBs are found to be either less effective, expensive, or rather too complex in most cases. Herein, a simple strategy is introduced to derive suitable anode materials for SIBs through a modified electrochemical exfoliation of graphite. The introduced exfoliation process is able to graft Fe3O4 (magnetite) on graphite allowing the structure to expand, supporting a swift intercalation and deintercalation of Na ions. The synthesized magnetite-functionalized graphene nanoplatelets are identified as a well-suited anode material for SIBs, with its efficient intercalation obtained through the expanded interlayer spacing of 3.9 Å and the surface redox pseudocapacitive activity attained through the surface-grafted magnetite. The effectiveness of the synthesized is reflected in the obtained high discharge capacitance of 420 mAh g-1, with 96% capacitive retention over 1000 cycles. The study opens new opportunities for prospective low-cost anode materials for energy storage applications.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400405"},"PeriodicalIF":11.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanosecond Laser Pulses Facilitating Efficient and Specific Cell Killing with Doxorubicin-Loaded Gold Nanoparticles Targeted to the Folate Receptor. 纳秒激光脉冲促进有效和特定的细胞杀伤与多柔比星负载金纳米颗粒靶向叶酸受体。

IF 11.1

Small Science Pub Date : 2024-12-19 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400234

Ilia Goemaere, Anna Cielo, Raffaella Daniele, Francesca Mastrotto, Stefaan C De Smedt, Winnok H De Vos, Stefano Salmaso, Kevin Braeckmans

{"title":"Nanosecond Laser Pulses Facilitating Efficient and Specific Cell Killing with Doxorubicin-Loaded Gold Nanoparticles Targeted to the Folate Receptor.","authors":"Ilia Goemaere, Anna Cielo, Raffaella Daniele, Francesca Mastrotto, Stefaan C De Smedt, Winnok H De Vos, Stefano Salmaso, Kevin Braeckmans","doi":"10.1002/smsc.202400234","DOIUrl":"https://doi.org/10.1002/smsc.202400234","url":null,"abstract":"Nanoparticle-based drug carrier systems with active targeting and a controlled release capacity are of considerable interest to bypass side effects of conventional chemotherapy. One appealing approach involves chemotherapeutic-loaded photothermal nanoparticles, where laser irradiation can release the loaded anticancer drug while also inducing local cytotoxicity through photothermal effects. This study investigates the potential of using nanosecond-pulsed laser light for efficient and specific killing of folate receptor (FR)-overexpressing cancer cells in combination with FR-targeted doxorubicin-loaded gold nanoparticles (AuNPs). Nanosecond pulsed laser irradiation allows the induction of mechanical forces alongside thermal effects. The effect of nanoparticle concentrations and laser fluences on cytotoxicity is systematically tested, achieving near-complete tumor cell killing under the most stringent conditions. FR targeting is confirmed using FR-positive and -negative cell lines, showing that folic acid functionalization of AuNPs results in more favorable nanoparticle-cell interactions and more efficient photothermal effects. Additionally, doxorubicin could be efficiently released from the AuNPs and endosomal compartments upon laser irradiation, adding to the observed cytotoxicity. Cell killing was precisely confined to irradiated cells, leaving surrounding cells unharmed. Overall, the significant reduction of tumor cell viability following the proposed combination demonstrates this approach to be a promising step toward safer, more effective anticancer therapies.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400234"},"PeriodicalIF":11.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dendritic Cell Vaccine Harboring Inactivated Mycobacteria Induces Immune Protection Against Tuberculosis in Murine Models and is Well Tolerated in Humans. 含有灭活分枝杆菌的树突状细胞疫苗在小鼠模型中诱导对结核病的免疫保护，并在人类中具有良好的耐受性。

IF 11.1

Small Science Pub Date : 2024-12-18 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400355

Zhidong Hu, Xuhui Liu, Jing Wang, Ling Gu, Zhenyan Chen, Lu Xia, Heng Yang, Jinchuan Xu, Xuejiao Huang, Huiling Wang, Shuihua Lu, Xiao-Yong Fan

