Small Science最新文献_第4页

A Corn-Based Electrically Conductive Glue for Integration of Edible Electronics. 一种用于食用电子产品集成的玉米基导电胶。

IF 11.1

Small Science Pub Date : 2024-12-05 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400373

Noemí Contreras-Pereda, Valerio Galli, Pietro Cataldi, Valerio Francesco Annese, Giulia Coco, Athanassia Athanassiou, Alessandro Luzio, Mario Caironi

{"title":"A Corn-Based Electrically Conductive Glue for Integration of Edible Electronics.","authors":"Noemí Contreras-Pereda, Valerio Galli, Pietro Cataldi, Valerio Francesco Annese, Giulia Coco, Athanassia Athanassiou, Alessandro Luzio, Mario Caironi","doi":"10.1002/smsc.202400373","DOIUrl":"https://doi.org/10.1002/smsc.202400373","url":null,"abstract":"Edible electronics leverages the electronic properties of food-grade materials to create non-toxic technologies that can be either environmentally degraded or digested by the body after the completion of their function. Various edible electronic components have been recently proposed, and their integration into more complex circuits and systems is urgently needed for point-of-care devices. In this context, developing a safe technology for interconnecting edible components is crucial. To this aim, here an edible electrically conductive adhesive made from zein, an edible protein derived from corn, and activated carbon, a food additive, are reported. Different formulations are proposed depending on the ratio between adhesive binder (zein) and electrically conductive filler (activated carbon), evidencing a trade-off between resistivity and adhesion, passing from a 3 × 103 Ω cm resistivity and 2 MPa lap shear adhesion strength to 5 × 102 Ω cm and 0.5 MPa values upon increasing the filler content. As a proof-of-concept, the conductive adhesive is validated in different applications relevant to edible electronics, such as mounting devices on top of innovative edible substrates, interconnecting state-of-the-art edible batteries, and conforming highly adhesive electrodes for fruit monitoring.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 1","pages":"2400373"},"PeriodicalIF":11.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An In vitro Caco2-Based Model for Measuring Intestinal Bioadhesion Comparable to Ex vivo Models. 与离体模型相比，基于caco2的体外肠道生物黏附测量模型

IF 11.1

Small Science Pub Date : 2024-12-03 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400461

Eliyahu Drori, Valeria Rahamim, Dhaval Patel, Yamm Anker, Sivan Meir, Gal Uzan, Shira Somech, Chen Drori, Tal Tzadok, Aharon Azagury

{"title":"An In vitro Caco2-Based Model for Measuring Intestinal Bioadhesion Comparable to Ex vivo Models.","authors":"Eliyahu Drori, Valeria Rahamim, Dhaval Patel, Yamm Anker, Sivan Meir, Gal Uzan, Shira Somech, Chen Drori, Tal Tzadok, Aharon Azagury","doi":"10.1002/smsc.202400461","DOIUrl":"https://doi.org/10.1002/smsc.202400461","url":null,"abstract":"This study presents an in vitro model using Caco-2 cells that can mimic the bioadhesion properties of the human intestinal epithelium, aiming to reduce the use of animal tissues, in line with the 3Rs principle-replacement, reduction, and refinement. Specifically, a texture analyzer was used to assess the bioadhesive strength of hydrogels (i.e., alginate (Alg), chitosan (Chit), and gelatin (Gel)) under various applied forces (20-200 mN) and contact times (120-420 s). The results demonstrate that the in vitro model effectively predicts the bioadhesive strength of the tested hydrogels to ex vivo tissues (i.e., from mice, sheep, and pigs), including the effects of applied force and contact time. Also provided is an analysis of the effect of microvilli morphology on bioadhesion where an inverse relationship was observed between microvilli linear density and bioadhesion strength, explaining the variability in results across animal models. This Caco-2-based model offers a practical, accessible, and cost-effective alternative to current ex vivo methods used for measuring bioadhesion fracture strength. It can be integrated into standardized testing protocols, providing a more ethical and scientifically robust approach to advancing bioadhesive drug delivery system research.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400461"},"PeriodicalIF":11.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly Selective Methanol Synthesis Using Electrochemical CO₂ Reduction with Defect-Engineered Cu₅₈ Nanoclusters. 缺陷工程Cu58纳米团簇电化学CO2还原制备高选择性甲醇。

IF 11.1

Small Science Pub Date : 2024-11-28 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400465

Sourav Biswas, Tomoya Tanaka, Haohong Song, Masaki Ogami, Yamato Shingyouchi, Sakiat Hossian, Maho Kamiyama, Taiga Kosaka, Riki Nakatani, Yoshiki Niihori, Saikat Das, Tokuhisa Kawawaki, De-En Jiang, Yuichi Negishi

{"title":"Highly Selective Methanol Synthesis Using Electrochemical CO2 Reduction with Defect-Engineered Cu58 Nanoclusters.","authors":"Sourav Biswas, Tomoya Tanaka, Haohong Song, Masaki Ogami, Yamato Shingyouchi, Sakiat Hossian, Maho Kamiyama, Taiga Kosaka, Riki Nakatani, Yoshiki Niihori, Saikat Das, Tokuhisa Kawawaki, De-En Jiang, Yuichi Negishi","doi":"10.1002/smsc.202400465","DOIUrl":"https://doi.org/10.1002/smsc.202400465","url":null,"abstract":"Atomically precise copper nanoclusters (Cu NCs) exhibit significant potential as catalysts for the electrocatalytic reduction of CO2. However, the range of products achievable with these NCs has been somewhat constrained. This study presents an innovative design strategy to enhance the catalytic activity of Cu NCs by engineering their active sites. These active sites are formed here by introducing defects on cubic Cu NCs through the partial dislocation of Cu atoms at their vertices, which creates surface ligand vacancies. This dislocation further refines the internal cationic geometry by altering cuprophilic interactions, leading to distinct modifications in the edges and vertices of the cubic geometry. These unique Cu(I) atom arrangements within the cluster effectively influence product specificity during electrochemical CO2 reduction. Density functional theory calculations correlate the enhanced selectivity for CH3OH in [Cu58H20(SPr)36(PPh3)7]2+ (Pr = CH2CH2CH3) NC to the increased reactivity of edge Cu atoms in binding CO and CHO intermediates, compared to [Cu58H20(SPr)36(PPh3)8]2+ and [Cu58H20(SEt)36(PPh3)6]2+ (Et = CH2CH3) NCs. Thus, this work underscores the potential of tailored structural designs of atomically precise nanocatalysts in directing electrochemical CO2 reduction toward unconventional products.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400465"},"PeriodicalIF":11.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible and Transparent Ultrathin Gold Electrodes via Ion Beam Smoothing. 通过离子束平滑的柔性透明超薄金电极。

IF 11.1

Small Science Pub Date : 2024-11-27 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400272

Giulio Ferrando, Carlo Mennucci, Matteo Barelli, Maria Caterina Giordano, Francesco Buatier de Mongeot

{"title":"Flexible and Transparent Ultrathin Gold Electrodes via Ion Beam Smoothing.","authors":"Giulio Ferrando, Carlo Mennucci, Matteo Barelli, Maria Caterina Giordano, Francesco Buatier de Mongeot","doi":"10.1002/smsc.202400272","DOIUrl":"https://doi.org/10.1002/smsc.202400272","url":null,"abstract":"Herein, a large-area nanofabrication process is proposed for flexible, ultrathin, and ultrasmooth gold films with extraordinary electro-optical performance, making them competitive as transparent conductive electrodes (TCEs). The approach circumvents the thermodynamic constraints associated with the physical deposition of thin film electrodes, where 3D growth and metal dewetting delay stable percolation until the deposited film thickness exceeds 8-10 nm. It is demonstrated that a postgrowth ion irradiation procedure of compact gold films with Ar+ beam at very low energies, around 100 eV, predominantly induces ballistic smoothing and grain boundary restructuring. This process finally leads to the formation of ultrasmooth and ultrathin gold films that remain compact even at a thickness of 4 nm, with a sheet resistance in the range of 60 Ω sq-1 and an optical transparency around 80%. Remarkably, the films remain percolated even at thicknesses as low as 3 nm, with a transparency exceeding 90% and a sheet resistance of 190 Ω sq-1. These figures are comparable to those of commercial TCEs and enable simple, scalable, all-metal transparent contacts on both rigid and flexible substrates, with significant potential for optoelectronic applications.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 1","pages":"2400272"},"PeriodicalIF":11.1,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound-Responsive Polymeric Piezoelectric Nanoparticles for Remote Activation and Neuronal Differentiation of Human Neural Stem Cells. 超声响应聚合物压电纳米颗粒用于人神经干细胞的远程激活和神经元分化。