{"title":"Dendritic Cell Vaccine Harboring Inactivated Mycobacteria Induces Immune Protection Against Tuberculosis in Murine Models and is Well Tolerated in Humans.","authors":"Zhidong Hu, Xuhui Liu, Jing Wang, Ling Gu, Zhenyan Chen, Lu Xia, Heng Yang, Jinchuan Xu, Xuejiao Huang, Huiling Wang, Shuihua Lu, Xiao-Yong Fan","doi":"10.1002/smsc.202400355","DOIUrl":"https://doi.org/10.1002/smsc.202400355","url":null,"abstract":"The limited success of tuberculosis (TB) control measures reflects the inadequacy of Bacille Calmette-Guérin (BCG), the only licensed TB vaccine. There is a recent resurgence of interest in intravenous administration of BCG. However, direct injection of live BCG bacteria into the bloodstream of human beings is not likely to be practical due to safety concerns. In this study, it is showed that debris of BCG-infected macrophages induces activation and maturation of dendritic cells (DCs) in vitro, and an intravenous DCs vaccine phagocytosing noninfective cell debris induces robust antigen-specific T-cell immune responses and immune protection against Mycobacterium tuberculosis infection in murine models. Further, an investigator-initiated clinical trial shows the safety of a DCs vaccine harboring the noninfective Mycobacterium vaccae vaccine. Infusions of naive DCs and DCs harboring Mycobacterium vaccae are well tolerated and safe in six active TB patients. Tests of the peripheral blood mononuclear cells of a patient who receives two doses of DCs vaccine infusion show enhanced secretion of IFN-γ, IL-2, IL-17, and TNF-α in both CD4 and CD8 T cells. The study provides evidence that DC-based vaccines harboring inactivated mycobacteria can expand T-cell immune responses in TB-infected mice and are well tolerated in patients with active TB disease.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400355"},"PeriodicalIF":11.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Assembled Peptide-Gold Nanoclusters with SiRNA Targeting Telomeric Response to Enhance Radiosensitivity in Lung Cancer Cells. 具有SiRNA靶向端粒反应的自组装肽金纳米团簇增强肺癌细胞的放射敏感性。

IF 11.1

Small Science Pub Date : 2024-12-16 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400156

Sean Moro, Mohammed Omrani, Sule Erbek, Muriel Jourdan, Catharina I Vandekerckhove, Cyril Nogier, Laetitia Vanwonterghem, Marie-Carmen Molina, Pau Bernadó, Aurélien Thureau, Jean-Luc Coll, Olivier Renaudet, Xavier Le Guével, Virginie Faure

{"title":"Self-Assembled Peptide-Gold Nanoclusters with SiRNA Targeting Telomeric Response to Enhance Radiosensitivity in Lung Cancer Cells.","authors":"Sean Moro, Mohammed Omrani, Sule Erbek, Muriel Jourdan, Catharina I Vandekerckhove, Cyril Nogier, Laetitia Vanwonterghem, Marie-Carmen Molina, Pau Bernadó, Aurélien Thureau, Jean-Luc Coll, Olivier Renaudet, Xavier Le Guével, Virginie Faure","doi":"10.1002/smsc.202400156","DOIUrl":"https://doi.org/10.1002/smsc.202400156","url":null,"abstract":"Lung cancer cells resistant to radiotherapy present a significant clinical challenge. Stable telomeric structures, maintained by the TRF2 protein, play a critical role in protecting cells from ionizing radiation. Reduced TRF2 expression increases DNA damage and radiosensitivity. We designed a self-assembling system utilizing ultra-small luminescent gold nanoclusters (AuNCs) with radiosensitizing properties, combined with siRNA targeting TRF2. The system forms ≈100 nm non-spherical structures with AuNCs enriched in the outer layer, exhibiting a 17.6-fold enhancement in red photoluminescence due to aggregation-induced effects. This nanoplatform efficiently penetrates lung cancer cells, reducing TRF2 expression by 50%. Under 5 Gy radiotherapy, cells treated with this system show a 1.5-fold radiosensitivity increase from AuNCs and a 2.3-fold reduction in clonogenic survival due to telomere deprotection. The AuNC-siRNATRF2 system combines enhanced optical properties with biological functionality, offering a promising approach to augment radiotherapy efficacy by disrupting telomeric protective mechanisms in cancer cells.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400156"},"PeriodicalIF":11.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly Efficient Lightweight Flexible Cu(In,Ga)Se₂ Solar Cells with a Narrow Bandgap Fabricated on Polyimide Substrates: Impact of Ag Alloying, Cs and Na Doping, and Front Shallow Ga Grading on Cell Performance. 基于聚酰亚胺衬底的高效轻质柔性Cu(In,Ga)Se2太阳能电池：银合金化、Cs和Na掺杂以及前浅Ga分级对电池性能的影响