IF 11.1

Small Science Pub Date : 2024-11-27 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400354

Arianna Bargero, Matteo Battaglini, Tommaso Curiale, Alessio Carmignani, Margherita Montorsi, Massimiliano Labardi, Carlotta Pucci, Attilio Marino, Gianni Ciofani

{"title":"Ultrasound-Responsive Polymeric Piezoelectric Nanoparticles for Remote Activation and Neuronal Differentiation of Human Neural Stem Cells.","authors":"Arianna Bargero, Matteo Battaglini, Tommaso Curiale, Alessio Carmignani, Margherita Montorsi, Massimiliano Labardi, Carlotta Pucci, Attilio Marino, Gianni Ciofani","doi":"10.1002/smsc.202400354","DOIUrl":"https://doi.org/10.1002/smsc.202400354","url":null,"abstract":"The regenerative capacity of the central nervous system (CNS) is limited. Understanding and enhancing the mechanisms that induce neural differentiation of neural stem cells (NSCs) is crucial for advancing regenerative medicine; one significant challenge in this effort is the remote delivery of pro-differentiation cues. In this framework, a nanotechnology-based solution able to remotely trigger the differentiation of human NSCs (hNSCs) into neurons is proposed. The approach involves organic piezoelectric nanotransducers, which can be remotely activated by low-intensity ultrasound (US) for local and noninvasive electrical stimulation. Highly biocompatible piezoelectric polymeric nanoparticles, when activated by US, demonstrate the ability to induce calcium influx, exit from the cell cycle, and neuronal differentiation in hNSCs, as evidenced by calcium imaging experiments and the expression analysis of the NeuN post-mitotic neural marker; additionally, an increased outgrowth of the developing axons is observed. Gene expression analysis moreover suggests that the neural differentiation mechanism induced by piezoelectric stimulation acts by upregulating the calcium signaling-sensitive NeuroD1 neural inducer and the Lamb1 marker, independently of the c-Jun/c-Fos pathway. Considering the high biocompatibility and the good piezoelectricity of the polymeric nanotransducers used in this work, it is believed that this \"wireless\" stimulation approach holds high potential in CNS regenerative medicine.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400354"},"PeriodicalIF":11.1,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Pulsed-Laser-Driven CO₂ Reduction Reaction for the Control of the Photoluminescence Quantum Yield of Organometallic Gold Nanocomposites". 对“脉冲激光驱动CO2还原反应控制有机金属金纳米复合材料光致发光量子产率”的修正。

IF 11.1

Small Science Pub Date : 2024-11-27 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400569

Tahir, Guilherme C Concas, Mariana Gisbert, Marco Cremona, Fernando Lazaro, Marcelo Eduardo H Maia da Costa, Suellen D T De Barros, Ricardo Q Aucélio, Tatiana Saint Pierre, José Marcus Godoy, Diogo Mendes, Gino Mariotto, Nicola Daldosso, Francesco Enrichi, Alexandre Cuin, Aldebarã F Ferreira, Walter M de Azevedo, Geronimo Perez, Celso SantAnna, Braulio Soares Archanjo, Yordy E Licea Fonseca, Andre L Rossi, Francis L Deepak, Rajwali Khan, Quaid Zaman, Sven Reichenberger, Theo Fromme, Giancarlo Margheri, José R Sabino, Gabriella Fibbi, Mario Del Rosso, Anastasia Chillá, Francesca Margheri, Anna Laurenzana, Tommaso Del Rosso

引用次数: 0

Strong Correlation Between A-Site Cation Order and Self-Trapped Exciton Emission in 0D Hybrid Perovskites. 0D杂化钙钛矿中a位阳离子序与自捕获激子发射的强相关性

IF 11.1

Small Science Pub Date : 2024-11-22 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400443

Feier Fang, Yongwang Shen, Yu Li, Kaimin Shih, Hanlin Hu, Haizhe Zhong, Yumeng Shi, Tom Tao Wu

{"title":"Strong Correlation Between A-Site Cation Order and Self-Trapped Exciton Emission in 0D Hybrid Perovskites.","authors":"Feier Fang, Yongwang Shen, Yu Li, Kaimin Shih, Hanlin Hu, Haizhe Zhong, Yumeng Shi, Tom Tao Wu","doi":"10.1002/smsc.202400443","DOIUrl":"https://doi.org/10.1002/smsc.202400443","url":null,"abstract":"Metal halide perovskites and their derived materials have garnered significant attention as promising materials for solar cell and light-emitting applications. Among them, 0D perovskites, characterized by unique crystallographic/electronic structures with isolated metal halide octahedra, exhibit tremendous potential as light emitters with self-trapped exciton (STE). However, the modulation of STE emission characteristics in 0D perovskites primarily focuses on regulating B- or X-site elements. In this work, a lead-free compound, Sb3+-doped ((C2H5)2NH2)3InCl6 single crystal, which exhibits a high photoluminescence quantum yield, is synthesized, and with increasing temperature, the A-site organic cations undergo a transition from an ordered configuration to a disordered one, accompanied by a redshift in the STE emission. Furthermore, Hirshfeld surface calculations reveal that high temperatures enhance the thermal vibrations of SbCl6 3- clusters and the octahedra distortion, which are responsible for the redshift. Since this thermally triggered transition of A-site order is reversible, it can be exploited for temperature-sensing applications. Overall, in this work, valuable insights are provided into the role of A-site cations in modulating STE emission and the design of efficient light emitters.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400443"},"PeriodicalIF":11.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

m6A Ribonucleic Acid Methylation in Fibrotic Diseases of Visceral Organs. 内脏器官纤维化疾病中的m6A核糖核酸甲基化。

IF 11.1

Small Science Pub Date : 2024-11-21 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400308

Xiaoniu Dai, Yusi Cheng, Wei Luo, Jing Wang, Cuifen Wang, Xinxin Zhang, Wei Zhang, Jie Chao

{"title":"m6A Ribonucleic Acid Methylation in Fibrotic Diseases of Visceral Organs.","authors":"Xiaoniu Dai, Yusi Cheng, Wei Luo, Jing Wang, Cuifen Wang, Xinxin Zhang, Wei Zhang, Jie Chao","doi":"10.1002/smsc.202400308","DOIUrl":"https://doi.org/10.1002/smsc.202400308","url":null,"abstract":"Fibrosis is a pathological process characterized by the excessive deposition of extracellular matrix in the tissue's extracellular space, leading to structural injury and organ dysfunction, and even organ failure, posing a threat to human life. Despite mounting evidence suggesting that fibrosis is reversible, effective treatments for fibrotic diseases are lacking. Accumulating evidence has elucidated that ribonucleic acid (RNA) modifications have emerged as novel mechanisms regulating gene expression. N6-methyladenosine (m6A) modification is a well-known prevalent RNA posttranscriptional modification that participates in essential biological processes such as RNA splicing, translation, and degradation. It is tightly implicated in a wide range of cellular processes and various human diseases, particularly in organ fibrosis. The m6A modification is a dynamic and reversible process regulated by methylases, commonly known as \"writers,\" and demethylases referred to as \"erasers,\" while m6A modifications are recognized by \"readers.\" Accumulating evidence suggests that m6A modification on RNAs is tightly associated with fibrotic diseases of visceral organs including the lungs, heart, liver, and kidney. In this review, recent advances in the impact of m6A methylation of RNAs on visceral organ fibrosis are highlighted and the potential prospects for therapy in treating fibrotic diseases of visceral organs are discussed.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400308"},"PeriodicalIF":11.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphenol-Mediated Multifunctional Human-Machine Interface Hydrogel Electrodes in Bioelectronics. 生物电子学中多酚介导的多功能人机界面水凝胶电极。