IF 11.1

Small Science Pub Date : 2024-12-16 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400404

Yukiko Kamikawa, Jiro Nishinaga, Takeshi Nishida, Shogo Ishizuka

{"title":"Highly Efficient Lightweight Flexible Cu(In,Ga)Se2 Solar Cells with a Narrow Bandgap Fabricated on Polyimide Substrates: Impact of Ag Alloying, Cs and Na Doping, and Front Shallow Ga Grading on Cell Performance.","authors":"Yukiko Kamikawa, Jiro Nishinaga, Takeshi Nishida, Shogo Ishizuka","doi":"10.1002/smsc.202400404","DOIUrl":"https://doi.org/10.1002/smsc.202400404","url":null,"abstract":"Herein, lightweight, flexible Cu(In,Ga)Se2 (CIGS) solar cells with a narrow bandgap of ≈1 eV are grown on polyimide substrates. The poor performance of the CIGS solar cells owing to a low growth temperature (≈400 °C) is considerably improved via Ag alloying, Na doping using alkali-silicate-glass thin layers (ASTLs) and the CsF postdeposition treatment (CsF-PDT), and front shallow Ga grading (surface field; SF). Along with improved device process, a notably high conversion efficiency of 21.2%, low V OC deficit of 0.346 V, and high J SC of ≈40 mA cm-2 are achieved. Ag alloying and Na doping using ASTLs predominantly improve the CIGS bulk quality, while the CsF-PDT and SF reduce carrier recombination at the CIGS/CdS interface and vicinity. Device simulations reveal that the SF increases the electrical field at the CIGS surface under the forward bias voltage close to V OC owing to electron injection from the CdS side, which increases the chemical potential. Thus, the SF effectively repulses holes and improves the interfacial property. Device simulations also reveal that a high CIGS absorber's quality is prerequisite to benefit from the SF. Thus, CIGS solar cells showing improved bulk quality due to optimum alkali doping and Ag alloying considerably benefit from the SF.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400404"},"PeriodicalIF":11.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

¹⁷⁷Lu-Gold Nanohybrids in Radiotherapeutic Approaches Against Cancer. [17]卢-金纳米杂化物在癌症放射治疗中的应用。

IF 11.1

Small Science Pub Date : 2024-12-12 eCollection Date: 2025-05-01 DOI: 10.1002/smsc.202400550

Mathilde Ponchelle, Marek Pruszyński, Edmond Gravel, Eric Doris

引用次数: 0

Nanoengineered Shape-Memory Hemostat. 纳米工程形状记忆止血器。

IF 11.1

Small Science Pub Date : 2024-12-11 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400321

Sarah E Hargett, Giriraj K Lokhande, Joseph Duran, Zanir Hirani, Lindy K Jang, Samantha Foster, Kaivalya A Deo, Sasha George, Mahjabeen Javed, Taylor H Ware, Duncan J Maitland, Akhilesh K Gaharwar