IF 11.1

Small Science Pub Date : 2024-11-21 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400362

Lili Jiang, Donglin Gan, Chuangyi Xu, Tingting Zhang, Mingyuan Gao, Chaoming Xie, Denghui Zhang, Xiong Lu

{"title":"Polyphenol-Mediated Multifunctional Human-Machine Interface Hydrogel Electrodes in Bioelectronics.","authors":"Lili Jiang, Donglin Gan, Chuangyi Xu, Tingting Zhang, Mingyuan Gao, Chaoming Xie, Denghui Zhang, Xiong Lu","doi":"10.1002/smsc.202400362","DOIUrl":"https://doi.org/10.1002/smsc.202400362","url":null,"abstract":"Human-machine interface (HMI) electrodes enable interactions between humans and bioelectronic devices by facilitating electrical stimulation and recording neural activity. However, reconciling the soft, hydrated nature of living human tissues with the rigid, dry properties of synthetic electronic systems is inherently challenging. Overcoming these significant differences, which is critical for developing compatible, effective, and stable interfaces, has become a key research area in materials science and technology. Recently, hydrogels have gained prominence for use in HMI electrodes because these soft, hydrated materials are similar in nature to human tissues and can be tuned through the incorporation of nanofillers. This review examines the functional requirements of HMI electrodes and highlights recent progress in the development of polyphenol-mediated multifunctional hydrogel-based HMI electrodes for bioelectronics. Furthermore, aspects such as mussel-inspired and polyphenol-mediated adhesion, underlying mechanisms, tissue-matching mechanical properties, electrochemical performance, biocompatibility, biofouling resistance, stability under physiological conditions, anti-inflammatory, and antioxidant properties are discussed. Finally, applications in bioelectronics and further perspectives are outlined. Advances in HMI hydrogel electrodes are expected to facilitate the unprecedented integration of biological systems and electronic devices, potentially revolutionizing various biomedical fields and enhancing the capabilities and performance of bioelectronic devices.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 1","pages":"2400362"},"PeriodicalIF":11.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micropatterning of Confined Surfaces with Polymer Brushes by Two-Photon-Initiated Reversible Addition-Fragmentation Chain-Transfer Polymerization. 双光子引发的可逆加成-破碎-链转移聚合聚合物刷在受限表面的微图像化。

IF 11.1

Small Science Pub Date : 2024-11-21 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400263

Stefan Helfert, Tommaso Zandrini, Andreas Rohatschek, Manuel Rufin, Peter Machata, Anna Zahoranová, Orestis G Andriotis, Philipp J Thurner, Aleksandr Ovsianikov, Robert Liska, Stefan Baudis

{"title":"Micropatterning of Confined Surfaces with Polymer Brushes by Two-Photon-Initiated Reversible Addition-Fragmentation Chain-Transfer Polymerization.","authors":"Stefan Helfert, Tommaso Zandrini, Andreas Rohatschek, Manuel Rufin, Peter Machata, Anna Zahoranová, Orestis G Andriotis, Philipp J Thurner, Aleksandr Ovsianikov, Robert Liska, Stefan Baudis","doi":"10.1002/smsc.202400263","DOIUrl":"https://doi.org/10.1002/smsc.202400263","url":null,"abstract":"Photopatterned polymer brushes provide a viable option to alter the surface properties of biosensors, substrates for tissue engineering, or microelectronic implants. Although the one-photon direct laser writing enables excellent control over pattern geometry, it has an inherently limited writing resolution caused by the used light source; moreover, no patterning of undercuts or channels is possible. This article describes the preparation of patterned polymer brushes on confined glass substrates using two-photon-initiated reversible addition-fragmentation chain-transfer (2PRAFT) polymerization of N-acryloylmorpholine as a hydrophilic model monomer. The polymer brushes prepared by 2PRAFT exhibit a height of 10 nm, as confirmed by atomic force microscopy. In addition, well-defined printed structures down to 5 μm size are prepared, which outperforms the currently achieved resolution of polymer brushes prepared by one-photon direct laser writing.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 1","pages":"2400263"},"PeriodicalIF":11.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0