{"title":"Nanoengineered Shape-Memory Hemostat.","authors":"Sarah E Hargett, Giriraj K Lokhande, Joseph Duran, Zanir Hirani, Lindy K Jang, Samantha Foster, Kaivalya A Deo, Sasha George, Mahjabeen Javed, Taylor H Ware, Duncan J Maitland, Akhilesh K Gaharwar","doi":"10.1002/smsc.202400321","DOIUrl":"https://doi.org/10.1002/smsc.202400321","url":null,"abstract":"Uncontrolled hemorrhage is the predominant cause of preventable combat deaths. Various biomaterials serve as hemostatic agents due to their procoagulant or absorptive activity. However, these biomaterials often lack expansion capabilities, which severely limits use in noncompressible wounds. This study combines a hemostatic nanocomposite with a shape-memory polymer foam to design a composite material with both hemostatic and physical expansion properties. This composite is fabricated in two formulations: a foam externally coated in a highly concentrated nanocomposite (\"coated composite\") and a foam containing a diluted nanocomposite infused throughout its pores (\"infused composite\"). Both formulations retain the shape-memory foam's expansion property. Further, the coated composite shows improved fluid uptake (>2-fold) versus infused composites or foam. The nanocomposite component dissociates from the foam under degradative conditions, with the foam remaining stable for 30 days. Hemostatic studies illustrate that the coated composite reduces the clotting time by ≈20%. Alternatively, the infused composite improves clotting over a larger distance (up to ≈2× distance from the composite). These results signify a modular hemostatic ability: the coated composite reduces clotting and improves fluid uptake, while the infused composite achieves diffuse clotting and maintains mechanical properties. Thus, these materials pose a strong potential for use in noncompressible wounds.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400321"},"PeriodicalIF":11.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decellularized Cell-Secreted Extracellular Matrices as Biomaterials for Tissue Engineering. 脱细胞细胞分泌细胞外基质作为组织工程生物材料。

IF 11.1

Small Science Pub Date : 2024-12-06 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400335

David H Ramos-Rodriguez, J Kent Leach

{"title":"Decellularized Cell-Secreted Extracellular Matrices as Biomaterials for Tissue Engineering.","authors":"David H Ramos-Rodriguez, J Kent Leach","doi":"10.1002/smsc.202400335","DOIUrl":"https://doi.org/10.1002/smsc.202400335","url":null,"abstract":"The extracellular matrix (ECM) is the naturally secreted biomaterial scaffold that provides support and regulates key aspects of cell behavior. This dynamic and complex network of structural proteins, proteoglycans, and soluble cues defines the cell microenvironment and is essential for tissue homeostasis. Because tissue engineering approaches aim to recapitulate aspects of the microenvironment to instruct tissue regeneration, ECM-inspired or -derived scaffolds are some of the earliest tissue-engineered constructs reported. However, conventional single-protein constructs fail to provide the biochemical and structural complexity of the native ECM. Decellularized ECM is under investigation to improve cell adhesion, cell remodeling, migration, proliferation, and differentiation within tissue-engineered constructs. However, challenges associated with poor mechanical properties and inherent chemical instability compared to synthetic or other natural polymers require additional considerations. This review describes the bioactive properties of ECM, current strategies to efficiently decellularize cell-secreted and tissue-derived ECM, standard fabrication techniques for ECM constructs, and current developments in the field of ECM-based musculoskeletal platforms.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400335"},"PeriodicalIF":11.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "An X-Ray Absorption Spectroscopy Investigation into the Fundamental Structure of Liquid Metal Alloys". 对“液态金属合金基本结构的x射线吸收光谱研究”的修正。

IF 11.1

Small Science Pub Date : 2024-12-06 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400581

Jaydon A Meilak, Karma Zuraiqi, Valerie Mitchell, Bernt Johannessen, Brittany V Kerr, Pierre H A Vaillant, Krystina Lamb, Patjaree Aukarasereenont, Caiden Parker, Taren Cataldo, Francois Malherbe, Andrew J Christofferson, Torben Daeneke, Rosalie K Hocking

引用次数: 0